Joseph Cursons

The cancer-natural killer cell immunity cycle

Nicholas D Huntington, Joseph Cursons, Jai Rautela

Journal article  |  2020  |  Nature Reviews Cancer

Harnessing Natural Killer Immunity in Metastatic SCLC.

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  Journal of Thoracic Oncology

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2019  |  Journal of Theoretical Biology

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..

Differential co-expression-based detection of conditional relationships in transcriptional data: comparative analysis and application to breast cancer

Dharmesh D Bhuva, Joseph Cursons, Gordon K Smyth, Melissa J Davis

Journal article  |  2019  |  Genome Biology

BACKGROUND: Elucidation of regulatory networks, including identification of regulatory mechanisms specific to a given biological c..

Using singscore to predict mutation status in acute myeloid leukemia from transcriptomic signatures

Dharmesh Bhuva, Momeneh Foroutan, Yi Xie, Ruqian Lyu, Joseph Cursons, Melissa Davis

Journal article  |  2019  |  F1000Research

Advances in RNA sequencing (RNA-seq) technologies that measure the transcriptome of biological samples have revolutionised our abi..

Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA)

Katherine A Pillman, Kaitlin G Scheer, Emily Hackett-Jones, Klay Saunders, Andrew G Bert, John Toubia, Holly J Whitfield, Sunil Sapkota, Laura Sourdin, Pham Hoang, Thuc D Le, Joseph Cursons, Melissa J Davis, Philip A Gregory, Gregory J Goodall, Cameron P Bracken

Journal article  |  2019  |  Nucleic Acids Research

Epithelial-mesenchymal transition (EMT) has been a subject of intense scrutiny as it facilitates metastasis and alters drug sensit..

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Jai Rautela, Laura F Dagley, Carolina C de Oliveira, Iona S Schuster, Soroor Hediyeh-Zadeh, Rebecca B Delconte, Joseph Cursons, Robert Hennessy, Dana S Hutchinson, Craig Harrison, Badia Kita, Eric Vivier, Andrew I Webb, Mariapia A Degli-Esposti, Melissa J Davis, Nicholas D Huntington, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2019  |  Science Signaling

Using singscore to predict mutation status in acute myeloid leukemia from transcriptomic signatures

Dharmesh Bhuva, Momeneh Foroutan, Yi Xie, Ruqian Lyu, Joseph Cursons, Melissa Davis

Journal article  |  2019  |  F1000Research

Advances in RNA sequencing (RNA-seq) technologies that measure the transcriptome of biological samples have revolutionised our abi..

A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients

Joseph Cursons, Fernando Souza-Fonseca-Guimaraes, Momeneh Foroutan, Ashley Anderson, Frederic HoHande, Soroor Hediyeh-Zadeh, Andreas Behren, Nicholas D Huntington, Melissa J Davis

Journal article  |  2019  |  Cancer Immunology Research

Using singscore to predict mutations in acute myeloid leukemia from transcriptomic signatures

Dharmesh Bhuva, Momeneh Foroutan, Yi Xie, Ruqian Lyu, Joseph Cursons, Melissa Davis

Journal article  |  2019  |  F1000Research

Advances in RNA sequencing (RNA-seq) technologies that measure the transcriptome of biological samples have revolutionised our abi..

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Nicholas D Huntington

Journal article  |  2019  |  Trends in Immunology

Using singscore to predict mutation status in acute myeloid leukemia from transcriptomic signatures.

Dharmesh D Bhuva, Momeneh Foroutan, Yi Xie, Ruqian Lyu, Joseph Cursons, Melissa J Davis

Journal article  |  2019  |  F1000Research

Advances in RNA sequencing (RNA-seq) technologies that measure the transcriptome of biological samples have revolutionised our abi..

Single sample scoring of molecular phenotypes

Momeneh Foroutan, Dharmesh D Bhuva, Ruqian Lyu, Kristy Horan, Joseph Cursons, Melissa J Davis

Journal article  |  2018  |  BMC Bioinformatics

Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT

Joseph Cursons, Katherine A Pillman, Kaitlin G Scheer, Philip A Gregory, Momeneh Foroutan, Soroor Hediyeh-Zadeh, John Toubia, Edmund J Crampin, Gregory J Goodall, Cameron P Bracken, Melissa J Davis

Journal article  |  2018  |  CELL SYSTEMS

Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2018  |  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

Defining a landscape of molecular phenotypes using a simple single sample scoring method

Momeneh Foroutan, Dharmesh Bhuva, Kristy Horan, Ruqian Lyu, Joseph Cursons, Melissa Davis

Journal article  |  2017

Abstract Background Gene set scoring provides a useful approach for quantifying concordance between sample transcriptomes and sele..

