Kate Jarman

Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents

William Nguyen, Jonathan Jacobson, Kate E Jarman, Timothy R Blackmore, Helene Jousset Sabroux, Sharon R Lewin, Damian F Purcell, Brad E Sleebs

Journal article  |  2020  |  European Journal of Medicinal Chemistry

A persistent latent reservoir of virus in CD4+ T cells is a major barrier to cure HIV. Activating viral transcription in latently ..

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

Daniel L Priebbenow, David J Leaver, Nguyen Nghi, Benjamin Cleary, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, David M Shackleford, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, et al.

Journal article  |  2020  |  Journal of Medicinal Chemistry

A high-throughput screen designed to discover new inhibitors of histone acetyltransferase KAT6A uncovered CTX-0124143 (1), a uniqu..

Structural basis of substrate recognition and catalysis by fucosyltransferase 8.

Michael A Järvå, Marija Dramicanin, James P Lingford, Runyu Mao, Alan John, Kate E Jarman, Rhys Grinter, Ethan D Goddard-Borger

Journal article  |  2020  |  Journal of Biological Chemistry

Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex..

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Paola Favuzza, Manuel de Lera Ruiz, Jennifer K Thompson, Tony Triglia, Anna Ngo, Ryan WJ Steel, Marissa Vavrek, Janni Christensen, Julie Healer, Christopher Boyce, Zhuyan Guo, Mengwei Hu, Tanweer Khan, Nicholas Murgolo, Lianyun Zhao, Jocelyn Sietsma Penington, Kitsanapong Reaksudsan, Kate Jarman, Melanie H Dietrich, Lachlan Richardson, et al.

Journal article  |  2020  |  Cell Host & Microbe

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmo..

A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells

Henry Beetham, Augustine Chen, Bryony J Telford, Andrew Single, Kate E Jarman, Kurt Lackovic, Andreas Luxenburger, Parry Guilford

Journal article  |  2019  |  Scientific Reports

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

David J Leaver, Benjamin Cleary, Nguyen Nghi, Daniel L Priebbenow, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, Michael A Walters, et al.

Journal article  |  2019  |  Journal of Medicinal Chemistry

A high-throughput screen for inhibitors of the histone acetyltransferase, KAT6A, led to identification of an aryl sulfonohydrazide..

Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

William Nguyen, Jonathan Jacobson, Kate E Jarman, Helene Jousset Sabroux, Leigh Harty, James McMahon, Sharon R Lewin, Damian F Purcell, Brad E Sleebs

Journal article  |  2019  |  Journal of Medicinal Chemistry

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E Au, Rachael M Lane, Katya J Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E Jarman, Sarah Ellis, Donald Metcalf, Shaun P Jackson, Simone M Schoenwaelder, Benjamin T Kile, Emma C Josefsson

Journal article  |  2018  |  Blood

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P-2 position of PEXEL peptidomimetics

William Nguyen, Anthony N Hodder, Richard Bestel de Lezongard, Peter E Czabotar, Kate E Jarman, Matthew T O'Neill, Jennifer K Thompson, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2018  |  European Journal of Medicinal Chemistry

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Phillip P Sharp, Jean-Marc Garnier, Tamas Hatfaludi, Zhen Xu, David Segal, Kate E Jarman, Helene Jousset, Alexandra Garnham, John T Feutrill, Anthony Cuzzupe, Peter Hall, Scott Taylor, Carl R Walkley, Dean Tyler, Mark A Dawson, Peter Czabotar, Andrew F Wilks, Stefan Glaser, David CS Huang, Christopher J Burns

Journal article  |  2017  |  ACS Medicinal Chemistry Letters

CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1.

Wenying Zhu, Kate E Jarman, Noor A Lokman, Heidi A Neubauer, Lorena T Davies, Briony L Gliddon, Houng Taing, Paul AB Moretti, Martin K Oehler, Melissa R Pitman, Stuart M Pitson

Journal article  |  2017  |  Cancer Research

Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between proapoptotic and prosurvival sphingolipids. Oncogeni..

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1.

W Zhu, BL Gliddon, KE Jarman, PAB Moretti, T Tin, LV Parise, JM Woodcock, JA Powell, A Ruszkiewicz, MR Pitman, SM Pitson

Journal article  |  2017  |  Oncogene

CIB1 (calcium and integrin binding protein 1) is a small intracellular protein with numerous interacting partners, and hence has b..

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition

George Au-Yeung, Franziska Lang, Walid J Azar, Chris Mitchell, Kate E Jarman, Kurt Lackovic, Diar Aziz, Carleen Cullinane, Richard B Pearson, Linda Mileshkin, Danny Rischin, Alison M Karst, Ronny Drapkin, Dariush Etemadmoghadam, David DL Bowtell

Journal article  |  2017  |  Clinical Cancer Research

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

Paul R Gilson, Cyrus Tan, Kate E Jarman, Kym N Lowes, Joan M Curtis, William Nguyen, Adrian E Di Rago, Hayley E Bullen, Boris Prinz, Sandra Duffy, Jonathan B Baell, Craig A Hutton, Helene Jousset Subroux, Brendan S Crabb, Vicky M Avery, Alan F Cowman, Brad E Sleebs

Journal article  |  2017  |  Journal of Medicinal Chemistry

Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Michelle Gazdik, Kate E Jarman, Matthew T O'Neill, Anthony N Hodder, Kym N Lowes, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2016  |  Bioorganic & Medicinal Chemistry

Sphingosine Kinases: Biochemistry, Regulation, and Roles

MR Pitman, KE Jarman, TM Leclercq, DH Pham, SM Pitson

Book Chapter  |  2013

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Michael J White, Simone M Schoenwaelder, Emma C Josefsson, Kate E Jarman, Katya J Henley, Chloe James, Marlyse A Debrincat, Shaun P Jackson, David CS Huang, Benjamin T Kile

Journal article  |  2012  |  Blood

Bcl-x(L)-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Simone M Schoenwaelder, Kate E Jarman, Elizabeth E Gardiner, My Hua, Jianlin Qiao, Michael J White, Emma C Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K Andrews, Kylie D Mason, Hatem H Salem, David CS Huang, Benjamin T Kile, Andrew W Roberts, Shaun P Jackson

Journal article  |  2011  |  Blood

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

Simone M Schoenwaelder, Akiko Ono, Warwick S Nesbitt, Joanna Lim, Kate Jarman, Shaun P Jackson

Journal article  |  2010  |  Journal of Biological Chemistry

Phosphoinositide (PI) 3-kinase (PI3K) signaling processes play an important role in regulating the adhesive function of integrin a..

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1.

Kate E Jarman, Paul AB Moretti, Julia R Zebol, Stuart M Pitson

Journal article  |  2010  |  Journal of Biological Chemistry

SK1 (sphingosine kinase 1) plays an important role in many aspects of cellular regulation. Most notably, elevated cellular SK1 act..