My research focuses on understanding how variations in the environment modulates the expression of genetic variation and its impact on genetic diversity. I focus on natural populations sourced from extreme climates both in model plant Arabidopsis thaliana and the model insect Drosophila melanogster to experiementally test their response to environmental stress such as temperature and light for plants and insecticide exposure for insects.
I have worked in four countries over three continents and studied three different organisms, trying to broaden the scope of my research. My current research programs involved cutting edge bioinformatics tools for the analysis of next generation genomics data but always grounding these in a real-life experimental setup.
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Alexandre Fournier-Level's selected work
Sublethal larval exposure to imidacloprid impacts adult behaviour in Drosophila melanogast..
Cis- and trans-acting variants contribute to survivorship in a naive Drosophila melanogast..
Displaying the 4 most recent projects by Alexandre Fournier-Level.
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Displaying the 32 most recent scholarly works by Alexandre Fournier-Level.
Sublethal larval exposure to imidacloprid impacts adult behaviour in Drosophila melanogaster
Helen K Young, Shane M Denecke, Charles Robin, Alexandre Fournier-Level
Journal article | 2019 | Journal of Evolutionary Biology
Pesticides are now chronically found in numerous ecosystems incurring widespread toxic effects on multiple organisms. For insects,..
instaGraminoid, a Novel Colorimetric Method to Assess Herbicide Resistance, Identifies Patterns of Cross-Resistance in Annual Ryegrass
Jefferson F Paril, Alexandre J Fournier-Level
Journal article | 2019 | Plant Phenomics
Herbicide resistance in agricultural weeds is a global problem with an increasing understanding that it is caused by multiple gene..
The spread of resistance to imidacloprid is restricted by thermotolerance in natural populations of Drosophila melanogaster
Alexandre Fournier-Level, Robert T Good, Stephen A Wilcox, Rahul Rane, Michelle Schiffer, Wei Chen, Paul Battlay, Trent Perry, Philip Batterham, Ary A Hoffmann, Charles Robin
Journal article | 2019 | Nature Ecology & Evolution
Cis and trans-acting variants contribute to survivorship in a naïve Drosophila melanogaster population exposed to ryanoid insecticides
Llewellyn Green, Paul Battlay, Alexandre Fournier-Level, Robert Good, Charles Robin
Journal article | 2018
Abstract Insecticide resistance is a paradigm of microevolution and insecticides are responsible for the strongest cases of recent..
Structural variants and selective sweep foci contribute to insecticide resistance in the Drosophila melanogaster genetic reference panel
Paul Battlay, Llewellyn Green, Pontus Leblanc, Joshua Schmidt, Alexandre Fournier-Level, Charles Robin
Journal article | 2018
Abstract Patterns of nucleotide polymorphism within populations of Drosophila melanogaster suggest that insecticides have been the..
