Sarah Londrigan

Mouse guanylate-binding protein 1 does not mediate antiviral activity against influenza virus in vitro or in vivo.

Melkamu B Tessema, Daniel Enosi Tuipulotu, Clare V Oates, Andrew G Brooks, Si Ming Man, Sarah L Londrigan, Patrick C Reading

Journal article  |  2023  |  Immunol Cell Biol

Many interferon (IFN)-stimulated genes are upregulated within host cells following infection with influenza and other viruses. Whi..

Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain

Fernando Villalon-Letelier, Rubaiyea Farrukee, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading

Journal article  |  2022  |  VIRUSES-BASEL

MARCH1 and MARCH8 are closely related E3 ubiquitin ligases that ubiquitinate an overlapping spectrum of host proteins and restrict..

Induction of Interferon-Stimulated Genes Correlates with Reduced Growth of Influenza A Virus in Lungs after RIG-I Agonist Treatment of Ferrets

Lara SU Schwab, Sarah L Londrigan, Andrew G Brooks, Aeron C Hurt, Anshupa Sahu, Yi-Mo Deng, Jean Moselen, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Intracellular RIG-I receptors represent key innate sensors of RNA virus infection, and RIG-I activation results in the induction o..

Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection

Lara SU Schwab, Rubaiyea Farrukee, Jean Francois Eleouet, Marie Anne Rameix-Welti, Sarah L Londrigan, Andrew G Brooks, Aeron C Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF INFECTIOUS DISEASES

Infections caused by human respiratory syncytial virus (RSV) are associated with substantial rates of morbidity and mortality. Tre..

Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection

Lara SU Schwab, Fernando Villalon-Letelier, Melkamu B Tessema, Sarah L Londrigan, Andrew G Brooks, Aeron Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  VIRUSES-BASEL

RIG-I is an innate sensor of RNA virus infection and its activation induces interferon-stimulated genes (ISGs). In vitro studies u..

Mouse Mx1 Inhibits Herpes Simplex Virus Type 1 Genomic Replication and Late Gene Expression In Vitro and Prevents Lesion Formation in the Mouse Zosteriform Model

Melkamu B Tessema, Rubaiyea Farrukee, Christopher E Andoniou, Mariapia A Degli-Esposti, Clare Oates, James B Barnes, Linda M Wakim, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Myxovirus resistance (Mx) proteins are dynamin-like GTPases that are inducible by interferons (IFNs) following virus infections. M..

SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

Wuji Zhang, Brendon Y Chua, Kevin J Selva, Lukasz Kedzierski, Thomas M Ashhurst, Ebene R Haycroft, Suzanne K Shoffner-Beck, Luca Hensen, David F Boyd, Fiona James, Effie Mouhtouris, Jason C Kwong, Kyra YL Chua, George Drewett, Ana Copaescu, Julie E Dobson, Louise C Rowntree, Jennifer R Habel, Lilith F Allen, Hui-Fern Koay, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying COVID-19. We examine cellular, humoral a..

Long-Read RNA Sequencing Identifies Polyadenylation Elongation and Differential Transcript Usage of Host Transcripts During SARS-CoV-2 In Vitro Infection

Jessie J-Y Chang, Josie Gleeson, Daniel Rawlinson, Ricardo De Paoli-Iseppi, Chenxi Zhou, Francesca L Mordant, Sarah L Londrigan, Michael B Clark, Kanta Subbarao, Timothy P Stinear, Lachlan JM Coin, Miranda E Pitt

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Better methods to interrogate host-pathogen interactions during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infec..

IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication

Tina Meischel, Svenja Fritzlar, Fernando Villalon-Letelier, Melkamu B Tessema, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

Journal article  |  2021  |  JOURNAL OF VIROLOGY

Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We..

MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells

Fernando Villalon-Letelier, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2021  |  MBIO

Membrane-associated RING-CH8 (MARCH8) impairs the cell surface expression of envelope glycoproteins from different viruses, reduci..