Peter Gawthrop

Energy-Based Modeling of the Feedback Control of Biomolecular Systems With Cyclic Flow Modulation

Peter J Gawthrop

Journal article  |  2021  |  IEEE Transactions on NanoBioscience

Energy-based modelling brings engineering insight to the understanding of biomolecular systems. It is shown how well-established c..

Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain

Peter J Gawthrop, Peter Cudmore, Edmund J Crampin

Journal article  |  2020  |  Journal of Theoretical Biology

Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistr..

Intermittent Control of Movement and Balance

Peter Gawthrop, Henrik Gollee, Martin Lakie, Ian D Loram

Reference Work  |  2020

The intermittent control hypothesis proposes that centrally integrated sensorimotor control systems cannot be described by continu..

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2019  |  Journal of Theoretical Biology

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..

Bond Graph Representation of Chemical Reaction Networks

Peter Gawthrop, Edmund J Crampin

Journal article  |  2018  |  IEEE Transactions on NanoBioscience

The Bond Graph approach and the Chemical Reaction Network approach for modeling the biomolecular systems were developed independen..

Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2018  |  Proceedings of the Royal Society A

Mathematical models of cardiac action potentials have become increasingly important in the study of heart disease and pharmacology..

Computing Biomolecular System Steady-States

Peter Gawthrop

Journal article  |  2018  |  IEEE Transactions on NanoBioscience

A new approach to compute the equilibria and the steady-states of biomolecular systems modeled by bond graphs is presented. The ap..

Biomolecular system energetics

PJ Gawthrop, EJ Crampin

Conference Proceedings  |  2018  |  Simulation Series

Efficient energy transduction is one driver of evolution; and thus understanding biomolecular energy transduction is crucial to un..

Visuo-manual tracking: does intermittent control with aperiodic sampling explain linear power and non-linear remnant without sensorimotor noise?

Henrik Gollee, Peter J Gawthrop, Martin Lakie, Ian D Loram

Journal article  |  2017  |  The Journal of Physiology

KEY POINTS: A human controlling an external system is described most easily and conventionally as linearly and continuously transl..

Bond graph modelling of chemoelectrical energy transduction

Peter J Gawthrop, Ivo Siekmann, Tatiana Kameneva, Susmita Saha, Michael R Ibbotson, Edmund J Crampin

Journal article  |  2017  |  IET Systems Biology

Energy-based bond graph modelling of biomolecular systems is extended to include chemoelectrical transduction thus enabling integr..