Sarah Dunstan

A Bayesian approach for estimating typhoid fever incidence from large-scale facility-based passive surveillance data

Maile T Phillips, James E Meiring, Merryn Voysey, Joshua L Warren, Stephen Baker, Buddha Basnyat, John D Clemens, Christiane Dolecek, Sarah J Dunstan, Gordon Dougan, Melita A Gordon, Deus Thindwa, Robert S Heyderman, Kathryn E Holt, Firdausi Qadri, Andrew J Pollard, Virginia E Pitzer

Journal article  |  2021  |  STATISTICS IN MEDICINE

Decisions about typhoid fever prevention and control are based on estimates of typhoid incidence and their uncertainty. Lack of sp..

Mitigating myopia in tuberculosis

Sarah J Dunstan, Thomas R Hawn

Journal article  |  2021  |  NATURE IMMUNOLOGY

Sources of Multidrug Resistance in Patients With Previous Isoniazid-Resistant Tuberculosis Identified Using Whole Genome Sequencing: A Longitudinal Cohort Study

Vijay Srinivasan, Vu TN Ha, Dao N Vinh, Phan VK Thai, Dang TM Ha, Nguyen H Lan, Hoang T Hai, Timothy M Walker, Do DA Thu, Sarah J Dunstan, Guy E Thwaites, Philip M Ashton, Maxine Caws, Nguyen TT Thuong

Journal article  |  2020  |  CLINICAL INFECTIOUS DISEASES

BACKGROUND: Meta-analysis of patients with isoniazid-resistant tuberculosis (TB) given standard first-line anti-TB treatment indic..

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

Gavin Band, Quang Si Le, Geraldine M Clarke, Katja Kivinen, Christina Hubbart, Anna E Jeffreys, Kate Rowlands, Ellen M Leffler, Muminatou Jallow, David J Conway, Fatoumatta Sisay-Joof, Giorgio Sirugo, Umberto d'Alessandro, Ousmane B Toure, Mahamadou A Thera, Salimata Konate, Sibiri Sissoko, Valentina D Mangano, Edith C Bougouma, Sodiomon B Sirima, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide associa..

Understanding the global tuberculosis epidemic: moving towards routine whole-genome sequencing.

SJ Dunstan, DA Williamson, JT Denholm

Journal article  |  2019  |  Int J Tuberc Lung Dis

Empirical ways to identify novel Bedaquiline resistance mutations in AtpE

Malancha Karmakar, Carlos HM Rodrigues, Kathryn E Holt, Sarah J Dunstan, Justin Denholm, David B Ascher

Journal article  |  2019  |  PLOS ONE

Clinical resistance against Bedaquiline, the first new anti-tuberculosis compound with a novel mechanism of action in over 40 year..

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Ola B Brynildsrud, Caitlin S Pepperell, Philip Suffys, Louis Grandjean, Johana Monteserin, Nadia Debech, Jon Bohlin, Kristian Alfsnes, John O-H Pettersson, Ingerid Kirkeleite, Fatima Fandinho, Marcia Aparecida da Silva, Joao Perdigao, Isabel Portugal, Miguel Viveiros, Taane Clark, Maxine Caws, Sarah Dunstan, Vuong Khac Thai Phan, Beatriz Lopez, et al.

Journal article  |  2018  |  SCIENCE ADVANCES

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find..

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepulveda, Taane G Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret Mackinnon, et al.

Journal article  |  2018  |  LANCET HAEMATOLOGY

BACKGROUND: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candid..

Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam

Kathryn E Holt, Paul McAdam, Vuong Khac Thai Phan, Thuy Thuong Thuong Nguyen, Thi Minh Ha Dang, Ngoc Lan Nguyen, Huu Lan Nguyen, Thi Quynh Nhu Nguyen, Thanh Hai Hoang, Thi Ngoc Ha Vu, Guy Thwaites, David J Edwards, Artika P Nath, Kym Pham, David B Ascher, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws, et al.

Journal article  |  2018  |  NATURE GENETICS

To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, ..

Could omics unlock the secret of surviving tuberculous meningitis?

Sarah J Dunstan, Maxine Caws

Journal article  |  2018  |  LANCET INFECTIOUS DISEASES