Nadia Kershaw

Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9

Jarrod J Sandow, Andrew I Webb, Dina Stockwell, Nadia J Kershaw, Cyrus Tan, Satoshi Ishido, Warren S Alexander, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola

Journal article  |  2021  |  PROTEOMICS

MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface ex..

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chueh, Judy Doherty, Francois Vaillant, Gwo-Yaw Ho, Matthew J Wakefield, Clare E Weeden, Alvin Kamili, Jayne Murray, Sela T Po'uha, Janet Weinstock, Serena R Kane, Maree C Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J Kershaw, et al.

Journal article  |  2021  |  CELL DEATH & DISEASE

Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limita..

Diversity in the intrinsic apoptosis pathway of nematodes

Neil D Young, Tiffany J Harris, Marco Evangelista, Sharon Tran, Merridee A Wouters, Tatiana P Soares da Costa, Nadia J Kershaw, Robin B Gasser, Brian J Smith, Erinna F Lee, W Douglas Fairlie

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, su..

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

Nicholas PD Liau, Artem Laktyushin, Rhiannon Morris, Jarrod J Sandow, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2019  |  CANCERS

Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cyt..

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.

Inga Pfeffer, Lennart Brewitz, Tobias Krojer, Sacha A Jensen, Grazyna T Kochan, Nadia J Kershaw, Kirsty S Hewitson, Luke A McNeill, Holger Kramer, Martin Münzel, Richard J Hopkinson, Udo Oppermann, Penny A Handford, Michael A McDonough, Christopher J Schofield

Journal article  |  2019  |  Nat Commun

AspH is an endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and tetratricopeptide ..

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses

Thomas J Hayman, Alan C Hsu, Tatiana B Kolesnik, Laura F Dagley, Joschka Willemsen, Michelle D Tate, Paul J Baker, Nadia J Kershaw, Lukasz Kedzierski, Andrew Webb, Peter A Wark, Katherine Kedzierska, Seth L Masters, Gabrielle T Belz, Marco Binder, Philip M Hansbro, Nicos A Nicola, Sandra E Nicholson

Journal article  |  2019  |  IMMUNOLOGY AND CELL BIOLOGY

The innate immune system is our first line of defense against viral pathogens. Host cell pattern recognition receptors sense viral..

The molecular details of cytokine signaling via the JAK/STAT pathway

Rhiannon Morris, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2018  |  PROTEIN SCIENCE

More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune re..

The molecular basis of JAK/STAT inhibition by SOCS1

Nicholas PD Liau, Artem Laktyushin, Isabelle S Lucet, James M Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2018  |  NATURE COMMUNICATIONS

The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway...

Identification of a second binding site on the TRIM25 B30.2 domain

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson

Journal article  |  2018  |  BIOCHEMICAL JOURNAL

The retinoic acid-inducible gene-I (RIG-I) receptor recognizes short 5'-di- and triphosphate base-paired viral RNA and is a critic..

JAK1 Takes a FERM Hold of Type II Cytokine Receptors

Jeffrey J Babon, Nicholas PD Liau, Nadia J Kershaw

Journal article  |  2016  |  STRUCTURE

Janus kinases (JAKs) initiate the intracellular signaling cascade triggered by exposure of cells to cytokines and interferons. In ..