Jessica Neil

Serologic Response to Messenger RNA Coronavirus Disease 2019 Vaccines in Inflammatory Bowel Disease Patients Receiving Biologic Therapies

Serre-Yu Wong, Rebekah Dixon, Vicky Martinez Pazos, Sacha Gnjatic, Jean-Frederic Colombel, Ken Cadwell

Journal article  |  2021  |  GASTROENTEROLOGY

Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome

Simone Dallari, Thomas Heaney, Adriana Rosas-Villegas, Jessica A Neil, Serre-Yu Wong, Judy J Brown, Kelly Urbanek, Christin Herrmann, Daniel P Depledge, Terence S Dermody, Ken Cadwell

Journal article  |  2021  |  CELL HOST & MICROBE

The contributions of the viral component of the microbiome-the virome-to the development of innate and adaptive immunity are large..

An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury

Yu Matsuzawa-Ishimoto, Ashley Hine, Yusuke Shono, Eugene Rudensky, Amina Lazrak, Frank Yeung, Jessica A Neil, Xiaomin Yao, Ying-Han Chen, Thomas Heaney, Samantha L Schuster, Erin E Zwack, Jordan E Axelrad, David Hudesman, Jennifer J Tsai, Katherine Nichols, M Zahidunnabi Dewan, Michael Cammer, Allison Beal, Sandra Hoffman, et al.

Journal article  |  2020  |  BLOOD

A goal in precision medicine is to use patient-derived material to predict disease course and intervention outcomes. Here, we use ..

IFN-I and IL-22 mediate protective effects of intestinal viral infection

Jessica A Neil, Yu Matsuzawa-Ishimoto, Elisabeth Kernbauer-Holzl, Samantha L Schuster, Stela Sota, Mericien Venzon, Simone Dallari, Antonio Galvao Neto, Ashley Hine, David Hudesmans, P'ng Loke, Timothy J Nice, Ken Cadwell

Journal article  |  2019  |  NATURE MICROBIOLOGY

Products derived from bacterial members of the gut microbiota evoke immune signalling pathways of the host that promote immunity a..

The Intestinal Virome and Immunity

Jessica A Neil, Ken Cadwell

Journal article  |  2018  |  JOURNAL OF IMMUNOLOGY

The composition of the human microbiome is considered a major source of interindividual variation in immunity and, by extension, s..

Tropism for tuft cells determines immune promotion of norovirus pathogenesis

Craig B Wilen, Sanghyun Lee, Leon L Hsieh, Robert C Orchard, Chandni Desai, Barry L Hykes, Michael R McAllaster, Dale R Balce, Taylor Feehley, Jonathan R Brestoff, Christina A Hickey, Christine C Yokoyama, Ya-Ting Wang, Donna A MacDuff, Darren Kreamalmayer, Michael R Howitt, Jessica A Neil, Ken Cadwell, Paul M Allen, Scott A Handley, et al.

Journal article  |  2018  |  SCIENCE

Complex interactions between host immunity and the microbiome regulate norovirus infection. However, the mechanism of host immune ..

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

Yu Matsuzawa-Ishimoto, Yusuke Shono, Luis E Gomez, Vanessa M Hubbard-Lucey, Michael Cammer, Jessica Neil, M Zahidunnabi Dewan, Sophia R Lieberman, Amina Lazrak, Jill M Marinis, Allison Beal, Philip A Harris, John Bertin, Chen Liu, Yi Ding, Marcel RM van den Brink, Ken Cadwell

Journal article  |  2017  |  JOURNAL OF EXPERIMENTAL MEDICINE

A variant of the autophagy gene ATG16L1 is associated with Crohn's disease, an inflammatory bowel disease (IBD), and poor survival..

Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling

Jessica A Pane, Fiona E Fleming, Kate L Graham, Helen E Thomas, Thomas WH Kay, Barbara S Coulson

Journal article  |  2016  |  SCIENTIFIC REPORTS

Rotavirus infection is associated with childhood progression to type 1 diabetes. Infection by monkey rotavirus RRV accelerates dia..

NSP1 of human rotaviruses commonly inhibits NF-kappa B signalling by inducing beta-TrCP degradation

Izabel JM Di Fiore, Jessica A Pane, Gavan Holloway, Barbara S Coulson

Journal article  |  2015  |  JOURNAL OF GENERAL VIROLOGY

Rotavirus is a leading cause of severe gastroenteritis in infants worldwide. Rotavirus nonstructural protein 1 (NSP1) is a virulen..

Lessons from the mouse: potential contribution of bystander lymphocyte activation by viruses to human type 1 diabetes

Jessica A Pane, Barbara S Coulson

Journal article  |  2015  |  DIABETOLOGIA

Viruses are considered to be potential key modulators of type 1 diabetes mellitus, with several possible mechanisms proposed for t..