profile icon
Prof

Danny Hatters

Professor
Biochemistry and Pharmacology
Protein aggregation
fluorescence
polyglutamine
Huntington's Disease
Motor Neuron Disease
science & technology
life sciences & biomedicine
humans
biochemistry & molecular biology
Danny Hatters's Profile Picture
Prof

Danny Hatters

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Protein conformations in cells. New techniques. Protein misfolding and aggregation.
Danny Hatters's Profile Picture
Prof

Danny Hatters

 
Print
Danny's  Short Profile
 

Projects

Displaying the 10 most recent projects from 22 for Danny Hatters.

Project icon

THE CASCADE OF CONSEQUENCES IN HUNTINGTON DISEASE FROM MUTANT HTTEX1 SYNTHESIS AND AGGREGATION

2020 - 2022
Active
Project icon

THE METASTABILITY OF PROTEOME FOLDEDNESS IN NEURODEGENERATIVE DISEASE

The research objective of this award is to develop a quantitative and mechanistic understanding of how the genomic material of viruses enter..

2019 - 2022
Active
Project icon

THE METASTABILITY OF PROTEOME FOLDEDNESS IN NEURODEGENERATIVE DISEASE

The research objective of this award is to develop a quantitative and mechanistic understanding of how the genomic material of viruses enter..

2019 - 2022
Active
Project icon

Defining the capacity of cells to keep the proteome folded over space and time

2017 - 2021
Active
Project icon

Surveillance of the mechanisms controlling proteome foldedness

This project aims to measure how cells keep the proteome folded. Cells have extensive quality control networks to govern synthesis, folding ..

2017 - 2020
Completed
Project icon

DISSECTING POLYQ-ATAXIN-1 TRAFFICKING AND NUCLEAR BODY DYNAMICS AS DRIVERS OF TOXICITY

Ataxias are a large group of neurodegenerative disorders in which balance, motor skills and memory are progressively lost. While mutations i..

2017 - 2019
Completed
Project icon

PATHOGENIC AND ADAPTIVE MOLECULAR INTERACTIONS WITH MUTANT HUNTINGTIN EXON 1

This project aims to determine how the gene mutation that causes Huntington’s disease (HD) damages cells in the brain. The diseased gene cre..

2016 - 2019
Completed
Project icon

B_YOND

2017 - 2018
Completed
Project icon

SPATIAL ORGANIZATION OF LCK AS A REGULATORY MECHANISM OF TCR SIGNALLING

To function in an immune response, T cell become activated when the interactions between the T cell receptor and the kinase Lck on the cell ..

2014 - 2016
Completed
Project icon

Role of Hsp40 and Hsp70 in huntingtin misfolding, oligomerization and inclusion assembly

Huntington disease results from a mutation that causes the Htt protein to become abnormally sticky and form toxic clusters in neurons. Cells..

2013 - 2016
Completed

22

Projects

Project Types

17

Research Grant

4

Internal Research Grant

1

Research Contracts

Scholarly Works

Displaying the 10 most recent scholarly works from 96 for Danny Hatters.

Scholarly works icon

The 2021 FASEB Virtual Science Research Conference on Protein Aggregation: Function, Dysfunction, and Disease, June 23-25, 2021.

Danny M Hatters, Randal Halfmann, Jean Baum

Journal article  |  2021  |  FASEB J

Scholarly works icon

A biosensor to gauge protein homeostasis resilience differences in the nucleus compared to cytosol of mammalian cells

Candice Raeburn, Angelique Ormsby, Nagaraj Moily, Dezerae Cox, Simon Ebbinghaus, Alex Dickson, Gawain McColl, Danny Hatters

Journal article  |  2021

An extensive network of chaperones and other proteins maintain protein homeostasis and guard against inappropriate protein aggrega..

Scholarly works icon

Hidden information on protein function in censuses of proteome foldedness

Dezerae Cox, Ching-Seng Ang, Nadinath Nillegoda, Gavin Reid, Danny Hatters

Journal article  |  2021

Methods: that assay protein foldedness with proteomics have generated censuses of protein folding stabilities in biological milie..

Scholarly works icon

Immiscible inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

Mona Radwan, Jordan D Lilley, Ching-Seng Ang, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  PLOS ONE

Poly(glycine-alanine) (polyGA) is one of the polydipeptides expressed in Frontotemporal Dementia and/or Amyotrophic Lateral Sclero..

Scholarly works icon

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters

Journal article  |  2020  |  PLOS ONE

Mutations that cause Huntington's Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntin..

Scholarly works icon

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control

Angelique Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny Hatters

Journal article  |  2020

Mutations that cause Huntington’s Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntin..

Scholarly works icon

Inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

Mona Radwan, Jordan Lilley, Ching-Seng Ang, Gavin Reid, Danny Hatters

Journal article  |  2020

ABSTRACT Poly(glycine-alanine) (polyGA) is one of the dipolypeptides expressed in Motor Neuron Disease caused by C9ORF72 mutations..

Scholarly works icon

Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity

Mona Radwan, Ching-Seng Ang, Angelique R Ormsby, Dezerae Cox, James C Daly, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  MOLECULAR & CELLULAR PROTEOMICS

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used qu..

Scholarly works icon

Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity.

Mona Radwan, Ching-Seng Ang, Angelique R Ormsby, Dezerae Cox, James C Daly, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  Mol Cell Proteomics

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used qu..

Scholarly works icon

Protein aggregation in cell biology: An aggregomics perspective of health and disease

Dezerae Cox, Candice Raeburn, Xiaojing Sui, Danny M Hatters

Journal article  |  2020  |  SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Maintaining protein homeostasis (proteostasis) is essential for cellular health and is governed by a network of quality control ma..

96

Scholarly Works

Keyword Analysis

Biochemistry and Cell Biology
Expanding Knowledge
Other Health
Clinical Health
Medical Biochemistry and Metabolomics
Medicinal and Biomolecular Chemistry
Neurosciences
Health Services and Systems
Immunology
Other Biological Sciences

Honours, Awards and Fellowships

2015

McAulay-Hope Prize for Original Biophysics

Australian Society for Biophysics
2009

Applied Biosystems Edman Award

ASBMB
2006

Boomerang Award

ASBMB

3

Awards

Credentials

Positions

Professor

Biochemistry and Pharmacology

Secretary Of Meeting

Lorne Conference on Protein Structure and Function

Education

PhD

University of Melbourne

Bachelor of science (Hons)

University of Melbourne

Links