Mark Dawson

CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity

AC Watt, P Cejas, MJ DeCristo, O Metzger-Filho, EYN Lam, X Qiu, H BrinJones, N Kesten, R Coulson, A Font-Tello, K Lim, R Vadhi, VW Daniels, J Montero, L Taing, CA Meyer, O Gilan, CC Bell, KD Korthauer, C Giambartolomei, et al.

Journal article  |  2021  |  Nature Cancer

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models

Emma Morrish, Anthony Copeland, Donia M Moujalled, Jason A Powell, Natasha Silke, Ann Lin, Kate E Jarman, Jarrod J Sandow, Gregor Ebert, Liana Mackiewicz, Jessica A Beach, Elizabeth L Christie, Alexander C Lewis, Giovanna Pomilio, Karla C Fischer, Laura MacPherson, David DL Bowtell, Andrew Webb, Marc Pellegrini, Mark A Dawson, et al.

Journal article  |  2020  |  Blood Advances

The specific targeting of inhibitor of apoptosis (IAP) proteins by Smac-mimetic (SM) drugs, such as birinapant, has been tested in..

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Ozgen Deniz, Mamataz Ahmed, Christopher D Todd, Ana Rio-Machin, Mark A Dawson, Miguel R Branco

Journal article  |  2020  |  Nature Communications

Acute myeloid leukemia (AML) is characterised by a series of genetic and epigenetic alterations that result in deregulation of tra..

Place Yours BETs in Combination Therapy

Brian J Liddicoat, Mark A Dawson

Journal article  |  2020  |  Molecular Cell

Combination therapy remains the cornerstone for cancer management, and understanding how to rationally partner drugs is imperative..

An Erg-driven transcriptional program controls B cell lymphopoiesis.

Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson, et al.

Journal article  |  2020  |  Nature Communications

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..

Translating Basic Cancer Discoveries to the Clinic

Elaine R Mardis, Mark A Dawson, Christina Curtis, Rui-Hua Xu, Georgina V Long, Richard A Scolyer, Samuel F Bakhoum, Do-Hyun Nam, Mathew Garnett, Annie Huang

Journal article  |  2020  |  Cancer Cell

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

Omer Gilan, Inmaculada Rioja, Kathy Knezevic, Matthew J Bell, Miriam M Yeung, Nicola R Harker, Enid YN Lam, Chun-wa Chung, Paul Bamborough, Massimo Petretich, Marjeta Urh, Stephen J Atkinson, Anna K Bassil, Emma J Roberts, Dane Vassiliadis, Marian L Burr, Alex GS Preston, Christopher Wellaway, Thilo Werner, James R Gray, et al.

Journal article  |  2020  |  Science

The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins enable chromatin binding to facilitate tran..

A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Lei Guo, Jia Li, Hongxiang Zeng, Anna G Guzman, Tingting Li, Minjung Lee, Yubin Zhou, Margaret A Goodell, Clifford Stephan, Peter JA Davies, Mark A Dawson, Deqiang Sun, Yun Huang

Journal article  |  2020  |  Nature Communications

Primary and acquired drug resistance imposes a major threat to achieving optimized clinical outcomes during cancer treatment. Aber..

HBO1 is required for the maintenance of leukaemia stem cells

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nguyen Nghi, et al.

Journal article  |  2020  |  Nature

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..

An Erg driven transcriptional program controls B-lymphopoiesis

Ashley Ng, Hannah Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy Johanson, Michael Sze Yuan Low, Charles Bell, Omer Gilan, Yih-Chih Chan, Andrew Kueh, Thomas Boudier, Ladina DiRago, Craig Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark Dawson, Rhys Allan, Marco Herold, et al.

Journal article  |  2019

Summary/Abstract B-cell development is initiated by the stepwise differentiation of hematopoietic stem cells into lineage committe..