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Prof

Danny Hatters

Professor
Biochemistry And Molecular Biology
polyglutamine
fluorescence
Protein aggregation
Huntington's Disease
Motor Neuron Disease
science & technology
life sciences & biomedicine
humans
biochemistry & molecular biology
Danny Hatters's Profile Picture
Prof

Danny Hatters

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Protein conformations in cells. New techniques. Protein misfolding and aggregation.
Danny Hatters's Profile Picture
Prof

Danny Hatters

 

Danny Hatters runs a program exploring how proteins change conformation in cells as part of normal and pathogenic processes, including those associated with misfolding and aggregation. Key elements of this research include the development and application of new fluorescence -based probes and biosensors to view protein dynamics in cells.

His major area of research is in Huntington's Disease with other programs in motor neuron disease and fundamental biology of protein-ligand associations as part of cellular mechanisms. He completed his PhD at the University of Melbourne in 2002. He then did a post doc at the Gladstone Institutes/University of California, San Francisco under the mentorship of Dr Karl Weisgraber for 5 years until 2007. There he studied how three variants of apolipoprotein E, apoE2, apoE3 and apoE4 differ in their conformation and biophysical properties as a basis for understanding the mechanisms underlying the elevated risk that the apoE4 isoform confers for Alzheimer's disease. In April 2007, he returned to Melbourne to take up a CR Roper Fellowship position in the Department of Biochemistry and Molecular Biology. In 2009 he was awarded the Grimwade Fellowship to continue developing his own research program focusing on how protein conformations lead to cellular dysfunction and disease. In 2012, he was awarded an ARC Future Fellowship. In 2019 he was awarded an NHMRC Senior Research Fellowship.

Projects

Displaying the 22 most recent projects by Danny Hatters.

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The Cascade Of Consequences In Huntington Disease From Mutant Httex1 Synthesis And Aggregation

2020 - 2022
Active
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The Metastability Of Proteome Foldedness In Neurodegenerative Disease

The research objective of this award is to develop a quantitative and mechanistic understanding of how the genomic material of viruses enter..

2019 - 2022
Active
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The Metastability Of Proteome Foldedness In Neurodegenerative Disease

The research objective of this award is to develop a quantitative and mechanistic understanding of how the genomic material of viruses enter..

2019 - 2022
Active
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Defining The Capacity Of Cells To Keep The Proteome Folded Over Space And Time

2017 - 2020
Active
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B_Yond

2017 - 2018
Completed
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Dissecting Polyq-Ataxin-1 Trafficking And Nuclear Body Dynamics As Drivers Of Toxicity

Ataxias are a large group of neurodegenerative disorders in which balance, motor skills and memory are progressively lost. While mutations i..

2017 - 2019
Completed
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Surveillance Of The Mechanisms Controlling Proteome Foldedness

This project aims to measure how cells keep the proteome folded. Cells have extensive quality control networks to govern synthesis, folding ..

2017 - 2020
Active
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Pathogenic And Adaptive Molecular Interactions With Mutant Huntingtin Exon 1

This project aims to determine how the gene mutation that causes Huntington’s disease (HD) damages cells in the brain. The diseased gene cre..

2016 - 2019
Completed
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Determining The Mechanism Of Toxicity Of C9orf72 Ran Translation Products

2015 - 2016
Completed
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Building A Research Capacity To Define The Protein Folding Energy Landscapes Of A Cell

2014 - 2014
Completed
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Spatial Organization Of Lck As A Regulatory Mechanism Of Tcr Signalling

To function in an immune response, T cell become activated when the interactions between the T cell receptor and the kinase Lck on the cell ..

2014 - 2016
Completed
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Role Of Hsp40 And Hsp70 In Huntingtin Misfolding, Oligomerization And Inclusion Assembly

Huntington disease results from a mutation that causes the Htt protein to become abnormally sticky and form toxic clusters in neurons. Cells..

