Danny Hatters

Immiscible inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

Mona Radwan, Jordan D Lilley, Ching-Seng Ang, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  PLoS One

Poly(glycine-alanine) (polyGA) is one of the polydipeptides expressed in Frontotemporal Dementia and/or Amyotrophic Lateral Sclero..

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters

Journal article  |  2020  |  PLoS One

Mutations that cause Huntington's Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntin..

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control

Angelique Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny Hatters

Journal article  |  2020

Abstract Mutations that cause Huntington’s Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 ..

Inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

Mona Radwan, Jordan Lilley, Ching-Seng Ang, Gavin Reid, Danny Hatters

Journal article  |  2020

ABSTRACT Poly(glycine-alanine) (polyGA) is one of the dipolypeptides expressed in Motor Neuron Disease caused by C9ORF72 mutations..

Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity

Mona Radwan, Ching-Seng Ang, Angelique R Ormsby, Dezerae Cox, James C Daly, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  Molecular and Cellular Proteomics

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used qu..

Protein aggregation in cell biology: An aggregomics perspective of health and disease

Dezerae Cox, Candice Raeburn, Xiaojing Sui, Danny M Hatters

Journal article  |  2020  |  Seminars in Cell & Developmental Biology

Maintaining protein homeostasis (proteostasis) is essential for cellular health and is governed by a network of quality control ma..

Widespread remodeling of proteome solubility in response to different protein homeostasis stresses

Xiaojing Sui, Douglas EV Pires, Angelique R Ormsby, Dezerae Cox, Shuai Nie, Giulia Vecchi, Michele Vendruscolo, David B Ascher, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

The accumulation of protein deposits in neurodegenerative diseases has been hypothesized to depend on a metastable subproteome vul..

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

Lorena Hidalgo San Jose, Mary Jean Sunshine, Christopher H Dillingham, Bernadette A Chua, Miriama Kruta, Yuning Hong, Danny M Hatters, Robert AJ Signer

Journal article  |  2020  |  Cell Reports

Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in prote..

Arginine valency in C9ORF72 dipolypeptides mediates promiscuous proteome binding that stalls ribosomes, disable actin cytoskeleton assembly and impairs arginine methylation of endogenous proteins

Mona Radwan, Ching-Seng Ang, Angelique Ormsby, Dezerae Cox, James Daly, Gavin Reid, Danny Hatters

Journal article  |  2019

ABSTRACT C9ORF72 -associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here ..

Probing thiol-reactivity to monitor proteome foldedness and conformational change under proteostasis stress

Danny Hatters

Conference Proceedings  |  2019  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY