Sophie Payne

Blood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model

Sophie C Payne, Glenn Ward, James B Fallon, Tomoko Hyakumura, Johannes B Prins, Sofianos Andrikopoulos, Richard J MacIsaac, Joel Villalobos

Journal article  |  2022  |  PHYSIOLOGICAL REPORTS

Vagus nerve stimulation is emerging as a promising treatment for type 2 diabetes. Here, we evaluated the ability of stimulation of..

Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces

Calvin D Eiber, Sophie C Payne, Natalia P Biscola, Leif A Havton, Janet R Keast, Peregrine B Osborne, James B Fallon

Journal article  |  2021  |  JOURNAL OF NEURAL ENGINEERING

Objective.Neuromodulation of visceral nerves is being intensively studied for treating a wide range of conditions, but effective t..

Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions

Sophie C Payne, Glenn Ward, Richard J MacIsaac, Tomoko Hyakumura, James B Fallon, Joel Villalobos

Journal article  |  2020  |  PHYSIOLOGICAL REPORTS

Despite advancements in pharmacotherapies, glycemia is poorly controlled in type 2 diabetic patients. As the vagus nerve regulates..

SPARC: Minimally Invasive Recording of Neural Activity During Natural Voiding in Anaesthetized Rats

Sophie Payne, Peregrine Osborne, Janet Keast, James Fallon

Conference Proceedings  |  2020  |  FASEB JOURNAL

Transmural impedance detects graded changes of inflammation in experimental colitis

Sophie C Payne, Jack Alexandrovics, Ross Thomas, Robert K Shepherd, John B Furness, James B Fallon

Journal article  |  2020  |  ROYAL SOCIETY OPEN SCIENCE

Ulcerative colitis is a chronic disease in which the mucosa of the colon or rectum becomes inflamed. An objective biomarker of inf..

Anti-inflammatory Effects of Abdominal Vagus Nerve Stimulation on Experimental Intestinal Inflammation

Sophie C Payne, John B Furness, Owen Burns, Alicia Sedo, Tomoko Flyakumurat, Robert K Shepherd, James B Fallon

Journal article  |  2019  |  FRONTIERS IN NEUROSCIENCE

Electrical stimulation of the cervical vagus nerve is an emerging treatment for inflammatory bowel disease (IBD). However, side ef..

Bioelectric neuromodulation for gastrointestinal disorders: effectiveness and mechanisms

Sophie C Payne, John B Furness, Martin J Stebbing

Journal article  |  2019  |  NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY

The gastrointestinal tract has extensive, surgically accessible nerve connections with the central nervous system. This provides t..

Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep

Sophie C Payne, Owen Burns, Martin Stebbing, Ross Thomas, Angel de Silva, Alicia Sedo, Frank Weissenborn, Tomoko Hyakumura, Mario Huynh, Clive N May, Richard A Williams, John B Furness, James B Fallon, Robert K Shepherd

Journal article  |  2018  |  Bioelectronics in Medicine

Aim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, ..

An objective in vivo diagnostic method for inflammatory bowel disease

Sophie C Payne, Robert K Shepherd, Alicia Sedo, James B Fallon, John B Furness

Journal article  |  2018  |  ROYAL SOCIETY OPEN SCIENCE

Inflammatory damage to the bowel, as occurs in inflammatory bowel disease (IBD), is debilitating to patients. In both patients and..

Peripheral injury of pelvic visceral sensory nerves alters GFR alpha (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord

Shelley L Forrest, Sophie C Payne, Janet P Keast, Peregrine B Osborne

Journal article  |  2015  |  FRONTIERS IN NEUROANATOMY

GDNF (glial cell line-derived neurotrophic factor), neurturin and artemin use their co-receptors (GFRα1, GFRα2 and GFRα3, respecti..