2013 - 2016
Completed
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Viewing The Cellular Responses In Huntington'S Disease Through An Aggreomics Framework

Huntington disease results from a mutation that causes the Htt protein to form abnormal toxic clusters in neurons that eventually leads to c..

2013 - 2016
Completed
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Defining The Cellular Impacts Of Protein Aggregation In Neurodegenerative Disease With An Aggreomics Platform

The brain disease Huntington’s is caused by abnormally shaped proteins that assemble into toxic clusters. This project will design new biopr..

2012 - 2016
Completed
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Tracking The Cellular Responses To Htt Aggregation With New Enabling Toolkits

2012 - 2013
Completed
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Building An "Aggreomics" Paradigm For Neurodegenerative Disease.

2012 - 2012
Completed
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Deciphering The Cellular Defenses Against Aggregating Proteins In Human Disease

Cells have inbuilt defences for coping with proteins that bend into abnormal sticky shapes that form toxic clusters. In many diseases, inclu..

2012 - 2014
Completed
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Biophysical Identification Of Natural Human Antibody Targets

A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to ..

2010 - 2013
Completed
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Biophysical Identification Of Natural Human Antibody Targets

A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to ..

2010 - 2013
Completed
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Understanding How Misshapen Proteins Accumulate And Kill Cells During Huntington'S Disease

Mutations in the huntingtin gene cause Huntington's disease by making the gene product aggregate together into non-normal and different size..

2009 - 2012
Completed
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Live-Cell Reporters Of Protein Conformation To Model Huntington'S Disease

2008 - 2008
Completed
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Real-Time Detection Of Misfolded Prion Conformations For Live-Cell Imaging

22

Projects

Project Types

17

Research Grant

4

Internal Research Grant

1

Research Contracts

Scholarly Works

Displaying the 90 most recent scholarly works by Danny Hatters.

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Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control

Angelique Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny Hatters

Journal article  |  2020

Abstract Mutations that cause Huntington’s Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 ..

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Inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

Mona Radwan, Jordan Lilley, Ching-Seng Ang, Gavin Reid, Danny Hatters

Journal article  |  2020

ABSTRACT Poly(glycine-alanine) (polyGA) is one of the dipolypeptides expressed in Motor Neuron Disease caused by C9ORF72 mutations..

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Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity

Mona Radwan, Ching-Seng Ang, Angelique R Ormsby, Dezerae Cox, James C Daly, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  Molecular & Cellular Proteomics

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used qu..

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Protein aggregation in cell biology: An aggregomics perspective of health and disease

Dezerae Cox, Candice Raeburn, Xiaojing Sui, Danny M Hatters

Journal article  |  2020  |  Seminars in Cell & Developmental Biology

Maintaining protein homeostasis (proteostasis) is essential for cellular health and is governed by a network of quality control ma..

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Widespread remodeling of proteome solubility in response to different protein homeostasis stresses

Xiaojing Sui, Douglas EV Pires, Angelique R Ormsby, Dezerae Cox, Shuai Nie, Giulia Vecchi, Michele Vendruscolo, David B Ascher, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

The accumulation of protein deposits in neurodegenerative diseases has been hypothesized to depend on a metastable subproteome vul..

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Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

Lorena Hidalgo San Jose, Mary Jean Sunshine, Christopher H Dillingham, Bernadette A Chua, Miriama Kruta, Yuning Hong, Danny M Hatters, Robert AJ Signer

Journal article  |  2020  |  Cell Reports

Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in prote..

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Arginine valency in C9ORF72 dipolypeptides mediates promiscuous proteome binding that stalls ribosomes, disable actin cytoskeleton assembly and impairs arginine methylation of endogenous proteins

Mona Radwan, Ching-Seng Ang, Angelique Ormsby, Dezerae Cox, James Daly, Gavin Reid, Danny Hatters

Journal article  |  2019

ABSTRACT C9ORF72 -associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here ..

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Probing thiol-reactivity to monitor proteome foldedness and conformational change under proteostasis stress

Danny Hatters

Conference Proceedings  |  2019  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

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Widespread remodelling of proteome solubility in response to different protein homeostasis stresses

Xiaojing Sui, Douglas Pires, Shuai Nie, Giulia Vecchi, Michele Vendruscolo, David Ascher, Gavin Reid, Danny Hatters

Journal article  |  2019

ABSTRACT The accumulation of protein deposits in neurodegenerative diseases involves the presence of a metastable subproteome vuln..

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The Asian Biophysics Association-supporting biophysics in the greater Asia region.

Danny Hatters, Hiroyuki Noji

Journal article  |  2019  |  Biophysical Reviews

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Proteome Aggregation Patterns Under Proteostasis Stress as Signatures for Understanding Huntington's Disease

Danny M Hatters

Conference Proceedings  |  2019  |  Biophysical Journal

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Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

Estella A Newcombe, Kiersten M Ruff, Ashish Sethi, Angelique R Ormsby, Yasmin M Ramdzan, Archa Fox, Anthony W Purcell, Paul R Gooley, Rohit Pappu, Danny M Hatters

Journal article  |  2018  |  Journal of Molecular Biology

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A biosensor-based framework to measure latent proteostasis capacity

Rebecca J Wood, Angelique R Ormsby, Mona Radwan, Dezerae Cox, Abhishek Sharma, Tobias Voepel, Simon Ebbinghaus, Mikael Oliveberg, Gavin E Reid, Alex Dickson, Danny M Hatters

Journal article  |  2018  |  Nature Communications

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A thiol probe for measuring unfolded protein load and proteostasis in cells

Moore Z Chen, Nagaraj S Moily, Jessica L Bridgford, Rebecca J Wood, Mona Radwan, Trevor A Smith, Zhegang Song, Ben Zhong Tang, Leann Tilley, Xiaohong Xu, Gavin E Reid, Mahmoud A Pouladi, Yuning Hong, Danny M Hatters

Journal article  |  2017  |  Nature communications

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Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways

Nagaraj S Moily, Angelique R Ormsby, Aleksandar Stojilovic, Yasmin M Ramdzan, Jeannine Diesch, Ross D Hannan, Michelle S Zajac, Anthony J Hannan, Alicia Oshlack, Danny M Hatters

Journal article  |  2017  |  Molecular and Cellular Neuroscience

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Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells

Estella Newcombe, Kiersten Ruff, Ashish Sethi, Angelique Ormsby, Yasmin Ramdzan, Archa Fox, Anthony Purcell, Paul Gooley, Rohit Pappu, Danny Hatters

Journal article  |  2017

ABSTRACT Soluble huntingtin exon 1 (Httex1) with expanded polyglutamine (polyQ) engenders neurotoxicity in Huntington’s disease. T..

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Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells

Steffen Buening, Abhishek Sharma, Shivang Vachharajani, Estella Newcombe, Angelique Ormsby, Mimi Gao, David Gnutt, Tobias Voepel, Danny M Hatters, Simon Ebbinghaus

Journal article  |  2017  |  Physical Chemistry Chemical Physics

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Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

Yasmin M Ramdzan, Mikhail M Trubetskov, Angelique R Ormsby, Estella A Newcombe, Xiaojing Sui, Mark J Tobin, Marie N Bongiovanni, Sally L Gras, Grant Dewson, Jason ML Miller, Steven Finkbeiner, Nagaraj S Moily, Jonathan Niclis, Clare L Parish, Anthony W Purcell, Michael J Baker, Jacqueline A Wilce, Saboora Waris, Diana Stojanovski, Till Bocking, et al.

