Nicola Cirillo

COVID-19 outbreak: succinct advice for dentists and oral healthcare professionals

Nicola Cirillo

Journal article  |  2020  |  Clinical Oral Investigations

Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells

Antonio Celentano, Tami Yap, Rita Paolini, Callisthenis Yiannis, Michiko Mirams, Kendrick Koo, Michael McCullough, Nicola Cirillo

Journal article  |  2020  |  Journal of Oral Pathology & Medicine

BACKGROUND: Matrix metalloproteinases (MMPs) play a crucial role in the malignant phenotype of cancer cells. In particular, active..

The molecular markers of cancer stem cells in head and neck tumors

Si Si Yu, Nicola Cirillo

Journal article  |  2020  |  Journal of Cellular Physiology

Head and neck cancer (HNC) is the six most common malignancy worldwide leading to more than 350,000 deaths annually. Despite recen..

Non-invasive screening of a microRNA-based dysregulation signature in oral cancer and oral potentially malignant disorders

T Yap, C Seers, K Koo, L Cheng, LJ Vella, AF Hill, E Reynolds, A Nastri, N Cirillo, M McCullough

Journal article  |  2019  |  Oral Oncology

The immunopathogenesis of oral lichen planus-Is there a role for mucosal associated invariant T cells?

Lara M DeAngelis, Nicola Cirillo, Michael J McCullough

Journal article  |  2019  |  Journal of Oral Pathology & Medicine

Oral lichen planus (OLP) is a chronic, T-cell-mediated, immune condition of unknown cause. OLP may present with painful symptoms r..

Functional and molecular effects of a green tea constituent on oral cancer cells

Simone Belobrov, Christine Seers, Eric Reynolds, Nicola Cirillo, Michael McCullough

Journal article  |  2019  |  Journal of Oral Pathology & Medicine

Prognostic significance of CD68( ) and CD163( ) tumor associated macrophages in head and neck squamous cell carcinoma: A systematic review and meta-analysis

Giuseppe Troiano, Vito Carlo Alberto Caponio, Iolanda Adipietro, Michele Tepedino, Rossella Santoro, Luigi Laino, Lucio Lo Russo, Nicola Cirillo, Lorenzo Lo Muzio

Journal article  |  2019  |  Oral Oncology

Abstract

Conference Proceedings  |  2019  |  Journal of Oral Pathology & Medicine

Glucocorticoids reduce chemotherapeutic effectiveness on OSCC cells via glucose-dependent mechanisms

Antonio Celentano, Michael McCullough, Nicola Cirillo

Journal article  |  2019  |  Journal of Cellular Physiology

A biophysically-defined hyaluronic acid-based compound accelerates migration and stimulates the production of keratinocyte-derived neuromodulators

Annalisa La Gatta, Antonella D'Agostino, Chiara Schiraldi, Giuseppe Colella, Nicola Cirillo

Journal article  |  2019  |  Cell Adhesion & Migration

Monospecies and polymicrobial biofilms differentially regulate the phenotype of genotype-specific oral cancer cells

Mohd Hafiz Arzmi, Nicola Cirillo, Jason C Lenzo, Deanne V Catmull, Neil O'Brien-Simpson, Eric C Reynolds, Stuart Dashper, Michael McCullough

Journal article  |  2019  |  Carcinogenesis

Glucocorticoids reduce chemotherapeutic effectiveness on OSCC cells via glucose-dependent mechanisms

Antonio Celentano, Michael McCullough, Nicola Cirillo

Journal article  |  2018  |  Journal of Cellular Physiology

Synthetic corticosteroids are routinely administered during the treatment of several diseases, including malignancies. However, re..

Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls

Tami Yap, Kendrick Koo, Lesley Cheng, Laura J Vella, Andrew F Hill, Eric Reynolds, Alf Nastri, Nicola Cirillo, Christine Seers, Michael McCullough

Journal article  |  2018  |  Cancer Prevention Research

Predictive Prognostic Value of Tissue-Based MicroRNA Expression in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.

