Paul Neeson

Myeloma NK cells are exhausted and have impaired regulation of activation.

Criselle D'Souza, Simon P Keam, Han Xian Aw Yeang, Michael Neeson, Kelden Richardson, Andy K Hsu, Rachael Canfield, Natalie Bezman, Michael Robbins, Hang Quach, David S Ritchie, Simon J Harrison, Joseph A Trapani, H Miles Prince, Paul A Beavis, Phillip K Darcy, Paul J Neeson

Journal article  |  2021  |  Haematologica

Not available.

γδ T Cells in Merkel Cell Carcinomas Have a Proinflammatory Profile Prognostic of Patient Survival.

Nicholas A Gherardin, Kelly Waldeck, Alex Caneborg, Luciano G Martelotto, Shiva Balachander, Magnus Zethoven, Pasquale M Petrone, Andrew Pattison, James S Wilmott, Sergio M Quiñones-Parra, Fernando Rossello, Atara Posner, Annie Wong, Alison M Weppler, Kerwin F Shannon, Angela Hong, Peter M Ferguson, Valerie Jakrot, Jeanette Raleigh, Athena Hatzimihalis, et al.

Journal article  |  2021  |  Cancer Immunology Research

Merkel cell carcinomas (MCC) are immunogenic skin cancers associated with viral infection or UV mutagenesis. To study T-cell infil..

Understanding the Role of T-Cells in the Antimyeloma Effect of Immunomodulatory Drugs

Criselle D'Souza, H Miles Prince, Paul J Neeson

Journal article  |  2021  |  Frontiers in Immunology

Immunomodulatory drugs (IMiDs) are effective treatments for patients with multiple myeloma. IMiDs have pleotropic effects includin..

A phase I/II study of stereotactic radiotherapy and pembrolizumab for oligometastatic renal tumours (RAPPORT): Clinical trial protocol

David Pryor, Mathias Bressel, Nathan Lawrentschuk, Ben Tran, Jennifer Mooi, Jeremy Lewin, Arun Azad, Duncan Colyer, Nitika Neha, Mark Shaw, Sarat Chander, Paul Neeson, Daniel Moon, Katharine Cuff, Simon Wood, Declan G Murphy, Shahneen Sandhu, Sherene Loi, Shankar Siva

Journal article  |  2021  |  Contemporary Clinical Trials Communications

Background: The management of oligometastatic clear cell renal cell carcinoma (ccRCC) varies widely, ranging from observation to r..

Clinical Trial Protocol for LuTectomy: A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of Lu-177-PSMA-617 Prior to Prostatectomy

Nattakorn Dhiantravan, John Violet, Renu Eapen, Omar Alghazo, Mark Scalzo, Price Jackson, Simon P Keam, Catherine Mitchell, Paul J Neeson, Shahneen Sandhu, Scott G Williams, Daniel Moon, Nathan Lawrentschuk, Arun Azad, Michael S Hofman, Declan G Murphy

Journal article  |  2021  |  European Urology Focus

LuTectomy is an open-label phase 1/2 nonrandomised clinical trial evaluating the dosimetry, efficacy, and toxicity of the lutetium..

Study of the dosimetry, safety, and potential benefit of 177Lu-PSMA-617 radionuclide therapy prior to radical prostatectomy in men with high-risk localized prostate cancer (LuTectomy study).

Omar Alghazo, Renu Eapen, Nattakorn Dhiantravan, John A Violet, Price Jackson, Mark Scalzo, Simon P Keam, Catherine Mitchell, Paul J Neeson, Shahneen Kaur Sandhu, Scott Williams, Daniel Moon, Nathan Lawrentschuk, Arun Azad, Michael S Hofman, Declan G Murphy

Conference Proceedings  |  2021  |  Journal of Clinical Oncology

TPS264 Background: High-risk localised prostate cancer (HRCaP) is treated by radical prostatectomy (RP) or radiotherapy. Despite ..

Stereotactic radiotherapy and pembrolizumab for oligometastatic renal tumors: The RAPPORT trial.

Shankar Siva, Mathias Bressel, Simon Wood, Mark Shaw, Sherene Loi, Shahneen Kaur Sandhu, Ben Tran, Arun Azad, Jeremy Howard Lewin, Katharine Cuff, Nitika Neha, Duncan Colyer, Paul J Neeson, Howard Liu, Sarat Chander, Daniel Moon, Jeremy Goad, Declan G Murphy, Nathan Lawrentschuk, David Pryor

Conference Proceedings  |  2021  |  Journal of Clinical Oncology

277 Background: Pembrolizumab monotherapy, whilst not standard of care, has demonstrated efficacy in clear cell renal cell carcin..

Tucatinib favourably modulates the immune microenvironment and synergises with anti-PD1 therapy in a trastuzumab resistant HER2 murine model

Ran Li, Sneha Sant, Emmaline Brown, Franco Caramia, Ann Byrne, Kylie Clarke, Michael Neeson, Paul J Neeson, Phillip K Darcy, Scott Peterson, Sherene Loi

Conference Proceedings  |  2021  |  Poster Session Abstracts

Chimeric Antigen Receptor beyond CAR-T Cells

Vicky Mengfei Qin, Criselle D'Souza, Paul J Neeson, Joe Jiang Zhu

Journal article  |  2021  |  Cancers

Chimeric antigen receptors (CAR) are genetically engineered receptors that can recognise specific antigens and subsequently activa..

Toward precision immunotherapy using multiplex immunohistochemistry and in silico methods to define the tumor immune microenvironment

Samuel S Widodo, Ryan A Hutchinson, Yitong Fang, Stefano Mangiola, Paul J Neeson, Phillip K Darcy, Alexander D Barrow, Christopher M Hovens, Marija Dinevska, Stanley S Stylli, Theo Mantamadiotis

Journal article  |  2021  |  Cancer Immunology, Immunotherapy

Recent developments in cancer immunotherapy promise better outcomes for cancer patients, although clinical trials for difficult to..