Journal article  |  2017  |  Cell reports

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Illuminating chaperone activity

Danny M Hatters

Journal article  |  2017  |  Nature Chemical Biology

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When Proteostasis Goes Bad: Protein Aggregation in the Cell

Mona Radwan, Rebecca J Wood, Xiaojing Sui, Danny M Hatters

Journal article  |  2017  |  IUBMB Life

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N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion

Moore Z Chen, Sue-Ann Mok, Angelique R Ormsby, Paul J Muchowski, Danny M Hatters

Journal article  |  2017  |  Journal of Huntington's Disease

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Walking the tightrope: proteostasis and neurodegenerative disease

Justin J Yerbury, Lezanne Ooi, Andrew Dillin, Darren N Saunders, Danny M Hatters, Philip M Beart, Neil R Cashman, Mark R Wilson, Heath Ecroyd

Journal article  |  2016  |  Journal of Neurochemistry

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Polyalanine expansions drive a shift into alpha-helical clusters without amyloid-fibril formation

Saskia Polling, Angelique R Ormsby, Rebecca J Wood, Kristie Lee, Cheryl Shoubridge, James N Hughes, Paul Q Thomas, Michael DW Griffin, Andrew F Hill, Quill Bowden, Till Boecking, Danny M Hatters

Journal article  |  2015  |  Nature Structural & Molecular Biology

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SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

Rafaa Zeineddine, Jay F Pundavela, Lisa Corcoran, Elise M Stewart, Dzung Do-Ha, Monique Bax, Gilles Guillemin, Kara L Vine, Danny M Hatters, Heath Ecroyd, Christopher M Dobson, Bradley J Turner, Lezanne Ooi, Mark R Wilson, Neil R Cashman, Justin J Yerbury

Journal article  |  2015  |  Molecular Neurodegeneration

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Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

Natalie E Farrawell, Isabella A Lambert-Smith, Sadaf T Warraich, Ian P Blair, Darren N Saunders, Danny M Hatters, Justin J Yerbury

Journal article  |  2015  |  Scientific Reports

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Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

Sven Hennig, Geraldine Kong, Taro Mannen, Agata Sadowska, Simon Kobelke, Amanda Blythe, Gavin J Knote, K Swaminathan Iyer, Diwei Ho, Estella A Newcombe, Kana Hosoki, Naoki Goshima, Tetsuya Kawaguchi, Danny Hatters, Laura Trinkle-Mulcahy, Tetsuro Hirose, Charles S Bond, Archa H Fox

Journal article  |  2015  |  Journal of Cell Biology

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The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9). (vol 288, pg 8313, 2013

Lin Chen, Jeffrey W Brown, Yee-Foong Mok, Danny M Hatters, C James McKnight

Journal article  |  2015  |  Journal of Biological Chemistry

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SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

Jodi A Lee, Justin J Yerbury, Natalie Farrawell, Robert F Shearer, Patrick Constantinescu, Danny M Hatters, Wayne A Schroder, Andreas Suhrbier, Mark R Wilson, Darren N Saunders, Marie Ranson

Journal article  |  2015  |  PLOS ONE

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Towards the quantification of the proteostasis capacity of a cell

Danny Hatters, Rebecca Wood, Tobias Voepel, Abhishek Sharma, Simon Ebbinghaus

Conference Proceedings  |  2015  |  FASEB JOURNAL

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Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations

WH Toh, FJ Houghton, CP Chia, YM Ramdzan, DM Hatters, PA Gleeson

Book Chapter  |  2015  |  Methods in Molecular Biology

© Springer Science+Business Media New York 2015. All rights are reserved.Pulse shape analysis (PulSA) is a flow cytometry-based me..

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Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations.

Wei Hong Toh, Fiona J Houghton, Pei Zhi Cheryl Chia, Yasmin M Ramdzan, Danny M Hatters, Paul A Gleeson

Journal article  |  2015  |  Methods in Molecular Biology

Pulse shape analysis (PulSA) is a flow cytometry-based method that involves the measurement of the pulse width and height of a flu..

