Dmitri Mouradov

A Biobank of Colorectal Cancer Patient-Derived Xenografts.

Suad M Abdirahman, Michael Christie, Adele Preaudet, Marie CU Burstroem, Dmitri Mouradov, Belinda Lee, Oliver M Sieber, Tracy L Putoczki

Journal article  |  2020  |  Cancers

Colorectal cancer (CRC) is a challenging disease, with a high mortality rate and limited effective treatment options, particularly..

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

David S Williams, Dmitri Mouradov, Clare Browne, Michelle Palmieri, Meg J Elliott, Rebecca Nightingale, Catherine G Fang, Rita Li, John M Mariadason, Ian Faragher, Ian T Jones, Leonid Churilov, Niall C Tebbutt, Peter Gibbs, Oliver M Sieber

Journal article  |  2020  |  Modern Pathology

TP53 mutations drive colorectal cancer development, with missense mutations frequently leading to accumulation of abnormal TP53 pr..

Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation

David S Williams, Dmitri Mouradov, Marsali R Newman, Elham Amini, David K Nickless, Catherine G Fang, Michelle Palmieri, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Iain Skinner, Ian Jones, Peter Gibbs, Oliver M Sieber

Journal article  |  2020  |  Modern Pathology

Mucinous colorectal adenocarcinoma (CRC) is conventionally defined by extracellular mucin comprising >50% of the tumour area, whil..

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

David K Lau, Dmitri Mouradov, Wiphawan Wasenang, Ian Y Luk, Cameron M Scott, David S Williams, Yvonne H Yeung, Temduang Limpaiboon, George F Iatropoulos, Laura J Jenkins, Camilla M Reehorst, Fiona Chionh, Mehrdad Nikfarjam, Daniel Croagh, Amardeep S Dhillon, Andrew J Weickhardt, Toshihide Muramatsu, Yoshimasa Saito, Niall C Tebbutt, Oliver M Sieber, et al.

Journal article  |  2019  |  iScience

Biliary tract cancers (BTCs) currently have no approved targeted therapies. Although genomic profiling of primary BTCs has identif..

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

David S Williams, Dmitri Mouradov, Robert N Jorissen, Marsali R Newman, Elham Amini, David K Nickless, Julie A Teague, Catherine G Fang, Michelle Palmieri, Marie J Parsons, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Ian Faragher, Ian T Jones, Peter Gibbs, Oliver M Sieber

Journal article  |  2019  |  Gut

MACROD2 deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer.

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Oliver M Sieber

Journal article  |  2018  |  Oncotarget

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

Enric Domingo, Carme Camps, Pamela J Kaisaki, Marie J Parsons, Dmitri Mouradov, Melissa M Pentony, Seiko Makino, Michelle Palmieri, Robyn L Ward, Nicholas J Hawkins, Peter Gibbs, Hanne Askautrud, Dahmane Oukrif, Haitao Wang, Joe Wood, Evie Tomlinson, Yasmine Bark, Kulvinder Kaur, Elaine C Johnstone, Claire Palles, et al.

Journal article  |  2018  |  The Lancet Gastroenterology & Hepatology

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Ruth N MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N Jorissen, Shan Li, Lachlan Whitehead, Tracy L Putoczki, Adele Preaudet, Cary Tsui, Cameron J Nowell, Robyn L Ward, Nicholas J Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, et al.

Journal article  |  2018  |  Cancer Discovery

Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-gamma-Dependent Manner

Moritz F Eissmann, Christine Dijkstra, Merridee A Wouters, David Baloyan, Dmitri Mouradov, Paul M Nguyen, Mercedes Davalos-Salas, Tracy L Putoczki, Oliver M Sieber, John M Mariadason, Matthias Ernst, Frederick Masson

Journal article  |  2018  |  Cancer Immunology Research

Somatic mutation footprinting reveals a unique tetranucleotide signature associated with intron-exon boundaries in lung cancer

Samuel Wormald, Anita Lerch, Dmitri Mouradov, Liam O'Connor

Journal article  |  2018  |  Carcinogenesis

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity

Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N Jorissen, Matthew C Chambers, Lisa J Zimmerman, Suhas Vasaikar, Christopher G Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert JC Coffey, Robbert JC Slebos, et al.

