Samuel Ngan

Results of phase II trial of intensified neoadjuvant treatment with interdigitating radiotherapy and chemotherapy with oxaliplatin, 5-fluorouracil and folinic acid in patients with locally advanced rectal cancer (PROARCT trial)

Sweet Ping Ng, Julie Chu, Sarat Chander, Mathias Bressel, Joseph McKendrick, Rachel Wong, Malcolm Steel, William K Murray, Trevor Leong, Alexander Heriot, Michael Michael, Samuel Y Ngan

Journal article  |  2021  |  Radiotherapy and Oncology

BACKGROUND AND PURPOSE: The chemotherapy exposure during chemoradiotherapy for rectal cancer is adequate for radiosensitization bu..

Characterising the immune microenvironment in liposarcoma, its impact on prognosis and the impact of radiotherapy

Hayden Snow, Catherine Mitchell, Shona Hendry, Madeleine McKinley, David Byrne, Sam Ngan, Sarat Chander, Julie Chu, Jayesh Desai, Susie Bae, Michael Henderson, Peter Choong, David Gyorki

Journal article  |  2020  |  Journal of Surgical Oncology

BACKGROUND AND OBJECTIVES: Limited literature exists examining the immune microenvironment in liposarcoma, particularly with regar..

Cutaneous leiomyosarcoma: dermal and subcutaneous

Gwyneth Natalie Wong, Angela Webb, David Gyorki, Chris McCormack, Phillip Tran, Samuel Y Ngan, John Slavin, Michael A Henderson

Journal article  |  2020  |  Australasian Journal of Dermatology

BACKGROUND AND OBJECTIVES: Leiomyosarcoma of skin (LMS) can be sub-classified on pathology appearances as Dermal or Subcutaneous. ..

Clinical Features of High-Grade Extremity and Trunk Sarcomas in Patients Aged 80 Years and Older: Why Are Outcomes Inferior?

Jungo Imanishi, Lester WM Chan, Matthew L Broadhead, Grant Pang, Samuel Y Ngan, John Slavin, Stephen Sharp, Peter FM Choong

Journal article  |  2019  |  Frontiers in Surgery

Background: The population of many countries is aging and a significant number of elderly patients with soft-tissue sarcoma are be..

Phase II trial PD-L1/PD-1 blockade avelumab with chemoradiotherapy for locally advanced resectable T3B-4/N1-2 rectal cancer: The Ave-Rec trial.

Michael Michael, Rachel Wong, Sanjeev Singh Gill, David Goldstein, Sam Ngan, Alexander Graham Heriot, Emma Link, Maria Farrell, Paul J Neeson, Robert George Ramsay, Kasmira Wilson, Catherine Mitchell, Jeanne Tie, Nick Pavlakis, John Raymond Zalcberg, Eva Segelov

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

TPS3622 Background: Standard neoadjuvant long course chemoradiotherapy (LCCRT) for locally advanced rectal cancer (LARC) results ..

A clinical trial with protracted infusion 5-fluorouracil and mitomycin C for localized squamous cell carcinoma of the anus

David Ngan, Julie Chu, Sarat Chander, Michael Michael, Alexander G Heriot, Samuel Y Ngan, Danny Rischin, Trevor Leong

Journal article  |  2019  |  Asia-Pacific Journal of Clinical Oncology

PURPOSE: Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interrupt..

Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

Joseph Cherng Huei Kong, Glen Robert Guerra, Rosemary Magdalena Millen, Sara Roth, Huiling Xu, Paul Joseph Neeson, Phillip Kevin Darcy, Michael Henry Kershaw, Shienny Sampurno, Jordane Malaterre, David Shi Hao Liu, Duc Pham Toan, Vignesh Narasimhan, Minyu Wang, Yu-Kuan Huang, Kumar Visvanathan, Jacob McCormick, Andrew Craig Lynch, Satish Warrier, Michael Michael, et al.

Journal article  |  2018  |  JCO Precision Oncology

Purpose The presence of tumor-infiltrating lymphocytes (TILs) in tumors is superior to conventional pathologic staging in predicti..

Treatment of patients with primary retroperitoneal sarcoma: predictors of outcome from an Australian specialist sarcoma centre

Hayden A Snow, Tatiana X Hitchen, Jessica Head, Alan Herschtal, Susie Bae, Sarat Chander, Julie Chu, Shona Hendry, Samuel Y Ngan, Jayesh Desai, Peter FM Choong, Michael Henderson, David E Gyorki

Journal article  |  2018  |  ANZ Journal of Surgery

BACKGROUND: Several unanswered questions surround the management of retroperitoneal sarcoma (RPS). Guidelines recommend treatment ..

Prognostic value of tumour regression grade in locally advanced rectal cancer: a systematic review and meta-analysis

JC Kong, GR Guerra, SK Warrier, A Craig Lynch, M Michael, SY Ngan, W Phillips, G Ramsay, AG Heriot

Journal article  |  2018  |  Colorectal Disease

AIM: The current standard of care for locally advanced rectal cancer involves neoadjuvant chemoradiotherapy (CRT) followed by tota..

Outcomes and prognostic factors of multimodality treatment for locally recurrent rectal cancer with curative intent

Thomas G Bird, Samuel Y Ngan, Julie Chu, Rene Kroon, Andrew C Lynch, Alexander G Heriot

Journal article  |  2018  |  International Journal of Colorectal Disease

PURPOSE: Radical management of locally recurrent rectal cancer (LRRC) can lead to prolonged survival. This study aims to assess ou..