Christine Seers

Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

Christine A Seers, A Sayeed M Mahmud, N Laila Huq, Keith J Cross, Eric C Reynolds

Journal article  |  2021  |  JOURNAL OF ORAL MICROBIOLOGY

Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors ..

Extracellular Vesicles in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review

Tami Yap, Neha Pruthi, Christine Seers, Simone Belobrov, Michael McCullough, Antonio Celentano

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles (EVs) are secreted from most cell types and utilized in a complex network of near and distant cell-to-cell ..

Non-invasive screening of a microRNA-based dysregulation signature in oral cancer and oral potentially malignant disorders

T Yap, C Seers, K Koo, L Cheng, LJ Vella, AF Hill, E Reynolds, A Nastri, N Cirillo, M McCullough

Journal article  |  2019  |  ORAL ONCOLOGY

INTRODUCTION: We have previously shown that oral swirls are a robust source of microRNA protected by extracellular vesicles, poten..

Molecular diagnostics in oral cancer and oral potentially malignant disorders-A clinician's guide

Tami Yap, Antonio Celentano, Christine Seers, Michael J McCullough, Camile S Farah

Journal article  |  2019  |  JOURNAL OF ORAL PATHOLOGY & MEDICINE

Current risk stratification of individuals for the development of oral squamous cell carcinoma (OSCC), including those with oral p..

Functional and molecular effects of a green tea constituent on oral cancer cells

Simone Belobrov, Christine Seers, Eric Reynolds, Nicola Cirillo, Michael McCullough

Journal article  |  2019  |  JOURNAL OF ORAL PATHOLOGY & MEDICINE

BACKGROUND: Green tea is heavily consumed on a global basis for its health benefits. The active ingredient, (-)-epigallocatechin g..

Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls

Tami Yap, Kendrick Koo, Lesley Cheng, Laura J Vella, Andrew F Hill, Eric Reynolds, Alf Nastri, Nicola Cirillo, Christine Seers, Michael McCullough

Journal article  |  2018  |  CANCER PREVENTION RESEARCH

Oral swirls are a noninvasive, rapidly collected source of salivary microRNA (miRNA) potentially useful in the early detection of ..

Porphyromonas gingivalis Gingipains Display Transpeptidation Activity

Lianyi Zhang, Paul D Veith, N Laila Huq, Yu-Yen Chen, Christine A Seers, Keith J Cross, Dhana G Gorasia, Eric C Reynolds

Journal article  |  2018  |  JOURNAL OF PROTEOME RESEARCH

Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface p..

A panel of microRNAs can be used to determine oral squamous cell carcinoma

Gareema Prasad, Christine Seers, Eric Reynolds, Michael J McCullough

Journal article  |  2017  |  JOURNAL OF ORAL PATHOLOGY & MEDICINE

BACKGROUND: Subjective histopathology is currently used to diagnose oral squamous cell carcinoma (OSCC). We tested if abundances o..

The assessment of the robustness of microRNAs from oral cytological scrapings

Gareema Prasad, Christine Seers, Eric Reynolds, Michael J McCullough

Journal article  |  2017  |  JOURNAL OF ORAL PATHOLOGY & MEDICINE

BACKGROUND: Sampling of suspect oral lesions in the general dental clinic may increase early carcinoma detection thus oral cancer ..

Oral swirl samples - a robust source of microRNA protected by extracellular vesicles

T Yap, LJ Vella, C Seers, A Nastri, E Reynolds, N Cirillo, M McCullough

Journal article  |  2017  |  ORAL DISEASES

BACKGROUND: MicroRNAs are small non-coding RNAs which are dysregulated in disease states, such as oral cancer. Extracellular vesic..