Jason Mackenzie

West Nile virus infection and interferon alpha treatment alter the spectrum and the levels of coding and noncoding host RNAs secreted in extracellular vesicles

Andrii Slonchak, Brian Clarke, Jason Mackenzie, Alberto Anastacio Amarilla, Yin Xiang Setoh, Alexander A Khromykh

Journal article  |  2019  |  BMC Genomics

Antiviral Candidates for Treating Hepatitis E Virus Infection

Natalie E Netzler, Daniel Enosi Tuipulotu, Subhash G Vasudevan, Jason M Mackenzie, Peter A White

Journal article  |  2019  |  Antimicrobial Agents and Chemotherapy

The Adenosine Analogue NITD008 has Potent Antiviral Activity against Human and Animal Caliciviruses.

Daniel Enosi Tuipulotu, Tulio M Fumian, Natalie E Netzler, Jason M Mackenzie, Peter A White

Journal article  |  2019  |  Viruses

The widespread nature of calicivirus infections globally has a substantial impact on the health and well-being of humans and anima..

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

Determinants of Zika virus host tropism uncovered by deep mutational scanning

Yin Xiang Setoh, Alberto A Amarilla, Nias YG Peng, Rebecca E Griffiths, Julio Carrera, Morgan E Freney, Eri Nakayama, Shinya Ogawa, Daniel Watterson, Naphak Modhiran, Faith Elizabeth Nanyonga, Francisco J Torres, Andrii Slonchak, Parthiban Periasamy, Natalie A Prow, Bing Tang, Jessica Harrison, Jody Hobson-Peters, Thom Cuddihy, Justin Cooper-White, et al.

Journal article  |  2019  |  Nature Microbiology

Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2 alpha Axis

Svenja Fritzlar, Turgut E Aktepe, Yi-Wei Chao, Nathan D Kenney, Michael R McAllaster, Craig B Wilen, Peter A White, Jason M Mackenzie

Journal article  |  2019  |  mBio

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Hanne Dubois, Frederic Sorgeloos, Soroush T Sarvestani, Liesbet Martens, Yvan Saeys, Jason M Mackenzie, Mohamed Lamkanfi, Geert van Loo, Ian Goodfellow, Andy Wullaert

Journal article  |  2019  |  PLOS Pathogens

The Microtubule-Associated Innate Immune Sensor GEF-H1 Does Not Influence Mouse Norovirus Replication in Murine Macrophages

Svenja Fritzlar, Peter A White, Jason M Mackenzie

Journal article  |  2019  |  Viruses

Using a Virion Assembly-Defective Dengue Virus as a Vaccine Approach

Chao Shan, Xuping Xie, Jing Zou, Roland Zust, Bo Zhang, Rebecca Ambrose, Jason Mackenzie, Katja Fink, Pei-Yong Shi

Journal article  |  2018  |  Journal of Virology

Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8( ) T Cell Recognition and Activation

Svenja Fritzlar, Sinthujan Jegaskanda, Turgut Esad Aktepe, Julia Emiley Prier, Lauren Elise Holz, Peter A White, Jason M Mackenzie

Journal article  |  2018  |  Journal of Virology

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection

Adam J Lopez-Denman, Alice Russo, Kylie M Wagstaff, Peter A White, David A Jans, Jason M Mackenzie

Journal article  |  2018  |  Cellular Microbiology

Shaping the flavivirus replication complex: It is curvaceous!

Turgut E Aktepe, Jason M Mackenzie

Journal article  |  2018  |  Cellular Microbiology

TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation

Daniel Enosi Tuipulotu, Natalie E Netzler, Jennifer H Lun, Jason M Mackenzie, Peter A White

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy

2017 international meeting of the Global Virus Network

Mike Catton, Glenda Gray, Diane Griffin, Hideki Hasegawa, Stephen J Kent, Jason Mackenzie, Edward McSweegan, Natalia Mercer, Linfa Wang

Journal article  |  2018  |  Antiviral Research

Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus

Susann Liebscher, Rebecca L Ambrose, Turgut E Aktepe, Andrea Mikulasova, Julia E Prier, Leah K Gillespie, Adam J Lopez-Denman, Thusitha WT Rupasinghe, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie

Journal article  |  2018  |  PLOS Pathogens

The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling

Turgut E Aktepe, Susann Liebscher, Julia E Prier, Cameron P Simmons, Jason M Mackenzie

Journal article  |  2017  |  Cell Reports

Broad-spectrum non-nucleoside inhibitors for caliciviruses

Natalie E Netzler, Daniel Enosi Tuipulotu, Auda A Eltahla, Jennifer H Lun, Salvatore Ferla, Andrea Brancale, Nadya Urakova, Michael Frese, Tanja Strive, Jason M Mackenzie, Peter A White