G Troiano, F Mastrangelo, VCA Caponio, L Laino, N Cirillo, L Lo Muzio

Journal article  |  2018  |  Journal of Dental Research

Oral squamous cell carcinoma (OSCC) is a common type of cancer characterized by a low survival rate, mostly due to local recurrenc..

Diagnostic patterns and delays in autoimmune blistering diseases of the mouth: A cross-sectional study

Y Hassona, N Cirillo, D Taimeh, H Al Khawaldeh, F Sawair

Journal article  |  2018  |  Oral Diseases

Role of tissue-specific steroid metabolism in oral disease: Is there any clinical implication?

N Cirillo

Journal article  |  2018  |  Oral Diseases

Oral keratinocytes synthesize CTACK: A new insight into the pathophysiology of the oral mucosa

Alison Marshall, Antonio Celentano, Nicola Cirillo, Michael McCullough, Stephen Porter

Journal article  |  2018  |  Experimental Dermatology

Characterisation of the cancer-associated glucocorticoid system: key role of 11 beta-hydroxysteroid dehydrogenase type 2

Nicola Cirillo, David J Morgan, Maria Carmela Pedicillo, Antonio Celentano, Lorenzo Lo Muzio, Michael J McCullough, Stephen S Prime

Journal article  |  2017  |  British Journal of Cancer

Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus

Alison Marshall, Antonio Celentano, Nicola Cirillo, Michiko Mirams, Michael McCullough, Stephen Porter

Journal article  |  2017  |  Journal of Oral Science

Delayed Diagnosis of a Nasal Type Lymphoma Misdiagnosed as Persistent Sinusitis

Antonio Celentano, Massimo Mascolo, Nicola Cirillo, Gaetano De Rosa, Michele Davide Mignogna

Journal article  |  2017  |  Journal of Adolescent and Young Adult Oncology

Oral swirl samples - a robust source of microRNA protected by extracellular vesicles

T Yap, LJ Vella, C Seers, A Nastri, E Reynolds, N Cirillo, M McCullough

Journal article  |  2017  |  Oral Diseases

Tissue-specific regulation of CXCL9/10/11 chemokines in keratinocytes: Implications for oral inflammatory disease

Alison Marshall, Antonio Celentano, Nicola Cirillo, Michael McCullough, Stephen Porter

Journal article  |  2017  |  PLOS ONE

Pathophysiology of the Desmo-Adhesome

Antonio Celentano, Michele Davide Mignogna, Michael McCullough, Nicola Cirillo

Journal article  |  2017  |  Journal of Cellular Physiology

Cover Image, Volume 232, Number 3, March 2017.

Antonio Celentano, Michele Davide Mignogna, Michael McCullough, Nicola Cirillo

Original Creative Work - Other  |  2017  |  Journal of Cellular Physiology

Cover: The cover image, by Celentano et al., is based on the Review Article Pathophysiology of the Desmo-Adhesome, DOI: 10.1002/jc..

Desmosomes in disease: a guide for clinicians

A Celentano, N Cirillo

Journal article  |  2017  |  Oral Diseases

Fibroblast activation and senescence in oral cancer

SS Prime, N Cirillo, Y Hassona, DW Lambert, IC Paterson, M Mellone, GJ Thomas, ENL James, EK Parkinson

Journal article  |  2017  |  Journal of Oral Pathology & Medicine

Cancer-associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-beta-dependent pathways in genotype-specific oral cancer

N Cirillo, Y Hassona, A Celentano, KP Lim, S Manchella, EK Parkinson, SS Prime

Journal article  |  2017  |  Carcinogenesis

Polymicrobial biofilm formation by Candida albicans, Actinomyces naeslundii, and Streptococcus mutans is Candida albicans strain and medium dependent

Mohd Hafiz Arzmi, Ali D Alnuaimi, Stuart Dashper, Nicola Cirillo, Eric C Reynolds, Michael McCullough

Journal article  |  2016  |  Medical Mycology

Monopathogenic vs multipathogenic explanations of pemphigus pathophysiology

A Razzaque Ahmed, Marco Carrozzo, Frederic Caux, Nicola Cirillo, Marian Dmochowski, Agustin Espana Alonso, Robert Gniadecki, Michael Hertl, Maria J Lopez-Zabalza, Roberta Lotti, Carlo Pincelli, Mark Pittelkow, Enno Schmidt, Animesh A Sinha, Eli Sprecher, Sergei A Grando

