Paul Neeson

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.

Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt

Journal article  |  2020  |  International Journal of Molecular Sciences

Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic ..

High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer.

Minyu Wang, Yu-Kuan Huang, Joseph Ch Kong, Yu Sun, Daniela G Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha Di Costanzo, Ian R Gordon, Catherine Mitchell, Laura K Mackay, Rita A Busuttil, Paul J Neeson, Alex Boussioutas

Journal article  |  2020  |  Clinical & Translational Immunology

Objectives: To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive stu..

A Distinct Pretreatment Immune Gene Signature in Lentigo Maligna Is Associated with Imiquimod Response

Heloise Halse, Franco Caramia, Catriona A McLean, Minyu Wang, Han Xian Aw Yeang, Simon P Keam, Andreas Behren, Lena Ly, Martin Haskett, Jonathan Cebon, Grant A McArthur, Paul J Neeson, Victoria J Mar

Journal article  |  2020  |  Journal of Investigative Dermatology

Lentigo maligna (LM) is a common subtype of in situ melanoma on chronically sun-exposed skin, particularly the head and neck of ol..

Tissue-resident memory T cells in breast cancer control and immunotherapy responses

Ann Byrne, Peter Savas, Sneha Sant, Ran Li, Balaji Virassamy, Stephen J Luen, Paul A Beavis, Laura K Mackay, Paul J Neeson, Sherene Loi

Journal article  |  2020  |  Nature Reviews Clinical Oncology

The presence of tumour-infiltrating lymphocytes (TILs) is associated with favourable outcomes in patients with breast cancer as we..

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Scott Williams, Simon P Keam, Heloise Halse, Nguyen Thu, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer

Anna S Trigos, Anupama Pasam, Patricia Diana Banks, Roslyn Wallace, Simon P Keam, Heather Thorne, Catherine Mitchell, David Clouston, Declan G Murphy, Nathan Lawrentschuk, Damien M Bolton, Daniel Moon, Elena Castro, David Olmos, Phillip K Darcy, Ygal Haupt, Scott Williams, David L Goode, Paul J Neeson, Shahneen Kaur Sandhu

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Validation and characterisation of prognostically significant PD-L1( ) immune cells in HPV plus oropharyngeal squamous cell carcinoma

Richard J Young, Mathias Bressel, Sandro Porceddu, Janez Cernelc, Peter Savas, Howard Liu, Damien Urban, Alesha A Thai, Caroline Cooper, Tsien Fua, Paul Neeson, Danny Rischin, Benjamin Solomon

Journal article  |  2020  |  Oral Oncology

We previously showed in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) that the presence of intra..

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik

Journal article  |  2020  |  Haematologica

Increased and co-localized CD4 FOXP3 and CD8 T cells is a strong independent prognostic indicator in gastric cancer

Minyu Wang, Yu-Kuan Huang, Joe Kong, Yu Sun, Daniela Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha di Costanzo, Ian Gordon, Catherine Mitchell, Laura Mackay, Rita Busuttil, Paul Neeson, Alex Boussioutas

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Simon Keam, Heloise Halse, Nguyen ThuNgoc, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott Williams, Paul Neeson

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Combination of avelumabwith peptide receptor radionuclide therapy (PRRT) or conventional fractionated radiotherapy (RT) in metastatic merkel cell carcinoma (mMCC) [GoTHAM study]

Shahneen Sandhu, Richard Tothill, Richard Scolyer, Alexander Guminski, Juergen Becker, Michael Poulsen, Victoria Atkinson, Paul Neeson, Mark Shackleton, David Pattison, Narelle Williams, Elizabeth Paton

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Identification of an excellent prognosis subset of human papillomavirus-associated oropharyngeal cancer patients by quantification of intratumoral CD103 immune cell abundance.

B Solomon, RJ Young, M Bressel, J Cernelc, P Savas, H Liu, D Urban, A Thai, C Cooper, T Fua, P Neeson, S Loi, SV Porceddu, D Rischin

Journal article  |  2019  |  Annals of oncology : official journal of the European Society for Medical Oncology

BACKGROUND: Accurate prognostic stratification of human papillomavirus-associated oropharyngeal cancers (HPV+OPSCC) is required to..