Journal article  |  2017  |  Antiviral Research

RNA sequencing of Murine Norovirus-Infected Cells Reveals Transcriptional Alteration of Genes Important to Viral recognition and Antigen Presentation

Daniel Enosi Tuipulotu, Natalie E Netzler, Jennifer H Lun, Jason M Mackenzie, Peter A White

Journal article  |  2017  |  Frontiers in Immunology

The Norovirus NS3 Protein Is a Dynamic Lipid- and Microtubule-Associated Protein Involved in Viral RNA Replication

Ben T Cotton, Jennifer L Hyde, Soroush T Sarvestani, Stanislav V Sosnovtsev, Kim Y Green, Peter A White, Jason M Mackenzie

Journal article  |  2017  |  Journal of Virology

The IMPORTance of the Nucleus during Flavivirus Replication

Adam J Lopez-Denman, Jason M Mackenzie

Journal article  |  2017  |  Viruses

Mouse Norovirus infection promotes autophagy induction to facilitate replication but prevents final autophagosome maturation

Tanya B O'Donnell, Jennifer L Hyde, Justine D Mintern, Jason M Mackenzie

Journal article  |  2016  |  Virology

Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response

Soroush T Sarvestani, Ben Cotton, Svenja Fritzlar, Tanya B O'Donnell, Jason M Mackenzie

Journal article  |  2016  |  Journal of Interferon & Cytokine Research

Recent advances in dengue pathogenesis and clinical management

Cameron P Simmons, Kirsty McPherson, Van Vinh Chau Nguyen, DT Hoai Tam, Paul Young, Jason Mackenzie, Bridget Wills

Journal article  |  2015  |  Vaccine

Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus

Turgut E Aktepe, Helen Pham, Jason M Mackenzie

Journal article  |  2015  |  Virology

Conserved amino acids within the N-terminus of the West Nile virus NS4A protein contribute to virus replication, protein stability and membrane proliferation

RL Ambrose, JM Mackenzie

Journal article  |  2015  |  Virology

A Nuclear Transport Inhibitor That Modulates the Unfolded Protein Response and Provides In Vivo Protection Against Lethal Dengue virus Infection

Johanna E Fraser, Satoru Watanabe, Chunxiao Wang, Wing Ki Kitti Chan, Belinda Maher, Adam Lopez-Denman, Caroline Hick, Kylie M Wagstaff, Jason M Mackenzie, Patrick M Sexton, Subhash G Vasudevan, David A Jans

Journal article  |  2014  |  The Journal of Infectious Diseases

Modulation of Hepatitis C Virus Genome Replication by Glycosphingolipids and Four-Phosphate Adaptor Protein 2

Irfan Khan, Divya S Katikaneni, Qingxia Han, Lorena Sanchez-Felipe, Kentaro Hanada, Rebecca L Ambrose, Jason M Mackenzie, Kouacou V Konan

Journal article  |  2014  |  Journal of Virology

Nonnucleoside Inhibitors of Norovirus RNA Polymerase: Scaffolds for Rational Drug Design

Auda A Eltahla, Kun Lee Lim, John-Sebastian Eden, Andrew G Kelly, Jason M Mackenzie, Peter A White

Journal article  |  2014  |  Antimicrobial Agents and Chemotherapy

The West Nile virus assembly process evades the conserved antiviral mechanism of the interferon-induced MxA protein

Antje Hoenen, Leah Gillespie, Garry Morgan, Peter van der Heide, Alexander Khromykh, Jason Mackenzie

Journal article  |  2014  |  Virology

Non-structural protein-1 is required for West Nile virus replication complex formation and viral RNA synthesis

Soonjeon Youn, Rebecca L Ambrose, Jason M Mackenzie, Michael S Diamond

Journal article  |  2013  |  Virology Journal

Flaviviral regulation of the unfolded protein response: can stress be beneficial?

