Dr Kiymet Bozaoglu is a Team Leader/Senior research officer with over 10 years of experience in complex disease genetics. She leads the autism stem cell program within the Neurogenetics Group of Associate Professor Paul Lockhart at MCRI.
Dr Bozaoglu currently leads the molecular aspects of the Genetics of Autism project at the Murdoch Children’s Research Institute which is funded by the NHMRC.She has developed an extensive stem cell modelling program where she can differentiate patient derived-stem cells into brain cells and determine how the mutations identified in our patients may be contributing to autism and also developed the downstream functional assays that are important in addressing this important question.Dr Bozaoglu completed her PhD at the Metabolic Research Unit, Deakin University in April 2009. Dr Bozaoglu is a functional geneticist and her research focuses on the genetics of complex diseases, and its subsequent translation into functional models for validation. Over the course of her career, Dr Bozaoglu has developed expertise in novel gene identification in large family cohorts and subsequent validation using functional models.Her research is multidisciplinary, and has extended to a number of complex diseases, including Type 2 diabetes, obesity, cardiovascular disease, schizophrenia and autism. She made a significant impact in obesity research with her discovery of a novel adipokine chemerin during her PhD. Being the first to describe chemerin as a novel adipokine associated with metabolic syndrome characteristics, her manuscripts around chemerin are highly cited (>1300 citations to date), demonstrating the significance of her research.During Dr Bozaoglu’s post-doctoral work on cardiovascular disease, she discovered a novel gene TRAK2, in a large family study and validated its role in CVD using functional models was published in the prestigious European Heart Journal highlighting the significance of the findings. Relative to opportunity (8.5 years FTE, including 2 periods of maternity leave), she has a strong track record of 26 publications, 6 as first author and 2 as last author and 3 book chapters. Apart from her passion and dedication for science, Dr Bozaoglu enjoys supervising and mentoring staff and students. Since 2010, she has co-supervised 2 PhD, 2 masters and 3 honours students. Her current team consists of 3 RAs and 2 PhD students and she is on 5 MCRI PhD advisory panels. She is also an official mentor for 3 postdocs and informally mentors 4 PhD students and 2 Research Assistants on research and career development.Dr Bozaoglu is also passionate about championing change in the Australian scientific community to increase diversity and inclusivity. She is heavily engaged in various institutional committees including co-chair of the MCRI postdoc society, chair of the MCRI Gender Equity Committee and is part of the advisory committee for the Women in Science Parkville Precinct. With these committee responsibilities, Dr Bozaoglu aims to bring equality in science. This is not just about achieving gender equality, but to empower all scientists to be the best that they can be in the absence of prejudices against their gender, race or religion.Science is about striving for excellence and making valuable contributions to our health systems and patient care.
Find out more about Kiymet Bozaoglu's experience
Kiymet Bozaoglu's highlights
Kiymet Bozaoglu's selected work
GENE EXPRESSION SUGGEST ALTERED GLUTAMATERGIC, DOPAMINERGIC AND ESTROGEN CLASSICAL PATHWAY..
Acute effects of active breaks during prolonged sitting on subcutaneous adipose tissue gen..
The effects of a muscarinic receptor 1 gene variant on executive and nonexecutive cognitio..
Displaying the 38 most recent scholarly works by Kiymet Bozaoglu.
Generation of seven iPSC lines from peripheral blood mononuclear cells suitable to investigate Autism Spectrum Disorder
Kiymet Bozaoglu, Yujing Gao, Edouard Stanley, Miriam Fanjul-Fernandez, Natasha J Brown, Kate Pope, Cherie C Green, Katerina Vlahos, Koula Sourris, Melanie Bahlo, Martin Delatycki, Ingrid Scheffer, Paul J Lockhart
Journal article | 2019 | Stem Cell Research
GENE EXPRESSION SUGGEST ALTERED GLUTAMATERGIC, DOPAMINERGIC AND ESTROGEN CLASSICAL PATHWAYS IN WORKING MEMORY DEFICIT IN SCHIZOPHRENIA
Elizabeth Thomas, Susan Rossell, Brian Dean, Eric Tan, Erica Neill, Tamsyn Van Rheenen, Sean Carruthers, Philip Sumner, Stephanie Louise, Kiymet Bozaoglu, Caroline Gurvich
Conference Proceedings | 2019 | Schizophrenia Bulletin
Acute effects of active breaks during prolonged sitting on subcutaneous adipose tissue gene expression: an ancillary analysis of a randomised controlled trial
Megan S Grace, Melissa F Formosa, Kiymet Bozaoglu, Audrey Bergouignan, Marta Brozynska, Andrew L Carey, Camilla Bertuzzo Veiga, Parneet Sethi, Francis Dillon, David A Bertovic, Michael Inouye, Neville Owen, David W Dunstan, Bronwyn A Kingwell
Journal article | 2019 | Scientific Reports
The effects of a muscarinic receptor 1 gene variant on executive and nonexecutive cognition in schizophrenia spectrum disorders
Sean P Carruthers, Vanessa Cropley, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Kiymet Bozaoglu, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Caroline T Gurvich, Susan L Rossell
Journal article | 2019 | Psychiatry Research
Do schizotypy dimensions reflect the symptoms of schizophrenia?