Identification of an excellent prognosis subset of human papillomavirus-associated oropharyngeal cancer patients by quantification of intratumoral CD103( ) immune cell abundance

B Solomon, RJ Young, M Bressel, J Cernelc, P Savas, H Liu, D Urban, A Thai, C Cooper, T Fua, P Neeson, S Loi, SV Porceddu, D Rischin

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: Accurate prognostic stratification of human papillomavirus-associated oropharyngeal cancers (HPV+OPSCC) is required to..

Phase II trial PD-L1/PD-1 blockade avelumab with chemoradiotherapy for locally advanced resectable T3B-4/N1-2 rectal cancer: The Ave-Rec trial.

Michael Michael, Rachel Wong, Sanjeev Singh Gill, David Goldstein, Sam Ngan, Alexander Graham Heriot, Emma Link, Maria Farrell, Paul J Neeson, Robert George Ramsay, Kasmira Wilson, Catherine Mitchell, Jeanne Tie, Nick Pavlakis, John Raymond Zalcberg, Eva Segelov

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

DEVELOPMENT OF NEXT GENERATION CAR'S TARGETING THE LEWIS Y ANTIGEN FOR THE TREATMENT OF CANCER

D Meyran, J Zhu, J Buttler, D Tantalo, M Neeson, P Ekert, M Kershaw, J Trapani, P Darcy, P Neeson

Conference Proceedings  |  2019  |  Cytotherapy

Direct evidence of a clonal and tumor-directed T cell response to prostate cancer brachytherapy.

Scott Williams, Simon Keam, Heloise Halse, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phil Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Safety and efficacy of stereotactic body radiotherapy and Pembrolizumab in advanced breast cancer patients with 1 to 5 metastases

SP David, P Savas, PJ Neeson, SJ Luen, F Foroudi, S Siva, S Loi

Conference Proceedings  |  2019  |  Poster Session Abstracts

Characterization of high TIL breast cancers reveals a prognostic and functionally distinct tissue-resident memory subpopulation

P Savas, B Virassamy, C Ye, A Salim, CP Mintoff, F Caramia, R Salgado, ZL Teo, S Dushyanthen, A Byrne, SJ Luen, SB Fox, TP Speed, LK Mackay, PJ Neeson, S Loi

Conference Proceedings  |  2019  |  Poster Discussion Abstracts

Accumulation of CD103( ) CD8( ) T cells in a cutaneous melanoma micrometastasis

Katharina Hochheiser, Han Xian Aw Yeang, Teagan Wagner, Candani Tutuka, Andreas Behren, Jason Waithman, Christopher Angel, Paul J Neeson, Thomas Gebhardt, David E Gyorki

Journal article  |  2019  |  Clinical & Translational Immunology

Objective: The immune system can halt cancer progression by suppressing outgrowth of clinically occult micrometastases in a state ..

Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

Joseph Cherng Huei Kong, Glen Robert Guerra, Rosemary Magdalena Millen, Sara Roth, Huiling Xu, Paul Joseph Neeson, Phillip Kevin Darcy, Michael Henry Kershaw, Shienny Sampurno, Jordane Malaterre, David Shi Hao Liu, Duc Pham Toan, Vignesh Narasimhan, Minyu Wang, Yu-Kuan Huang, Kumar Visvanathan, Jacob McCormick, Andrew Craig Lynch, Satish Warrier, Michael Michael, et al.

Journal article  |  2018  |  JCO Precision Oncology

LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins

Damien Zanker, Kenneth Pang, Sara Oveissi, Chunni Lu, Pierre Faou, Cameron Nowell, George W Mbogo, Sebastian Carotta, Cathy Quillici, Guna Karupiah, Margaret L Hibbs, Stephen L Nutt, Paul Neeson, Hamsa Puthalakath, Weisan Chen

Journal article  |  2018  |  Immunology and Cell Biology

High mammographic density in women is associated with protumor inflammation

Cecilia W Huo, Prue Hill, Grace Chew, Paul J Neeson, Heloise Halse, Elizabeth D Williams, Michael A Henderson, Erik W Thompson, Kara L Britt

Journal article  |  2018  |  Breast Cancer Research

Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue

Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Gisela Mir Arnau, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Scott G Williams, Ygal Haupt

Journal article  |  2018  |  Radiation and Environmental Biophysics

Multiplex immunohistochemistry accurately defines the immune context of metastatic melanoma