Rebecca L Ambrose, Jason M Mackenzie

Journal article  |  2013  |  Future Virology

ATF6 Signaling Is Required for Efficient West Nile Virus Replication by Promoting Cell Survival and Inhibition of Innate Immune Responses

Rebecca L Ambrose, Jason M Mackenzie

Journal article  |  2013  |  Journal of Virology

The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers

Sook-San Wong, Gholamreza Haqshenas, Eric J Gowans, Jason Mackenzie

Journal article  |  2012  |  FEBS Letters

Mouse Norovirus 1 Utilizes the Cytoskeleton Network To Establish Localization of the Replication Complex Proximal to the Microtubule Organizing Center

Jennifer L Hyde, Leah K Gillespie, Jason M Mackenzie

Journal article  |  2012  |  Journal of Virology

A Conserved Peptide in West Nile Virus NS4A Protein Contributes to Proteolytic Processing and Is Essential for Replication

RL Ambrose, JM Mackenzie

Journal article  |  2011  |  Journal of Virology

West Nile Virus Differentially Modulates the Unfolded Protein Response To Facilitate Replication and Immune Evasion

Rebecca L Ambrose, Jason M Mackenzie

Journal article  |  2011  |  Journal of Virology

Comparison of the replication properties of murine and human calicivirus RNA-dependent RNA polymerases

Rowena A Bull, Jennifer Hyde, Jason M Mackenzie, Grant S Hansman, Tomoichiro Oka, Naokazu Takeda, Peter A White

Journal article  |  2011  |  Virus Genes

Subcellular localization of the MNV-1 ORF1 proteins and their potential roles in the formation of the MNV-1 replication complex

Jennifer L Hyde, Jason M Mackenzie

Journal article  |  2010  |  Virology

The Endoplasmic Reticulum Provides the Membrane Platform for Biogenesis of the Flavivirus Replication Complex

Leah K Gillespie, Antje Hoenen, Gary Morgan, Jason M Mackenzie

Journal article  |  2010  |  Journal of Virology

Mouse Norovirus Replication Is Associated with Virus-Induced Vesicle Clusters Originating from Membranes Derived from the Secretory Pathway

Jennifer L Hyde, Stanislav V Sosnovtsev, Kim Y Green, Christiane Wobus, Herbert W Virgin, Jason M Mackenzie

Journal article  |  2009  |  Journal of Virology

Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors

John C Martyn, Anthony J Cardin, Bruce D Wines, Angela Cendron, Shuo Li, Jason Mackenzie, Maree Powell, Eric J Gowans

Journal article  |  2009  |  Archives of Virology

Vectorial entry and release of hepatitis a virus in polarized human hepatocytes

Michelle J Snooks, Purnima Bhat, Jason Mackenzie, Natalie A Counihan, Nicola Vaughan, David A Anderson

Journal article  |  2008  |  Journal of Virology

Role of nonstructural protein NS2A in flavivirus assembly

Jason Y Leung, Gorben P Pijlman, Natasha Kondratieva, Jennifer Hyde, Jason M Mackenzie, Alexander A Khromykh

Journal article  |  2008  |  Journal of Virology

West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein

Antje Hoenen, Wenjun Liu, Georg Kochs, Alexander A Khromykh, Jason M Mackenzie

Journal article  |  2007  |  Journal of General Virology

Cholesterol manipulation by west nile virus perturbs the cellular immune response

Jason M Mackenzie, Alexander A Khromykh, Robert G Parton

Journal article  |  2007  |  Cell Host & Microbe

Crystal structure of the RNA polymerase domain of the West Nile Virus non-structural protein 5

Helene Malet, Marie-Pierre Egloff, Barbara Selisko, Rebecca E Butcher, Peter J Wright, Michael Roberts, Arnaud Gruez, Gerlind Sulzenbacher, Clemens Vonrhein, Gerard Bricogne, Jason M Mackenzie, Alexander A Khromykh, Andrew D Davidson, Bruno Canard

Journal article  |  2007  |  Journal of Biological Chemistry

West Nile virus strain Kunjin NS5 polymerase is a phosphoprotein localized at the cytoplasmic site of viral RNA synthesis

Jason M Mackenzie, Mark T Kenney, Edwin G Westaway

Journal article  |  2007  |  Journal of General Virology

Hepatitis C virus p7 protein is localized in the endoplasmic reticulum when it is encoded by a replication-competent genome

G Haqshenas, JM Mackenzie, X Dong, EJ Gowans

Journal article  |  2007  |  Journal of General Virology

The ORF7b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is expressed in virus-infected cells and incorporated into SARS-CoV particles

Scott R Schaecher, Jason M Mackenzie, Andrew Pekosz

Journal article  |  2007  |  Journal of Virology

Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum

Silke Stertz, Mike Reichelt, Jacomine Krijnse-Locker, Jason Mackenzie, Jeremy C Simpson, Otto Haller, Georg Kochs

Journal article  |  2006  |  Journal of Interferon and Cytokine Research

Regulated cleavages at the West Nile virus NS4A-2K-NS4B junctions play a major role in rearranging cytoplasmic membranes and Golgi trafficking of the NS4A protein

J Roosendaal, EG Westaway, A Khromykh, JM Mackenzie

Journal article  |  2006  |  Journal of Virology

Wrapping things up about virus RNA replication

J Mackenzie

Journal article  |  2005  |  Traffic

Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages

CE Wobus, SM Karst, LB Thackray, KO Chang, SV Sosnovtsev, G Belliot, A Krug, JM Mackenzie, KY Green, HW Virgin

Journal article  |  2004  |  PLoS Biology

Comparisons of physical separation methods of Kunjin virus-induced membranes

M Kim, JA Mackenzie, EG Westaway

Journal article  |  2004  |  JOURNAL OF VIROLOGICAL METHODS

Comparisons of physical separation methods of Kunjin virus-induced membranes.

