Clare Slaney

Insights into Cancer Immunotherapies: Recent Breakthroughs, Opportunities, and Challenges

Evan G Pappas, Michael H Kershaw, Clare Y Slaney

Journal article  |  2023  |  CANCERS

This Special Issue reminds us that, although incredible developments have occurred in the field of cancer immunotherapy, there is ..

Editorial: Combining chemo/radio therapy and immunotherapy for cancers-perfect mix of old and new

Clare Y Slaney, Peng Luo, Feng-Ming Kong, Linlang Guo, Jian Zhang

Journal article  |  2023  |  FRONTIERS IN IMMUNOLOGY

Enhancing Adoptive Cell Transfer with Combination BRAF-MEK and CDK4/6 Inhibitors in Melanoma

Peter Kar Han Lau, Carleen Cullinane, Susan Jackson, Rachael Walker, Lorey K Smith, Alison Slater, Laura Kirby, Riyaben P Patel, Bianca von Scheidt, Clare Y Slaney, Grant A McArthur, Karen E Sheppard

Journal article  |  2021  |  CANCERS

Despite the success of immune checkpoint inhibitors that target cytotoxic lymphocyte antigen-4 (CTLA-4) and programmed-cell-death-..

Cellular networks controlling T cell persistence in adoptive cell therapy

Jack D Chan, Junyun Lai, Clare Y Slaney, Axel Kallies, Paul A Beavis, Phillip K Darcy

Journal article  |  2021  |  NATURE REVIEWS IMMUNOLOGY

The antitumour activity of endogenous or adoptively transferred tumour-specific T cells is highly dependent on their differentiati..

A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Aesha Ali, Minyu Wang, Bianca von Scheidt, Pilar M Dominguez, Aaron J Harrison, Daniela GM Tantalo, Jian Kang, Amanda J Oliver, Jack D Chan, Xin Du, Yuchen Bai, Belinda Lee, Ricky W Johnstone, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2021  |  CLINICAL CANCER RESEARCH

PURPOSE: In this article, we describe a combination chimeric antigen receptor (CAR) T-cell therapy that eradicated the majority of..

Priming and boosting immunity in pancreatic cancer: strong anti-tumour effects by combining a CD40 agonist with IL-15 treatment

Jonas Van Audenaerde, Elly Marcq, Bianca Von Scheidt, Ashleigh Davey, Amanda Oliver, Jorrit De Waele, Delphine Quatannens, Jinthe Van Loenhout, Patrick Pauwels, Geert Roeyen, Filip Lardon, Clare Slaney, Marc Peeters, Michael Kershaw, Phil Darcy, Evelien Smits

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Daniela GM Tantalo, Amanda J Oliver, Bianca von Scheidt, Aaron J Harrison, Scott N Mueller, Michael H Kershaw, Clare Y Slaney

Journal article  |  2021  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Rapid advances in immunotherapy have identified adoptive cell transfer as one of the most promising approaches for the treatment o..

Enhancing co-stimulation of CAR T cells to improve treatment outcomes in solid cancers.

Aaron J Harrison, Xin Du, Bianca von Scheidt, Michael H Kershaw, Clare Y Slaney

Journal article  |  2021  |  Immunother Adv

Co-stimulation is a fundamental component of T cell biology and plays a key role in determining the quality of T cell proliferatio..

NOVEL COMBINATION IMMUNOTHERAPY FOR BOOSTING AND PRIMING IMMUNE RESPONSES IN PANCREATIC CANCER: STRONG ANTI-TUMOUR EFFECTS WITH INTERLEUKIN-15 AND CD40 AGONIST TREATMENT

Jonas Van Audenaerde, Elly Marcq, Bianca von Scheidt, Ashleigh Davey, Amanda Oliver, Jorrit De Waele, Delphine Quatannens, Jinthe Van Loenhout, Patrick Pauwels, Geert Roeyen, Filip Lardon, Clare Slaney, Marc Peeters, Michael Kershaw, Phillip Darcy, Evelien Smits

Conference Proceedings  |  2020  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Background With the poorest 5-year survival of all cancers, improving treatment for pancreatic cancer is one of the biggest chall..

Challenges and Opportunities for Effective Cancer Immunotherapies

Clare Y Slaney, Michael H Kershaw

Journal article  |  2020  |  CANCERS

Using immunotherapy to treat cancers can be traced back to the 1890s, where a New York physician William Coley used heat-killed ba..