H Halse, AJ Colebatch, P Petrone, MA Henderson, JK Mills, H Snow, JA Westwood, S Sandhu, JM Raleigh, A Behren, J Cebon, PK Darcy, MH Kershaw, GA McArthur, DE Gyorki, PJ Neeson

Journal article  |  2018  |  Scientific Reports

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Peter Savas, Balaji Virassamy, Chengzhong Ye, Agus Salim, Christopher P Mintoff, Franco Caramia, Roberto Salgado, David J Byrne, Zhi L Teo, Sathana Dushyanthen, Ann Byrne, Lironne Wein, Stephen J Luen, Catherine Poliness, Sophie S Nightingale, Anita S Skandarajah, David E Gyorki, Chantel M Thornton, Paul A Beavis, Stephen B Fox, et al.

Journal article  |  2018  |  Nature Medicine

Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data-independent acquisition (DIA) mass spectrometry

Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Ygal Haupt, Scott G Williams

Journal article  |  2018  |  The Prostate

Human blood MAIT cell subsets defined using MR1 tetramers

Nicholas A Gherardin, Michael NT Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia BG Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov, David P Fairlie, David S Ritchie, Paul J Neeson, Daniel G Pellicci, Adam P Uldrich, James McCluskey, Dale I Godfrey

Journal article  |  2018  |  Immunology and Cell Biology

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey

Journal article  |  2018  |  Scientific Reports

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

AJ Davenport, RS Cross, KA Watson, Y Liao, W Shi, HM Prince, PA Beavis, JA Trapani, MH Kershaw, DS Ritchie, PK Darcy, PJ Neeson, MR Jenkins

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

IPH4102, a monoclonal antibody directed against the immune receptor molecule KIR3DL2, for the treatment of cutaneous T-cell lymphoma

Carrie Van Der Weyden, Martine Bagot, Paul Neeson, Phil K Darcy, H Miles Prince

Journal article  |  2018  |  Expert Opinion on Investigational Drugs

The Transcriptional Landscape of Radiation-Treated Human Prostate Cancer: Analysis of a Prospective Tissue Cohort

Simon P Keam, Franco Caramia, Cristina Gamell, Piotr J Paul, Gisela Mir Arnau, Paul J Neeson, Scott G Williams, Ygal Haupt

Journal article  |  2018  |  International Journal of Radiation Oncology*Biology*Physics

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Sathana Dushyanthen, Zhi Ling Teo, Franco Caramia, Peter Savas, Christopher P Mintoff, Balaji Virassamy, Melissa A Henderson, Stephen J Luen, Mariam Mansour, Michael H Kershaw, Joseph A Trapani, Paul J Neeson, Roberto Salgado, Grant A McArthur, Justin M Balko, Paul A Beavis, Phillip K Darcy, Sherene Loi

Journal article  |  2017  |  Nature Communications

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid YN Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, et al.

Journal article  |  2017  |  Nature

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y Slaney, Bianca von Scheidt, Alexander J Davenport, Paul A Beavis, Jennifer A Westwood, Sherly Mardiana, David C Tscharke, Sarah Ellis, H Miles Prince, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth, Michele W Teng, Aesha Ali, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo, Paul Neeson, Phillip K Darcy, Michael H Kershaw

Journal article  |  2017  |  Clinical Cancer Research

PD-1 blockade enhances elotuzumab efficacy in mouse tumor models

Natalie A Bezman, Amy Jhatakia, Alper Y Kearney, Ty Brender, Mark Maurer, Karla Henning, Misty R Jenkins, Amy J Rogers, Paul J Neeson, Alan J Korman, Michael D Robbins, Robert F Graziano

Journal article  |  2017  |  Blood Advances

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Sherly Mardiana, Liza B John, Melissa A Henderson, Clare Y Slaney, Bianca von Scheidt, Lauren Giuffrida, Alexander J Davenport, Joseph A Trapani, Paul J Neeson, Sherene Loi, Nicole M Haynes, Michael H Kershaw, Paul A Beavis, Phillip K Darcy

Journal article  |  2017  |  Cancer Research

Immunological battlefield in gastric cancer and role of immunotherapies

Minyu Wang, Rita A Busuttil, Sharon Pattison, Paul J Neeson, Alex Boussioutas

Journal article  |  2016  |  World Journal of Gastroenterology

The use of ipilimumab in patients with rheumatoid arthritis and metastatic melanoma

