Mark Dawson

Place Your BETs in Combination Therapy.

Brian J Liddicoat, Mark A Dawson

Journal article  |  2020  |  Molecular Cell

Combination therapy remains the cornerstone for cancer management, and understanding how to rationally partner drugs is imperative..

An Erg-driven transcriptional program controls B cell lymphopoiesis.

Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson, et al.

Journal article  |  2020  |  Nature Communications

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..

Translating Basic Cancer Discoveries to the Clinic

Elaine R Mardis, Mark A Dawson, Christina Curtis, Rui-Hua Xu, Georgina V Long, Richard A Scolyer, Samuel F Bakhoum, Do-Hyun Nam, Mathew Garnett, Annie Huang

Journal article  |  2020  |  Cancer Cell

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

Omer Gilan, Inmaculada Rioja, Kathy Knezevic, Matthew J Bell, Miriam M Yeung, Nicola R Harker, Enid YN Lam, Chun-wa Chung, Paul Bamborough, Massimo Petretich, Marjeta Urh, Stephen J Atkinson, Anna K Bassil, Emma J Roberts, Dane Vassiliadis, Marian L Burr, Alex GS Preston, Christopher Wellaway, Thilo Werner, James R Gray, et al.

Journal article  |  2020  |  Science

The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins enable chromatin binding to facilitate tran..

A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells.

Lei Guo, Jia Li, Hongxiang Zeng, Anna G Guzman, Tingting Li, Minjung Lee, Yubin Zhou, Margaret A Goodell, Clifford Stephan, Peter JA Davies, Mark A Dawson, Deqiang Sun, Yun Huang

Journal article  |  2020  |  Nature Communications

Primary and acquired drug resistance imposes a major threat to achieving optimized clinical outcomes during cancer treatment. Aber..

HBO1 is required for the maintenance of leukaemia stem cells

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nguyen Nghi, et al.

Journal article  |  2020  |  Nature

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..

An Erg driven transcriptional program controls B-lymphopoiesis

Ashley Ng, Hannah Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy Johanson, Michael Sze Yuan Low, Charles Bell, Omer Gilan, Yih-Chih Chan, Andrew Kueh, Thomas Boudier, Ladina DiRago, Craig Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark Dawson, Rhys Allan, Marco Herold, et al.

Journal article  |  2019

Summary/Abstract B-cell development is initiated by the stepwise differentiation of hematopoietic stem cells into lineage committe..

Epigenetic therapies in acute myeloid leukemia: where to from here?

Katie A Fennell, Charles C Bell, Mark A Dawson

Journal article  |  2019  |  Blood

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon, et al.

Journal article  |  2019  |  Cancer Cell

Prospective testing of circulating tumour DNA in metastatic breast cancer facilitates clinical trial enrollment and precision oncology

AZ Bujak, C-F Weng, M-J Silva, M Yeung, L Lo, S Ftouni, C Litchfield, A Ko, K Kuykhoven, C van Geelen, S Chandrashekar, MA Dawson, S Loi, SQ Wong, S-J Dawson

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

The roles of DNA, RNA and histone methylation in ageing and cancer

Ewa M Michalak, Marian L Burr, Andrew J Bannister, Mark A Dawson

Journal article  |  2019  |  Nature Reviews Molecular Cell Biology

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins and RNA. The methylation of chromatin compone..

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

Mark D McKenzie, Margherita Ghisi, Ethan P Oxley, Steven Ngo, Luisa Cimmino, Cecile Esnault, Ruijie Liu, Jessica M Salmon, Charles C Bell, Nouraiz Ahmed, Michael Erlichster, Matthew T Witkowski, Grace J Liu, Michael Chopin, Aleksandar Dakic, Emilia Simankowicz, Giovanna Pomilio, Tina Vu, Pavle Krsmanovic, Shian Su, et al.

