Victor Streltsov

Quantitative proteomics of tau and A beta in n detergent fractions from Alzheimer's disease brains

Soumya Mukherjee, Celine Dubois, Keyla Perez, Shiji Varghese, Ian E Birchall, Miranda Leckey, Natalia Davydova, Catriona McLean, Rebecca M Nisbet, Blaine R Roberts, Qiao-Xin Li, Colin L Masters, Victor A Streltsov

Journal article  |  2022  |  JOURNAL OF NEUROCHEMISTRY

The two hallmarks of Alzheimer's disease (AD) are amyloid-β (Aβ) plaques and neurofibrillary tangles marked by phosphorylated tau...

The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases.

Sukanya Luang, Xavier Fernández-Luengo, Alba Nin-Hill, Victor A Streltsov, Julian G Schwerdt, Santiago Alonso-Gil, James R Ketudat Cairns, Stéphanie Pradeau, Sébastien Fort, Jean-Didier Maréchal, Laura Masgrau, Carme Rovira, Maria Hrmova

Journal article  |  2022  |  Nat Commun

In the barley β-D-glucan glucohydrolase, a glycoside hydrolase family 3 (GH3) enzyme, the Trp286/Trp434 clamp ensures β-D-glucosid..

Quantitative proteomics of detergent insoluble tangles derived from Alzheimer's disease brains

S Mukherjee, C Dubois, K Perez, RM Nisbet, QX Li, S Varghese, LC Lago, S Klatt, I Birchall, L Jin, C McLean, V Streltsov, KJ Barnham, LJ Vella, CL Masters

Journal article  |  2021  |  Alzheimer's & dementia : the journal of the Alzheimer's Association

BACKGROUND: Ionic detergent N-laurly sarcosine (Sarkosyl) has been the general choice of extraction and enrichment of detergent-in..

Citrullination of Amyloid-beta Peptides in Alzheimer's Disease

Soumya Mukherjee, Keyla A Perez, Celine Dubois, Rebecca M Nisbet, Qiao-Xin Li, Shiji Varghese, Liang Jin, Ian Birchall, Victor A Streltsov, Laura J Vella, Catriona McLean, Kevin J Barham, Blaine R Roberts, Colin L Masters

Journal article  |  2021  |  ACS CHEMICAL NEUROSCIENCE

Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullinatio..

Redox state and photoreduction control using X-ray spectroelectrochemical techniques: advances in design and fabrication through additive engineering

Stephen Peter Best, Victor A Streltsov, Christopher Thomas Chantler, Wangzhe Li, Philip A Ash, Shusaku Hayama, Sofia Diaz-Moreno

Journal article  |  2021  |  Journal of Synchrotron Radiation

The design and performance of an electrochemical cell and solution flow system optimized for the collection of X-ray absorption sp..

Substitutions at H134 and in the 430-loop region in influenza B neuraminidases can confer reduced susceptibility to multiple neuraminidase inhibitors

Peter G Mohr, Janelle Williams, Masato Tashiro, Victor A Streltsov, Jennifer L McKimm-Breschkin

Journal article  |  2020  |  ANTIVIRAL RESEARCH

With the introduction of the influenza specific neuraminidase inhibitors (NAIs) in 1999, there were concerns about the emergence a..

Passaging of an influenza A(H1N1)pdm09 virus in a difluoro sialic acid inhibitor selects for a novel, but unfit I106M neuraminidase mutant

Jennifer L McKimm-Breschkin, Susan Barrett, Charley McKenzie-Kludas, Julie McAuley, Victor A Streltsov, Stephen G Withers

Journal article  |  2019  |  ANTIVIRAL RESEARCH

An influenza A(H1N1)pdm09 and an influenza B virus were passaged in 3-fluoro(eq)-4-guanidino difluoro sialic acid (3Feq4Gu DFSA), ..

Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site.

Victor A Streltsov, Sukanya Luang, Alys Peisley, Joseph N Varghese, James R Ketudat Cairns, Sebastien Fort, Marcel Hijnen, Igor Tvaroška, Ana Ardá, Jesús Jiménez-Barbero, Mercedes Alfonso-Prieto, Carme Rovira, Fernanda Mendoza, Laura Tiessler-Sala, José-Emilio Sánchez-Aparicio, Jaime Rodríguez-Guerra, José M Lluch, Jean-Didier Maréchal, Laura Masgrau, Maria Hrmova

Journal article  |  2019  |  Nat Commun

Substrates associate and products dissociate from enzyme catalytic sites rapidly, which hampers investigations of their trajectori..

Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion-domain stalk

Victor A Streltsov, Peter M Schmidt, Jennifer L McKimm-Breschkin

Journal article  |  2019  |  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

The influenza neuraminidase (NA) is a homotetramer with head, stalk, transmembrane and cytoplasmic regions. The structure of the N..

Structural Insight into Redox Dynamics of Copper Bound N-Truncated Amyloid-beta Peptides from in Situ X-ray Absorption Spectroscopy

Victor A Streltsov, Ruwini SK Ekanayake, Simon C Drew, Christopher T Chantler, Stephen P Best

Journal article  |  2018  |  INORGANIC CHEMISTRY

X-ray absorption spectroscopy of CuII amyloid-β peptide (Aβ) under in situ electrochemical control (XAS-EC) has allowed elucidatio..