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A Biosensor of Src Family Kinase Conformation by Exposable Tetracysteine Useful for Cell-Based Screening

Sevgi Irtegun, Rebecca Wood, Kurt Lackovic, Joerg Schweiggert, Yasmin M Ramdzan, David CS Huang, Terrence D Mulhern, Danny M Hatters

Journal article  |  2014  |  ACS Chemical Biology

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High-Throughput Quantitation of Intracellular Trafficking and Organelle Disruption by Flow Cytometry

Pei Zhi Cheryl Chia, Yasmin M Ramdzan, Fiona J Houghton, Danny M Hatters, Paul A Gleeson

Journal article  |  2014  |  Traffic

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Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

Saskia Polling, Yee-Foong Mok, Yasmin M Ramdzan, Bradley J Turner, Justin J Yerbury, Andrew F Hill, Danny M Hatters

Journal article  |  2014  |  Journal of Biological Chemistry

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A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70

Angelique R Ormsby, Yasmin M Ramdzan, Yee-Foong Mok, Kristijan D Jovanoski, Danny M Hatters

Journal article  |  2013  |  Journal of Biological Chemistry

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Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src

Sevgi Irtegun, Rebecca J Wood, Angelique R Ormsby, Terrence D Mulhern, Danny M Hatters

Journal article  |  2013  |  PLoS One

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Simultaneous Binding of the Anti-Cancer IgM Monoclonal Antibody PAT-SM6 to Low Density Lipoproteins and GRP78

Zachary Rosenes, Yee-Foong Mok, Shuo Yang, Michael DW Griffin, Terrence D Mulhern, Danny M Hatters, Frank Hensel, Geoffrey J Howlett

Journal article  |  2013  |  PLoS One

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The Allosteric Mechanism Induced by Protein Kinase A (PKA) Phosphorylation of Dematin (Band 4.9)

Lin Chen, Jeffrey W Brown, Yee-Foong Mok, Danny M Hatters, C James McKnight

Journal article  |  2013  |  Journal of Biological Chemistry

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Pulse shape analysis (PulSA) to track protein translocalization in cells by flow cytometry: applications for polyglutamine aggregation.

Yasmin M Ramdzan, Rebecca Wood, Danny M Hatters

Journal article  |  2013  |  Methods in Molecular Biology

Pulse shape analysis (PulSA) is a flow cytometry-based method that can be used to study protein localization patterns in cells. Ex..

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Preface

DM Hatters, AJ Hannan

Book  |  2013  |  Methods in Molecular Biology

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Size Analysis of Polyglutamine Protein Aggregates Using Fluorescence Detection in an Analytical Ultracentrifuge

Saskia Polling, Danny M Hatters, Yee-Foong Mok

Book Chapter  |  2013  |  Methods in Molecular Biology

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Preface

DM Hatters, AJ Hannan

Book Chapter  |  2013  |  Methods in Molecular Biology

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Size analysis of polyglutamine protein aggregates using fluorescence detection in an analytical ultracentrifuge.

Saskia Polling, Danny M Hatters, Yee-Foong Mok

Journal article  |  2013  |  Methods in Molecular Biology

Defining the aggregation process of proteins formed by poly-amino acid repeats in cells remains a challenging task due to a lack o..

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Pulse Shape Analysis (PulSA) to Track Protein Translocalization in Cells by Flow Cytometry: Applications for Polyglutamine Aggregation

Yasmin M Ramdzan, Rebecca Wood, Danny M Hatters

Book Chapter  |  2013  |  Methods in Molecular Biology

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Putting Huntingtin "Aggregation" in View with Windows into the Cellular Milieu

Danny M Hatters

Journal article  |  2012  |  Current Topics in Medicinal Chemistry

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The Anti-Cancer IgM Monoclonal Antibody PAT-SM6 Binds with High Avidity to the Unfolded Protein Response Regulator GRP78

Zachary Rosenes, Terrence D Mulhern, Danny M Hatters, Leodevico L Ilag, Barbara E Power, Chris Hosking, Frank Hensel, Geoffrey J Howlett, Yee-Foong Mok

Journal article  |  2012  |  PLoS One

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Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure

Clare Peters-Libeu, Jason Miller, Earl Rutenber, Yvonne Newhouse, Preethi Krishnan, Kenneth Cheung, Danny Hatters, Elizabeth Brooks, Kartika Widjaja, Tran Tina, Siddhartha Mitra, Montserrat Arrasate, Luis A Mosquera, Dean Taylor, Karl H Weisgraber, Steven Finkbeiner