Journal article  |  2019  |  Cell Stem Cell

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

P Khoueiry, A Ward Gahlawat, M Petretich, AM Michon, D Simola, E Lam, EE Furlong, V Benes, MA Dawson, RK Prinjha, G Drewes, P Grandi

Journal article  |  2019  |  Epigenetics & Chromatin

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

Charles C Bell, Katie A Fenne, Yih-Chih Chan, Florian Rambow, Miriam M Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G Martelotto, Aljosja Rogiers, Brandon E Kremer, Olena Barbash, Helai P Mohammad, Timothy M Johanson, Marian L Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S Tyler, Laura MacPherson, et al.

Journal article  |  2019  |  Nature Communications

Prediction and monitoring of relapse in stage III melanoma using circulating tumor DNA

L Tan, S Sandhu, RJ Lee, J Li, J Callahan, S Ftouni, N Dhomen, P Middlehurst, A Wallace, J Raleigh, A Hatzimihalis, MA Henderson, M Shackleton, A Haydon, V Mar, DE Gyorki, D Oudit, MA Dawson, RJ Hicks, P Lorigan, et al.

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: The advent of effective adjuvant therapies for patients with resected melanoma has highlighted the need to stratify pa..

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Rishu Agarwal, Yih-Chih Chan, Constantine S Tam, Tane Hunter, Dane Vassiliadis, Charis E Teh, Rachel Thijssen, Paul Yeh, Stephen Q Wong, Sarah Ftouni, Enid YN Lam, Mary Ann Anderson, Christiane Pott, Omer Gilan, Charles C Bell, Kathy Knezevic, Piers Blombery, Kathleen Rayeroux, Adrian Zordan, Jason Li, et al.

Journal article  |  2019  |  Nature Medicine

Understanding resistance mechanisms to BTK and BCL2 inhibitors in mantle cell lymphoma: implications for design of clinical trials

Rishu Agarwal, Mark A Dawson, Martin Dreyling, Constantine S Tam

Journal article  |  2018  |  Leukemia & Lymphoma

5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells

Eun-Ang Raiber, Guillem Portella, Sergio Martinez Cuesta, Robyn Hardisty, Pierre Murat, Zhe Li, Mario Iurlaro, Wendy Dean, Julia Spindel, Dario Beraldi, Zheng Liu, Mark A Dawson, Wolf Reik, Shankar Balasubramanian

Journal article  |  2018  |  Nature Chemistry

A Phase I Study of Molibresib (GSK525762), a Selective Bromodomain (BRD) and Extra Terminal Protein (BET) Inhibitor: Results from Part 1 of a Phase I/II Open Label Single Agent Study in Subjects with Non-Hodgkin's Lymphoma (NHL)

Michael Dickinson, Manali Kamdar, Brian JP Huntly, Carlos Fernandez De larrea, Raul Cordoba, Maria-Victoria Mateos, Adrian Alegre, Won-Seog Kim, Jin Seok Kim, Mark Dawson, Paul Sung-Hao Yeh, Faisal Basheer, Paolo Gallipoli, Aristeidis Chaidos, Alejandro Martin, Thierry Horner, James Winnberg, Lijoy K Mathew, Jeffrey Botbyl, Natalie Karpinich, et al.

Conference Proceedings  |  2018  |  Blood

TARGETING MYCN OVER-EXPRESSION WITH BRD4 INHIBITION IN THE PROLIFERATIVE C5 SUBTYPE OF HIGH GRADE SEROUS OVARIAN CANCER (HGSOC)

GY Ho, O Kondrashova, C Vandenberg, E Kyran, E Lieschke, V Heong, M Milevskiy, T Papenfuss, J Schroeder, J Weroha, M Dawson, D Bowtell, H Barker, M Wakefield, C Scott

Conference Proceedings  |  2018  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma

Constantine S Tam, Mary Ann Anderson, Christiane Pott, Rishu Agarwal, Sasanka Handunnetti, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David Westerman, Stephen Lade, Martin Dreyling, Sarah-Jane Dawson, Mark A Dawson, John F Seymour, Andrew W Roberts

