Louise Cheng

Tumor-derived MMPs regulate cachexia in a Drosophila cancer model

William Lodge, Michael Zavortink, Sofia Golenkina, Francesca Froldi, Callum Dark, Shane Cheung, Benjamin L Parker, Ronnie Blazev, Daniel Bakopoulos, Elizabeth L Christie, Verena C Wimmer, Brigette C Duckworth, Helena E Richardson, Louise Y Cheng

Journal article  |  2021  |  DEVELOPMENTAL CELL

Cachexia, the wasting syndrome commonly observed in advanced cancer patients, accounts for up to one-third of cancer-related morta..

Glial Hedgehog signalling and lipid metabolism regulate neural stem cell proliferation in Drosophila

Qian Dong, Michael Zavortink, Francesca Froldi, Sofya Golenkina, Tammy Lam, Louise Y Cheng

Journal article  |  2021  |  EMBO REPORTS

The final size and function of the adult central nervous system (CNS) are determined by neuronal lineages generated by neural stem..

Getting in shape: ATP pumps up the volume in Hh signalling

Qian Dong, Louise Y Cheng

Journal article  |  2020  |  EMBO JOURNAL

Glycolysis is a major metabolic process which ensures the break down of glucose into pyruvate via multiple enzymatic steps, but if..

Interorgan communication in development and cancer

Edel Alvarez-Ochoa, Francesca Froldi, Louise Y Cheng

Journal article  |  2020  |  WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY

Studies in model organisms have demonstrated that extensive communication occurs between distant organs both during development an..

Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS

Francesca Froldi, Panayotis Pachnis, Milan Szuperak, Olivia Costas, Tharindu Fernando, Alex P Gould, Louise Y Cheng

Journal article  |  2019  |  EMBO JOURNAL

Rewired metabolism of glutamine in cancer has been well documented, but less is known about other amino acids such as histidine. H..

The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate

Joseph HA Vissers, Francesca Froldi, Jan Schroder, Anthony T Papenfuss, Louise Y Cheng, Kieran F Harvey

Journal article  |  2018  |  CELL REPORTS

The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scallo..

Drosophila Models of Human Disease

Louise Cheng, Antonio Baonza, Daniela Grifoni

Journal article  |  2018  |  BIOMED RESEARCH INTERNATIONAL

Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility

Mohi U Ahmed, Ashish K Maurya, Louise Cheng, Erika C Jorge, Frank R Schubert, Pascal Maire, M Albert Basson, Philip W Ingham, Susanne Dietrich

Journal article  |  2017  |  DEVELOPMENTAL BIOLOGY

Chordates are characterised by contractile muscle on either side of the body that promotes movement by side-to-side undulation. In..

Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua

Liu Yang, Sayantanee Paul, Kenneth G Trieu, Lucas G Dent, Francesca Froldi, Marta Fores, Kaitlyn Webster, Kellee R Siegfried, Shu Kondo, Kieran Harvey, Louise Cheng, Gerardo Jimenez, Stanislav Y Shvartsman, Alexey Veraksa

Journal article  |  2016  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcriptional repressor Capicua (Cic) controls tissue patterning and restricts organ growth, and has been recently implicate..

The Hippo Pathway Regulates Neuroblasts and Brain Size in Drosophila melanogaster

Carole LC Poon, Katrina A Mitchell, Shu Kondo, Louise Y Cheng, Kieran F Harvey

Journal article  |  2016  |  CURRENT BIOLOGY

A key question in developmental neurobiology is how neural stem cells regulate their proliferative potential and cellular diversit..