Sarah Dunstan

MUC5AC genetic variation is associated with tuberculous meningitis CSF cytokine responses and mortality.

Michelle C Sabo, Nguyen TT Thuong, Xuling Chang, Edwin Ardiansyah, Trinh TB Tram, Hoang T Hai, Ho DT Nghia, Nguyen D Bang, Sofiati Dian, A Rizal Ganiem, Shima Shaporifar, Vinod Kumar, Zheng Li, Martin Hibberd, Chiea Chuen Khor, Guy E Thwaites, Dorothee Heemskerk, Arjan van Laarhoven, Reinout van Crevel, Sarah J Dunstan, et al.

Journal article  |  2023  |  J Infect Dis

BACKGROUND: The purpose of this study was to assess if single nucleotide polymorphisms (SNPs) in lung mucins MUC5B and MUC5AC are ..

The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis

Timothy M Walker, Paolo Miotto, Claudio U Koser, Philip W Fowler, Jeff Knaggs, Zamin Iqbal, Martin Hunt, Leonid Chindelevitch, Maha R Farhat, Daniela Maria Cirillo, Inaki Comas, James Posey, Shaheed V Omar, Timothy EA Peto, Anita Suresh, Swapna Uplekar, Sacha Laurent, Rebecca E Colman, Carl-Michael Nathanson, Matteo Zignol, et al.

Journal article  |  2022  |  LANCET MICROBE

BACKGROUND: Molecular diagnostics are considered the most promising route to achieving rapid, universal drug susceptibility testin..

REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk

Javeed A Shah, Alex J Warr, Andrew D Graustein, Aparajita Saha, Sarah J Dunstan, Nguyen TT Thuong, Guy E Thwaites, Maxine Caws, Phan VK Thai, Nguyen D Bang, Tran TH Chau, Chiea Chuen Khor, Zheng Li, Martin Hibberd, Xuling Chang, Felicia K Nguyen, Carlo A Hernandez, Madison A Jones, Christopher M Sassetti, Katherine A Fitzgerald, et al.

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

The major human genes regulating Mycobacterium tuberculosis-induced immune responses and tuberculosis (TB) susceptibility are poor..

Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study

James E Meiring, Mila Shakya, Farhana Khanam, Merryn Voysey, Maile T Phillips, Susan Tonks, Deus Thindwa, Thomas C Darton, Sabina Dongol, Abilasha Karkey, K Zaman, Stephen Baker, Christiane Dolecek, Sarah J Dunstan, Gordon Dougan, Kathryn E Holt, Robert S Heyderman, Firdausi Qadri, Virginia E Pitzer, Buddha Basnyat, et al.

Journal article  |  2021  |  LANCET GLOBAL HEALTH

BACKGROUND: Enteric fever is a serious public health concern in many low-income and middle-income countries. Numerous data gaps ex..

A Bayesian approach for estimating typhoid fever incidence from large-scale facility-based passive surveillance data

Maile T Phillips, James E Meiring, Merryn Voysey, Joshua L Warren, Stephen Baker, Buddha Basnyat, John D Clemens, Christiane Dolecek, Sarah J Dunstan, Gordon Dougan, Melita A Gordon, Deus Thindwa, Robert S Heyderman, Kathryn E Holt, Firdausi Qadri, Andrew J Pollard, Virginia E Pitzer

Journal article  |  2021  |  STATISTICS IN MEDICINE

Decisions about typhoid fever prevention and control are based on estimates of typhoid incidence and their uncertainty. Lack of sp..

Mitigating myopia in tuberculosis

Sarah J Dunstan, Thomas R Hawn

Journal article  |  2021  |  NATURE IMMUNOLOGY

Sources of Multidrug Resistance in Patients With Previous Isoniazid-Resistant Tuberculosis Identified Using Whole Genome Sequencing: A Longitudinal Cohort Study

Vijay Srinivasan, Vu TN Ha, Dao N Vinh, Phan VK Thai, Dang TM Ha, Nguyen H Lan, Hoang T Hai, Timothy M Walker, Do DA Thu, Sarah J Dunstan, Guy E Thwaites, Philip M Ashton, Maxine Caws, Nguyen TT Thuong

Journal article  |  2020  |  CLINICAL INFECTIOUS DISEASES

BACKGROUND: Meta-analysis of patients with isoniazid-resistant tuberculosis (TB) given standard first-line anti-TB treatment indic..

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

Gavin Band, Quang Si Le, Geraldine M Clarke, Katja Kivinen, Christina Hubbart, Anna E Jeffreys, Kate Rowlands, Ellen M Leffler, Muminatou Jallow, David J Conway, Fatoumatta Sisay-Joof, Giorgio Sirugo, Umberto d'Alessandro, Ousmane B Toure, Mahamadou A Thera, Salimata Konate, Sibiri Sissoko, Valentina D Mangano, Edith C Bougouma, Sodiomon B Sirima, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide associa..

Understanding the global tuberculosis epidemic: moving towards routine whole-genome sequencing.

SJ Dunstan, DA Williamson, JT Denholm

Journal article  |  2019  |  Int J Tuberc Lung Dis

Empirical ways to identify novel Bedaquiline resistance mutations in AtpE

Malancha Karmakar, Carlos HM Rodrigues, Kathryn E Holt, Sarah J Dunstan, Justin Denholm, David B Ascher

Journal article  |  2019  |  PLOS ONE

Clinical resistance against Bedaquiline, the first new anti-tuberculosis compound with a novel mechanism of action in over 40 year..