Olga Kondrashova

Heritable defects in telomere and mitotic function selectively predispose to sarcomas.

Mandy L Ballinger, Swetansu Pattnaik, Piyushkumar A Mundra, Milita Zaheed, Emma Rath, Peter Priestley, Jonathan Baber, Isabelle Ray-Coquard, Nicholas Isambert, Sylvain Causeret, Winette TA van der Graaf, Ajay Puri, Florence Duffaud, Axel Le Cesne, Beatrice Seddon, Coonoor Chandrasekar, Joshua D Schiffman, Andrew S Brohl, Paul A James, Jean-Emmanuel Kurtz, et al.

Journal article  |  2023  |  Science

Cancer genetics has to date focused on epithelial malignancies, identifying multiple histotype-specific pathways underlying cancer..

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin

Gwo Yaw Ho, Elizabeth L Kyran, Justin Bedo, Matthew J Wakefield, Darren P Ennis, Hasan B Mirza, Cassandra J Vandenberg, Elizabeth Lieschke, Andrew Farrell, Anthony Hadla, Ratana Lim, Genevieve Dall, James E Vince, Ngee Kiat Chua, Olga Kondrashova, Rosanna Upstill-Goddard, Ulla-Maja Bailey, Suzanne Dowson, Patricia Roxburgh, Rosalind M Glasspool, et al.

Journal article  |  2022  |  CANCER RESEARCH

UNLABELLED: Ovarian carcinosarcoma (OCS) is an aggressive and rare tumor type with limited treatment options. OCS is hypothesized ..

Analysis of hereditary cancer gene variant classifications from ClinVar indicates a need for regular reassessment of clinical assertions.

Aimee L Davidson, Olga Kondrashova, Conrad Leonard, Scott Wood, Emma Tudini, Georgina E Hollway, John V Pearson, Felicity Newell, Amanda B Spurdle, Nicola Waddell

Journal article  |  2022  |  Hum Mutat

The clinical classification of variants may change with new information, however, there is limited guidance on how often significa..

Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels.

P Ramarao-Milne, O Kondrashova, A-M Patch, K Nones, LT Koufariotis, F Newell, V Addala, V Lakis, O Holmes, C Leonard, S Wood, Q Xu, P Mukhopadhyay, MM Naeini, D Steinfort, JP Williamson, M Bint, C Pahoff, PT Nguyen, S Twaddell, et al.

Journal article  |  2022  |  ESMO Open

BACKGROUND: Next-generation sequencing is used in cancer research to identify somatic and germline mutations, which can predict se..

Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma

Jenette Creaney, Ann-Marie Patch, Venkateswar Addala, Sophie A Sneddon, Katia Nones, Ian M Dick, YC Gary Lee, Felicity Newell, Ebony J Rouse, Marjan M Naeini, Olga Kondrashova, Vanessa Lakis, Apostolos Nakas, David Waller, Annabel Sharkey, Pamela Mukhopadhyay, Stephen H Kazakoff, Lambros T Koufariotis, Aimee L Davidson, Priya Ramarao-Milne, et al.

Journal article  |  2022  |  GENOME MEDICINE

BACKGROUND: Malignant pleural mesothelioma (MPM) has a poor overall survival with few treatment options. Whole genome sequencing (..

Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer.

Vanessa F Bonazzi, Olga Kondrashova, Deborah Smith, Katia Nones, Asmerom T Sengal, Robert Ju, Leisl M Packer, Lambros T Koufariotis, Stephen H Kazakoff, Aimee L Davidson, Priya Ramarao-Milne, Vanessa Lakis, Felicity Newell, Rebecca Rogers, Claire Davies, James Nicklin, Andrea Garrett, Naven Chetty, Lewis Perrin, John V Pearson, et al.

Journal article  |  2022  |  Genome Med

BACKGROUND: Endometrial cancer (EC) is a major gynecological cancer with increasing incidence. It comprises four molecular subtype..

Deep learning in cancer diagnosis, prognosis and treatment selection.

Khoa A Tran, Olga Kondrashova, Andrew Bradley, Elizabeth D Williams, John V Pearson, Nicola Waddell

Journal article  |  2021  |  Genome Med

Deep learning is a subdiscipline of artificial intelligence that uses a machine learning technique called artificial neural networ..

Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma

Ksenija Nesic, Olga Kondrashova, Rachel M Hurley, Cordelia D McGehee, Cassandra J Vandenberg, Gwo-Yaw Ho, Elizabeth Lieschke, Genevieve Dall, Nirashaa Bound, Kristy Shield-Artin, Marc Radke, Ashan Musafer, Zi Qing Chai, Mohammad Reza Eftekhariyan Ghamsari, Maria Harrell, Damien Kee, Inger Olesen, Orla McNally, Nadia Traficante, Anna DeFazio, et al.

Journal article  |  2021  |  CANCER RESEARCH

In high-grade serous ovarian carcinoma (HGSC), deleterious mutations in DNA repair gene RAD51C are established drivers of defectiv..

Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance

Rachel M Hurley, Cordelia D McGehee, Ksenija Nesic, Cristina Correia, Taylor M Weiskittel, Rebecca L Kelly, Annapoorna Venkatachalam, Xiaonan Hou, Nicholas M Pathoulas, X Wei Meng, Olga Kondrashova, Marc R Radke, Paula A Schneider, Karen S Flatten, Kevin L Peterson, Marc A Becker, Ee Ming Wong, Melissa S Southey, Alexander Dobrovic, Kevin K Lin, et al.

Journal article  |  2021  |  NAR CANCER

Acquired PARP inhibitor (PARPi) resistance in BRCA1- or BRCA2-mutant ovarian cancer often results from secondary mutations that re..

Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development.

Olga Kondrashova, Jannah Shamsani, Tracy A O'Mara, Felicity Newell, Amy E McCart Reed, Sunil R Lakhani, Judy Kirk, John V Pearson, Nicola Waddell, Amanda B Spurdle

Journal article  |  2021  |  Cancers (Basel)

Risk of endometrial cancer (EC) is increased ~2-fold for women with a family history of cancer, partly due to inherited pathogenic..