Christine Seers is a Senior Research Fellow in the Melbourne Dental School. Most of her current research fits under the umbrella of oral disease, particularly the chronic human disease periodontitis and oral cancer.Her research has involved determination of the molecular interactions that underpin the relationships of oral pathobionts and the human host as well as biomarkers of oral malignancy.
Christine is undertaking research into bacterial virulence factors important in oral colonisation and disease, development of a vaccine for prevention of periodontitis and use of saliva as a non-invasive patient sample containing biomarkers useful for early diagnosis of oral carcinoma. The long-term aim of these studies is to develop novel strategies for the prevention and treatment of oral diseases. Christine is an author on high impact peer reviewed publications with the research funded by the NH&MRC, the Cooperative Research Center scheme and Australian Dental Research Foundation. Christine has received the Colgate Young Investigator Award, the International Association for Dental Research (IADR)-EH Hatton Award and the IADR John A. Gray Fellowship. Christine is an active member of The Australian Society for Microbiology (Vic Branch committee, Secretary and Treasurer). She has been a research leader in two Oral Health Cooperative Research Centres (2003-2019) and the spin-off biotech company Denteric, where she is involved in the translation of basic research into commercial products. She has supervised PhD, Doctor of Clinical Dentistry and BSc(Hons) students to completion. She has had a research role the Melbourne Dental School for over 30 years.
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Christine Seers' highlights
Christine Seers' selected work
The Effect Of Gingipain Propeptides On P. Gingivalis Biofilm Formation And The Effect Of G..
Non-invasive screening of a microRNA-based dysregulation signature in oral cancer and oral..
Molecular diagnostics in oral cancer and oral potentially malignant disorders-A clinician'..
Displaying the 5 most recent projects by Christine Seers.
Displaying the 37 most recent scholarly works by Christine Seers.
Extracellular Vesicles in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review
Tami Yap, Neha Pruthi, Christine Seers, Simone Belobrov, Michael McCullough, Antonio Celentano
Journal article | 2020 | International Journal of Molecular Sciences
Extracellular vesicles (EVs) are secreted from most cell types and utilized in a complex network of near and distant cell-to-cell ..
Molecular diagnostics in oral cancer and oral potentially malignant disorders-A clinician's guide
Tami Yap, Antonio Celentano, Christine Seers, Michael J McCullough, Camile S Farah
Journal article | 2019 | Journal of Oral Pathology & Medicine
Current risk stratification of individuals for the development of oral squamous cell carcinoma (OSCC), including those with oral p..
Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls
Tami Yap, Kendrick Koo, Lesley Cheng, Laura J Vella, Andrew F Hill, Eric Reynolds, Alf Nastri, Nicola Cirillo, Christine Seers, Michael McCullough
Journal article | 2018 | Cancer Prevention Research
Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors
Stuart G Dashper, Helen L Mitchell, Christine A Seers, Simon L Gladman, Torsten Seemann, Dieter M Bulach, P Scott Chandry, Keith J Cross, Steven M Cleal, Ericc Reynolds
Journal article | 2017 | FRONTIERS IN MICROBIOLOGY
PG1058 Is a Novel Multidomain Protein Component of the Bacterial Type IX Secretion System
Jacqueline E Heath, Christine A Seers, Paul D Veith, Catherine A Butler, Nor A Nor Muhammad, Yu-Yen Chen, Nada Slakeski, Benjamin Peng, Lianyi Zhang, Stuart G Dashper, Keith J Cross, Steven M Cleal, Caroline Moore, Eric C Reynolds
Journal article | 2016 | PLOS ONE
The Porphyromonas gingivalis Ferric Uptake Regulator Orthologue Binds Hemin and Regulates Hemin-Responsive Biofilm Development
Catherine A Butler, Stuart G Dashper, Lianyi Zhang, Christine A Seers, Helen L Mitchell, Deanne V Catmull, Michelle D Glew, Jacqueline E Heath, Yan Tan, Hasnah SG Khan, Eric C Reynolds
Journal article | 2014 | PLOS ONE
Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses
Kheng H Tan, Christine A Seers, Stuart G Dashper, Helen L Mitchell, James S Pyke, Vincent Meuric, Nada Slakeski, Steven M Cleal, Jenny L Chambers, Malcolm J McConville, Eric C Reynolds
Journal article | 2014 | PLOS PATHOGENS
FimR and FimS: Biofilm Formation and Gene Expression in Porphyromonas gingivalis
Alvin Lo, Christine Seers, Stuart Dashper, Catherine Butler, Glenn Walker, Katrina Walsh, Deanne Catmull, Brigitte Hoffmann, Steven Cleal, Patricia Lissel, John Boyce, Eric Reynolds
Journal article | 2010 | Journal of Bacteriology
Response of Porphyromonas gingivalis to Heme Limitation in Continuous Culture
Stuart G Dashper, Ching-Seng Ang, Paul D Veith, Helen L Mitchell, Alvin WH Lo, Christine A Seers, Katrina A Walsh, Nada Slakeski, Dina Chen, J Patricia Lissel, Catherine A Butler, Neil M O'Brien-Simpson, Ian G Barr, Eric C Reynolds
Journal article | 2009 | Journal of Bacteriology
The RgpB C-terminal domain has a role in attachment of RgpB to the outer membrane and belongs to a novel C-terminal-domain family found in Porphyromonas gingivalis
Christine A Seers, Nada Slakeski, Paul D Veith, Todd Nikolof, Yu-Yen Chen, Stuart G Dashper, Eric C Reynolds
Journal article | 2006 | Journal of Bacteriology
COMPLETE NUCLEOTIDE-SEQUENCE OF A GENE PRTR OF PORPHYROMONAS-GINGIVALIS W50 ENCODING A 132KDA PROTEIN THAT CONTAINS AN ARGININE-SPECIFIC THIOL ENDOPEPTIDASE DOMAIN AND A HEMAGGLUTININ DOMAIN
L KIRSZBAUM, C SOTIROPOULOS, C JACKSON, S CLEAL, N SLAKESKI, EC REYNOLDS
Journal article | 1995 | Biochemical and Biophysical Research Communications
Honours, Awards and Fellowships
John A GrayFellowship
Edward H. Hatton Award Predoctoral category
Colgate Prize for Dental Research
Dora Lush Biomedical Research Sholarship
Senior Research Fellow
Melbourne Dental School
American Society for Microbiology
Australian Society for Microbiology
International Association for Dental Research
Doctor of Philosophy
University of Melbourne
Bachelor of Science