Grant McArthur

A Phase Ib/II Trial of Combined BRAF and EGFR Inhibition in BRAF V600E Positive Metastatic Colorectal Cancer and Other Cancers: The EVICT (Erlotinib and Vemurafenib In Combination Trial) Study.

Lavinia Tan, Ben Tran, Jeanne Tie, Ben Markman, Sumi Ananda, Niall C Tebbutt, Michael Michael, Emma Link, Stephen Q Wong, Sushma Chandrashekar, Jerick Guinto, David Ritchie, Rachel Koldej, Benjamin J Solomon, Grant A McArthur, Rodney J Hicks, Peter Gibbs, Sarah-Jane Dawson, Jayesh Desai

Journal article  |  2023  |  Clin Cancer Res

PURPOSE: BRAF V600E mutant metastatic colorectal cancer represents a significant clinical problem, with combination approaches bei..

Combination Immune Checkpoint Inhibition: Is First Line Best?

Grant A McArthur

Journal article  |  2023  |  J Clin Oncol

Overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study.

Paolo A Ascierto, Daniil Stroyakovskiy, Helen Gogas, Caroline Robert, Karl Lewis, Svetlana Protsenko, Rodrigo P Pereira, Thomas Eigentler, Piotr Rutkowski, Lev Demidov, Natalia Zhukova, Jacob Schachter, Yibing Yan, Ivor Caro, Christian Hertig, Cloris Xue, Lieke Kusters, Grant A McArthur, Ralf Gutzmer

Journal article  |  2023  |  Lancet Oncol

BACKGROUND: Primary analysis of the phase 3 IMspire150 study showed improved investigator-assessed progression-free survival with ..

Correlation of MRI signal characteristics of intracranial melanoma metastases with BRAF mutation status

Arian Lasocki, Grant A McArthur

Journal article  |  2022  |  MELANOMA RESEARCH

BRAF V600 mutations (BRAF mut ) are associated with more pigmentation in primary melanomas, but data on melanin content of metasta..

Clinical validation and implementation of droplet digital PCR for the detection of BRAF mutations from cell-free DNA

Rainer Arnolda, Kerry Howlett, Timmy Chan, Jeanette Raleigh, Athena Hatzimihalis, Anthony Bell, Andrew Fellowes, Shahneen Sandhu, Grant A Mcarthur, Stephen B Fox, Sarah-jane Dawson, Chelsee Hewitt, Kate Jones, Stephen Q Wong

Journal article  |  2022  |  PATHOLOGY

Droplet digital PCR (ddPCR) has been demonstrated in many research studies to be a sensitive method in the analysis of circulating..

813P Time to development of central nervous system (CNS) metastases (mets) with atezolizumab (A) or placebo (P) combined with vemurafenib (V) cobimetinib (C): Updated results from the phase III IMspire150 study

K Lewis, C Robert, R Ramella Munhoz, G Liszkay, L de la Cruz Merino, J Olah, P Queirolo, J Mackiewicz, H Li, Q Zhu, C Hertig, N Paranthaman, EF McKenna, R Gutzmer, G McArthur, PA Ascierto

Journal article  |  2022  |  Annals of Oncology

1670P Circulating tumor DNA (ctDNA) dynamics of response and resistance in BRAF V600E mutant (mt) metastatic colorectal (mCRC) and other cancers: Data from EVICT (erlotinib and vemurafenib in combination trial)

L Tan, B Tran, J Tie, E Link, SQ Wong, S Chandrashekar, J Guinto, B Markman, S Ananda, NC Tebbutt, M Michael, BJ Solomon, G McArthur, P Gibbs, S-J Dawson, J Desai

Journal article  |  2022  |  Annals of Oncology

First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors

Tae Won Kim, Howard A Burris, Maria J de Miguel Luken, Michael J Pishvaian, Yung-Jue Bang, Michael Gordon, Ahmad Awada, D Ross Camidge, F Stephen Hodi, Grant A McArthur, Wilson H Miller, Andres Cervantes, Laura Q Chow, Alexander M Lesokhin, Annemie Rutten, Mario Sznol, Deepali Rishipathak, Shang-Chiung Chen, Eric Stefanich, Tony Pourmohamad, et al.

Journal article  |  2022  |  CLINICAL CANCER RESEARCH

PURPOSE: OX40, a receptor transiently expressed by T cells upon antigen recognition, is associated with costimulation of effector ..

Prospective comparison of volumetric post-contrast T1-Sampling Perfection with Application optimized Contrasts by using different flip angle Evolutions and Magnetization-Prepared Rapid Acquisition with Gradient Echo in patients with metastatic melanoma.

Arian Lasocki, Lauren Caspersz, Grant A McArthur

Journal article  |  2022  |  Neuroradiol J

INTRODUCTION: Volumetric turbo spin echo (3D-TSE) T1-weighted imaging techniques such as T1-SPACE (Sampling Perfection with Applic..

EE460 Predicting the Population Budget Impact of Current and New Listings for Melanoma: The PRIMCAT-MEL Model

F Franchini, K Degeling, J Soon, YH To, K Trapani, G McArthur, M IJzerman

Journal article  |  2022  |  Value in Health