Joseph Cursons

Modular assembly of dynamic models in systems biology.

Michael Pan, Peter J Gawthrop, Joseph Cursons, Edmund J Crampin

Journal article  |  2021  |  PLoS Comput Biol

It is widely acknowledged that the construction of large-scale dynamic models in systems biology requires complex modelling proble..

The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome.

Momeneh Foroutan, Ramyar Molania, Aline Pfefferle, Corina Behrenbruch, Sebastian Scheer, Axel Kallies, Terence P Speed, Joseph Cursons, Nicholas D Huntington

Journal article  |  2021  |  Cancer Immunol Res

Immunotherapy success in colorectal cancer is mainly limited to patients whose tumors exhibit high microsatellite instability (MSI..

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer.

Emily Golden, Rabab Rashwan, Eleanor A Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth KM Johnstone, Heng B See, Ciara Duffy, Jeremy Parry, Kim A Lagerborg, Piotr Czapiewski, Javier A Menendez, Adam Gorczyński, et al.

Journal article  |  2021  |  Nat Commun

Adipogenesis associated Mth938 domain containing (AAMDC) represents an uncharacterized oncogene amplified in aggressive estrogen r..

Stable gene expression for normalisation and single-sample scoring

Dharmesh D Bhuva, Joseph Cursons, Melissa J Davis

Journal article  |  2020  |  NUCLEIC ACIDS RESEARCH

Gene expression signatures have been critical in defining the molecular phenotypes of cells, tissues, and patient samples. Their m..

Harnessing Natural Killer Immunity in Metastatic SCLC

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  JOURNAL OF THORACIC ONCOLOGY

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

The cardiac Na /K ATPase: An updated, thermodynamically consistent model

Michael Pan, Peter J Gawthrop, Joseph Cursons, Kenneth Tran, Edmund J Crampin

Journal article  |  2020  |  Physiome

The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over ..

The cardiac Na /K ATPase: An updated, thermodynamically consistent model

Michael Pan, Peter J Gawthrop, Joseph Cursons, Kenneth Tran, Edmund J Crampin

Journal article  |  2020  |  Physiome

The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over ..

The cancer-natural killer cell immunity cycle

Nicholas D Huntington, Joseph Cursons, Jai Rautela

Journal article  |  2020  |  NATURE REVIEWS CANCER

Immunotherapy with checkpoint blockade induces rapid and durable immune control of cancer in some patients and has driven a monume..

Stable gene expression for normalisation and single-sample scoring

Dharmesh Bhuva, Joseph Cursons, Melissa Davis

Journal article  |  2020

Background Transcriptomic signatures are useful in defining the molecular phenotypes of cells, tissues, and patient samples. Their..

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2019  |  JOURNAL OF THEORETICAL BIOLOGY

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..