Peter Gawthrop

Modular dynamic biomolecular modelling with bond graphs: the unification of stoichiometry, thermodynamics, kinetics and data

Peter J Gawthrop, Michael Pan, Edmund J Crampin

Journal article  |  2021  |  JOURNAL OF THE ROYAL SOCIETY INTERFACE

Renewed interest in dynamic simulation models of biomolecular systems has arisen from advances in genome-wide measurement and appl..

Energy-Based Modeling of the Feedback Control of Biomolecular Systems With Cyclic Flow Modulation

Peter J Gawthrop

Journal article  |  2021  |  IEEE TRANSACTIONS ON NANOBIOSCIENCE

Energy-based modelling brings engineering insight to the understanding of biomolecular systems. It is shown how well-established c..

The cardiac Na /K ATPase: An updated, thermodynamically consistent model

Michael Pan, Peter J Gawthrop, Joseph Cursons, Kenneth Tran, Edmund J Crampin

Journal article  |  2020  |  Physiome

The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over ..

The cardiac Na /K ATPase: An updated, thermodynamically consistent model

Michael Pan, Peter J Gawthrop, Joseph Cursons, Kenneth Tran, Edmund J Crampin

Journal article  |  2020  |  Physiome

The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over ..

Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain

Peter J Gawthrop, Peter Cudmore, Edmund J Crampin

Journal article  |  2020  |  Journal of Theoretical Biology

Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistr..

Intermittent Control of Movement and Balance

Peter Gawthrop, Henrik Gollee, Martin Lakie, Ian D Loram

Reference Work  |  2020

The intermittent control hypothesis proposes that centrally integrated sensorimotor control systems cannot be described by continu..

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2019  |  JOURNAL OF THEORETICAL BIOLOGY

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..

Bond Graph Representation of Chemical Reaction Networks

Peter Gawthrop, Edmund J Crampin

Journal article  |  2018  |  IEEE TRANSACTIONS ON NANOBIOSCIENCE

The Bond Graph approach and the Chemical Reaction Network approach for modeling the biomolecular systems were developed independen..

Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2018  |  PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Mathematical models of cardiac action potentials have become increasingly important in the study of heart disease and pharmacology..

Computing Biomolecular System Steady-States

Peter Gawthrop

Journal article  |  2018  |  IEEE TRANSACTIONS ON NANOBIOSCIENCE

A new approach to compute the equilibria and the steady-states of biomolecular systems modeled by bond graphs is presented. The ap..