Journal article  |  2018  |  New England Journal of Medicine

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

Mikhail M Savitski, Nico Zinn, Maria Faelth-Savitski, Daniel Poeckel, Stephan Gade, Isabelle Becher, Marcel Muelbaier, Anne J Wagner, Katrin Strohmer, Thilo Werner, Stephanie Melchert, Massimo Petretich, Anna Rutkowska, Johanna Vappiani, Holger Franken, Michael Steidel, Gavain M Sweetman, Omer Gilan, Enid YN Lam, Mark A Dawson, et al.

Journal article  |  2018  |  Cell

TFIID and MYB Share a Therapeutic Handshake in AML

Charles C Bell, Mark A Dawson

Journal article  |  2018  |  Cancer Cell

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Phillip P Sharp, Jean-Marc Garnier, Tamas Hatfaludi, Zhen Xu, David Segal, Kate E Jarman, Helene Jousset, Alexandra Garnham, John T Feutrill, Anthony Cuzzupe, Peter Hall, Scott Taylor, Carl R Walkley, Dean Tyler, Mark A Dawson, Peter Czabotar, Andrew F Wilks, Stefan Glaser, David CS Huang, Christopher J Burns

Journal article  |  2017  |  ACS Medicinal Chemistry Letters

5-Formylcytosine controls nucleosome positioning through covalent histone-DNA interaction

Eun-Ang Raiber, Guillem Portella, Sergio Martínez Cuesta, Robyn Hardisty, Pierre Murat, Zhe Li, Mario Iurlaro, Wendy Dean, Julia Spindel, Dario Beraldi, Mark Dawson, Wolf Reik, Shankar Balasubramanian

Journal article  |  2017

Nucleosomes are the basic unit of chromatin that ensure genome integrity and control access to the genetic information. The organi..

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

Imran G House, Colin M House, Amelia J Brennan, Omer Gilan, Mark A Dawson, James C Whisstock, Ruby HP Law, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2017  |  EMBO reports

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid YN Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, et al.

Journal article  |  2017  |  Nature

Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML

Laura MacPherson, Mark A Dawson

Journal article  |  2017  |  Cell Stem Cell

SPOP tips the balance of BETs in cancer

Katie A Fennell, Mark A Dawson

Journal article  |  2017  |  Nature Medicine

Click chemistry enables preclinical evaluation of targeted epigenetic therapies

Dean S Tyler, Johanna Vappiani, Tatiana Caneque, Enid YN Lam, Aoife Ward, Omer Gilan, Yih-Chih Chan, Antje Hienzsch, Anna Rutkowska, Thilo Werner, Anne J Wagner, Dave Lugo, Richard Gregory, Cesar Ramirez Molina, Neil Garton, Christopher R Wellaway, Susan Jackson, Laura MacPherson, Margarida Figueiredo, Sabine Stolzenburg, et al.

Journal article  |  2017  |  Science

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harrison, James D Rozario, et al.

Journal article  |  2017  |  Blood

Combination ibrutinib (Ibr) and venetoclax (Ven) for the treatment of mantle cell lymphoma (MCL): Primary endpoint assessment of the phase 2 AIM study.

Constantine Si Lun Tam, Andrew Warwick Roberts, Mary Ann Anderson, Sarah-Jane Dawson, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David A Westerman, Rishu Agarwal, Christiane Pott, Martin H Dreyling, Mark A Dawson, John Francis Seymour

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes

Paul Yeh, Michael Dickinson, Sarah Ftouni, Tane Hunter, Devbarna Sinha, Stephen Q Wong, Rishu Agarwal, Ravikiran Vedururu, Kenneth Doig, Chun Yew Fong, Piers Blombery, David Westerman, Mark A Dawson, Sarah-Jane Dawson

Journal article  |  2017  |  Blood

Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

Paul Yeh, Tane Hunter, Devbarna Sinha, Sarah Ftouni, Elise Wallach, Damian Jiang, Yih-Chih Chan, Stephen Q Wong, Maria Joao Silva, Ravikiran Vedururu, Kenneth Doig, Enid Lam, Gisela Mir Arnau, Timothy Semple, Meaghan Wall, Andjelija Zivanovic, Rishu Agarwal, Pasquale Petrone, Kate Jones, David Westerman, et al.

