Allan Motyer

Using single cell DNA-seq to decipher disease mechanisms for MS

JP Rubio, A Motyer, S Jackson, DA Markalanda, I Harliwong, C Ye, A Shiu, T Tian, JL Fink, A Harding, M Barnett, SJ Leslie

Conference Proceedings  |  2020  |  MULTIPLE SCLEROSIS JOURNAL

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard MR Coulson, William Astle, Chiara Baldini, Francesco Bonatti, Maria C Cid, Heather Elding, Giacomo Emmi, Joerg Epplen, Loic Guillevin, David RW Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A Little, Davide Martorana, et al.

Journal article  |  2019  |  Nature Communications

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-ne..

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolas A Patsopoulos, Sergio E Baranzini, Adams Santaniello, Parisa Shoostari, Chris Cotsapas, Garrett Wong, Ashley H Beecham, Tojo James, Joseph Replogle, Ioannis S Vlachos, Cristin McCabe, Tune H Pers, Aaron Brandes, Charles White, Brendan Keenan, Maria Cimpean, Phoebe Winn, Ioannis-Pavlos Panteliadis, Allison Robbins, Till FM Andlauer, et al.

Journal article  |  2019  |  Science

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O'Connell, Adrian Cortes, Samantha Welsh, Alan Young, Mark Effingham, Gil McVean, Stephen Leslie, Naomi Allen, Peter Donnelly, Jonathan Marchini

Journal article  |  2018  |  Nature

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest

DJ Pappas, A Lizee, V Paunic, KR Beutner, A Motyer, D Vukcevic, S Leslie, J Biesiada, J Meller, KD Taylor, X Zheng, LP Zhao, P-A Gourraud, JA Hollenbach, SJ Mack, M Maiers

Journal article  |  2018  |  PHARMACOGENOMICS JOURNAL

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest.

DJ Pappas, A Lizee, V Paunic, KR Beutner, A Motyer, D Vukcevic, S Leslie, J Biesiada, J Meller, KD Taylor, X Zheng, LP Zhao, P-A Gourraud, JA Hollenbach, SJ Mack, M Maiers

Journal article  |  2018  |  The Pharmacogenomics Journal

Four single nucleotide polymorphism (SNP)-based human leukocyte antigen (HLA) imputation methods (e-HLA, HIBAG, HLA*IMP:02 and MAG..

Large-scale imputation of killer cell immunoglobulin-like receptor copy number in psoriatic arthritis

R Ahn, D Vukcevic, A Motyer, D Ellinghaus, LC Tsoi, RP Nair, C Palmer, J Oksenberg, J Foerster, JT Elder, A Franke, S Leslie, W Liao

Conference Proceedings  |  2017  |  BRITISH JOURNAL OF DERMATOLOGY

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank

Adrian Cortes, Calliope A Dendrou, Allan Motyer, Luke Jostins, Damjan Vukcevic, Alexander Dilthey, Peter Donnelly, Stephen Leslie, Lars Fugger, Gil McVean

Journal article  |  2017  |  Nature Genetics

Genome-wide genetic data on ~500,000 UK Biobank participants

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O’Connell, Adrian Cortes, Samantha Welsh, Gil McVean, Stephen Leslie, Peter Donnelly, Jonathan Marchini

Journal article  |  2017  |  bioRxiv

The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across the United Kingdom, aged between 40..

Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1

DJ Martino, S Ashley, J Koplin, J Ellis, R Saffery, SC Dharmage, L Gurrin, MC Matheson, B Kalb, I Marenholz, K Beyer, Y-A Lee, X Hong, X Wang, D Vukcevic, A Motyer, S Leslie, KJ Allen, MAR Ferreira

Journal article  |  2017  |  CLINICAL AND EXPERIMENTAL ALLERGY