Mark Dawson

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Michael Y He, Michael M Halford, Ruofei Liu, James P Roy, Zoe L Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A Dawson, Marc G Achen, Steven A Stacker

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant an..

Abstract 1130: First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER breast cancer with KAT6A dysregulation

Shikhar Sharma, Jay Chung, Sean Uryu, Amanda Rickard, Natalie Nady, Showkhin Khan, Zhenxiong Wang, Yong Zhang, Haikuo Zhang, Pei-Pei Kung, Eric Greenwald, Karen Maegley, Patrick Bingham, Hieu Lam, Ylva E Bozikis, Hendrik Falk, Elizabeth Allan, Vicky M Avery, Miriam S Butler, Michelle A Camerino, et al.

Conference Proceedings  |  2021  |  Experimental and Molecular Therapeutics

Epigenetic mechanisms of malignant clonal dominance and immune evasion.

Mark A Dawson

Conference Proceedings  |  2021  |  CANCER RESEARCH

First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER plus breast cancer with KAT6A dysregulation.

Shikhar Sharma, Jay Chung, Sean Uryu, Amanda Rickard, Natalie Nady, Showkhin Khan, Zhenxiong Wang, Yong Zhang, Haikuo Zhang, Pei-Pei Kung, Eric Greenwald, Karen Maegley, Patrick Bingham, Hieu Lam, Ylva E Bozikis, Hendrik Falk, Elizabeth Allan, Vicky M Avery, Miriam S Butler, Michelle A Camerino, et al.

Conference Proceedings  |  2021  |  CANCER RESEARCH

Detection of cell-free microbial DNA using a contaminant-controlled analysis framework

Enrique Zozaya-Valdes, Stephen Q Wong, Jeanette Raleigh, Athena Hatzimihalis, Sarah Ftouni, Anthony T Papenfuss, Shahneen Sandhu, Mark A Dawson, Sarah-Jane Dawson

Journal article  |  2021  |  GENOME BIOLOGY

BACKGROUND: The human microbiome plays an important role in cancer. Accumulating evidence indicates that commensal microbiome-deri..

HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults

Nila J Dharan, Paul Yeh, Mark Bloch, Miriam M Yeung, David Baker, Jerick Guinto, Norman Roth, Sarah Ftouni, Katherine Ognenovska, Don Smith, Jennifer F Hoy, Ian Woolley, Catherine Pell, David J Templeton, Neil Fraser, Nectarios Rose, Jolie Hutchinson, Kathy Petoumenos, Sarah-Jane Dawson, Mark N Polizzotto, et al.

Journal article  |  2021  |  NATURE MEDICINE

People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and..

BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation

Zlata Vershinin, Michal Feldman, Thilo Werner, Lital Estrella Wei, Margarita Kublanovsky, Elina Abaev-Schneiderman, Menachem Sklarz, Enid YN Lam, Khawla Alasad, Sarah Picaud, Barak Rotblat, Ruth A McAdam, Vered Chalifa-Caspi, Marcus Bantscheff, Trevor Chapman, Huw D Lewis, Panagis Filippakopoulos, Mark A Dawson, Paola Grandi, Rab K Prinjha, et al.

Journal article  |  2021  |  SCIENCE ADVANCES

The transcriptional coactivator BRD4 has a fundamental role in transcription regulation and thus became a promising epigenetic the..

MSL pushes genomic instability over the edge

Ali Motazedian, Mark A Dawson

Journal article  |  2021  |  NATURE CELL BIOLOGY

Mutation alters injury response to drive cancer

Dane Vassiliadis, Mark A Dawson

Journal article  |  2021  |  NATURE

CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity

April C Watt, Paloma Cejas, Molly J DeCristo, Otto Metzger-Filho, Enid YN Lam, Xintao Qiu, Haley BrinJones, Nikolas Kesten, Rhiannon Coulson, Alba Font-Tello, Klothilda Lim, Raga Vadhi, Veerle W Daniels, Joan Montero, Len Taing, Clifford A Meyer, Omer Gilan, Charles C Bell, Keegan D Korthauer, Claudia Giambartolomei, et al.

Journal article  |  2021  |  NATURE CANCER

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to induce cancer cell cycle arrest. Recent stu..