Journal article  |  2016  |  Experimental Dermatology

The Non-Conventional Effects of Glucocorticoids in Cancer

Simra Azher, Omid Azami, Caterina Amato, Michael McCullough, Antonio Celentano, Nicola Cirillo

Journal article  |  2016  |  Journal of Cellular Physiology

Antimicrobial activity and regulation of CXCL9 and CXCL10 in oral keratinocytes

Alison Marshall, Antonio Celentano, Nicola Cirillo, Michele D Mignogna, Michael McCullough, Stephen Porter

Journal article  |  2016  |  European Journal of Oral Sciences

Oral lichen planus: a literature review and update

Mohammad S Alrashdan, Nicola Cirillo, Michael McCullough

Journal article  |  2016  |  Archives of Dermatological Research

Original Research

Conference Proceedings  |  2016  |  Oral Diseases

The predictive power of the desmo-adhesome

Nicola Cirillo, Stephen S Prime

Journal article  |  2016  |  Cellular and Molecular Life Sciences

Desmosome assembly, homeostasis, and desmosomal disease

Nicola Cirillo

Journal article  |  2016  |  Cell Health and Cytoskeleton

Smoking habits and clinical patterns can alter the inflammatory infiltrate in oral lichenoid lesions

Mohammad S Alrashdan, Christopher Angel, Nicola Cirillo, Michael McCullough

Journal article  |  2016  |  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Coaggregation of Candida albicans, Actinomyces naeslundii and Streptococcus mutans is Candida albicans strain dependent

Mohd Hafiz Arzmi, Stuart Dashper, Deanne Catmull, Nicola Cirillo, Eric C Reynolds, Michael McCullough

Journal article  |  2015  |  FEMS Yeast Research

A Hyaluronic Acid-Based Compound Inhibits Fibroblast Senescence Induced by Oxidative Stress In Vitro and Prevents Oral Mucositis In Vivo

Nicola Cirillo, Antonio Vicidomini, Michael McCullough, Antonio Gambardella, Yazan Hassona, Stephen S Prime, Giuseppe Colella

Journal article  |  2015  |  Journal of Cellular Physiology

Introducing CREATING, a plan for dental higher education in Saudi Arabia

Nicola Cirillo

Journal article  |  2015  |  The Saudi Dental Journal

CREATING: a sustainable plan for biomedical higher education in Saudi Arabia. Phase I

Nicola Cirillo, Emad AlShwaimi, Stephen S Prime, Abdulmonem Al-Hayani

Journal article  |  2015  |  International journal of health sciences

Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion

Y Hassona, N Cirillo, K Heesom, EK Parkinson, SS Prime

Journal article  |  2014  |  British Journal of Cancer

Unexpected resilience to experimental gingivitis of subepithelial connective tissue grafts in gingival recession defects: a clinical-molecular evaluation

A Graziano, N Cirillo, S Pallotti, L Cricenti, F Romano, M Aimetti

Journal article  |  2014  |  Journal of Periodontal Research

GAINING MORE INSIGHT INTO THE DETERMINANTS OF CANDIDA SPECIES PATHOGENICITY IN THE ORAL CAVITY

MH Arzmi, E Alshwaimi, WH Himratul-Aznita, F Abdul Razak, F Farina, MJ McCullough, N Cirillo

Journal article  |  2014  |  Inflammation

150th anniversary series: Desmosomes in physiology and disease

Nicola Cirillo

Journal article  |  2014  |  Cell Communication & Adhesion

Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of plakophilin 3 and its detachment from desmoglein 3

Nicola Cirillo, Emad AlShwaimi, Michael McCullough, Stephen S Prime

Journal article  |  2014  |  Autoimmunity

Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-beta

Yazan Hassona, Nicola Cirillo, Kue Peng Lim, Andrew Herman, Max Mellone, Gareth J Thomas, Gayani N Pitiyage, E Ken Parkinson, Stephen S Prime

Journal article  |  2013  |  Carcinogenesis

Desmosomal adhesion and pemphigus vulgaris: the first half of the story

Nicola Cirillo, Badr A Al-Jandan

Journal article  |  2013  |  Cell Communication & Adhesion

Urban legends: pemphigus vulgaris.