Journal article  |  2012  |  Journal of Molecular Biology

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Tracking protein aggregation and mislocalization in cells with flow cytometry

Yasmin M Ramdzan, Saskia Polling, Cheryl PZ Chia, Ivan HW Ng, Angelique R Ormsby, Nathan P Croft, Anthony W Purcell, Marie A Bogoyevitch, Dominic CH Ng, Paul A Gleeson, Danny M Hatters

Journal article  |  2012  |  Nature Methods

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Identifying polyglutamine protein species in situ that best predict neurodegeneration (vol 7, pg 925, 2011)

Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peters Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra, Kartika Widjaja, Benjamin A Shaby, Gregor P Lotz, Yvonne Newhouse, Emily J Mitchell, Alex Osmand, Michelle Gray, Vanitha Thulasiramin, Frederic Saudou, Mark Segal, et al.

Journal article  |  2012  |  Nature Chemical Biology

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AMP-Activated Protein Kinase beta-Subunit Requires Internal Motion for Optimal Carbohydrate Binding

Michael Bieri, Jesse I Mobbs, Ann Koay, Gavin Louey, Yee-Foong Mok, Danny M Hatters, Jong-Tae Park, Kwan-Hwa Park, Dietbert Neumann, David Stapleton, Paul R Gooley

Journal article  |  2012  |  Biophysical Journal

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POLYGLUTAMINE AGGREGATION IN HUNTINGTON AND RELATED DISEASES

Saskia Polling, Andrew F Hill, Danny M Hatters

Journal article  |  2012  |  Advances in Experimental Medicine and Biology

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Cargo sorting and endosome-to-Golgi retrograde transport pathways.

PZ Chia, FJ Houghton, DM Hatters, PA Gleeson

Journal article  |  2012  |  MOLECULAR BIOLOGY OF THE CELL

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Polyglutamine Aggregation in Huntington and Related Diseases

Saskia Polling, Andrew F Hill, Danny M Hatters

Book Chapter  |  2012  |  Advances in Experimental Medicine and Biology

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Identifying polyglutamine protein species in situ that best predict neurodegeneration

Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peters Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra, Kartika Widjaja, Benjamin A Shaby, Gregor P Lotz, Yvonne Newhouse, Emily J Mitchell, Alex Osmand, Michelle Gray, Vanitha Thulasiramin, Frederic Saudou, Mark Segal, et al.

Journal article  |  2011  |  Nature Chemical Biology

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ReAsH/FlAsH Labeling and Image Analysis of Tetracysteine Sensor Proteins in Cells

Sevgi Irtegun, Yasmin M Ramdzan, Terrence D Mulhern, Danny M Hatters

Journal article  |  2011  |  Journal of Visualized Experiments

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Sedimentation velocity analysis of amyloid oligomers and fibrils using fluorescence detection

Yee-Foong Mok, Timothy M Ryan, Shuo Yang, Danny M Hatters, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2011  |  Methods

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Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

Maud Bernoux, Thomas Ve, Simon Williams, Christopher Warren, Danny Hatters, Eugene Valkov, Xiaoxiao Zhang, Jeffrey G Ellis, Bostjan Kobe, Peter N Dodds

Journal article  |  2011  |  Cell Host & Microbe

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Diagnostics for Amyloid Fibril Formation: Where to Begin?