Min Kim, Jason M Mackenzie, Edwin G Westaway

Journal article  |  2004  |  Journal of Virological Methods

The two sets of connected membranes induced in Kunjin virus-infected cells are characterized by the presence of NS3 helicase/prote..

West nile virus core protein: Tetramer structure and ribbon formation

T Dokland, M Walsh, JM Mackenzie, AA Khromykh, KH Ee, SF Wang

Journal article  |  2004  |  Structure

Kunjin virus replicon vectors for human immunodeficiency virus vaccine development

TJ Harvey, I Anraku, R Linedale, D Harrich, J Mackenzie, A Suhrbier, AA Khromykh

Journal article  |  2003  |  Journal of Virology

Kunjin RNA replication and applications of Kunjin replicons

EG Westaway, JM Mackenzie, AA Khromykh

Other  |  2003  |  Advances in Virus Research

Inducible system in human hepatoma cell lines for hepatitis C virus production

SP Lim, HM Soo, YH Tan, S Brenner, H Horstmann, JM MacKenzie, ML Ng, SG Lim, WJ Hong

Journal article  |  2002  |  Virology

Differential requirements for COPI coats in formation of replication complexes among three genera of Picornaviridae

EV Gazina, JM Mackenzie, RJ Gorrell, DA Anderson

Journal article  |  2002  |  Journal of Virology

Replication and gene function in Kunjin virus

EG Westaway, JM Mackenzie, AA Khromykh

Other  |  2002  |  Current Topics in Microbiology and Immunology

Expression of the hepatitis C virus structural proteins in mammalian cells induces morphology similar to that in natural infection

SJ Greive, RL Webb, JM Mackenzie, EJ Gowans

Journal article  |  2002  |  Journal of Viral Hepatitis

Assembly and maturation of the flavivirus Kunjin virus appear to occur in the rough endoplasmic reticulum and along the secretory pathway, respectively

JM MacKenzie, EG Westaway

Journal article  |  2001  |  Journal of Virology

Stable expression of noncytopathic Kunjin replicons simulates both ultrastructural and biochemical characteristics observed during replication of Kunjin virus

JM Mackenzie, AA Khromykh, EG Westaway

Journal article  |  2001  |  Virology

Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction

MG Jacobs, PJ Robinson, C Bletchly, JM Mackenzie, PR Young

Journal article  |  2000  |  The FASEB Journal

Loss of dimerisation of the nonstructural protein NS1 of Kunjin virus delays viral replication and reduces virulence in mice, but still allows secretion of NS1

RA Hall, AA Khromykh, JM Mackenzie, JH Scherret, TI Khromykh, JS Mackenzie

Journal article  |  1999  |  Virology

Markers for trans-Golgi membranes and the intermediate compartment localize to induced membranes with distinct replication functions in flavivirus-infected cells

JM Mackenzie, MK Jones, EG Westaway

Journal article  |  1999  |  Journal of Virology

Nascent flavivirus RNA colocalized in situ with double-stranded RNA in stable replication complexes

EG Westaway, AA Khromykh, JM Mackenzie

Journal article  |  1999  |  Virology

Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A

JM Mackenzie, AA Khromykh, MK Jones, EG Westaway

Journal article  |  1998  |  Virology

Ultrastructure of Kunjin virus-infected cells: Colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures

EG Westaway, JM MacKenzie, MT Kenney, MK Jones, AA Khromykh

Journal article  |  1997  |  Journal of Virology

Proteins C and NS4B of the flavivirus Kunjin translocate independently into the nucleus

EG Westaway, AA Khromykh, MT Kenney, JM Mackenzie, MK Jones

Journal article  |  1997  |  Virology

Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication

JM Mackenzie, MK Jones, YR Young

Journal article  |  1996  |  Virology

Improved membrane preservation of flavivirus-infected cells with cryosectioning

JM Mackenzie, MK Jones, PR Young

Journal article  |  1996  |  Journal of Virological Methods