Connie Li Wai Suen

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

Margaret A Potts, Shinsuke Mizutani, Alexandra L Garnham, Connie SN Li Wai Suen, Andrew J Kueh, Lin Tai, Martin Pal, Andreas Strasser, Marco J Herold

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of t..

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells (Feb,10.1038/s41418-023-01122-3, 2023)

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

The original version of this article contained a mistake. When preparing the revised version of this paper the authors omitted a n..

A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection

Simon P Preston, Cody C Allison, Jan Schaefer, William Clow, Stefanie M Bader, Sophie Collard, Wasan O Forsyth, Michelle P Clark, Alexandra L Garnham, Connie SN Li-Wai-Suen, Thanushi Peiris, Jack Teale, Liana Mackiewicz, Sophia Davidson, Marcel Doerflinger, Marc Pellegrini

Journal article  |  2023  |  CELL DEATH & DISEASE

Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue da..

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

Emma C Tovey C Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie SN Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, Andre L Samson, James M Murphy, Joanne M Hildebrand

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and ..

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah TT Diepstraten, Catherine Chang, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver MM Sieber, Jane Visvader, Gemma LL Kelly, Andreas Strasser

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of ..

Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels.

Amanda E Au, Jason E Corbin, Marion Lebois, Pradnya Gangatirkar, Fatme Yassinson, Stephanie Rose Hyslop, Ping Cannon, Kylie D Mason, Connie Sn Li-Wai-Suen, Alexandra L Garnham, Diane Moujalled, Luisa Cimmino, Warren S Alexander, Emma C Josefsson

Journal article  |  2022  |  Blood Adv

Platelets have been shown to enhance the survival of lymphoma cell lines, but it is unclear if they play a role in lymphoma. Here ..

Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest

Johannes Wichmann, Catherine Pitt, Samantha Eccles, Alexandra L Garnham, Connie SN Li-Wai-Suen, Rose May, Elizabeth Allan, Stephen Wilcox, Marco J Herold, Gordon K Smyth, Brendon J Monahan, Tim Thomas, Anne K Voss

Journal article  |  2022  |  CELL DEATH & DISEASE

Histone acetylation is essential for initiating and maintaining a permissive chromatin conformation and gene transcription. Dysreg..

Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria

Stephanie Studniberg, Lisa J Ioannidis, Retno AS Utami, Leily Trianty, Yang Liao, Waruni Abeysekera, Connie SN Li-Wai-Suen, Halina M Pietrzak, Julie Healer, Agatha M Puspitasari, Dwi Apriyanti, Farah Coutrier, Jeanne R Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K Smyth, Alan F Cowman, Ric N Price, et al.

Journal article  |  2022  |  MOLECULAR SYSTEMS BIOLOGY

Clinical immunity to P. falciparum malaria is non-sterilizing, with adults often experiencing asymptomatic infection. Historically..

Blood transcriptomics identifies immune signatures indicative of infectious complications in childhood cancer patients with febrile neutropenia

Gabrielle M Haeusler, Alexandra L Garnham, Connie Sn Li-Wai-Suen, Julia E Clark, Franz E Babl, Zoe Allaway, Monica A Slavin, Francoise Mechinaud, Gordon K Smyth, Bob Phillips, Karin A Thursky, Marc Pellegrini, Marcel Doerflinger

Journal article  |  2022  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: Febrile neutropenia (FN) is a major cause of treatment disruption and unplanned hospitalization in childhood cancer pa..

The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21

Dimitra Zotos, Isaak Quast, Connie SN Li-Wai-Suen, Craig I McKenzie, Marcus J Robinson, Andrey Kan, Gordon K Smyth, Philip D Hodgkin, David M Tarlinton

Journal article  |  2021  |  NATURE COMMUNICATIONS

Humoral immune responses require germinal centres (GC) for antibody affinity maturation. Within GC, B cell proliferation and mutat..