Danny M Hatters, Michael DW Griffin

Journal article  |  2011  |  Methods in Molecular Biology

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Structural basis of disease resistance in flax against flax rust

Thomas Ve, Simon Williams, Eugene Valkov, Anna Stamp, Maud Bernoux, Danny Hatters, Jeffrey G Ellis, Peter N Dodds, Bostjan Kobe

Conference Proceedings  |  2011  |  Acta Crystallographica Section A Foundations of Crystallography

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Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool

Maya A Olshina, Lauren M Angley, Yasmin M Ramdzan, Jinwei Tang, Michael F Bailey, Andrew F Hill, Danny M Hatters

Journal article  |  2010  |  Journal of Biological Chemistry

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VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation

Sarada D Tetali, Madhu S Budamagunta, Catalina Simion, Laura J den Hartigh, Tamas Kalai, Kalman Hideg, Danny M Hatters, Karl H Weisgraber, John C Voss, John C Rutledge

Journal article  |  2010  |  Journal of Lipid Research

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Conformation Sensors that Distinguish Monomeric Proteins from Oligomers in Live Cells

Yasmin M Ramdzan, Rebecca M Nisbet, Jason Miller, Steven Finkbeiner, Andrew F Hill, Danny M Hatters

Journal article  |  2010  |  Chemistry & Biology

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Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence

Bradley M Coleman, Rebecca M Nisbet, Sen Han, Roberto Cappai, Danny M Hatters, Andrew F Hill

Journal article  |  2009  |  Biochemical and Biophysical Research Communications

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Insight on the Molecular Envelope of Lipid-Bound Apolipoprotein E from Electron Paramagnetic Resonance Spectroscopy

Danny M Hatters, John C Voss, Madhu S Budamagunta, Yvonne N Newhouse, Karl H Weisgraber

Journal article  |  2009  |  Journal of Molecular Biology

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Protein Misfolding Inside Cells: The Case of Huntingtin and Huntington's Disease

Danny A Hatters

Journal article  |  2008  |  IUBMB Life

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Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils

Danny M Hatters, Ning Zhong, Earl Rutenber, Karl H Weisgraber

Journal article  |  2006  |  Journal of Molecular Biology

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Apolipoprotein E structure: insights into function

Danny M Hatters, Clare A Peters-Libeu, Karl H Weisgraber

Journal article  |  2006  |  Trends in Biochemical Sciences

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Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine

CA Peters-Libeu, Y Newhouse, DM Hatters, KH Weisgraber

Journal article  |  2006  |  Journal of Biological Chemistry

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Modulation of apolipoprotein E structure by domain interaction - Differences in lipid-bound and lipid-free forms

DM Hatters, MS Budamagunta, JC Voss, KH Weisgraber

Journal article  |  2005  |  Journal of Biological Chemistry

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Engineering conformational destabilization into mouse apolipoprotein E - A model for a unique property of human apolipoprotein E4

DM Hatters, CA Peters-Libeu, KH Weisgraber

Journal article  |  2005  |  Journal of Biological Chemistry

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Designing a mouse model of apolipoprotein E4: Introduction of a molten globule state

DM Hatters, C Peters-Libeu, KH Weisgraber

Conference Proceedings  |  2004  |  PROTEIN SCIENCE

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Fibrillar amyloid proteins present in human atheroma activate CD36-signal transduction

LA Medeiros, JB El Khoury, CL Pham, DM Hatters, GJ Howlett, KD O'Brien, KJ Moore

Conference Proceedings  |  2004  |  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

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Fibrillar amyloid protein present in atheroma activates CD36 signal transduction

LA Medeiros, T Khan, JB El Khoury, CLL Pham, DM Hatters, GJ Howlett, R Lopez, KD O'Brien, KJ Moore

Journal article  |  2004  |  Journal of Biological Chemistry

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Phospholipid complexation and association with apolipoprotein C-II: Insights from mass spectrometry

CL Hanson, LL Ilag, J Malo, DM Hatters, GJ Howlett, CV Robinson

Journal article  |  2003  |  Biophysical Journal

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The circularization of amyloid fibrils formed by apolipoprotein C-II

DM Hatters, CA MacRaild, R Daniels, WS Gosal, NH Thomson, JA Jones, JJ Davis, CE MacPhee, CM Dobson, GJ Howlett

Journal article  |  2003  |  Biophysical Journal

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Sedimentation velocity analysis of flexible macromolecules: Self-association and tangling of amyloid fibrils