B Lee, A Wong, D Kee, P Neeson, M Shackleton, G McArthur, S Sandhu

Journal article  |  2016  |  Annals of Oncology

Allogeneic CAR19 cells clear ALL

Paul Neeson

Journal article  |  2016  |  Blood

Reprogramming the tumor microenvironment to enhance adoptive cellular therapy

Paul A Beavis, Clare Y Slaney, Michael H Kershaw, David Gyorki, Paul J Neeson, Phillip K Darcy

Journal article  |  2016  |  Seminars in Immunology

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

Nicholas A Gherardin, Andrew N Keller, Rachel E Woolley, Jerome Le Nours, David S Ritchie, Paul J Neeson, Richard W Birkinshaw, Sidonia BG Eckle, John N Waddington, Ligong Liu, David P Fairlie, Adam P Uldrich, Daniel G Pellicci, James McCluskey, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2016  |  Immunity

Myelosuppressive Therapies Significantly Increase ProInflammatory Cytokines and Directly Cause Bone Loss

Julie M Quach, Maria Askmyr, Tanja Jovic, Emma K Baker, Nicole C Walsh, Simon J Harrison, Paul Neeson, David Ritchie, Peter R Ebeling, Louise E Purton

Journal article  |  2015  |  Journal of Bone and Mineral Research

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

Alexander J Davenport, Misty R Jenkins, Ryan S Cross, Carmen S Yong, H Miles Prince, David S Ritchie, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  Cancer Immunology Research

A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation, and Onset of Graft-versus-Host Disease in Mice

Joanne E Davis, Michael Harvey, Nicholas A Gherardin, Rachel Koldej, Nicholas Huntington, Paul Neeson, Joseph A Trapani, David S Ritchie

Journal article  |  2015  |  Biology of Blood and Marrow Transplantation

CD3(bright) signals on gamma delta T cells identify IL-17A-producing V gamma 6V delta 1( ) T cells

C Paget, MT Chow, NA Gherardin, PA Beavis, AP Uldrich, H Duret, M Hassane, F Souza-Fonseca-Guimaraes, DA Mogilenko, D Staumont-Salle, NK Escalante, GR Hill, P Neeson, DS Ritchie, D Dombrowicz, T Mallevaey, F Trottein, GT Belz, DI Godfrey, MJ Smyth

Journal article  |  2015  |  Immunology & Cell Biology

Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib

Paul J Neeson, Andy K Hsu, Yin R Chen, Heloise M Halse, Joanna Loh, Reece Cordy, Kate Fielding, Joanne Davis, Josh Noske, Alex J Davenport, Camilla A Lindqvist-Gigg, Robin Humphreys, Tsin Tai, H Miles Prince, Joseph A Trapani, Mark J Smyth, David S Ritchie

Journal article  |  2015  |  OncoImmunology

Adoptive immunotherapy: a new era for the treatment of cancer

Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  Immunotherapy

Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression

Paul A Beavis, Clare Y Slaney, Michael H Kershaw, Paul J Neeson, Phillip K Darcy

Journal article  |  2015  |  Immunotherapy

CAR-T cells are serial killers

Alexander J Davenport, Misty R Jenkins, David S Ritchie, H Miles Prince, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  OncoImmunology

B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21

Magdalena Hagn, Sue E Blackwell, Thamara Beyer, Verena Ebel, Dorit Fabricius, Stefanie Lindner, Stefan Stilgenbauer, Thomas Simmet, Constantine Tam, Paul Neeson, Joseph A Trapani, Hubert Schrezenmeier, George J Weiner, Bernd Jahrsdoerfer

Journal article  |  2014  |  International Immunology

OMIP-021: Simultaneous Quantification of Human Conventional and Innate-Like T-Cell Subsets

Nicholas A Gherardin, David S Ritchie, Dale I Godfrey, Paul J Neeson

Journal article  |  2014  |  Cytometry Part A

The Drug Vehicle and Solvent N-Methylpyrrolidone Is an Immunomodulator and Antimyeloma Compound

Jake Shortt, Andy K Hsu, Benjamin P Martin, Karen Doggett, Geoffrey M Matthews, Maria A Doyle, Jason Ellul, Tina E Jockel, Daniel M Andrews, Simon J Hogg, Andrea Reitsma, David Faulkner, P Leif Bergsagel, Marta Chesi, Joan K Heath, William A Denny, Philip E Thompson, Paul J Neeson, David S Ritchie, Grant A McArthur, et al.

