Joseph Cursons

High temporal resolution RNA-seq time course data reveals widespread synchronous activation between mammalian lncRNAs and neighboring protein-coding genes

Walter Muskovic, Eve Slavich, Ben Maslen, Dominik CC Kaczorowski, Joseph Cursons, Edmund Crampin, Maria Kavallaris

Journal article  |  2022  |  GENOME RESEARCH

The advent of massively parallel sequencing revealed extensive transcription beyond protein-coding genes, identifying tens of thou..

Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin

Jean Berthelet, Momeneh Foroutan, Dharmesh D Bhuva, Holly J Whitfield, Farrah El-Saafin, Joseph Cursons, Antonin Serrano, Michal Merdas, Elgene Lim, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Matthias Ernst, Frederic Hollande, Robin L Anderson, Bhupinder Pal, Belinda Yeo, Melissa J Davis, Delphine Merino

Journal article  |  2022  |  CANCERS

The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast can..

Modular assembly of dynamic models in systems biology

Michael Pan, Peter J Gawthrop, Joseph Cursons, Edmund J Crampin

Journal article  |  2021  |  PLOS COMPUTATIONAL BIOLOGY

It is widely acknowledged that the construction of large-scale dynamic models in systems biology requires complex modelling proble..

The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome

Momeneh Foroutan, Ramyar Molania, Aline Pfefferle, Corina Behrenbruch, Sebastian Scheer, Axel Kallies, Terence P Speed, Joseph Cursons, Nicholas D Huntington

Journal article  |  2021  |  CANCER IMMUNOLOGY RESEARCH

Immunotherapy success in colorectal cancer is mainly limited to patients whose tumors exhibit high microsatellite instability (MSI..

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer.

Emily Golden, Rabab Rashwan, Eleanor A Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth KM Johnstone, Heng B See, Ciara Duffy, Jeremy Parry, Kim A Lagerborg, Piotr Czapiewski, Javier A Menendez, Adam Gorczyński, et al.

Journal article  |  2021  |  Nat Commun

Adipogenesis associated Mth938 domain containing (AAMDC) represents an uncharacterized oncogene amplified in aggressive estrogen r..

FP10.02 Investigating the Immunophenotype of Small Cell Lung Cancer to Improve Immunotherapeutic Targeting

S Best, J Hess, F Souza-Fonseca Guimaraes, J Cursons, A Kersbergen, Y You, J Ng, M Davis, T Leong, L Irving, M Ritchie, D Steinfort, N Huntington, K Sutherland

Journal article  |  2021  |  Journal of Thoracic Oncology

Stable gene expression for normalisation and single-sample scoring

Dharmesh D Bhuva, Joseph Cursons, Melissa J Davis

Journal article  |  2020  |  NUCLEIC ACIDS RESEARCH

Gene expression signatures have been critical in defining the molecular phenotypes of cells, tissues, and patient samples. Their m..

Harnessing Natural Killer Immunity in Metastatic SCLC

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  JOURNAL OF THORACIC ONCOLOGY

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

The cardiac Na /K ATPase: An updated, thermodynamically consistent model

Michael Pan, Peter J Gawthrop, Joseph Cursons, Kenneth Tran, Edmund J Crampin

Journal article  |  2020  |  Physiome

The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over ..

The cardiac Na /K ATPase: An updated, thermodynamically consistent model

Michael Pan, Peter J Gawthrop, Joseph Cursons, Kenneth Tran, Edmund J Crampin

Journal article  |  2020  |  Physiome

The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over ..