N Cirillo, E Cozzani, M Carrozzo, SA Grando

Journal article  |  2012  |  Oral Diseases

Pemphigus vulgaris (PV) is the most common type of pemphigus. PV pathogenesis is still debated, and treatment remains challenging...

Molecular insights into the effects of sodium hyaluronate preparations in keratinocytes.

G Colella, A Vicidomini, V Soro, A Lanza, N Cirillo

Journal article  |  2012  |  Clinical and Experimental Dermatology

BACKGROUND: Hyaluronic acid (HA) preparations are widely used in clinical practice to accelerate wound healing, but it is not clea..

Merging experimental data and in silico analysis: a systems-level approach to autoimmune disease and cancer.

Nicola Cirillo

Journal article  |  2012  |  Expert Review of Clinical Immunology

Systems biology, or more specifically network biology, is driven by the assumption that a single gene is seldom accountable for a ..

Characterization of a novel oral glucocorticoid system and its possible role in disease.

N Cirillo, Y Hassona, M Pignatelli, TH Gasparoto, DJ Morgan, SS Prime

Journal article  |  2012  |  Journal of Dental Research

Synthetic corticosteroids are used widely for the treatment of a variety of diseases of the mouth. However, little is known as to ..

A comparison of salivary substitutes versus a natural sialogogue (citric acid) in patients complaining of dry mouth as an adverse drug reaction: a clinical, randomized controlled study.

Felice Femiano, Rosario Rullo, Federica di Spirito, Alessandro Lanza, Vincenzo Maria Festa, Nicola Cirillo

Journal article  |  2011  |  Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

OBJECTIVE: We aimed to compare the efficacy of saliva substitutes and citric acid long-term therapy for oral dryness relief and un..

Keratinocytes synthesize and activate cortisol.

Nicola Cirillo, Stephen S Prime

Journal article  |  2011  |  Journal of Cellular Biochemistry

The bioavailability of circulating and/or endogenous hydrocortisone (cortisol) in epidermal cells is a key determinant in inflamma..

Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma.

Kue Peng Lim, Nicola Cirillo, Yazan Hassona, Wenbin Wei, Johanna K Thurlow, Sok Ching Cheong, Gayani Pitiyage, E Ken Parkinson, Stephen S Prime

Journal article  |  2011  |  Journal of Pathology

Oral cancer is a highly aggressive malignancy with poor prognosis. This study examined the behaviour of fibroblast strains from no..

Techniques in epidermal biology: An integrated approach to autoimmune skin disease

N Cirillo

Book  |  2011

Deregulation of PERK in the autoimmune disease pemphigus vulgaris occurs via IgG-independent mechanisms.

A Lanza, M Lanza, R Santoro, V Soro, SS Prime, N Cirillo

Journal article  |  2011  |  British Journal of Dermatology

BACKGROUND: Serum and IgG isolated from patients with the autoimmune blistering disease pemphigus vulgaris (PV) trigger complex in..

Micro-Raman spectroscopy of tissue samples for oral pathology follow-up monitoring

I Delfino, C Camerlingo, F Zenone, G Perna, V Capozzi, N Cirillo, GM Gaeta, M Lepore

Conference Proceedings  |  2010  |  Biophotonics: Photonic Solutions for Better Health Care II

Controversial role of antibodies against linear epitopes of desmoglein 3 in pemphigus vulgaris, as revealed by semiquantitative living cell immunofluorescence microscopy and in-cell ELISA.

A Lanza, L Perillo, C Landi, F Femiano, F Gombos, N Cirillo

Journal article  |  2010  |  International Journal of Immunopathology and Pharmacology

A novel explanation of pemphigus vulgaris (PV) pathogenesis suggests that serum autoantibodies may affect desmoglein 3 (Dsg3)-medi..

