Nadia Kershaw

Diversity in the intrinsic apoptosis pathway of nematodes

Neil D Young, Tiffany J Harris, Marco Evangelista, Sharon Tran, Merridee A Wouters, Tatiana P Soares da Costa, Nadia J Kershaw, Robin B Gasser, Brian J Smith, Erinna F Lee, W Douglas Fairlie

Journal article  |  2020  |  Communications Biology

Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, su..

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

Nicholas PD Liau, Artem Laktyushin, Rhiannon Morris, Jarrod J Sandow, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2019  |  Cancers

Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cyt..

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.

Inga Pfeffer, Lennart Brewitz, Tobias Krojer, Sacha A Jensen, Grazyna T Kochan, Nadia J Kershaw, Kirsty S Hewitson, Luke A McNeill, Holger Kramer, Martin Münzel, Richard J Hopkinson, Udo Oppermann, Penny A Handford, Michael A McDonough, Christopher J Schofield

Journal article  |  2019  |  Nature Communications

AspH is an endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and tetratricopeptide ..

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses

Thomas J Hayman, Alan C Hsu, Tatiana B Kolesnik, Laura F Dagley, Joschka Willemsen, Michelle D Tate, Paul J Baker, Nadia J Kershaw, Lukasz Kedzierski, Andrew Webb, Peter A Wark, Katherine Kedzierska, Seth L Masters, Gabrielle T Belz, Marco Binder, Philip M Hansbro, Nicos A Nicola, Sandra E Nicholson

Journal article  |  2019  |  Immunology & Cell Biology

The innate immune system is our first line of defence against viral pathogens. Host cell pattern recognition receptors (PRRs) sens..

The molecular details of cytokine signaling via the JAK/STAT pathway

Rhiannon Morris, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2018  |  Protein Science

The molecular basis of JAK/STAT inhibition by SOCS1

Nicholas PD Liau, Artem Laktyushin, Isabelle S Lucet, James M Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2018  |  Nature Communications

Identification of a second binding site on the TRIM25 B30.2 domain

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson

Journal article  |  2018  |  Biochemical Journal

JAK1 Takes a FERM Hold of Type II Cytokine Receptors

Jeffrey J Babon, Nicholas PD Liau, Nadia J Kershaw

Journal article  |  2016  |  Structure

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Roybel R Ramiscal, Ian A Parish, Robert S Lee-Young, Jeffrey J Babon, Julianna Blagih, Alvin Pratama, Jaime Martin, Naomi Hawley, Jean Y Cappello, Pablo F Nieto, Julia I Ellyard, Nadia J Kershaw, Rebecca A Sweet, Christopher C Goodnow, Russell G Jones, Mark A Febbraio, Carola G Vinuesa, Vicki Athanasopoulos

Journal article  |  2015  |  eLife

alpha/beta-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

James W Checco, Erinna F Lee, Marco Evangelista, Nerida J Sleebs, Kelly Rogers, Anne Pettikiriarachchi, Nadia J Kershaw, Geoffrey A Eddinger, David G Belair, Julia L Wilson, Chelcie H Eller, Ronald T Raines, William L Murphy, Brian J Smith, Samuel H Gellman, W Douglas Fairlie

Journal article  |  2015  |  Journal of the American Chemical Society