Jarmon Lees

Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction.

Andrew R Kompa, David W Greening, Anne M Kong, Paul J McMillan, Haoyun Fang, Ritika Saxena, Raymond CB Wong, Jarmon G Lees, Priyadharshini Sivakumaran, Andrew E Newcomb, Bakhos A Tannous, Cameron Kos, Lina Mariana, Thomas Loudovaris, Derek J Hausenloy, Shiang Y Lim

Journal article  |  2021  |  Cardiovascular Research

AIMS: To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells..

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Omar Lozano, Christian Silva-Platas, Hector Chapoy-Villanueva, Baruc E Perez, Jarmon G Lees, Chrishan JA Ramachandra, Flavio F Contreras-Torres, Anay Lazaro-Alfaro, Estefania Luna-Figueroa, Judith Bernal-Ramirez, Aldemar Gordillo-Galeano, Alfredo Benitez, Yuriana Oropeza-Almazan, Elena C Castillo, Poh Ling Koh, Derek J Hausenloy, Shiang Y Lim, Gerardo Garcia-Rivas

Journal article  |  2020  |  Particle and Fibre Toxicology

BACKGROUND: Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such a..

Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells

Jarmon G Lees, David K Gardner, Alexandra J Harvey

Journal article  |  2020  |  Stem Cells

Nicotinamide adenine dinucleotide (NAD+ ) and its precursor metabolites are emerging as important regulators of both cell metaboli..

Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Jarmon G Lees, Anne M Kong, Yi C Chen, Priyadharshini Sivakumaran, Damian Hernandez, Alice Pebay, Alexandra J Harvey, David K Gardner, Shiang Y Lim

Journal article  |  2019  |  Stem Cells International

Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle

Anne M Kong, Kiryu K Yap, Shiang Y Lim, Diego Marre, Alice Pebay, Yi-wen Gerrand, Jarmon G Lees, Jason A Palmer, Wayne A Morrison, Geraldine M Mitchell

Journal article  |  2019  |  Acta Biomaterialia

Tissue flaps are used to cover large/poorly healing wounds, but involve complex surgery and donor site morbidity. In this study a ..

Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux

Jarmon G Lees, Timothy S Cliff, Amanda Gammilonghi, James G Ryall, Stephen Dalton, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  Stem Cells International

Mitochondrial and glycolytic remodeling during nascent neural differentiation of human pluripotent stem cells

Jarmon G Lees, David K Gardner, Alexandra J Harvey

Journal article  |  2018  |  Development

Mitochondrial and glycolytic metabolism decreases during neural differentiation of human embryonic stem cells.

Jarmon G Lees, David Gardner, A Harvey

Conference Proceedings  |  2018

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

Jarmon G Lees, David K Gardner, Alexandra J Harvey

Journal article  |  2017  |  Stem Cells International

Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen

Jarmon G Lees, Joy Rathjen, John R Sheedy, David K Gardner, Alexandra J Harvey

Journal article  |  2015  |  REPRODUCTION