Nadia Kershaw

The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo.

Karen Doggett, Narelle Keating, Farhad Dehkhoda, Grace M Bidgood, Lizeth G Meza Guzman, Evelyn Leong, Andrew Kueh, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon, Warren S Alexander, Sandra E Nicholson

Journal article  |  2023  |  Cytokine

Suppressor Of Cytokine Signaling (SOCS) 1 is a critical negative regulator of cytokine signaling and required to protect against a..

S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer.

Ronnie Ren Jie Low, Ka Yee Fung, Hugh Gao, Adele Preaudet, Laura F Dagley, Jumana Yousef, Belinda Lee, Samantha J Emery-Corbin, Paul M Nguyen, Rune H Larsen, Nadia J Kershaw, Antony W Burgess, Peter Gibbs, Frédéric Hollande, Michael DW Griffin, Sean M Grimmond, Tracy L Putoczki

Journal article  |  2023  |  Cell Death Differ

Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT, and mesenchymal states, each of whic..

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.

Kunlun Li, Lizeth G Meza Guzman, Lachlan Whitehead, Evelyn Leong, Andrew Kueh, Warren S Alexander, Nadia J Kershaw, Jeffrey J Babon, Karen Doggett, Sandra E Nicholson

Journal article  |  2022  |  Biosci Rep

Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice ..

The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis

Rhiannon Morris, Liesl Butler, Andrew Perkins, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2022  |  PHARMACEUTICALS

LNK is a member of the SH2B family of adaptor proteins and is a non-redundant regulator of cytokine signalling. Cytokines are secr..

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Edmond M Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J Calleja, Narelle Keating, Rebecca Feltham, Andrew J Brooks, Shawn S Li, Sachdev S Sidhu, Jeffrey J Babon, Nadia J Kershaw, Sandra E Nicholson

Journal article  |  2021  |  NATURE COMMUNICATIONS

Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Sig..

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK

Rhiannon Morris, Yaoyuan Zhang, Julia Ellyard, Carola G Vinuesa, James M Murphy, Artem Laktyushin, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2021  |  NATURE COMMUNICATIONS

The SH2B family of adaptor proteins, SH2-B, APS, and LNK are key modulators of cellular signalling pathways. Whilst SH2-B and APS ..

Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9

Jarrod J Sandow, Andrew I Webb, Dina Stockwell, Nadia J Kershaw, Cyrus Tan, Satoshi Ishido, Warren S Alexander, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola

Journal article  |  2021  |  PROTEOMICS

MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface ex..

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chueh, Judy Doherty, Francois Vaillant, Gwo-Yaw Ho, Matthew J Wakefield, Clare E Weeden, Alvin Kamili, Jayne Murray, Sela T Po'uha, Janet Weinstock, Serena R Kane, Maree C Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J Kershaw, et al.

Journal article  |  2021  |  CELL DEATH & DISEASE

Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limita..

Diversity in the intrinsic apoptosis pathway of nematodes

Neil D Young, Tiffany J Harris, Marco Evangelista, Sharon Tran, Merridee A Wouters, Tatiana P Soares da Costa, Nadia J Kershaw, Robin B Gasser, Brian J Smith, Erinna F Lee, W Douglas Fairlie

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, su..

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

Nicholas PD Liau, Artem Laktyushin, Rhiannon Morris, Jarrod J Sandow, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2019  |  CANCERS

Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cyt..