Sarah Londrigan

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda E Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca L Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Timothy P Stinear, Sarah L Londrigan, Michael B Clark, Deborah A Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2021  |  Cell Reports

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses subgenomic RNA (sgRNA) to produce viral proteins for replication..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI insight

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Tim Stinear, Sarah Londrigan, Michael Clark, Deborah Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2020

Summary SARS-CoV-2 uses subgenomic (sg)RNA to produce viral proteins for replication and immune evasion. We applied long-read RNA ..

Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses

Rubaiyea Farrukee, Malika Ait-Goughoulte, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Journal article  |  2020  |  Viruses

The paramyxo- and pneumovirus family includes a wide range of viruses that can cause respiratory and/or systemic infections in hum..

Influenza A virus interactions with macrophages: Lessons from epithelial cells

Tina Meischel, Fernando Villalon-Letelier, Philippa M Saunders, Patrick C Reading, Sarah L Londrigan

Journal article  |  2020  |  Cellular Microbiology

Influenza viruses are an important cause of respiratory infection worldwide. In humans, infection with seasonal influenza A virus ..

IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages

Sarah L Londrigan, Linda M Wakim, Jeffrey Smith, Anne J Haverkate, Andrew G Brooks, Patrick C Reading

Journal article  |  2020  |  Virology

Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to co..

Virology Downunder, a meeting commentary from the 2019 Lorne Infection and Immunity Conference, Australia

Gregor Ebert, Prasad N Paradkar, Sarah L Londrigan

Journal article  |  2019  |  Virology Journal

The aim of this article is to summarise the virology content presented at the 9th Lorne Infection and Immunity Conference, Austral..

Virology at the Lorne Infection and Immunity Conference 2019

Sarah L Londrigan, Gregor Ebert, Prasad N Paradkar

Journal article  |  2019  |  Virologica Sinica

Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo

Joel Z Ma, Wy Ching Ng, Luke Zappia, Linden J Gearing, Moshe Olshansky, Kym Pham, Karey Cheong, Arthur Hsu, Stephen J Turner, Odilia Wijburg, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading

Journal article  |  2019  |  Journal of Virology

Airway epithelial cells and macrophages differ markedly in their responses to influenza A virus (IAV) infection. To investigate tr..

Host Cell Restriction Factors that Limit Influenza A Infection

Fernando Villalon-Letelier, Andrew G Brooks, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Journal article  |  2017  |  Viruses

Viral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (IS..