Journal article  |  2014  |  Cell Reports

Early thymus and activation-regulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant

Simon J Harrison, Andy K Hsu, Paul Neeson, Anas Younes, Anna Sureda, Andreas Engert, H Miles Prince, Martha Li, Paula Savage, Roberto Bugarini, Denise Williams, Margaret Squier, David S Ritchie

Journal article  |  2014  |  Leukemia & Lymphoma

Manipulating immune cells for adoptive immunotherapy of cancer

Phillip K Darcy, Paul Neeson, Carmen SM Yong, Michael H Kershaw

Journal article  |  2014  |  Current Opinion in Immunology

Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy

AC Chan, P Neeson, E Leeansyah, K Tainton, H Quach, HM Prince, SJ Harrison, DI Godfrey, D Ritchie, SP Berzins

Journal article  |  2014  |  Clinical and Experimental Immunology

Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia

David S Ritchie, Paul J Neeson, Amit Khot, Stefan Peinert, Tsin Tai, Kellie Tainton, Karen Chen, Mandy Shin, Dominic M Wall, Dirk Hoenemann, Peter Gambell, David A Westerman, Javier Haurat, Jennifer A Westwood, Andrew M Scott, Lucy Kravets, Michael Dickinson, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, et al.

Journal article  |  2013  |  Molecular Therapy

Chimeric antigen receptor-redirected T cells display multifunctional capacity and enhanced tumor-specific cytokine secretion upon secondary ligation of chimeric receptor

Melissa A Henderson, Carmen SM Yong, Connie PM Duong, Alexander J Davenport, Liza B John, Christel Devaud, Paul Neeson, Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  Immunotherapy

Are the immuno-stimulatory properties of Lenalidomide extinguished by co-administration of Dexamethasone?

Andy Hsu, David S Ritchie, Paul Neeson

Journal article  |  2012  |  OncoImmunology

Response Dexamethasone dose alters expression of NK activating receptors in vivo

Andy Hsu, Hang Quach, Tsin Tai, H Miles Prince, Simon J Harrison, Joseph A Trapani, Mark J Smyth, Paul J Neeson, David S Ritchie

Journal article  |  2011  |  Blood

A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma

Simon J Harrison, Hang Quach, Emma Link, John F Seymour, David S Ritchie, Sam Ruell, Joanne Dean, Henry Januszewicz, Ricky Johnstone, Paul Neeson, Michael Dickinson, Jean Nichols, H Miles Prince

Journal article  |  2011  |  Blood

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy

Andy K Hsu, Hang Quach, Tsin Tai, H Miles Prince, Simon J Harrison, Joseph A Trapani, Mark J Smyth, Paul Neeson, David S Ritchie

Journal article  |  2011  |  Blood

The level of glycolytic metabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome

Patries M Herst, Rebecca A Howman, Paul J Neeson, Michael V Berridge, David S Ritchie

Journal article  |  2011  |  Journal of Leukocyte Biology

Biology and Clinical Observations of Regulatory T Cells in Cancer Immunology

Michele WL Teng, David S Ritchie, Paul Neeson, Mark J Smyth

Journal article  |  2011  |  Current Topics in Microbiology and Immunology

Tumor Ablation by Gene-Modified T Cells in the Absence of Autoimmunity

Leanne XJ Wang, Jennifer A Westwood, Maria Moeller, Connie PM Duong, Wei-Zen Wei, Jordane Malaterre, Joseph A Trapani, Paul Neeson, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2010  |  Cancer Research

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8( ) T cells with effector and central memory-like phenotype

P Neeson, A Shin, KM Tainton, P Guru, HM Prince, SJ Harrison, S Peinert, MJ Smyth, JA Trapani, MH Kershaw, PK Darcy, DS Ritchie

Journal article  |  2010  |  Gene Therapy

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen

S Peinert, HM Prince, PM Guru, MH Kershaw, MJ Smyth, JA Trapani, P Gambell, S Harrison, AM Scott, FE Smyth, PK Darcy, K Tainton, P Neeson, DS Ritchie, D Hoenemann

Journal article  |  2010  |  Gene Therapy

Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients

AC Chan, P Neeson, E Leeansyah, K Tainton, H Quach, HM Prince, DI Godfrey, D Ritchie, SP Berzins

