Ruili Li

The Majority of Boys Having Orchidopexy for Congenital Nonsyndromic Cryptorchidism during Minipuberty Exhibited Normal Reproductive Hormonal Profiles

Simone Hildorf, Andrea E Hildorf, Erik Clasen-Linde, Dina Cortes, Soren Walther-Larsen, Ruili Li, John M Hutson, Jorgen Thorup

Journal article  |  2021  |  EUROPEAN JOURNAL OF PEDIATRIC SURGERY

INTRODUCTION:  The activation of the hypothalamic-pituitary-gonadal axis that occurs in male minipuberty during the first 5 months..

During infancy low levels of follicle-stimulating hormone may result in high rate of germ cell apoptosis

Simone Hildorf, Dina Cortes, Jorgen Thorup, Erik Clasen-Linde, John Hutson, Ruili Li

Journal article  |  2021  |  JOURNAL OF PEDIATRIC SURGERY

PURPOSE: It has been suggested that follicle-stimulating hormone (FSH) plays a role in preventing germ cell apoptosis. We aimed to..

Bcl2-Associated X (BAX) Knockout in Mice Resulted in Persistence of Neonatal Testicular Germ Cells (Gonocytes)

Ruil Li, Shengde Wu, Manpreet Kaur, Shan Zong, Sanduni A Abeydeera, Tuya Bao, Shaista Arif, John M Hutson

Journal article  |  2020  |  SEXUAL DEVELOPMENT

During early testicular development, neonatal gonocytes transform into spermatogonial stem cells (SSC), and any untransformed gono..

The role of gonadotrophins in gonocyte transformation during minipuberty

Emily Burton, Sanduni Amaya Abeydeera, Gulcan Sarila, Hyun-Jung Cho, Shengde Wu, Melissa Yixin Tien, John Hutson, Ruili Li

Journal article  |  2020  |  PEDIATRIC SURGERY INTERNATIONAL

PURPOSE: Postnatal surge of gonadotrophins, Luteinizing hormone (LH) and Follicle-Stimulating hormone (FSH) known as minipuberty, ..

Interplay between collagenase and undescended testes in Adamts16 knockout rats

Gulcan Sarila, Tuya Bao, Sanduni Amaya Abeydeera, Ruili Li, Blair Mell, Bina Joe, Angelique Catubig, John Hutson

Journal article  |  2020  |  JOURNAL OF PEDIATRIC SURGERY

BACKGROUND: The inguinoscrotal stage of testicular descent is characterized by an increase in cell density and collagen fibers as ..

Does the apoptosis pathway play a critical role in gonocyte transformation?

Melissa Yixin Tien, Sanduni Amaya Abeydeera, Hyun-Jung Cho, Gulcan Sarila, Angelique Catubig, Emily Burton, John Hutson, Ruili Li

Journal article  |  2020  |  JOURNAL OF PEDIATRIC SURGERY

PURPOSE: Undescended Testes (UDT) are prevalent in 2%-5% of male infants and cause malignancy and infertility. During germ cell de..

Cryptorchidism, gonocyte development, and the risks of germ cell malignancy and infertility: A systematic review

Moshe Loebenstein, Jorgen Thorup, Dina Cortes, Erik Clasen-Linde, John M Hutson, Ruili Li

Journal article  |  2020  |  JOURNAL OF PEDIATRIC SURGERY

BACKGROUND/AIM: Cryptorchidism, or undescended testis (UDT) occurs in 1%-4% of newborn males and leads to a risk of infertility an..

Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death?

Vanessa Wilson, Jorgen Thorup, Erick Clasen-Linde, Dina Cortes, John M Hutson, Ruili Li

Journal article  |  2019  |  PEDIATRIC SURGERY INTERNATIONAL

PURPOSE: Undescended testes (UDT) are subjected to heat stress, which can disturb gonocyte transformation as well as apoptosis. Th..

Postnatal germ cell development during first 18 months of life in testes from boys with non-syndromic cryptorchidism and complete or partial androgen insensitivity syndrome

Ruili Li, Damian Azzollini, Ruidong Shen, Jorgen Thorup, Erick Clasen-Linde, Dina Cortes, John M Hutson

Journal article  |  2019  |  JOURNAL OF PEDIATRIC SURGERY

INTRODUCTION: Neonatal testicular germ cells/gonocytes, transform into stem cells for spermatogenesis during 'minipuberty', drivin..

Postnatal Germ Cell Development in the Cryptorchid Testis: The Key to Explain Why Early Surgery Decreases the Risk of Malignancy

Jorgen Thorup, Erik Clasen-Linde, Ruili Li, Susanne Reinhardt, Kolja Kvist, Jaya Vikraman, Bridget R Southwell, John M Hutson, Dina Cortes

Journal article  |  2018  |  EUROPEAN JOURNAL OF PEDIATRIC SURGERY

PURPOSE:  Cryptorchidism is a risk factor for testicular malignancy and surgical treatment lowers this risk. This study aimed to i..