Brunda Nijagal

Minimal expression of dysferlin prevents development of dysferlinopathy in dysferlin exon 40a knockout mice.

Joe Yasa, Claudia E Reed, Adam M Bournazos, Frances J Evesson, Ignatius Pang, Mark E Graham, Jesse R Wark, Brunda Nijagal, Kim H Kwan, Thomas Kwiatkowski, Rachel Jung, Noah Weisleder, Sandra T Cooper, Frances A Lemckert

Journal article  |  2023  |  Acta Neuropathol Commun

Dysferlin is a Ca2+-activated lipid binding protein implicated in muscle membrane repair. Recessive variants in DYSF result in dys..

CD98 defines a metabolically flexible, proinflammatory subset of low-density neutrophils in systemic lupus erythematosus.

Katherine R Martin, Jessica A Day, Jacinta A Hansen, Damian B D'Silva, Huon L Wong, Alexandra Garnham, Jarrod J Sandow, Brunda Nijagal, Nicholas Wilson, Ian P Wicks

Journal article  |  2023  |  Clin Transl Med

BACKGROUND: Low-density neutrophils (LDN) are a distinct subset of neutrophils rarely detected in healthy people but appear in the..

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

Kenji M Fujihara, Bonnie Z Zhang, Thomas D Jackson, Moses O Ogunkola, Brunda Nijagal, Julia Milne, David A Sallman, Ching-Seng Ang, Iva Nikolic, Conor J Kearney, Simon J Hogg, Carlos S Cabalag, Vivien R Sutton, Sally Watt, Asuka T Fujihara, Joseph A Trapani, Kaylene J Simpson, Diana Stojanovski, Silke Leimkuhler, Sue Haupt, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, although the clinical dev..

A Mycoplasma gallisepticum Glycerol ABC Transporter Involved in Pathogenicity

Sara Mahdizadeh, Yumiko Masukagami, Chi-Wen Tseng, Philip F Markham, David P De Souza, Brunda Nijagal, Dedreia Tull, Liliana Tatarczuch, Glenn F Browning, Fiona M Sansom

Journal article  |  2021  |  APPLIED AND ENVIRONMENTAL MICROBIOLOGY

MalF has been shown to be required for virulence in the important avian pathogen Mycoplasma gallisepticum To characterize the func..

The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring

Gerard Wong, Jacquelyn M Weir, Priti Mishra, Kevin Huynh, Brunda Nijagal, Varsha Gupta, Birit FP Broekman, Mary Foong-Fong Chong, Shiao-Yng Chan, Kok Hian Tan, Dedreia Tull, Malcolm McConville, Philip C Calder, Keith M Godfrey, Yap Seng Chong, Peter D Gluckman, Michael J Meaney, Peter J Meikle, Neerja Karnani

Journal article  |  2021  |  TRANSLATIONAL PSYCHIATRY

While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determina..

High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort

Anne HY Chu, Mya T Tint, Hsin F Chang, Gerard Wong, Wen Lun Yuan, Dedreia Tull, Brunda Nijagal, Vinod K Narayana, Peter J Meikle, Kenneth TE Chang, Rohan M Lewis, Claudia Chi, Fabian KP Yap, Kok Hian Tan, Lynette P Shek, Yap-Seng Chong, Peter D Gluckman, Yung Seng Lee, Marielle Fortier, Keith M Godfrey, et al.

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF OBESITY

Background/Objectives Maternal glycaemia promotes fetal adiposity. Inositol, an insulin sensitizer, has been trialled for gestatio..

Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium

Andre Mu, Glen P Carter, Lucy Li, Nicole S Isles, Alison F Vrbanac, James T Morton, Alan K Jarmusch, David P De Souza, Vinod K Narayana, Komal Kanojia, Brunda Nijagal, Malcolm J McConville, Rob Knight, Benjamin P Howden, Timothy P Stinear

Journal article  |  2020  |  MSYSTEMS

Vancomycin-resistant Enterococcus faecium (VREfm) is an emerging antibiotic-resistant pathogen. Strain-level investigations are be..

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2020  |  INFECTION AND IMMUNITY

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

A combined metabolomic and bioinformatic approach to investigate the function of transport proteins of the important pathogen Mycoplasma bovis

Yumiko Masukagami, Brunda Nijagal, Sara Mandizadeh, Chi-Wen Tseng, Saravanan Dayalan, Kelly A Tivendale, Philip F Markham, Glenn F Browning, Fiona M Sansom

Journal article  |  2019  |  VETERINARY MICROBIOLOGY

Mycoplasma bovis is an economically important pathogen of the cattle industry worldwide, and there is an urgent need for a more ef..

Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis

Leilah K Grant, Suzanne Ftouni, Brunda Nijagal, David P De Souza, Dedreia Tull, Malcolm J McConville, Shantha MW Rajaratnam, Steven W Lockley, Clare Anderson

Journal article  |  2019  |  SCIENTIFIC REPORTS

Establishing circadian and wake-dependent changes in the human metabolome are critical for understanding and treating human diseas..