Multiple P450s and Variation in Neuronal Genes Underpins the Response to the Insecticide Imidacloprid in a Population of Drosophila melanogaster
Shane Denecke, Roberto Fusetto, Felipe Martelli, Alex Giang, Paul Battlay, Alexandre Fournier-Level, Richard A O'Hair, Philip Batterham
Journal article | 2017 | Scientific Reports
Predicting the evolutionary dynamics of seasonal adaptation to novel climates in Arabidopsis thaliana
Alexandre Fournier-Level, Emily O Perry, Jonathan A Wang, Peter T Braun, Andrew Migneault, Martha D Cooper, C Jessica E Metcalf, Johanna Schmitt
Journal article | 2016 | Proceedings of the National Academy of Sciences
Repeated local emergence of carbapenem-resistant Acinetobacter baumannii in a single hospital ward
Mark B Schultz, Pham Thanh Duy, Tran Do Hoan Nhu, Ryan R Wick, Danielle J Ingle, Jane Hawkey, David J Edwards, Johanna J Kenyon, Phu Huong Lan Nguyen, James I Campbell, Guy Thwaites, Thi Khanh Nhu Nguyen, Ruth M Hall, Alexandre Fournier-Level, Stephen Baker, Kathryn E Holt
Journal article | 2016 | MICROBIAL GENOMICS
Genome-Wide Prediction Methods in Highly Diverse and Heterozygous Species: Proof-of-Concept through Simulation in Grapevine
Agota Fodor, Vincent Segura, Marie Denis, Samuel Neuenschwander, Alexandre Fournier-Level, Philippe Chatelet, Felix Abdel Aziz Homa, Thierry Lacombe, Patrice This, Loic Le Cunff
Journal article | 2014 | PLoS ONE
Haplotype diversity of VvTFL1A gene and association with cluster traits in grapevine (V. vinifera)
Lucie Fernandez, Loic Le Cunff, Javier Tello, Thierry Lacombe, Jean Michel Boursiquot, Alexandre Fournier-Level, Gema Bravo, Sandrine Lalet, Laurent Torregrosa, Patrice This, Jose Miguel Martinez-Zapater
Journal article | 2014 | BMC Plant Biology
Selection of candidate genes for grape proanthocyanidin pathway by an integrative approach
Gregory Carrier, Yung-Fen Huang, Loic Le Cunff, Alexandre Fournier-Level, Sandrine Vialet, Jean-Marc Souquet, Veronique Cheynier, Nancy Terrier, Patrice This
Journal article | 2013 | Plant Physiology and Biochemistry
Paths to selection on life history loci in different natural environments across the native range of Arabidopsis thaliana
Alexandre Fournier-Level, Amity M Wilczek, Martha D Cooper, Judith L Roe, Jillian Anderson, Deren Eaton, Brook T Moyers, Renee H Petipas, Robert N Schaeffer, Bjorn Pieper, Matthieu Reymond, Maarten Koornneef, Stephen M Welch, David L Remington, Johanna Schmitt
Journal article | 2013 | Molecular Ecology
Characterization of single nucleotide polymorphism in Tunisian grapevine genome and their potential for population genetics and evolutionary studies
Leila Riahi, Nejia Zoghlami, Alexandre Fournier-Level, Alexis Dereeper, Loic Le Cunff, Valerie Laucou, Ahmed Mliki, Patrice This
Journal article | 2013 | Genetic Resources and Crop Evolution
Dissecting genetic architecture of grape proanthocyanidin composition through quantitative trait locus mapping
Yung-Fen Huang, Agnes Doligez, Alexandre Fournier-Level, Loic Le Cunff, Yves Bertrand, Aurelie Canaguier, Cecile Morel, Valerie Miralles, Frederic Veran, Jean-Marc Souquet, Veronique Cheynier, Nancy Terrier, Patrice This
Journal article | 2012 | BMC Plant Biology
Quantitative Genetic Bases of Anthocyanin Variation in Grape (Vitis vinifera L. ssp sativa) Berry: A Quantitative Trait Locus to Quantitative Trait Nucleotide Integrated Study
Alexandre Fournier-Level, Loic Le Cunff, Camila Gomez, Agnes Doligez, Agnes Ageorges, Catherine Roux, Yves Bertrand, Jean-Marc Souquet, Veronique Cheynier, Patrice This
Journal article | 2009 | Genetics
Construction of nested genetic core collections to optimize the exploitation of natural diversity in Vitis vinifera L. subsp sativa
Loiec Le Cunff, Alexandre Fournier-Level, Valerie Laucou, Silvia Vezzulli, Thierry Lacombe, Anne-Francoise Adam-Blondon, Jean-Michel Boursiquot, Patrice This
Journal article | 2008 | BMC Plant Biology
Honours, Awards and Fellowships
Human Frontier in Science Fellow
PhD in Biology
University of Montpellier
Masters in Biology
University of Montpellier
Bachelor in Horticulture
Ecole Superieure d'Agriculture d'Angers