Post-transcriptional control of EMT is coordinated through combinatorial targeting by multiple microRNAs

Joseph Cursons, Katherine Pillman, Kaitlin Scheer, Philip Gregory, Momeneh Foroutan, Soroor Hediyeh Zadeh, John Toubia, Edmund Crampin, Gregory Goodall, Cameron Bracken, Melissa Davis

Journal article  |  2017

Abstract Epithelial-mesenchymal transition (EMT) is a process whereby cells undergo reversible phenotypic change, losing epithelia..

A Transcriptional Program for Detecting TGF beta-Induced EMT in Cancer

Momeneh Foroutan, Joseph Cursons, Soroor Hediyeh-Zadeh, Erik W Thompson, Melissa J Davis

Journal article  |  2017  |  Molecular Cancer Research

Determining the Significance of Protein Network Features and Attributes Using Permutation Testing

Joseph Cursons, Melissa J Davis

Journal article  |  2017  |  Methods in molecular biology (Clifton, N.J.)

The complexities and caveats of lineage tracing in the mammary gland

Anne C Rios, Nai Yang Fu, Joseph Cursons, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2016  |  Breast Cancer Research

Systems analysis identifies miR-29b regulation of invasiveness in melanoma

Miles C Andrews, Joseph Cursons, Daniel G Hurley, Matthew Anaka, Jonathan S Cebon, Andreas Behren, Edmund J Crampin

Journal article  |  2016  |  Molecular Cancer

Toward Community Standards and Software for Whole-Cell Modeling

Dagmar Waltemath, Jonathan R Karr, Frank T Bergmann, Vijayalakshmi Chelliah, Michael Hucka, Marcus Krantz, Wolfram Liebermeister, Pedro Mendes, Chris J Myers, Pinar Pir, Begum Alaybeyoglu, Naveen K Aranganathan, Kambiz Baghalian, Arne T Bittig, Paulo E Pinto Burke, Matteo Cantarelli, Yin Hoon Chew, Rafael S Costa, Joseph Cursons, Tobias Czauderna, et al.

Journal article  |  2016  |  IEEE Transactions on Biomedical Engineering

NAIL, a software toolset for inferring, analyzing and visualizing regulatory networks

Daniel G Hurley, Joseph Cursons, Yi Kan Wang, David M Budden, Cristin G Print, Edmund J Crampin

Journal article  |  2015  |  Bioinformatics

Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis

J CURSONS, CE Angel, DG Hurley, CG Print, PR Dunbar, MD Jacobs, EC Crampin

Journal article  |  2015  |  GigaScience

Hierarchical bond graph modelling of biochemical networks

PG Gawthrop, J CURSONS, EJ Crampin

Journal article  |  2015  |  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

Journal article  |  2015  |  Cell Communication and Signaling

Regulation of ERK-MAPK signaling in human epidermis

J Cursons, J Gao, DG Hurley, CG Print, PR Dunbar, MD Jacobs, EJ Crampin

Journal article  |  2015  |  BMC Systems Biology

The skin is largely comprised of keratinocytes within the interfollicular epidermis. Over approximately two weeks these cells diff..

Predicting expression: the complementary power of histone modification and transcription factor binding data

David M Budden, Daniel G Hurley, Joseph Cursons, John F Markham, Melissa J Davis, Edmund J Crampin

Journal article  |  2014  |  Epigenetics & Chromatin

Inference of an in situ Epidermal Intracellular Signaling Cascade

Joseph Cursons, Daniel Hurley, Catherine E Angel, Rod Dunbar, Edmund J Crampin, Marc D Jacobs

Conference Proceedings  |  2010  |  Conference Proceedings of the IEEE Engineering in Medicine and Biology Society

Stable gene expression for normalisation and single-sample scoring

Dharmesh D Bhuva, Joseph Cursons, Melissa J Davis

Journal article

AbstractBackgroundTranscriptomic signatures are useful in defining the molecular phenotypes of cells, tissues, and patient samples..