Long-standing oral ulcers: Proposal for a new 'S-C-D classification system': Authors' reply

D Compilato, N Cirillo, N Termine, AR Kerr, C Paderni, D Ciavarella, G Campisi

Journal article  |  2010  |  Journal of Oral Pathology & Medicine

Pilot study on recurrent aphthous stomatitis (RAS): a randomized placebo-controlled trial for the comparative therapeutic effects of systemic prednisone and systemic montelukast in subjects unresponsive to topical therapy.

F Femiano, C Buonaiuto, F Gombos, A Lanza, N Cirillo

Journal article  |  2010  |  Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

BACKGROUND: Recurrent aphthous stomatitis (RAS) is characterized by recurrent painful oral ulcers whose etiology remains largely u..

Induction of hyper-adhesion attenuates autoimmune-induced keratinocyte cell-cell detachment and processing of adhesion molecules via mechanisms that involve PKC.

Nicola Cirillo, Alessandro Lanza, Stephen S Prime

Journal article  |  2010  |  Experimental Cell Research

In confluent keratinocyte monolayers, desmosomal adhesion gradually becomes calcium-independent and this is associated with an inc..

Desmosomal interactome in keratinocytes: a systems biology approach leading to an understanding of the pathogenesis of skin disease.

Nicola Cirillo, Stephen S Prime

Journal article  |  2009  |  Cellular and Molecular Life Sciences

We provide the first description of the desmosome network in keratinocytes using a systems level approach. The desmo-adhesome cons..

Serum of patients with oral pemphigus vulgaris impairs keratinocyte wound repair in vitro: a time-lapse study on the efficacy of methylprednisolone and pyridostigmine bromide.

A Lanza, A Stellavato, I Heulfe, C Landi, F Gombos, N Cirillo

Journal article  |  2009  |  Oral Diseases

OBJECTIVES: Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting primarily oral mucosa and skin. Among the drugs ..

Oral pathology follow-up by means of micro-Raman spectroscopy on tissue and blood serum samples: An application of wavelet and multivariate data analysis

I Delfino, C Camerlingo, F Zenone, G Perna, V Capozzi, N Cirillo, GM Gaeta, E De Mol, M Lepore

Conference Proceedings  |  2009  |  Lasers in Dentistry XV

Pyostomatitis vegetans: a review of the literature.

Felice Femiano, Alessandro Lanza, Curzio Buonaiuto, Letizia Perillo, Antonio Dell'Ermo, Nicola Cirillo

Journal article  |  2009  |  Medicina Oral, Patologia Oral y Cirugia Bucal

Pyostomatitis vegetans (PV) is a rare condition characterized by pustules that affect the oral mucosa. It is a highly specific mar..

Long-standing oral ulcers: proposal for a new 'S-C-D classification system'.

D Compilato, N Cirillo, N Termine, AR Kerr, C Paderni, D Ciavarella, G Campisi

Journal article  |  2009  |  Journal of Oral Pathology and Medicine

Persistent oral ulcers and erosions can be the final common manifestation, sometimes clinically indistinguishable, of a diverse sp..

High-dose pemphigus antibodies against linear epitopes of desmoglein 3 (Dsg3) can induce acantholysis and depletion of Dsg3 from keratinocytes.

Nicola Cirillo, Felice Femiano, Fernando Gombos, Alessandro Lanza

Journal article  |  2009  |  Immunology Letters

We have previously demonstrated that serum autoantibodies of patients with pemphigus vulgaris (PV) may affect desmoglein 3 (Dsg3)-..

Aminoacid-enriched sodium hyaluronate enhances keratinocyte scattering, chemotaxis and wound healing through integrin B1-dependent mechanisms

G Colella, A Vicidomini, N Cirillo, GM Gaeta, S D'Amato

Journal article  |  2009  |  Journal of Stomatological Investigation

Oral Pigmentation as a Sign of Addison’s Disease: A Brief Reappraisal

A Lanza, I Heulfe, L Perillo, A Dell'Ermo, N Cirillo

Journal article  |  2009  |  The Open Dermatology Journal

Cleavage of desmoglein 3 can explain its depletion from keratinocytes in pemphigus vulgaris.

