Joseph Cursons

Stable gene expression for normalisation and single-sample scoring

Dharmesh D Bhuva, Joseph Cursons, Melissa J Davis

Journal article  |  2020  |  Nucleic Acids Research

Gene expression signatures have been critical in defining the molecular phenotypes of cells, tissues, and patient samples. Their m..

Harnessing Natural Killer Immunity in Metastatic SCLC

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  Journal of Thoracic Oncology

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

The cancer-natural killer cell immunity cycle

Nicholas D Huntington, Joseph Cursons, Jai Rautela

Journal article  |  2020  |  Nature Reviews Cancer

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2019  |  Journal of Theoretical Biology

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..

Differential co-expression-based detection of conditional relationships in transcriptional data: comparative analysis and application to breast cancer

Dharmesh D Bhuva, Joseph Cursons, Gordon K Smyth, Melissa J Davis

Journal article  |  2019  |  Genome Biology

BACKGROUND: Elucidation of regulatory networks, including identification of regulatory mechanisms specific to a given biological c..

Using singscore to predict mutation status in acute myeloid leukemia from transcriptomic signatures

Dharmesh Bhuva, Momeneh Foroutan, Yi Xie, Ruqian Lyu, Joseph Cursons, Melissa Davis

Journal article  |  2019  |  F1000Research

Advances in RNA sequencing (RNA-seq) technologies that measure the transcriptome of biological samples have revolutionised our abi..

Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA)

Katherine A Pillman, Kaitlin G Scheer, Emily Hackett-Jones, Klay Saunders, Andrew G Bert, John Toubia, Holly J Whitfield, Sunil Sapkota, Laura Sourdin, Pham Hoang, Thuc D Le, Joseph Cursons, Melissa J Davis, Philip A Gregory, Gregory J Goodall, Cameron P Bracken

Journal article  |  2019  |  Nucleic Acids Research

Epithelial-mesenchymal transition (EMT) has been a subject of intense scrutiny as it facilitates metastasis and alters drug sensit..

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Jai Rautela, Laura F Dagley, Carolina C de Oliveira, Iona S Schuster, Soroor Hediyeh-Zadeh, Rebecca B Delconte, Joseph Cursons, Robert Hennessy, Dana S Hutchinson, Craig Harrison, Badia Kita, Eric Vivier, Andrew I Webb, Mariapia A Degli-Esposti, Melissa J Davis, Nicholas D Huntington, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2019  |  Science Signaling

Using singscore to predict mutation status in acute myeloid leukemia from transcriptomic signatures

Dharmesh Bhuva, Momeneh Foroutan, Yi Xie, Ruqian Lyu, Joseph Cursons, Melissa Davis

Journal article  |  2019  |  F1000Research

Advances in RNA sequencing (RNA-seq) technologies that measure the transcriptome of biological samples have revolutionised our abi..

A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients

Joseph Cursons, Fernando Souza-Fonseca-Guimaraes, Momeneh Foroutan, Ashley Anderson, Frederic HoHande, Soroor Hediyeh-Zadeh, Andreas Behren, Nicholas D Huntington, Melissa J Davis

Journal article  |  2019  |  Cancer Immunology Research