Journal article  |  2017  |  Gastroenterology

Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer

Nirosha Suraweera, Dmitri Mouradov, Shan Li, Robert N Jorissen, Debbie Hampson, Anil Ghosh, Neel Sengupta, Mohamed Thaha, Shafi Ahmed, Michael Kirwan, Floor Aleva, David Propper, Roger M Feakins, Tom Vulliamy, Ngaire J Elwood, Pei Tian, Robyn L Ward, Nicholas J Hawkins, Zheng-Zhou Xu, Peter L Molloy, et al.

Journal article  |  2016  |  Oncotarget

Focusing the Spotlight on the Zebrafish Intestine to Illuminate Mechanisms of Colorectal Cancer

Viola H Lobert, Dmitri Mouradov, Joan K Heath

Book Chapter  |  2016  |  Advances in Experimental Medicine and Biology

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

Robert N Jorissen, Michael Christie, Dmitri Mouradov, Anuratha Sakthianandeswaren, Shan Li, Christopher Love, Zheng-Zhou Xu, Peter L Molloy, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Antony W Burgess, Dana Busam, Qi Zhao, Robert L Strausberg, Lara Lipton, Jayesh Desai, et al.

Journal article  |  2015  |  British Journal of Cancer

FunRich: An open access standalone functional enrichment and interaction network analysis tool

Mohashin Pathan, Shivakumar Keerthikumar, Ching-Seng Ang, Lahiru Gangoda, Camelia YJ Quek, Nicholas A Williamson, Dmitri Mouradov, Oliver M Sieber, Richard J Simpson, Agus Salim, Antony Bacic, Andrew F Hill, David A Stroud, Michael T Ryan, Johnson I Agbinya, John M Mariadason, Antony W Burgess, Suresh Mathivanan

Journal article  |  2015  |  PROTEOMICS

Single Nucleotide Polymorphism Array Profiling Identifies Distinct Chromosomal Aberration Patterns Across Colorectal Adenomas and Carcinomas

Peter Zarzour, Lies Boelen, Fabio Luciani, Dominik Beck, Anuratha Sakthianandeswaren, Dmitri Mouradov, Oliver M Sieber, Nicholas J Hawkins, Luke B Hesson, Robyn L Ward, Jason WH Wong

Journal article  |  2015  |  Genes, Chromosomes and Cancer

Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

Dmitri Mouradov, Clare Sloggett, Robert N Jorissen, Christopher G Love, Shan Li, Antony W Burgess, Diego Arango, Robert L Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor, Jennifer L Wilding, David Bicknell, Ian PM Tomlinson, Walter F Bodmer, John M Mariadason, Oliver M Sieber

Journal article  |  2014  |  Cancer Research

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

Sally M Dewhurst, Nicholas McGranahan, Rebecca A Burrell, Andrew J Rowan, Eva Groenroos, David Endesfelder, Tejal Joshi, Dmitri Mouradov, Peter Gibbs, Robyn L Ward, Nicholas J Hawkins, Zoltan Szallasi, Oliver M Sieber, Charles Swanton

Journal article  |  2014  |  Cancer Discovery

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

Dmitri Mouradov, Enric Domingo, Peter Gibbs, Robert N Jorissen, Shan Li, Pik Ying Soo, Lara Lipton, Jayesh Desai, Havard E Danielsen, Dahmane Oukrif, Marco Novelli, Christopher Yau, Christopher C Holmes, Ian T Jones, Stephen McLaughlin, Peter Molloy, Nicholas J Hawkins, Robyn Ward, Rachel Midgely, David Kerr, et al.