Nicola Cirillo, Giuseppina Campisi, Fernando Gombos, Letizia Perillo, Felice Femiano, Alessandro Lanza

Journal article  |  2008  |  Experimental Dermatology

We have previously demonstrated that serum of patients with pemphigus vulgaris induces reduction of desmoglein 3 (Dsg3) half-life ..

Burning mouth disorder (BMD) and taste: a hypothesis.

Felice Femiano, Alessandro Lanza, Curzio Buonaiuto, Fernando Gombos, Nicola Cirillo

Journal article  |  2008  |  Medicina Oral, Patologia Oral y Cirugia Bucal

BACKGROUND: Burning mouth disorder (BMD) is a burning or stinging sensation affecting the oral mucosa, lips, and/or tongue, in the..

Oral malignant melanoma: a review of the literature.

Felice Femiano, Alessandro Lanza, Curzio Buonaiuto, Fernando Gombos, Federica Di Spirito, Nicola Cirillo

Journal article  |  2008  |  Journal of Oral Pathology and Medicine

Primary oral melanoma (POM) is an uncommon malignant tumor that originates from the proliferation of melanocytes. Such tumors can ..

Oral aphthous-like lesions, PFAPA syndrome: a review.

Felice Femiano, Alessandro Lanza, Curzio Buonaiuto, Fernando Gombos, Nicola Cirillo

Journal article  |  2008  |  Journal of Oral Pathology and Medicine

Aphthous ulcers are the most common oral mucosal lesions in the general population. Several precipitating factors for aphthous ulc..

Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction

Alessandro Lanza, Luigi Laino, Luigi Rossiello, Letizia Perillo, Antonio Dell Ermo, Nicola Cirillo

Journal article  |  2008  |  The Open Dentistry Journal

A wide range of diseases may present with radiographic features of osteolysis. Periapical inflammation, cysts and benign tumours, ..

Oral manifestations of adverse drug reactions: guidelines.

F Femiano, A Lanza, C Buonaiuto, F Gombos, R Rullo, V Festa, N Cirillo

Journal article  |  2008  |  European Academy of Dermatology and Venereology Journal

BACKGROUND: Adverse drug reactions are noxious and unintended responses to a medicinal product. Many drugs have the potential to i..

An investigation on micro-Raman spectra and wavelet data analysis for pemphigus vulgaris follow-up monitoring

C Camerlingo, F Zenone, G Perna, V Capozzi, N Cirillo, GM Gaeta, M Lepore

Journal article  |  2008  |  Sensors

Wavelet data analysis of micro-Raman spectra for follow-up monitoring in oral pathologies

C Camerlingo, F Zenone, G Perna, V Capozzi, N Cirillo, GM Gaeta, M Lepore

Conference Proceedings  |  2008  |  Lasers in Dentistry XIV

Evidence of key role of Cdk2 overexpression in pemphigus vulgaris.

Alessandro Lanza, Nicola Cirillo, Raffaele Rossiello, Monica Rienzo, Luisa Cutillo, Amelia Casamassimi, Filomena de Nigris, Concetta Schiano, Luigi Rossiello, Felice Femiano, Fernando Gombos, Claudio Napoli

Journal article  |  2008  |  Journal of Biological Chemistry

The pathogenesis of pemphigus vulgaris (PV) is still poorly understood. Autoantibodies present in PV patients can promote detrimen..

Fatty acid profile of erythrocyte membranes as possible biomarker of longevity.

Annibale A Puca, Peter Andrew, Valeria Novelli, Chiara Viviani Anselmi, Francesco Somalvico, Nicola A Cirillo, Chryssostomos Chatgilialoglu, Carla Ferreri

Journal article  |  2008  |  Rejuvenation Research

Offspring of long-lived individuals are a useful model to discover biomarkers of longevity. The lipid composition of erythrocyte m..

The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery.