Journal article  |  2017  |  Nature Communications

The cancer epigenome: Concepts, challenges, and therapeutic opportunities

Mark A Dawson

Journal article  |  2017  |  Science

Circulating Tumor DNA Analysis and Functional Imaging Provide Complementary Approaches for Comprehensive Disease Monitoring in Metastatic Melanoma

Stephen Q Wong, Jeanette M Raleigh, Jason Callahan, Ismael A Vergara, Sarah Ftouni, Athena Hatzimihalis, Andrew J Colebatch, Jason Li, Timothy Semple, Kenneth Doig, Christopher Mintoff, Devbarna Sinha, Paul Yeh, Maria Joao Silva, Kathryn Alsop, Heather Thorne, David D Bowtell, David E Gyorki, Gisela Mir Arnau, Carleen Cullinane, et al.

Journal article  |  2017  |  JCO Precision Oncology

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Margherita Ghisi, Lev Kats, Frederick Masson, Jason Li, Tobias Kratina, Eva Vidacs, Omer Gilan, Maria A Doyle, Andrea Newbold, Jessica E Bolden, Kirsten A Fairfax, Carolyn A de Graaf, Matthew Firth, Johannes Zuber, Ross A Dickins, Lynn M Corcoran, Mark A Dawson, Gabrielle T Belz, Ricky W Johnstone

Journal article  |  2016  |  Cancer Cell

Functional interdependence of BRD4 and DOT1L in MLL leukemia

Omer Gilan, Enid YN Lam, Isabelle Becher, Dave Lugo, Ester Cannizzaro, Gerard Joberty, Aoife Ward, Meike Wiese, Chun Yew Fong, Sarah Ftouni, Dean Tyler, Kym Stanley, Laura MacPherson, Chen-Fang Weng, Yih-Chih Chan, Margherita Ghisi, David Smil, Christopher Carpenter, Peter Brown, Neil Garton, et al.

Journal article  |  2016  |  Nature Structural & Molecular Biology

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells

Lars Togel, Rebecca Nightingale, Anderly C Chueh, Aparna Jayachandran, Hoanh Tran, Toby Phesse, Rui Wu, Oliver M Sieber, Diego Arango, Amardeep S Dhillon, Mark A Dawson, Beatriz Diez-Dacal, Timothy C Gahman, Panagis Filippakopoulos, Andrew K Shiau, John M Mariadason

Journal article  |  2016  |  Molecular Cancer Therapeutics

Regulating BETs at central station

Mark A Dawson

Journal article  |  2015  |  Journal of Experimental Medicine

BET inhibitor resistance emerges from leukaemia stem cells

Chun Yew Fong, Omer Gilan, Enid YN Lam, Alan F Rubin, Sarah Ftouni, Dean Tyler, Kym Stanley, Devbarna Sinha, Paul Yeh, Jessica Morison, George Giotopoulos, Dave Lugo, Philip Jeffrey, Stanley Chun-Wei Lee, Christopher Carpenter, Richard Gregory, Robert G Ramsay, Steven W Lane, Omar Abdel-Wahab, Tony Kouzarides, et al.

Journal article  |  2015  |  Nature

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

Iva A Tchasovnikarova, Richard T Timms, Nicholas J Matheson, Kim Wals, Robin Antrobus, Berthold Goettgens, Gordon Dougan, Mark A Dawson, Paul J Lehner

Journal article  |  2015  |  Science

CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo

GP Gregory, SJ Hogg, LM Kats, E Vidacs, AJ Baker, O Gilan, M Lefebure, BP Martin, MA Dawson, RW Johnstone, J Shortt

Journal article  |  2015  |  Leukemia

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2

Sarah A Kinkel, Roman Galeev, Christoffer Flensburg, Andrew Keniry, Kelsey Breslin, Omer Gilan, Stanley Lee, Joy Liu, Kelan Chen, Linden J Gearing, Darcy L Moore, Warren S Alexander, Mark Dawson, Ian J Majewski, Alicia Oshlack, Jonas Larsson, Marnie E Blewitt

Journal article  |  2015  |  Blood

Epigenetics in the hematologic malignancies

Chun Yew Fong, Jessica Morison, Mark A Dawson

Journal article  |  2014  |  Haematologica

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

MA Dawson, EJ Gudgin, SJ Horton, G Giotopoulos, E Meduri, S Robson, E Cannizzaro, H Osaki, M Wiese, S Putwain, CY Fong, C Grove, J Craig, A Dittmann, D Lugo, P Jeffrey, G Drewes, K Lee, L Bullinger, RK Prinjha, et al.

Journal article  |  2014  |  Leukemia

BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms

BS Wyspianska, AJ Bannister, I Barbieri, J Nangalia, A Godfrey, FJ Calero-Nieto, S Robson, I Rioja, J Li, M Wiese, E Cannizzaro, MA Dawson, B Huntly, RK Prinjha, AR Green, B Gottgens, T Kouzarides

Journal article  |  2014  |  Leukemia

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

Michaela Waibel, Vanessa S Solomon, Deborah A Knight, Rachael A Ralli, Sang-Kyu Kim, Kellie-Marie Banks, Eva Vidacs, Clemence Virely, Keith CS Sia, Lauryn S Bracken, Racquel Collins-Underwood, Christina Drenberg, Laura B Ramsey, Sara C Meyer, Megumi Takiguchi, Ross A Dickins, Ross Levine, Jacques Ghysdael, Mark A Dawson, Richard B Lock, et al.

Journal article  |  2013  |  Cell Reports

The pathogenesis, diagnosis, and treatment of polycythaemia vera

MA Dawson, BJP Huntly

Book Chapter  |  2013

Bromodomains as therapeutic targets in cancer

Isaia Barbieri, Ester Cannizzaro, Mark A Dawson

Journal article  |  2013  |  Briefings in Functional Genomics

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

Rachel Deplus, Benjamin Delatte, Marie K Schwinn, Matthieu Defrance, Jacqui Mendez, Nancy Murphy, Mark A Dawson, Michael Volkmar, Pascale Putmans, Emilie Calonne, Alan H Shih, Ross L Levine, Olivier Bernard, Thomas Mercher, Eric Solary, Marjeta Urh, Danette L Daniels, Francois Fuks

Journal article  |  2013  |  The EMBO Journal

Three Distinct Patterns of Histone H3Y41 Phosphorylation Mark Active Genes

Mark A Dawson, Samuel D Foster, Andrew J Bannister, Samuel C Robson, Rebecca Hannah, Xiaonan Wang, Blerta Xhemalce, Andrew D Wood, Anthony R Green, Berthold Goettgens, Tony Kouzarides

Journal article  |  2012  |  Cell Reports

Targeting Epigenetic Readers in Cancer

Mark A Dawson, Tony Kouzarides, Brian JP Huntly

Journal article  |  2012  |  New England Journal of Medicine

Cancer Epigenetics: From Mechanism to Therapy

Mark A Dawson, Tony Kouzarides

Journal article  |  2012  |  Cell

Nuclear Functions of the Janus Kinases

Mark A Dawson, Andrew J Bannister

Book Chapter  |  2012

Nuclear JAK2

Mark A Dawson, Andrew J Bannister, Lindsay Saunders, Omar-Abdel Wahab, Fan Liu, Stephen D Nimer, Ross L Levine, Berthold Goettgens, Tony Kouzarides, Anthony R Green

Journal article  |  2011  |  Blood

The Transcriptional Coactivator Cbp Regulates Self-Renewal and Differentiation in Adult Hematopoietic Stem Cells

Wai-In Chan, Rebecca L Hannah, Mark A Dawson, Clare Pridans, Donna Foster, Anagha Joshi, Berthold Goettgens, Jan M Van Deursen, Brian JP Huntly

Journal article  |  2011  |  Molecular and Cellular Biology

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A Dawson, Rab K Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M Savitski, Carola Huthmacher, Emma Gudgin, Dave Lugo, Soren Beinke, Trevor D Chapman, Emma J Roberts, Peter E Soden, Kurt R Auger, Olivier Mirguet, Konstanze Doehner, et al.

Journal article  |  2011  |  Nature

Genome-Wide Analysis of Transcriptional Reprogramming in Mouse Models of Acute Myeloid Leukaemia

Nicolas Bonadies, Samuel D Foster, Wai-In Chan, Brynn T Kvinlaug, Dominik Spensberger, Mark A Dawson, Elaine Spooncer, Anthony D Whetton, Andrew J Bannister, Brian J Huntly, Berthold Goettgens

Journal article  |  2011  |  PLoS ONE

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

Dean S Griffiths, Juan Li, Mark A Dawson, Matthew WB Trotter, Yi-Han Cheng, Aileen M Smith, William Mansfield, Pentao Liu, Tony Kouzarides, Jennifer Nichols, Andrew J Bannister, Anthony R Green, Berthold Goettgens

Journal article  |  2011  |  Nature Cell Biology

AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disorders

Mark A Dawson, Jayne E Curry, Kelly Barber, Philip A Beer, Brent Graham, John F Lyons, Caroline J Richardson, Mike A Scott, Tomoko Smyth, Matthew S Squires, Neil T Thompson, Anthony R Green, Nicola G Wallis

Journal article  |  2010  |  British Journal of Haematology

Demethylases Go Mental

Mark A Dawson, Andrew J Bannister

Journal article  |  2010  |  Molecular Cell

Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm

Philip A Beer, Francois Delhommeau, Jean-Pierre LeCouedic, Mark A Dawson, Edwin Chen, David Bareford, Rajko Kusec, Mary Frances McMullin, Claire N Harrison, Alessandro M Vannucchi, William Vainchenker, Anthony R Green

Journal article  |  2010  |  Blood

Primary Cardiac Lymphoma

Justin A Mariani, Mark A Dawson, Sharon Avery, Andrew J Taylor

Journal article  |  2010  |  Journal of the American College of Cardiology

JAK2 phosphorylates histone H3Y41 and excludes HP1 alpha from chromatin

Mark A Dawson, Andrew J Bannister, Berthold Goettgens, Samuel D Foster, Till Bartke, Anthony R Green, Tony Kouzarides

Journal article  |  2009  |  Nature

ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling

Andrew D Wood, Edwin Chen, Ian J Donaldson, Shilpa Hattangadi, Karly A Burke, Mark A Dawson, Diego Miranda-Saavedra, Harvey F Lodish, Anthony R Green, Berthold Goettgens

Journal article  |  2009  |  Blood

Burkitt lymphoma in the setting of common variable immunodeficiency

Mark N Polizzotto, Jeremy S McComish, Mark A Dawson, Stephen S Opat, Merrole F Cole-Sinclair

Journal article  |  2009  |  Annals of Hematology

Phosphorylation of Histone H3 Thr-45 Is Linked to Apoptosis

Paul J Hurd, Andrew J Bannister, Karen Halls, Mark A Dawson, Michiel Vermeulen, Jesper V Olsen, Heba Ismail, Joanna Somers, Matthias Mann, Tom Owen-Hughes, Ivan Gout, Tony Kouzarides

Journal article  |  2009  |  Journal of Biological Chemistry

The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development

Nicola K Wilson, Diego Miranda-Saavedra, Sarah Kinston, Nicolas Bonadies, Samuel D Foster, Fernando Calero-Nieto, Mark A Dawson, Ian J Donaldson, Stephanie Dumon, Jonathan Frampton, Rekin's Janky, Xiao-Hong Sun, Sarah A Teichmann, Andrew J Bannister, Berthold Goettgens

Journal article  |  2009  |  Blood

Clinical and Immunohistochemical Features Associated with a Response to Bortezomib in Patients with Multiple Myeloma

Mark A Dawson, Stephen S Opat, Yamna Taouk, Mark Donovan, Michele Zammit, Katherine Monaghan, Noemi Horvath, Andrew W Roberts, H Miles Prince, Mark Hertzberg, Catriona A McLean, Andrew Spencer

Journal article  |  2009  |  Clinical Cancer Research

The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia

Alberto Catalano, Mark A Dawson, Karthiga Somana, Stephen Opat, Anthony Schwarer, Lynda J Campbell, Harry Iland

Journal article  |  2007  |  Blood

Blood transfusion requirements for patients undergoing chemotherapy for acute myeloid leukemia how much is enough?

Mark A Dawson, Sharon Avery, Zoe K McQuilten, Michael J Bailey, Jake Shortt, Mark N Polizzotto, Erica M Wood, Merrole F Cole-Sinclair

Journal article  |  2007  |  Haematologica

Mature neutrophils with multiple Auer rods: a rarity in normal karyotype acute myeloid leukaemia.

Mark A Dawson, Susan Whitehead

Journal article  |  2007  |  British Journal of Haematology

Extramedullary relapse of multiple myeloma associated with a shift in secretion from intact immunoglobulin to light chains

Mark A Dawson, Sushrut Patil, Andrew Spencer

Journal article  |  2007  |  Haematologica

AIDS-related plasmablastic lymphoma of the oral cavity associated with an IGH/MYC translocation--treatment with autologous stem-cell transplantation in a patient with severe haemophilia-A.

Mark A Dawson, Anthony P Schwarer, Catriona McLean, Paul Oei, Lynda J Campbell, Edwina Wright, Jake Shortt, Alison M Street

Journal article  |  2007  |  Haematologica

Plasmablastic lymphoma is an AIDS related lymphoma that continues to have a poor prognosis despite significant advances in the man..

Extramedullary relapse of multiple myeloma presenting as hematemesis and melena

MA Dawson, MN Polizzotto, A Gordon, SK Roberts, A Spencer

Journal article  |  2006  |  Nature Clinical Practice Oncology

The successful treatment of primary cardiac lymphoma with a dose-dense schedule of rituximab plus CHOP.

MA Dawson, J Mariani, A Taylor, G Koulouris, S Avery

Journal article  |  2006  |  Annals of Oncology

Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited

MA Dawson, A Davis, P Elliott, M Cole-Sinclair

Journal article  |  2005  |  Internal Medicine Journal

Successful mobilization of peripheral blood stem cells using recombinant human stem cell factor in heavily pretreated patients who have failed a previous attempt with a granulocyte colony-stimulating factor-based regimen

MA Dawson, AP Schwarer, JL Muirhead, MJ Bailey, GM Bollard, A Spencer

Journal article  |  2005  |  Bone Marrow Transplantation

Transjugular liver biopsy is a safe and effective intervention to guide management for patients with a congenital bleeding disorder infected with hepatitis C

MA Dawson, PH McCarthy, ME Walsh, CA McLean, K Thomson, S Roberts, AM Street

Journal article  |  2005  |  Internal Medicine Journal

Failure of rituximab monotherapy in lymphomatoid granulomatosis

MN Polizzotto, MA Dawson, SS Opat

Journal article  |  2005  |  European Journal of Haematology

Successful use of haploidentical stem-cell transplantation with KIR mismatch as initial therapy for poor-risk myelodysplastic syndrome

MA Dawson, A Spencer

Journal article  |  2005  |  Journal of Clinical Oncology