Paul Neeson

Regulatory T Cells Shape the Differential Impact of Radiation Dose-Fractionation Schedules on Host Innate and Adaptive Antitumor Immune Defenses.

Joseph Sia, Jim Hagekyriakou, Ioana Chindris, Hassan Albarakati, Trevor Leong, Ramona Schlenker, Simon P Keam, Scott G Williams, Paul J Neeson, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2021  |  Int J Radiat Oncol Biol Phys

PURPOSE: We examined how radiation dose per fraction (DPF) and total dose, as represented by biological effective dose (BED), can ..

Myeloma natural killer cells are exhausted and have impaired regulation of activation

Criselle D'Souza, Simon P Keam, Han Xian Aw Yeang, Michael Neeson, Kelden Richardson, Andy K Hsu, Rachael Canfield, Natalie Bezman, Michael Robbins, Hang Quach, David S Ritchie, Simon J Harrison, Joseph A Trapani, H Miles Prince, Paul A Beavis, Phillip K Darcy, Paul J Neeson

Journal article  |  2021  |  HAEMATOLOGICA

Not available.

Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II) The Trans Tasman Radiation Oncology Group 13.01 Phase 2 Randomized Clinical Trial

Shankar Siva, Mathias Bressel, Tao Mai, Hien Le, Shalini Vinod, Harini de Silva, Sean Macdonald, Marketa Skala, Nicholas Hardcastle, Angela Rezo, David Pryor, Suki Gill, Braden Higgs, Kassandra Wagenfuehr, Rebecca Montgomery, Raef Awad, Brent Chesson, Thomas Eade, Wenchang Wong, Giuseppe Sasso, et al.

Journal article  |  2021  |  JAMA ONCOLOGY

Importance: Evidence is lacking from randomized clinical trials to guide the optimal approach for stereotactic ablative body radio..

Characterisation of immune checkpoints in Richter syndrome identifies LAG3 as a potential therapeutic target

Clare Gould, Jennifer Lickiss, Yamuna Kankanige, Satwica Yemeni, Stephen Lade, Maher K Gandhi, Collin Chin, Costas K Yannakou, Diego Villa, Graham W Slack, John F Markham, Constantine S Tam, Niles Nelson, John F Seymour, Michael Dickinson, Paul J Neeson, David Westerman, Piers Blombery

Journal article  |  2021  |  BRITISH JOURNAL OF HAEMATOLOGY

Richter syndrome (RS), an aggressive lymphoma occurring in the context of chronic lymphocytic leukaemia/small lymphocytic lymphoma..

Early-phenotype CAR-T cells for the treatment of pediatric cancers.

D Meyran, RL Terry, JJ Zhu, M Haber, DS Ziegler, PG Ekert, JA Trapani, PK Darcy, PJ Neeson

Journal article  |  2021  |  Ann Oncol

Chimeric antigen receptor (CAR)-T-cell therapy is a promising approach for the treatment of childhood cancers, particularly high-r..

MAIT cells regulate NK cell-mediated tumor immunity

Emma Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Simon P Keam, Junyun Lai, Imran G House, Jasmine Li, Magnus Zethoven, Amanda XY Chen, Amanda J Oliver, Jessica Michie, Andrew J Freeman, Lauren Giuffrida, Jack D Chan, Angela Pizzolla, Jeffrey YW Mak, Timothy R McCulloch, Fernando Souza-Fonseca-Guimaraes, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT ce..

Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression

Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G Williams, Anthony J Costello, Paul J Neeson, Bhupinder Pal, Nicholas D Huntington, et al.

Journal article  |  2021  |  BMC CANCER

BACKGROUND: Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings ..

Abstract 3044: The unexplored immune landscape of high-risk pediatric cancers

Chelsea Mayoh, Rachael L Terry, Marie Wong, Loretta M Lau, Dong Anh Khuong-Quang, Marion K Mateos, Vanessa Tyrrell, Michelle Haber, David S Ziegler, Mark J Cowley, Joseph A Trapani, Paul J Neeson, Paul G Ekert

Conference Proceedings  |  2021  |  Tumor Biology

The unexplored immune landscape of high-risk pediatric cancers.

Chelsea Mayoh, Rachael L Terry, Marie Wong, Loretta M Lau, Dong Anh Khuong-Quang, Marion K Mateos, Vanessa Tyrrell, Michelle Haber, David S Ziegler, Mark J Cowley, Joseph A Trapani, Paul J Neeson, Paul G Ekert

Conference Proceedings  |  2021  |  CANCER RESEARCH

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L Nutt, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigen..