Reem Saleh

Role of circular RNAs in colorectal tumor microenvironment

Jasni Viralippurath Ashraf, Varun Sasidharan Nair, Reem Saleh, Eyad Elkord

Journal article  |  2021  |  BIOMEDICINE & PHARMACOTHERAPY

Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which were previously considered as a byproduct of RNA splicing ..

Transcriptome of CD8( ) tumor-infiltrating T cells: a link between diabetes and colorectal cancer

Reem Saleh, Varun Sasidharan Nair, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord, Ranad Shaheen

Journal article  |  2021  |  CANCER IMMUNOLOGY IMMUNOTHERAPY

There is an increased risk of colorectal cancer (CRC) development in patients with non-insulin-dependent type 2 diabetes. CD8+ T c..

Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment

Varun Sasidharan Nair, Reem Saleh, Salman M Toor, Farhan S Cyprian, Eyad Elkord

Journal article  |  2021  |  CANCER IMMUNOLOGY IMMUNOTHERAPY

Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to change..

Epigenetic regulation of immune checkpoints and T cell exhaustion markers in tumor-infiltrating T cells of colorectal cancer patients

Varun Sasidharan Nair, Reem Saleh, Salman M Toor, Rowaida Z Taha, Ayman A Ahmed, Mohamed A Kurer, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord

Journal article  |  2020  |  EPIGENOMICS

Aim: To elucidate the epigenetic alterations behind the upregulation of immune checkpoints and T cell exhaustion markers in colore..

RNA-Seq Analysis of Colorectal Tumor-Infiltrating Myeloid-Derived Suppressor Cell Subsets Revealed Gene Signatures of Poor Prognosis

Reem Saleh, Varun Sasidharan Nair, Mahmood Al-Dhaheri, Mahwish Khawar, Mohamed Abu Nada, Nehad M Alajez, Eyad Elkord

Journal article  |  2020  |  FRONTIERS IN ONCOLOGY

Elevated levels of myeloid-derived suppressor cells (MDSCs), including polymorphonuclear MDSCs (PMN-MDSCs) and immature MDSCs (I-M..

Targeting TIM-3 in solid tumors: innovations in the preclinical and translational realm and therapeutic potential

Reem Saleh, Salman M Toor, Eyad Elkord

Journal article  |  2020  |  EXPERT OPINION ON THERAPEUTIC TARGETS

INTRODUCTION: Immune checkpoint inhibitors (ICIs) have shown a great therapeutic efficacy in cancer patients. However, a significa..

T-cell responses and therapies against SARS-CoV-2 infection

Salman M Toor, Reem Saleh, Varun Sasidharan Nair, Rowaida Z Taha, Eyad Elkord

Journal article  |  2020  |  IMMUNOLOGY

Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, a novel coronavirus strain. Some studies suggest that COVID-19 could ..

FoxP3( ) T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets

Reem Saleh, Eyad Elkord

Journal article  |  2020  |  CANCER LETTERS

T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain immune homeostasis and inhibit immune re..

Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression

Reem Saleh, Eyad Elkord

Journal article  |  2020  |  SEMINARS IN CANCER BIOLOGY

In the tumor microenvironment (TME), tumor cells are constantly evolving to reduce neoantigen generation and the mutational burden..

Differential gene expression of tumor-infiltrating CD33( )myeloid cells in advanced- versus early-stage colorectal cancer

Salman M Toor, Rowaida Z Taha, Varun Sasidharan Nair, Reem Saleh, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord

Journal article  |  2020  |  CANCER IMMUNOLOGY IMMUNOTHERAPY

Colorectal cancer (CRC) has high mortality rates, especially in patients with advanced disease stages, who often do not respond to..