CA MacRaild, DM Hatters, LJ Lawrence, GJ Howlett

Journal article  |  2003  |  Biophysical Journal

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Apolipoprotein E4 forms a molten globule - A potential basis for its association with disease

JA Morrow, DM Hatters, B Lu, P Hochtl, KA Oberg, B Rupp, KH Weisgraber

Journal article  |  2002  |  Journal of Biological Chemistry

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Cross-linking and amyloid formation by N- and C-terminal cysteine derivatives of human apolipoprotein C-II

CLL Pham, DM Hatters, LJ Lawrence, GJ Howlett

Journal article  |  2002  |  Biochemistry

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Determination of lipid binding specificity and topology by mass spectrometry: The case of apolipoprotein C-II

CL Hanson, J Malo, LL Ilag, DM Hatters, CV Robinson

Conference Proceedings  |  2002  |  Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics

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Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin

DM Hatters, MR Wilson, SB Easterbrook-Smith, GJ Howlett

Journal article  |  2002  |  European Journal of Biochemistry

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Macromolecular crowding accelerates amyloid formation by human apolipoprotein C-II

DM Hatters, AP Minton, GJ Howlett

Journal article  |  2002  |  Journal of Biological Chemistry

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The structural basis for amyloid formation by plasma apolipoproteins: a review

DM Hatters, GJ Howlett

Journal article  |  2002  |  European Biophysics Journal with Biophysics Letters

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The molecular chaperone, alpha-crystallin, inhibits amyloid formation by apolipoprotein C-II

DM Hatters, RA Lindner, JA Carver, GJ Howlett

Journal article  |  2001  |  Journal of Biological Chemistry

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Sedimentation analysis of novel DNA structures formed by homo-oligonucleotides

DM Hatters, L Wilson, BW Atcliffe, TD Mulhern, N Guzzo-Pernell, GJ Howlett

Journal article  |  2001  |  Biophysical Journal

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NMR structure of human apolipoprotein C-II in the presence of sodium dodecyl sulfate

CA MacRaild, DM Hatters, GJ Howlett, PR Gooley

Journal article  |  2001  |  Biochemistry

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Sub-micellar phospholipid accelerates amyloid formation by apolipoprotein C-II

DM Hatters, LJ Lawrence, GJ Howlett

Journal article  |  2001  |  FEBS Letters

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Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops

DM Hatters, CE MacPhee, LJ Lawrence, WH Sawyer, GJ Howlett

Journal article  |  2000  |  Biochemistry

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Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

CE MacPhee, DM Hatters, WH Sawyer, GJ Howlett

Journal article  |  2000  |  Biochemistry

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Crystal structure of the TIR domain from the flax disease resistance protein L6

T Ve, M Bernoux, S Williams, E Valkov, C Warren, D Hatters, JG Ellis, PN Dodds, B Kobe

Journal article

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Measuring proteostasis capacity using transiently transfected bait proteins by flow cytometry

Danny Hatters, Rebecca Wood, Candice Raeburn, Angelique Ormsby, Mikael Oliveberg, Alex Dickson, Danny Hatters

Journal article  |  Protocol Exchange

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Scholarly Works

Keyword Analysis

Biochemistry and Cell Biology
Expanding Knowledge
Non-Oriented Research
Other Health
Medical Biochemistry and Metabolomics
Clinical Health (organs, Diseases and Abnormal Conditions)
Macromolecular Chemistry
Neurosciences
Other Medical and Health Sciences
Immunology

Honours, Awards and Fellowships

2015

McAulay-Hope Prize for Original Biophysics

Australian Society for Biophysics
2009

Applied Biosystems Edman Award

ASBMB
2006

Boomerang Award

ASBMB

3

Awards

Credentials

Positions

Professor

Biochemistry And Molecular Biology

Secretary Of Meeting

Lorne Conference on Protein Structure and Function

Education

PhD

University of Melbourne

Bachelor of science (Hons)

University of Melbourne

Links