Journal article  |  2010  |  Leukemia

Drug-mediated and cellular immunotherapy in multiple myeloma

David S Ritchie, Hang Quach, Kate Fielding, Paul Neeson

Journal article  |  2010  |  Immunotherapy

Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma

H Quach, D Ritchie, AK Stewart, P Neeson, S Harrison, MJ Smyth, HM Prince

Journal article  |  2010  |  Leukemia

The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells

Patries M Herst, Joanne E Davis, Paul Neeson, Michael V Berridge, David S Ritchie

Journal article  |  2009  |  Haematologica

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

JA Westwood, WK Murray, M Trivett, A Shin, P Neeson, DP MacGregor, NM Haynes, JA Trapani, P Mayura-Guru, S Fox, S Peinert, D Honemann, HM Prince, D Ritchie, AM Scott, FE Smyth, MJ Smyth, PK Darcy, MH Kershaw

Journal article  |  2008  |  Gene Therapy

Listeriolysin O is an improved protein carrier for lymphoma immunoglobulin idiotype and provides systemic protection against 38C13 lymphoma

Paul Neeson, Zhen Kun Pan, Yvonne Paterson

Journal article  |  2008  |  Cancer Immunology, Immunotherapy

A DNA prime-oral Listeria boost vaccine in rhesus macaques induces a SIV-specific CD8 T cell mucosal response characterized by high levels Of alpha(4)beta(7) integrin and an effector memory phenotype

Paul Neeson, Jean Boyer, Sanjeev Kumar, Mark G Lewis, Lennox Mattias, Ron Veazey, David Weiner, Yvonne Paterson

Journal article  |  2006  |  Virology

Effects of the tumor microenvironment on the efficacy of tumor immunotherapy

Paul Neeson, Yvonne Paterson

Journal article  |  2006  |  Immunological Investigations

Tumor sensitivity to IFN-gamma is required for successful antigen-specific immunotherapy of a transplantable mouse tumor model for HPV-transformed tumors

ME Dominiecki, GL Beatty, ZK Pan, P Neeson, Y Paterson

Journal article  |  2005  |  Cancer Immunology, Immunotherapy

A new multi-parameter flow cytometric assay for monitoring lymphoma growth and spread in a pre-clinical murine model for human lymphoma

P Neeson, Y Paterson

Journal article  |  2004  |  Cytometry

Lymphocyte-facilitated tumour cell adhesion to endothelial cells: the role of high affinity leucocyte integrins

PJ Neeson, PJ Thurlow, GP Jamieson, C Bradley

Journal article  |  2003  |  Pathology

Lymphocyte-facilitated tumour cell adhesion to endothelial cells: The role of high affinity leucocyte integrins

PJ Neeson, PJ Thurlow, GP Jamieson, C Bradley

Journal article  |  2003  |  Pathology

ELISA is the superior method for detecting antineutrophil cytoplasmic antibodies in the diagnosis of systemic necrotising vasculitis

J Savige, P Neeson, M Trevisin, P Gambel, W Pollock

Journal article  |  2000  |  Journal of Clinical Pathology

Characterization of activated lymphocyte-tumor cell adhesion

PJ Neeson, PJ Thurlow, GP Jamieson

Journal article  |  2000  |  Journal of Leukocyte Biology

Clinical associations and characterisation of antineutrophil cytoplasmic antibodies directed against bactericidal/permeability-increasing protein and azurocidin

T Cooper, J Savige, L Nassis, B Paspaliaris, P Neeson, J Neil, KR Knight, M Daskalakis, JCG Doery

Journal article  |  2000  |  Rheumatology International

Detection of anti-phosphatidylethanolamine antibodies using flow cytometry

KA Drouvalakis, PJ Neeson, RRC Buchanan

Journal article  |  1999  |  Cytometry

Antithyroid and antiadrenal autoantibodies in antiglomerular basement membrane disease, thin basement membrane disease and Alport syndrome

JA Savige, P Branley, P Neeson, S Holdsworth, P Thurlow

Journal article  |  1998  |  Pathology

ACQUIRED PROTEIN-S DEFICIENCY IN A PATIENT WITH SYSTEMIC LUPUS-ERYTHEMATOSUS CAUSING CENTRAL RETINAL VEIN-THROMBOSIS

HM PRINCE, PJ THURLOW, RC BUCHANAN, KMA IBRAHIM, PJ NEESON

Journal article  |  1995  |  Journal of Clinical Pathology