Mark Dawson

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

Christina E Sparbier, Andrea Gillespie, Juliana Gomez, Nishi Kumari, Ali Motazedian, Kah Lok Chan, Charles C Bell, Omer Gilan, Yih-Chih Chan, Sarah Popp, Daniel J Gough, Melanie A Eckersley-Maslin, Sarah-Jane Dawson, Paul J Lehner, Kate D Sutherland, Patricia Ernst, Gerard M McGeehan, Enid YN Lam, Marian L Burr, Mark A Dawson

Journal article  |  2023  |  NATURE CELL BIOLOGY

Precise control of activating H3K4me3 and repressive H3K27me3 histone modifications at bivalent promoters is essential for normal ..

In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis.

C Biben, TS Weber, KS Potts, J Choi, DC Miles, A Carmagnac, T Sargeant, CA de Graaf, KA Fennell, A Farley, OJ Stonehouse, MA Dawson, DJ Hilton, SH Naik, S Taoudi

Journal article  |  2023  |  Nat Commun

During embryogenesis, haematopoietic and endothelial lineages emerge closely in time and space. It is thought that the first blood..

A phase I/II open-label study of molibresib for the treatment of relapsed/refractory hematologic malignancies.

Mark A Dawson, Gautam Borthakur, Brian Huntly, Anastasios Karadimitris, Adrian Alegre, Aristeidis Chaidos, Dan T Vogl, Daniel A Pollyea, Faith E Davies, Gareth J Morgan, Jacob Glass, Manali Kamdar, Maria-Victoria Mateos Manteca, Natalia Tovar, Paul Yeh, Regina García Delgado, Faisal Basheer, Ludovica Marando, Paolo Gallipoli, Anastasia Wyce, et al.

Journal article  |  2022  |  Clin Cancer Res

PURPOSE: Molibresib is a selective, small molecule inhibitor of the BET protein family. This was an open-label, two-part, Phase I/..

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

Kah Lok Chan, Juliana Gomez, Chelisa Cardinez, Nishi Kumari, Christina E Sparbier, Enid YN Lam, Miriam M Yeung, Sylvain Garciaz, James A Kuzich, Doen Ming Ong, Fiona C Brown, Yih-Chih Chan, Dane Vassiliadis, Elanor N Wainwright, Ali Motazedian, Andrea Gillespie, Katie A Fennell, Junyun Lai, Imran G House, Laura Macpherson, et al.

Journal article  |  2022  |  CANCER CELL

There is increasing recognition of the prognostic significance of tumor cell major histocompatibility complex (MHC) class II expre..

Cross presentation: more exotic pathwaysEpigenetic repression of MHC class I antigen presentation enables immune evasion in cancer

Marian Burr, Christina Sparbier, Kah Lok Chan, Paul Lehner, Kate Sutherland, Mark Dawson

Journal article  |  2022  |  Molecular Immunology

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death

Sylvain Garciaz, Andrew A Guirguis, Sebastian Muller, Fiona C Brown, Yih-Chih Chan, Ali Motazediani, Caitlin L Rowe, James A Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid YN Lam, Tatiana Caneque, Marian L Burr, Veronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Cancer cell metabolism is increasingly recognized as providing an exciting therapeutic opportunity. However, a drug th..

3123 – DELINEATING THE HIERARCHICAL ORGANIZATION AND LINEAGE HETEROGENEITY OF THE MOUSE HSC AND MPP NETWORK

Dawn Lin, Pia Sommerkamp, Andreas Narr, Katie Fennell, Dane Vassiliadis, Shalin naik, Mark Dawson, Andreas Trumpp

Journal article  |  2022  |  Experimental Hematology

3122 – SUMOYLATION OF DNMT1 REGULATES RESPONSE TO CATALYTIC INHIBITION OF DNMT1 IN ACUTE MYELOID LEUKAEMIA

Brian Liddicoat, Wendy Jia, Naiara Garcia-Bediaga, Andrew Das, Laura Scolamiero, Andrea Gillespie, Christa Maarel, Andrew Guirguis, Enid Lam, Cassie Litchfield, Laure Talarmain, Tao Wang, Francesca Zappacosta, Roland Annan, Rabinder Prinjha, Sarah-Jane Dawson, Michael McCabe, Melissa Pappalardi, Ching-Seng Ang, Mark Dawson

Journal article  |  2022  |  Experimental Hematology

Non-genetic determinants of malignant clonal fitness at single-cell resolution

Katie A Fennell, Dane Vassiliadis, Enid YN Lam, Luciano G Martelotto, Jesse J Balic, Sebastian Hollizeck, Tom S Weber, Timothy Semple, Qing Wang, Denise C Miles, Laura MacPherson, Yih-Chih Chan, Andrew A Guirguis, Lev M Kats, Emily S Wong, Sarah-Jane Dawson, Shalin H Naik, Mark A Dawson

Journal article  |  2021  |  NATURE

All cancers emerge after a period of clonal selection and subsequent clonal expansion. Although the evolutionary principles impart..

Pharmacological Reduction of Mitochondrial Iron in AML Triggers a BAX/BAK Dependent Non-Canonical Cell Death Synergistic with Venetoclax

Sylvain Garciaz, Sebastian Muller, Andew Guirguis, Fiona C Brown, Yih Chih Chan, Mathilde Paplineau, Kevin Tran, Kah-Lok Chan, Laura Mac Pherson, Brian Liddicoat, Enid YN Lam, Tatiana Caneque, Marian L Burr, Veronique Litalien, Giovanna Pomilio, Estelle Duprez, David CS Huang, Sarah-Jane Dawson, Georg Ramm, Andrew G Cox, et al.

Conference Proceedings  |  2021  |  BLOOD

Abstract Although the BCL2 inhibitor venetoclax have been transformative in the management of AML, therapeutic resi..