Jason Mackenzie

SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon.

Maya Shemesh, Turgut E Aktepe, Joshua M Deerain, Julie L McAuley, Michelle D Audsley, Cassandra T David, Damian FJ Purcell, Victoria Urin, Rune Hartmann, Gregory W Moseley, Jason M Mackenzie, Gideon Schreiber, Daniel Harari

Journal article  |  2021  |  PLoS Pathog

Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral infection. Resultantly, many vir..

Nuclear localisation of West Nile virus NS5 protein modulates host gene expression

Adam J Lopez-Denman, Daniel E Tuipulotu, Jessica B Ross, Alice M Trenerry, Peter A White, Jason M Mackenzie

Journal article  |  2021  |  VIROLOGY

The involvement of the nucleus during flavivirus infection has been observed in only a small number of cases and can be limited to..

Lipid droplets and lipid mediators in viral infection and immunity

Ebony A Monson, Alice M Trenerry, Jay L Laws, Jason M Mackenzie, Karla J Helbig

Journal article  |  2021  |  FEMS MICROBIOLOGY REVIEWS

Lipid droplets (LDs) contribute to key pathways important for the physiology and pathophysiology of cells. In a homeostatic view, ..

A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses

Alberto A Amarilla, Julian DJ Sng, Rhys Parry, Joshua M Deerain, James R Potter, Yin Xiang Setoh, Daniel J Rawle, Thuy T Le, Naphak Modhiran, Xiaohui Wang, Nias YG Peng, Francisco J Torres, Alyssa Pyke, Jessica J Harrison, Morgan E Freney, Benjamin Liang, Christopher LD McMillan, Stacey TM Cheung, Darwin J Da Costa Guevara, Joshua M Hardy, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The current COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We demonstrate that d..

A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication

Andrea Mikulasova, Leah K Gillespie, Rebecca L Ambrose, Turgut E Aktepe, Alice M Trenerry, Susann Liebscher, Jason M Mackenzie

Journal article  |  2021  |  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Flavivirus replication is intimately associated with re-organized cellular membranes. These virus-induced changes in membrane arch..

Liquid Chalk Is an Antiseptic against SARS-CoV-2 and Influenza A Respiratory Viruses

Julie L McAuley, Joshua M Deerain, William Hammersla, Turgut E Aktepe, Damian FJ Purcell, Jason M Mackenzie, Matthew B Frieman

Journal article  |  2021  |  MSPHERE

The COVID-19 pandemic has impacted and enforced significant restrictions within our societies, including the attendance of public ..

Modulation of acyl-carnitines, the broad mechanism behind Wolbachia-mediated inhibition of medically important flaviviruses in Aedes aegypti

Gayathri Manokaran, Heather A Flores, Conor T Dickson, Vinod K Narayana, Komal Kanojia, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie, Cameron P Simmons

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wolbachia-infected mosquitoes are refractory to flavivirus infections, but the role of lipids in Wolbachia-mediated virus blocking..

Tenth Scientific Biennial Meeting of the Australasian Virology Society-AVS10 2019

Karla J Helbig, Rowena A Bull, Rebecca Ambrose, Michael R Beard, Helen Blanchard, Till Bocking, Brendon Chua, Agathe MG Colmant, Keaton M Crosse, Damian FJ Purcell, Johanna Fraser, Joshua A Hayward, Stuart T Hamilton, Matloob Husain, Robin MacDiarmid, Jason M Mackenzie, Gregory W Moseley, Thi HO Nguyen, Miguel E Quinones-Mateu, Karl Robinson, et al.

Journal article  |  2020  |  VIRUSES-BASEL

The Australasian Virology Society (AVS) aims to promote, support and advocate for the discipline of virology in the Australasian r..

Monocyte apoptotic bodies are vehicles for influenza A virus propagation

Georgia K Atkin-Smith, Mubing Duan, Damien J Zanker, Liyen Loh, Thi HO Nguyen, Marios Koutsakos, Tien Nguyen, Xiangrui Jiang, Julio Carrera, Thanh Kha Phan, Chuanxin Liu, Stephanie Paone, Sara Oveissi, Amy L Hodge, Amy A Baxter, Katherine Kedzierska, Jason M Mackenzie, Mark D Hulett, Pamuk Bilsel, Weisan Chen, et al.

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

The disassembly of apoptotic cells into small membrane-bound vesicles termed apoptotic bodies (ApoBDs) is a hallmark of apoptosis;..

West Nile virus infection and interferon alpha treatment alter the spectrum and the levels of coding and noncoding host RNAs secreted in extracellular vesicles

Andrii Slonchak, Brian Clarke, Jason Mackenzie, Alberto Anastacio Amarilla, Yin Xiang Setoh, Alexander A Khromykh

Journal article  |  2019  |  BMC GENOMICS

BACKGROUND: Extracellular vesicles (EVs) are small membrane vesicles secreted by the cells that mediate intercellular transfer of ..