Nicola Cirillo, Michele Lanza, Alfredo De Rosa, Marcella Cammarota, Annalisa La Gatta, Fernando Gombos, Alessandro Lanza

Journal article  |  2008  |  Journal of Cellular Biochemistry

Apoptotic cells are known to regulate the ordered dismantling of intercellular contacts through caspase activity. Despite the impo..

The specific proteolysis hypothesis of pemphigus: does the song remain the same?

Nicola Cirillo, Antonio Dell' Ermo, Fernando Gombos, Alessandro Lanza

Journal article  |  2008  |  Medical Hypotheses

Within the last decade, a number of theories on the pathogenesis of pemphigus vulgaris (PV) have followed one another. Of these, p..

Fate of desmoglein 3 and E-cadherin in anchorage-independent growth and adhesion to substrates of oral squamous carcinoma cells

N Cirillo, S Boutros

Journal article  |  2008  |  Journal of Stomatological Investigation

Mucocutaneous pemphigus vulgaris carrying high-titre antidesmoglein 1 antibodies with skin lesions resembling pemphigus erythematosus.

N Cirillo, R Santoro, M Lanza, P Annese, F Gombos, A Lanza

Journal article  |  2008  |  Clinical and Experimental Dermatology

Patients with pemphigus vulgaris (PV) who have both antidesmoglein (Dsg)1 and anti-Dsg3 antibodies usually develop flaccid blister..

Burning mouth syndrome and burning mouth in hypothyroidism: proposal for a diagnostic and therapeutic protocol.

Felice Femiano, Alessandro Lanza, Curzio Buonaiuto, Fernando Gombos, Monica Nunziata, Luisa Cuccurullo, Nicola Cirillo

Journal article  |  2008  |  Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

BACKGROUND: Burning mouth syndrome (BMS) is a common disorder frequently affecting women past the 5th decade of age. It is charact..

At least three phosphorylation events induced by pemphigus vulgaris sera are pathogenically involved in keratinocyte acantholysis.

N Cirillo, M Lanza, A De Rosa, F Femiano, F Gombos, A Lanza

Journal article  |  2008  |  International Journal of Immunopathology and Pharmacology

Intercellular adhesion among keratinocytes is guaranteed by desmosomes. Disruption of desmosomal integrity leads to cell-cell deta..

Vesicular and bullous disorders: pemphigus.

Adone Baroni, Alessandro Lanza, Nicola Cirillo, Giampiero Brunetti, Eleonora Ruocco, Vincenzo Ruocco

Journal article  |  2007  |  Dermatologic Clinics

Pemphigus is a chronic, autoimmune disease involving the skin and Malpighian mucous membranes. Pemphigus leads to progressive blis..

If pemphigus vulgaris IgG are the cause of acantholysis, new IgG-independent mechanisms are the concause.

Nicola Cirillo, Michele Lanza, Felice Femiano, Giovanni Maria Gaeta, Alfredo De Rosa, Fernando Gombos, Alessandro Lanza

Journal article  |  2007  |  Journal of Cellular Physiology

Pemphigus vulgaris (PV) is a disease of epidermal adhesion. Its pathogenesis is currently traced back to the action of autoantibod..

Guidelines for diagnosis and management of aphthous stomatitis.

Felice Femiano, Alessandro Lanza, Curzio Buonaiuto, Fernando Gombos, Monica Nunziata, Silvia Piccolo, Nicola Cirillo

Journal article  |  2007  |  The Pediatric Infectious Disease Journal

Aphthous ulcers are the most common oral mucosal lesions in the general population. These often are recurrent and periodic lesions..

Defining the involvement of proteinases in pemphigus vulgaris: evidence of matrix metalloproteinase-9 overexpression in experimental models of disease.

Nicola Cirillo, Michele Lanza, Luigi Rossiello, Fernando Gombos, Alessandro Lanza

Journal article  |  2007  |  Journal of Cellular Physiology

Pemphigus vulgaris (PV) acantholysis represents a complex phenomenon wherein a number of factors cooperates. PV serum is known to ..

Pemphigus vulgaris immunoglobulin G can recognize a 130 000 MW antigen other than desmoglein 3 on peripheral blood mononuclear cell surface.

