Dmitri Mouradov

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis

Camilla M Reehorst, Rebecca Nightingale, Ian Y Luk, Laura Jenkins, Frank Koentgen, David S Williams, Charbel Darido, Fiona Tan, Holly Anderton, Michael Chopin, Kael Schoffer, Moritz F Eissmann, Michael Buchert, Dmitri Mouradov, Oliver M Sieber, Matthias Ernst, Amardeep S Dhillon, John M Mariadason

Journal article  |  2021  |  DEVELOPMENT

Ets homologous factor (EHF) is a member of the epithelial-specific Ets (ESE) family of transcription factors. To investigate its r..

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

Anderly C Chueh, Gahana Advani, Momeneh Foroutan, Jai Smith, Nadia Ng, Harshal Nandurkar, Daisy S Lio, Hong-Jian Zhu, Yuh-Ping Chong, Heather Verkade, Donald J Fujita, Jeffrey Bjorge, Faiza Basheer, Jet Phey Lim, Ian Luk, Amardeep Dhillon, Anuratha Sakthianandeswaren, Dmitri Mouradov, Oliver Sieber, Frederic Hollande, et al.

Journal article  |  2021  |  ONCOGENE

Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC..

Genomic Signature of Oral Squamous Cell Carcinomas from Non-Smoking Non-Drinking Patients

Kendrick Koo, Dmitri Mouradov, Christopher M Angel, Tim A Iseli, David Wiesenfeld, Michael J McCullough, Antony W Burgess, Oliver M Sieber

Journal article  |  2021  |  CANCERS

Molecular alterations in 176 patients with oral squamous cell carcinomas (OSCC) were evaluated to delineate differences in non-smo..

Diversity of dinoflagellate assemblages in coastal temperate and offshore tropical waters of Australia

Tahnee Manning, Arjun Venkatesh Thilagaraj, Dmitri Mouradov, Richard Piola, Clare Grandison, Matthew Gordon, Jeff Shimeta, Aidyn Mouradov

Journal article  |  2021  |  BMC ECOLOGY AND EVOLUTION

BACKGROUND: Dinoflagellates are a ubiquitous and ecologically important component of marine phytoplankton communities, with partic..

Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers.

Peter Georgeson, Bernard J Pope, Christophe Rosty, Mark Clendenning, Khalid Mahmood, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Susan Preston, Julia Como, Sharelle Joseland, Aung Ko Win, Finlay A Macrae, John L Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M Sieber, Dylan E O'Sullivan, Darren R Brenner, Steve Gallinger, et al.

Journal article  |  2021  |  Gut

OBJECTIVE: Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and in the base excision repair gene MUTYH un..

A Biobank of Colorectal Cancer Patient-Derived Xenografts

Suad M Abdirahman, Michael Christie, Adele Preaudet, Marie CU Burstroem, Dmitri Mouradov, Belinda Lee, Oliver M Sieber, Tracy L Putoczki

Journal article  |  2020  |  CANCERS

Colorectal cancer (CRC) is a challenging disease, with a high mortality rate and limited effective treatment options, particularly..

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

David S Williams, Dmitri Mouradov, Clare Browne, Michelle Palmieri, Meg J Elliott, Rebecca Nightingale, Catherine G Fang, Rita Li, John M Mariadason, Ian Faragher, Ian T Jones, Leonid Churilov, Niall C Tebbutt, Peter Gibbs, Oliver M Sieber

Journal article  |  2020  |  MODERN PATHOLOGY

TP53 mutations drive colorectal cancer development, with missense mutations frequently leading to accumulation of abnormal TP53 pr..

Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation

David S Williams, Dmitri Mouradov, Marsali R Newman, Elham Amini, David K Nickless, Catherine G Fang, Michelle Palmieri, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Iain Skinner, Ian Jones, Peter Gibbs, Oliver M Sieber

Journal article  |  2020  |  MODERN PATHOLOGY

Mucinous colorectal adenocarcinoma (CRC) is conventionally defined by extracellular mucin comprising >50% of the tumour area, whil..

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

David K Lau, Dmitri Mouradov, Wiphawan Wasenang, Ian Y Luk, Cameron M Scott, David S Williams, Yvonne H Yeung, Temduang Limpaiboon, George F Iatropoulos, Laura J Jenkins, Camilla M Reehorst, Fiona Chionh, Mehrdad Nikfarjam, Daniel Croagh, Amardeep S Dhillon, Andrew J Weickhardt, Toshihide Muramatsu, Yoshimasa Saito, Niall C Tebbutt, Oliver M Sieber, et al.

Journal article  |  2019  |  ISCIENCE

Biliary tract cancers (BTCs) currently have no approved targeted therapies. Although genomic profiling of primary BTCs has identif..

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

David S Williams, Dmitri Mouradov, Robert N Jorissen, Marsali R Newman, Elham Amini, David K Nickless, Julie A Teague, Catherine G Fang, Michelle Palmieri, Marie J Parsons, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Ian Faragher, Ian T Jones, Peter Gibbs, Oliver M Sieber

Journal article  |  2019  |  GUT

OBJECTIVE: Tumour-infiltrating lymphocyte (TIL) response and deficient DNA mismatch repair (dMMR) are determinants of prognosis in..