Elizabeth HX Thomas, Susan L Rossell, Eric J Tan, Erica Neill, Tamsyn E Van Rheenen, Sean P Carruthers, Philip J Sumner, Stephanie Louise, Kiymet Bozaoglu, Caroline Gurvich
Journal article | 2019 | Australian & New Zealand Journal of Psychiatry
Working Memory and Attention Influence Antisaccade Error Rate in Schizophrenia
Elizabeth HX Thomas, Susan L Rossell, Jessica B Myles, Eric J Tan, Erica Neill, Sean P Carruthers, Philip J Sumner, Kiymet Bozaoglu, Caroline Gurvich
Journal article | 2019 | Journal of the International Neuropsychological Society
Generation of iPSC lines from peripheral blood mononuclear cells from 5 healthy adults
Katerina Vlahos, Koula Sourris, Robyn Mayberry, Penelope McDonald, Freya F Bruveris, Jacqueline V Schiesser, Kiymet Bozaoglu, Paul J Lockhart, Edouard G Stanley, Andrew G Elefanty
Journal article | 2019 | Stem Cell Research
The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers
CR Bain, DF Draxler, R Taylor, S Wallace, O Gouldthorpe, TB Corcoran, PS Myles, RL Medcalf, K Bozaoglu
Journal article | 2018 | Anaesthesia
Dexamethasone is often administered to surgical patients for anti-emetic prophylaxis. This study examined the early (up to 24 h) i..
TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis
Nicole J Lake, Rachael L Taylor, Hugh Trahair, KN Harikrishnan, Joanne E Curran, Marcio Almeida, Hemant Kulkarni, Nigora Mukhamedova, Hoang Anh, Hann Low, Andrew J Murphy, Matthew P Johnson, Thomas D Dyer, Michael C Mahaney, Harald HH Goring, Eric K Moses, Dmitri Sviridov, John Blangero, Jeremy BM Jowett, Kiymet Bozaoglu
Journal article | 2017 | European Heart Journal
THE NEUREGULIN-1 GENE IS ASSOCIATED WITH SCHIZOTYPY IN THE GENERAL POPULATION
Elizabeth Thomas, Susan Rossell, Sean Carruthers, Philip Sumner, Erica Neill, Tamsyn Van Rheenen, Stephanie Louise, Eric Tan, Kiymet Bozaoglu, Caroline Gurvich
Conference Proceedings | 2017 | European Neuropsychopharmacology
N-acetylcysteine (NAC) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms
Susan L Rossell, Paul S Francis, Cherrie Galletly, Anthony Harris, Dan Siskind, Michael Berk, Kiymet Bozaoglu, Frances Dark, Olivia Dean, Dennis Liu, Denny Meyer, Erica Neill, Andrea Phillipou, Jerome Sarris, David J Castle
Journal article | 2016 | BMC Psychiatry
Investigation of Genetic Variation Underlying Central Obesity amongst South Asians
William R Scott, Weihua Zhang, Marie Loh, Sian-Tsung Tan, Benjamin Lehne, Uzma Afzal, Juan Peralta, Richa Saxena, Sarju Ralhan, Gurpreet S Wander, Kiymet Bozaoglu, Dharambir K Sanghera, Paul Elliott, James Scott, John C Chambers, Jaspal S Kooner
Journal article | 2016 | PLOS ONE
South Asians are 1/4 of the world's population and have increased susceptibility to central obesity and related cardiometabolic di..
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study
John C Chambers, Marie Loh, Benjamin Lehne, Alexander Drong, Jennifer Kriebel, Valeria Motta, Simone Wahl, Hannah R Elliott, Federica Rota, William R Scott, Weihua Zhang, Sian-Tsung Tan, Gianluca Campanella, Marc Chadeau-Hyam, Loic Yengo, Rebecca C Richmond, Martyna Adamowicz-Brice, Uzma Afzal, Kiymet Bozaoglu, Zuan Yu Mok, et al.
Journal article | 2015 | The Lancet Diabetes & Endocrinology
BACKGROUND: Indian Asians, who make up a quarter of the world's population, are at high risk of developing type 2 diabetes. We inv..
The structure of vanin 1: a key enzyme linking metabolic disease and inflammation
Ykelien L Boersma, Janet Newman, Timothy E Adams, Nathan Cowieson, Guy Krippner, Kiymet Bozaoglu, Thomas S Peat
Journal article | 2014 | Acta Crystallographica Section D Biological Crystallography
Although part of the coenzyme A pathway, vanin 1 (also known as pantetheinase) sits on the cell surface of many cell types as an e..
