Alison Farley

In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis.

C Biben, TS Weber, KS Potts, J Choi, DC Miles, A Carmagnac, T Sargeant, CA de Graaf, KA Fennell, A Farley, OJ Stonehouse, MA Dawson, DJ Hilton, SH Naik, S Taoudi

Journal article  |  2023  |  Nat Commun

During embryogenesis, haematopoietic and endothelial lineages emerge closely in time and space. It is thought that the first blood..

Cerebral vasculature exhibits dose-dependent sensitivity to thrombocytopenia that is limited to fetal/neonatal life

Alison M Farley, Merle Dayton, Christine Biben, Olivia Stonehouse, Antoine Terreaux, Samir Taoudi

Journal article  |  2022  |  BLOOD

Whether increasing platelet counts in fetal and neonatal alloimmune thrombocytopenia (FNAIT) is effective at preventing intracereb..

Vaccine-induced immune thrombosis and thrombocytopenia syndrome following adenovirus-vectored severe acute respiratory syndrome coronavirus 2 vaccination: a novel hypothesis regarding mechanisms and implications for future vaccine development

Paul Monagle, Ashley P Ng, Matthew Linden, Vera Ignjatovic, Alison Farley, Samir Taoudi, Sant Rayn Pasricha, Joseph Torresi

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

We hypothesize that thrombosis with thrombocytopenia syndrome recently described after administration of adenovirus-vectored vacci..

Severe thrombocytopenia is sufficient for fetal and neonatal intracerebral hemorrhage to occur

Alison Farley, Sarah Lloyd, Merle Dayton, Christine Biben, Olivia Stonehouse, Samir Taoudi

Journal article  |  2021  |  BLOOD

Intracerebral hemorrhage (ICH) has a devastating impact on the neonatal population. Whether thrombocytopenia is sufficient to caus..

2017 – THE MESODERMAL LINEAGES OF THE YOLK SAC ARE SEEDED BY HAEMANGIOBLAST, HAEMATOMESOBLAST, AND MESENCHYMOANGIOBLAST PRECURSORS

Christine Biben, Tom Weber, Kathryn Potts, Jarny Choi, Denise Miles, Amandine Carmagnac, Tobias Sargent, Carolyn de Graaf, Katie Fennell, Alison Farley, Olivia Stonehouse, Mark Dawson, Douglas Hilton, Shalin Naik, Samir Taoudi

Journal article  |  2021  |  Experimental Hematology

Membrane budding is a major mechanism of in vivo platelet biogenesis

Kathryn S Potts, Alison Farley, Caleb A Dawson, Joel Rimes, Christine Biben, Carolyn de Graaf, Margaret A Potts, Olivia J Stonehouse, Amandine Carmagnac, Pradnya Gangatirkar, Emma C Josefsson, Casey Anttila, Daniela Amann-Zalcenstein, Shalin Naik, Warren S Alexander, Douglas J Hilton, Edwin D Hawkins, Samir Taoudi

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

How platelets are produced by megakaryocytes in vivo remains controversial despite more than a century of investigation. Megakaryo..

Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development.

Dong Liu, Anastasia I Kousa, Kathy E O'Neill, Paul Rouse, Martyna Popis, Alison M Farley, Simon R Tomlinson, Svetlana Ulyanchenko, Francois Guillemot, Philip A Seymour, Mette C Jørgensen, Palle Serup, Ute Koch, Freddy Radtke, C Clare Blackburn

Journal article  |  2020  |  Development

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T ce..

Antibodies to a CA 19-9 Related Antigen Complex Identify SOX9 Expressing Progenitor Cells In Human Foetal Pancreas and Pancreatic Adenocarcinoma

Alison M Farley, David R Braxton, Jonathan Li, Karl Trounson, Subhanwita Sakar-Dey, Bhavana Nayer, Tatsuhiko Ikeda, Kevin X Lau, Winita Hardikar, Kouichi Hasegawa, Martin F Pera

Journal article  |  2019  |  SCIENTIFIC REPORTS

The Sialyl Lewis A antigen, or CA 19-9, is the prototype serum biomarker for adenocarcinoma of the pancreas. Despite extensive cli..

Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus

Svetlana Ulyanchenko, Kathy E O'Neill, Tanya Medley, Alison M Farley, Harsh J Vaidya, Alistair M Cook, Natalie F Blair, C Clare Blackburn

Journal article  |  2016  |  CELL REPORTS

Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TEC..

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation (vol 96, pg 2071, 1999)

Jian-Guo Zhang, Alison Farley, Sandra E Nicholson, Tracy A Willson, Lisa M Zugaro, Richard J Simpson, Robert L Moritz, Dale Cary, Rachael Richardson, George Hausmann, Benjamin T Kile, Stephen BH Kent, Warren S Alexander, Donald Metcalf, Douglas J Hilton, Nicos A Nicola, Manuel Baca

Journal article  |  2015  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA