Danny Hatters runs a program exploring how proteins change conformation in cells as part of normal and pathogenic processes, including those associated with misfolding and aggregation. Key elements of this research include the development and application of new fluorescence -based probes and biosensors to view protein dynamics in cells.
His major area of research is in Huntington's Disease with other programs in motor neuron disease and fundamental biology of protein-ligand associations as part of cellular mechanisms. He completed his PhD at the University of Melbourne in 2002. He then did a post doc at the Gladstone Institutes/University of California, San Francisco under the mentorship of Dr Karl Weisgraber for 5 years until 2007. There he studied how three variants of apolipoprotein E, apoE2, apoE3 and apoE4 differ in their conformation and biophysical properties as a basis for understanding the mechanisms underlying the elevated risk that the apoE4 isoform confers for Alzheimer's disease. In April 2007, he returned to Melbourne to take up a CR Roper Fellowship position in the Department of Biochemistry and Molecular Biology. In 2009 he was awarded the Grimwade Fellowship to continue developing his own research program focusing on how protein conformations lead to cellular dysfunction and disease. In 2012, he was awarded an ARC Future Fellowship. In 2019 he was awarded an NHMRC Senior Research Fellowship.
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Danny Hatters' highlights
FEATURED Journal article
Polyalanine expansions drive a shift into alpha-helical clusters without amyloid-fibril formation
Read moreDanny Hatters' selected work
Projects
Displaying the 22 most recent projects by Danny Hatters.
Project Types
17
Research Grant
4
Internal Research Grant
1
Research Contracts
Scholarly Works
Displaying the 81 most recent scholarly works by Danny Hatters.
Honours, Awards and Fellowships
McAulay-Hope Prize for Original Biophysics
Applied Biosystems Edman Award
Boomerang Award
Credentials
Positions
Professor
Biochemistry And Molecular Biology
Secretary Of Meeting
Lorne Conference on Protein Structure and Function
Education
PhD
University of Melbourne
Bachelor of science (Hons)
University of Melbourne