Plasma Levels of Soluble Interleukin 1 Receptor Accessory Protein Are Reduced in Obesity
Kiymet Bozaoglu, Chantal Attard, Hemant Kulkarni, Nik Cummings, Vincent P Diego, Melanie A Carless, Katherine A Shields, Matthew P Johnson, Sudhir Kowlessur, Thomas D Dyer, Anthony G Comuzzie, Laura Almasy, Paul Zimmet, Eric K Moses, Harald HH Goering, Joanne E Curran, John Blangero, Jeremy BM Jowett
Journal article | 2014 | The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Adipokines actuate chronic, low-grade inflammation through a complex network of immune markers, but the current understan..
Elevated Chemerin Levels in Pakistani Men: An Interrelation with Metabolic Syndrome Phenotypes
Syeda Sadia Fatima, Kiymet Bozaoglu, Rehana Rehman, Faiza Alam, Abdul Shakoor Memon
Journal article | 2013 | PLoS One
Chemerin is a novel protein linked to adipocyte differentiation and the development of metabolic imbalances. We sought to examine ..
Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass
N Cummings, KA Shields, JE Curran, K Bozaoglu, J Trevaskis, K Gluschenko, G Cai, AG Comuzzie, TD Dyer, KR Walder, P Zimmet, GR Collier, J Blangero, JBM Jowett
Journal article | 2012 | International Journal of Obesity
OBJECTIVE: The SH3-domain GRB2-like (endophilin)-interacting protein 1 (SGIP1) gene has been shown to be differentially expressed ..
Approaches for Dissection of the Genetic Basis of Complex Disease Development in Humans
Nicole J Lake, Kiymet Bozaoglu, Abdul W Khan, Jeremy BM Jowett
Book Chapter | 2012
The purpose of the book is to provide a glimpse into the dynamic process of genetic diversity of microorganisms by presenting the ..
Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
MA Carless, DC Glahn, MP Johnson, JE Curran, K Bozaoglu, TD Dyer, AM Winkler, SA Cole, L Almasy, JW MacCluer, R Duggirala, EK Moses, HHH Goering, J Blangero
Journal article | 2011 | Molecular Psychiatry
Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar ..
The characterization of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome
Matthew J Prior, Victoria C Foletta, Jeremy B Jowett, David H Segal, Melanie A Carless, Joanne E Curran, Tom D Dyer, Eric K Moses, Andrew J McAinch, Nicky Konstantopoulos, Kiymet Bozaoglu, Greg R Collier, David Cameron-Smith, John Blangero, Ken R Walder
Journal article | 2010 | Metabolism
The human Abelson helper integration site-1 (AHI1) gene is associated with both neurologic and hematologic disorders; however, it ..
Chemerin, a Novel Adipokine in the Regulation of Angiogenesis
Kiymet Bozaoglu, Joanne E Curran, Claire J Stocker, Mohamed S Zaibi, David Segal, Nicky Konstantopoulos, Shona Morrison, Melanie Carless, Thomas D Dyer, Shelley A Cole, Harald HH Goring, Eric K Moses, Ken Walder, Michael A Cawthorne, John Blangero, Jeremy BM Jowett
Journal article | 2010 | The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Chemerin is a new adipokine associated with obesity and the metabolic syndrome. Gene expression levels of chemerin were e..
Chemerin Is Associated with Metabolic Syndrome Phenotypes in a Mexican-American Population
Kiymet Bozaoglu, David Segal, Katherine A Shields, Nik Cummings, Joanne E Curran, Anthony G Comuzzie, Michael C Mahaney, David L Rainwater, John L VandeBerg, Jean W MacCluer, Greg Collier, John Blangero, Ken Walder, Jeremy BM Jowett
Journal article | 2009 | The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Chemerin is a novel adipokine previously associated with metabolic syndrome phenotypes in a small sample of subjects from..
Chemerin is a novel adipokine associated with obesity and metabolic syndrome
Kiymet Bozaoglu, Kristy Bolton, Janine McMillan, Paul Zimmet, Jeremy Jowett, Greg Collier, Ken Walder, David Segal
Journal article | 2007 | Endocrinology
Soluble protein hormones are key regulators of a number of metabolic processes, including food intake and insulin sensitivity. We ..
Association of genetic variation within UBL5 with phenotypes of metabolic syndrome
Kiymet Bozaoglu, Joanne E Curran, Kate S Elliott, Ken R Walder, Thomas D Dyer, David L Rainwater, John L Vandeberg, Anthony G Comuzzie, Greg R Collier, Paul Zimmet, Jean W Maccluer, Jeremy B Jowett, John Blangero
Journal article | 2006 | Human Biology
The BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples col..
Honours, Awards and Fellowships
E.H Flack Fellowship
Paediatrics Royal Children'S Hospital
Member Of The Society
International Society for Autism Research
Member Of The Society
Australian Society for Autism Research
Member Of The Society
Genetics Society of Australasia
Member Of The Society
International Society for Stem Cell Research
Member Of The Society
Australian Genome Technologies Australia
Doctor of Philosophy
Bachelor of Science
La Trobe University