Journal article  |  2013  |  American Journal of Gastroenterology

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

Nicholas I Fleming, Robert N Jorissen, Dmitri Mouradov, Michael Christie, Anuratha Sakthianandeswaren, Michelle Palmieri, Fiona Day, Shan Li, Cary Tsui, Lara Lipton, Jayesh Desai, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Hong-Jian Zhu, John M Mariadason, Antony W Burgess, et al.

Journal article  |  2013  |  CANCER RESEARCH

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

Neel Sengupta, Christopher Yau, Anuratha Sakthianandeswaren, Dmitri Mouradov, Peter Gibbs, Nirosha Suraweera, Jean-Baptiste Cazier, Guadalupe Polanco-Echeverry, Anil Ghosh, Mohamed Thaha, Shafi Ahmed, Roger Feakins, David Propper, Sina Dorudi, Oliver Sieber, Andrew Silver, Cecilia Lai

Journal article  |  2013  |  Molecular Cancer

Proteomic and Electron Microscopy Survey of Large Assemblies in Macrophage Cytoplasm

Bohumil Maco, Ian L Ross, Michael J Landsberg, Dmitri Mouradov, Neil FW Saunders, Ben Hankamer, Bostjan Kobe

Journal article  |  2011  |  MOLECULAR & CELLULAR PROTEOMICS

Hybrid Methods for Protein Structure Prediction

D Mouradov, B Kobe, NE Dixon, T Huber

Book Chapter  |  2010

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

Christopher Yau, Dmitri Mouradov, Robert N Jorissen, Stefano Colella, Ghazala Mirza, Graham Steers, Adrian Harris, Jiannis Ragoussis, Oliver Sieber, Christopher C Holmes

Journal article  |  2010  |  GENOME BIOLOGY

Identification of disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-mass spectrometry.

Gordon J King, Alun Jones, Bostjan Kobe, Thomas Huber, Dmitri Mouradov, David A Hume, Ian L Ross

Journal article  |  2008  |  ANALYTICAL CHEMISTRY

Cross-linking can be used to identify spatial relationships between amino acids in proteins or protein complexes. A rapid and sens..

Overview of the pipeline for structural and functional characterization of macrophage proteins at the university of queensland.

Weining Meng, Jade K Forwood, Gregor Guncar, Gautier Robin, Nathan P Cowieson, Pawel Listwan, Dmitri Mouradov, Gordon King, Ian L Ross, Jodie Robinson, Munish Puri, Justine M Hill, Stuart Kellie, Thomas Huber, David A Hume, Jennifer L Martin, Bostjan Kobe

Journal article  |  2008  |  Methods in molecular biology (Clifton, N.J.)

This chapter describes the methodology adopted in a project aimed at structural and functional characterization of proteins that p..

Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling.

Dmitri Mouradov, Gordon King, Ian L Ross, Jade K Forwood, David A Hume, Andrea Sinz, Jennifer L Martin, Bostjan Kobe, Thomas Huber

Journal article  |  2008  |  Methods in molecular biology (Clifton, N.J.)

Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multido..

Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation

Jade K Forwood, Anil S Thakur, Gregor Guncar, Mary Marfori, Dmitri Mouradov, Weining Meng, Jodie Robinson, Thomas Huber, Stuart Kellie, Jennifer L Martin, David A Hume, Bostjan Kobe

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

D Mouradov, A Craven, JK Forwood, JU Flanagan, R Garcia-Castellanos, FX Gomis-Ruth, DA Hume, JL Martin, B Kobe, T Huber

Journal article  |  2006  |  Protein Engineering, Design and Selection

Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins

K Ozawa, MJ Headlam, D Mouradov, SJ Watt, JL Beck, KJ Rodgers, RT Dean, T Huber, G Otting, NE Dixon

Journal article  |  2005  |  FEBS Journal