Nicola Cirillo, Fernando Gombos, Alessandro Lanza

Journal article  |  2007  |  Immunology

Pemphigus vulgaris (PV) is considered to be an autoimmune disease affecting skin and mucous membranes. Traditionally, PV autoantib..

A novel method to investigate pemphigus-induced keratinocyte dysmorphisms through living cell immunofluorescence microscopy.

Nicola Cirillo, Felice Femiano, Antonio Dell'Ermo, Pietro Arnese, Fernando Gombos, Alessandro Lanza

Journal article  |  2007  |  Virchows Archiv

Pemphigus vulgaris (PV) blistering occurs as a result of the disruption of intercellular contacts among keratinocytes, or acanthol..

Metalloproteinase 9 is the outer executioner of desmoglein 3 in apoptotic keratinocytes.

N Cirillo, F Femiano, F Gombos, A Lanza

Journal article  |  2007  |  Oral Diseases

OBJECTIVE: To investigate the specific matrix metalloproteinases (MMPs) targeting desmoglein 3 (Dsg3) in apoptotic keratinocytes. ..

Oral ulcers: three questions on their physiopathology.

G Campisi, D Compilato, N Cirillo, D Ciavarella, V Panzarella, S Amato, L Lo Muzio

Journal article  |  2007  |  Minerva stomatologica

Ulcers and/or erosions can be the final common manifestation, often clinically indistinguishable, of a wide and complex spectrum o..

Searching for experimental models of Pemphigus vulgaris.

Nicola Cirillo, Fernando Gombos, Vincenzo Ruocco, Alessandro Lanza

Journal article  |  2007  |  Archives of Dermatological Research

The current knowledge on Pemphigus vulgaris (PV) pathophysiology suggests that blister formation relies on both PV IgG and non-IgG..

Internalization of non-clustered desmoglein 1 without depletion of desmoglein 1 from adhesion complexes in an experimental model of the autoimmune disease pemphigus foliaceus.

A Lanza, A De Rosa, F Femiano, P Annese, E Ruocco, F Gombos, M Lanza, N Cirillo

Journal article  |  2007  |  International Journal of Immunopathology and Pharmacology

Serum antibodies against desmoglein 1 (Dsg1) are known to induce the clinical and histological manifestations of pemphigus foliace..

Changes in desmoglein 1 expression and subcellular localization in cultured keratinocytes subjected to anti-desmoglein 1 pemphigus autoimmunity.

Nicola Cirillo, Fernando Gombos, Alessandro Lanza

Journal article  |  2007  |  Journal of Cellular Physiology

The complexity of pemphigus acantholysis together with the weak expression of desmoglein 1 (Dsg1) in cultured keratinocytes have m..

Caspase-dependent cleavage of desmoglein 1 depends on the apoptotic stimulus.

A Lanza, N Cirillo

Journal article  |  2007  |  British Journal of Dermatology

How does acantholysis occur in pemphigus vulgaris: a critical review.

Alessandro Lanza, Nicola Cirillo, Felice Femiano, Fernando Gombos

Journal article  |  2006  |  Journal of Cutaneous Pathology

BACKGROUND: Pemphigus vulgaris is a life-threatening autoimmune blistering disease targeting skin and mucous membranes, characteri..

Serum from pemphigus vulgaris reduces desmoglein 3 half-life and perturbs its de novo assembly to desmosomal sites in cultured keratinocytes.

Nicola Cirillo, Felice Femiano, Fernando Gombos, Alessandro Lanza

Journal article  |  2006  |  FEBS Letters

Defects of cell-cell adhesion underlie disruption of epithelial integrity observed in patients with pemphigus vulgaris (PV), an au..

The N-terminal fraction of desmoglein 3 encompassing its immunodominant domain is present in human serum: implications for pemphigus vulgaris autoimmunity.

A Lanza, F Femiano, A De Rosa, M Cammarota, M Lanza, N Cirillo

Journal article  |  2006  |  International Journal of Immunopathology and Pharmacology

Pemphigus vulgaris (PV) is considered as an autoimmune disease against a tissue-restricted antigen, desmoglein 3, a 130 kDa glycop..