Sarah Londrigan

MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells.

Fernando Villalón-Letelier, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2021  |  mBio

Membrane-associated RING-CH8 (MARCH8) impairs the cell surface expression of envelope glycoproteins from different viruses, reduci..

Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity.

Wuji Zhang, Brendon Chua, Kevin Selva, Lukasz Kedzierski, Thomas Ashhurst, Ebene Haycroft, Suzanne Shoffner, Luca Hensen, David Boyd, Fiona James, Effie Mouhtouris, Jason Kwong, Kyra Chua, George Drewett, Ana Copaescu, Julie Dobson, Louise Rowntree, Jennifer Habel, Lilith Allen, Hui-Fern Koay, et al.

Journal article  |  2021

Although the respiratory tract is the primary site of SARS-CoV-2 infection and the ensuing immunopathology, respiratory immune res..

IFITM proteins that restrict the early stages of respiratory virus infection do not influence late-stage replication.

Tina Meischel, Svenja Fritzlar, Fernando Villalon-Letelier, Melkamu B Tessema, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

Journal article  |  2021  |  J Virol

Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We..

The 1918 influenza and COVID-19 pandemics: The effect of age on outcomes

Paul T King, Sarah L Londrigan

Journal article  |  2021  |  RESPIROLOGY

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda E Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca L Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Timothy P Stinear, Sarah L Londrigan, Michael B Clark, Deborah A Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2021  |  CELL REPORTS

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses subgenomic RNA (sgRNA) to produce viral proteins for replication..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Tim Stinear, Sarah Londrigan, Michael Clark, Deborah Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2020

Summary SARS-CoV-2 uses subgenomic (sg)RNA to produce viral proteins for replication and immune evasion. We applied long-read RNA ..

Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses

Rubaiyea Farrukee, Malika Ait-Goughoulte, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Journal article  |  2020  |  VIRUSES-BASEL

The paramyxo- and pneumovirus family includes a wide range of viruses that can cause respiratory and/or systemic infections in hum..

Influenza A virus interactions with macrophages: Lessons from epithelial cells

Tina Meischel, Fernando Villalon-Letelier, Philippa M Saunders, Patrick C Reading, Sarah L Londrigan

Journal article  |  2020  |  CELLULAR MICROBIOLOGY

Influenza viruses are an important cause of respiratory infection worldwide. In humans, infection with seasonal influenza A virus ..

IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages

Sarah L Londrigan, Linda M Wakim, Jeffrey Smith, Anne J Haverkate, Andrew G Brooks, Patrick C Reading

Journal article  |  2020  |  VIROLOGY

Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to co..