Alison Farley

Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus

Svetlana Ulyanchenko, Kathy E O'Neill, Tanya Medley, Alison M Farley, Harsh J Vaidya, Alistair M Cook, Natalie F Blair, C Clare Blackburn

Journal article  |  2016  |  Cell Reports

Dynamics of thymus organogenesis and colonization in early human development.

Alison M Farley, Lucy X Morris, Eric Vroegindeweij, Marianne LG Depreter, Harsh Vaidya, Frances H Stenhouse, Simon R Tomlinson, Richard A Anderson, Tom Cupedo, Jan J Cornelissen, C Clare Blackburn

Journal article  |  2013  |  Development

The thymus is the central site of T-cell development and thus is of fundamental importance to the immune system, but little inform..

Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions.

Zhijie Liu, Alison Farley, Lizhen Chen, Beth J Kirby, Christopher S Kovacs, C Clare Blackburn, Nancy R Manley

Journal article  |  2010  |  PLoS Genetics

In mammals, parathyroid hormone (PTH) is a key regulator of extracellular calcium and inorganic phosphorus homeostasis. Although t..

Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells.

Paola Bonfanti, Stéphanie Claudinot, Alessandro W Amici, Alison Farley, C Clare Blackburn, Yann Barrandon

Journal article  |  2010  |  Nature

The thymus develops from the third pharyngeal pouch of the anterior gut and provides the necessary environment for thymopoiesis (t..

Thymus organogenesis and development of the thymic stroma.

Craig S Nowell, Alison M Farley, C Clare Blackburn

Journal article  |  2007  |  Methods in molecular biology (Clifton, N.J.)

T-cell development occurs principally in the thymus. Here, immature progenitor cells are guided through the differentiation and se..

Functional evidence for a single endodermal origin for the thymic epithelium.

Julie Gordon, Valerie A Wilson, Natalie F Blair, Julie Sheridan, Alison Farley, Linda Wilson, Nancy R Manley, C Clare Blackburn

Journal article  |  2004  |  Nature Immunology

T cell development depends critically on several distinct thymic epithelial cell types that are organized into two main compartmen..

Identification and characterization of thymic epithelial progenitor cells.

Andrea R Bennett, Alison Farley, Natalie F Blair, Julie Gordon, Linda Sharp, C Clare Blackburn

Journal article  |  2002  |  Immunity

T cell differentiation and repertoire selection depend critically on several distinct thymic epithelial cell types, whose lineage ..

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

JG Zhang, A Farley, SE Nicholson, TA Willson, LM Zugaro, RJ Simpson, RL Moritz, D Cary, R Richardson, G Hausmann, BJ Kile, SBH Kent, WS Alexander, D Metcalf, DJ Hilton, NA Nicola, M Baca

Journal article  |  1999  |  Proceedings of the National Academy of Sciences of the United States of America

Negative regulation of cytokine signaling by the SOCS proteins

NA Nicola, SE Nicholson, D Metcalf, JG Zhang, M Baca, A Farley, TA Willson, R Starr, W Alexander, DJ Hilton

Conference Proceedings  |  1999  |  Cold Spring Harbor Symposia on Quantitative Biology

Thymus Organogenesis and Development of the Thymic Stroma

Craig S Nowell, Alison M Farley, C Clare Blackburn

Book Chapter