Steffi Cheung Tung Shing

A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein

Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balazs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, et al.

Journal article  |  2022  |  EMBO MOLECULAR MEDICINE

C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We re..

C-reactive protein, immunothrombosis and venous thromboembolism

Caroline Dix, Johannes Zeller, Hannah Stevens, Steffen U Eisenhardt, Karen S Cheung Tung Shing, Tracy L Nero, Craig J Morton, Michael W Parker, Karlheinz Peter, James D McFadyen

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical pract..

Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases

J Zeller, B Bogner, JD McFadyen, J Kiefer, D Braig, G Pietersz, G Krippner, TL Nero, CJ Morton, KS Cheung Tung Shing, MW Parker, K Peter, SU Eisenhardt

Journal article  |  2022  |  PHARMACOLOGY & THERAPEUTICS

C-reactive protein (CRP) is the prototypic acute-phase reactant that has long been recognized almost exclusively as a marker of in..

Messing with beta c: A unique receptor with many goals

Winnie L Kan, Karen S Cheung Tung Shing, Tracy L Nero, Timothy R Hercus, Denis Tvorogov, Michael W Parker, Angel F Lopez

Journal article  |  2021  |  SEMINARS IN IMMUNOLOGY

Our understanding of the biological role of the βc family of cytokines has evolved enormously since their initial identification a..

EPO does not promote interaction between the erythropoietin and beta-common receptors (vol 8, 12457, 2018)

Karen S Cheung Tung Shing, Sophie E Broughton, Tracy L Nero, Kevin Gillinder, Melissa D Ilsley, Hayley Ramshaw, Angel F Lopez, Michael DW Griffin, Michael W Parker, Andrew C Perkins, Urmi Dhagat

Journal article  |  2019  |  SCIENTIFIC REPORTS

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been..

EPO does not promote interaction between the erythropoietin and beta-common receptors

Karen S Cheung Tung Shing, Sophie E Broughton, Tracy L Nero, Kevin Gillinder, Melissa D Ilsley, Hayley Ramshaw, Angel F Lopez, Michael DW Griffin, Michael W Parker, Andrew C Perkins, Urmi Dhagat

Journal article  |  2018  |  SCIENTIFIC REPORTS

A direct interaction between the erythropoietin (EPOR) and the beta-common (βc) receptors to form an Innate Repair Receptor (IRR) ..

Role of the beta Common (beta c) Family of Cytokines in Health and Disease

Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.

Journal article  |  2018  |  COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL..

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  NATURE COMMUNICATIONS

The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is ov..

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

Urmi Dhagat, Timothy R Hercus, Sophie E Broughton, Tracy L Nero, Karen S Cheung Tung Shing, Emma F Barry, Christy A Thomson, Steve Bryson, Emil F Pai, Barbara J McClure, John W Schrader, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  MABS

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that can stimulate a variety of cells, ..