Prudence Francis

Trastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials

J Bergh, K Pritchard, S Swain, D Cameron, K Albain, S Anderson, R Arriagada, J Bartlett, E Bergsten-Nordstrom, J Bliss, R Bradley, E Brain, J Braybrooke, L Carey, M Clarke, R Coleman, J Cuzick, N Davidson, L Del Mastro, A Di Leo, et al.

Journal article  |  2021  |  LANCET ONCOLOGY

BACKGROUND: Trastuzumab targets the extracellular domain of the HER2 protein. Adding trastuzumab to chemotherapy for patients with..

Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021.

HJ Burstein, G Curigliano, B Thürlimann, WP Weber, P Poortmans, MM Regan, HJ Senn, EP Winer, M Gnant, undefined Panelists of the St Gallen Consensus Conference

Journal article  |  2021  |  Ann Oncol

The 17th St Gallen International Breast Cancer Consensus Conference in 2021 was held virtually, owing to the global COVID-19 pande..

Assessment of Ovarian Function in Phase 3 (Neo)adjuvant Breast Cancer Clinical Trials: A Systematic Evaluation.

Wanyuan Cui, Prudence A Francis, Sherene Loi, Martha Hickey, Catharyn Stern, Lumine Na, Ann H Partridge, Sibylle Loibl, Richard A Anderson, Karla J Hutt, Louise A Keogh, Kelly-Anne Phillips

Journal article  |  2021  |  J Natl Cancer Inst

BACKGROUND: Loss of ovarian function is a recognized adverse effect of chemotherapy for breast cancer, and of great importance to ..

Heparanase: a potential marker of worse prognosis in estrogen receptor-positive breast cancer

Tamar Zahavi, Mali Salmon-Divon, Roberto Salgado, Michael Elkin, Esther Hermano, Ariel M Rubinstein, Prudence A Francis, Angelo Di Leo, Giuseppe Viale, Evandro de Azambuja, Lieveke Ameye, Christos Sotiriou, Asher Salmon, Nataly Kravchenko-Balasha, Amir Sonnenblick

Journal article  |  2021  |  NPJ BREAST CANCER

Heparanase promotes tumor growth in breast tumors. We now evaluated heparanase protein and gene-expression status and investigated..

Feasibility of implementing a pharmacist-led DPYD gene testing service for patients commencing 5-fluorouracil (5FU) or capecitabine.

Benjamin Lee, Sarah Glewis, Marliese Alexander, Danny Rischin, Prudence A Francis, Michael Jefford, Hui-Li Wong, Jeanne Tie, Michael Michael, Senthil Lingaratnam

Conference Proceedings  |  2021  |  Journal of Clinical Oncology

e18644 Background: Polymorphisms in the DPYD gene, which encodes for dihydropyrimidine dehydrogenase (DPD), may impair DPD metabo..

Challenges in Adjuvant Therapy for Premenopausal Women Diagnosed With Luminal Breast Cancers.

Ines Vaz-Luis, Prudence A Francis, Antonio Di Meglio, Vered Stearns

Journal article  |  2021  |  Am Soc Clin Oncol Educ Book

More than 90% of women with newly diagnosed breast cancer present with stage I to III disease and, with optimal multidisciplinary ..

The role of CYP2D6 mediated tamoxifen metabolism in the suppression of ovarian function trial (SOFT)

Matthew P Goetz, Gini F Fleming, Mary Kuffel, John R Hawse, John L Black, Richard Weinshilboum, James N Ingle, Patrizia dell'Orto, Olivia Biasi, Roswitha Kammler, Sherene Loi, Marco Colleoni, Giuseppe Viale, Prudence A Francis, Meredith M Regan

Conference Proceedings  |  2021  |  CANCER RESEARCH

5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)

F Cardoso, S Paluch-Shimon, E Senkus, G Curigliano, MS Aapro, F Andre, CH Barrios, J Bergh, GS Bhattacharyya, L Biganzoli, F Boyle, M-J Cardoso, LA Carey, J Cortes, NS El Saghir, M Elzayat, A Eniu, L Fallowfield, PA Francis, K Gelmon, et al.

Journal article  |  2020  |  ANNALS OF ONCOLOGY

Response to letter commenting on: Fulvestrant falsely elevates oestradiol levels in immunoassays in postmenopausal women with breast cancer

Evangeline Samuel, Cherie Chiang, Ross Jennens, David Faulkner, Prudence A Francis

Journal article  |  2020  |  EUROPEAN JOURNAL OF CANCER

Differential Benefit of Adjuvant Docetaxel-Based Chemotherapy in Patients With Early Breast Cancer According to Baseline Body Mass Index

Christine Desmedt, Marco Fornili, Florian Clatot, Romano Demicheli, Davide De Bortoli, Angelo Di Leo, Giuseppe Viale, Evandro de Azambuja, John Crown, Prudence A Francis, Christos Sotiriou, Martine Piccart, Elia Biganzoli

Journal article  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

PURPOSE: Lipophilic drugs, such as taxanes, have a high affinity for adipose tissue and a resulting higher volume of distribution...