Christine Seers

A multicentre study reveals dysbiosis in the microbial co-infection and antimicrobial resistance gene profile in the nasopharynx of COVID-19 patients.

A Sayeed M Mahmud, Christine A Seers, Aftab Ali Shaikh, Tarannum Taznin, Mohammad Samir Uzzaman, Eshrar Osman, Md Ahashan Habib, Shahina Akter, Tanjina Akhtar Banu, Md Murshed Hasan Sarkar, Barna Goswami, Iffat Jahan, Chioma M Okeoma, Md Salim Khan, Eric C Reynolds

Journal article  |  2023  |  Sci Rep

The impact of SARS-CoV-2 infection on the nasopharyngeal microbiome has not been well characterised. We sequenced genetic material..

Type B CTD Proteins Secreted by the Type IX Secretion System Associate with PorP-like Proteins for Cell Surface Anchorage

Dhana G Gorasia, Christine A Seers, Jacqueline E Heath, Michelle D Glew, Hamid Soleimaninejad, Catherine A Butler, Mark J McBride, Paul D Veith, Eric C Reynolds

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Bacteroidetes type IX secretion system (T9SS) consists of at least 20 components that translocate proteins with type A or type..

Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

Christine A Seers, A Sayeed M Mahmud, N Laila Huq, Keith J Cross, Eric C Reynolds

Journal article  |  2021  |  JOURNAL OF ORAL MICROBIOLOGY

Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors ..

Extracellular Vesicles in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review

Tami Yap, Neha Pruthi, Christine Seers, Simone Belobrov, Michael McCullough, Antonio Celentano

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles (EVs) are secreted from most cell types and utilized in a complex network of near and distant cell-to-cell ..

Non-invasive screening of a microRNA-based dysregulation signature in oral cancer and oral potentially malignant disorders

T Yap, C Seers, K Koo, L Cheng, LJ Vella, AF Hill, E Reynolds, A Nastri, N Cirillo, M McCullough

Journal article  |  2019  |  ORAL ONCOLOGY

INTRODUCTION: We have previously shown that oral swirls are a robust source of microRNA protected by extracellular vesicles, poten..

Molecular diagnostics in oral cancer and oral potentially malignant disorders-A clinician's guide

Tami Yap, Antonio Celentano, Christine Seers, Michael J McCullough, Camile S Farah

Journal article  |  2019  |  JOURNAL OF ORAL PATHOLOGY & MEDICINE

Current risk stratification of individuals for the development of oral squamous cell carcinoma (OSCC), including those with oral p..

Functional and molecular effects of a green tea constituent on oral cancer cells

Simone Belobrov, Christine Seers, Eric Reynolds, Nicola Cirillo, Michael McCullough

Journal article  |  2019  |  JOURNAL OF ORAL PATHOLOGY & MEDICINE

BACKGROUND: Green tea is heavily consumed on a global basis for its health benefits. The active ingredient, (-)-epigallocatechin g..

Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls

Tami Yap, Kendrick Koo, Lesley Cheng, Laura J Vella, Andrew F Hill, Eric Reynolds, Alf Nastri, Nicola Cirillo, Christine Seers, Michael McCullough

Journal article  |  2018  |  CANCER PREVENTION RESEARCH

Oral swirls are a noninvasive, rapidly collected source of salivary microRNA (miRNA) potentially useful in the early detection of ..

Porphyromonas gingivalis Gingipains Display Transpeptidation Activity

Lianyi Zhang, Paul D Veith, N Laila Huq, Yu-Yen Chen, Christine A Seers, Keith J Cross, Dhana G Gorasia, Eric C Reynolds

Journal article  |  2018  |  JOURNAL OF PROTEOME RESEARCH

Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface p..

A panel of microRNAs can be used to determine oral squamous cell carcinoma

Gareema Prasad, Christine Seers, Eric Reynolds, Michael J McCullough

Journal article  |  2017  |  JOURNAL OF ORAL PATHOLOGY & MEDICINE

BACKGROUND: Subjective histopathology is currently used to diagnose oral squamous cell carcinoma (OSCC). We tested if abundances o..