Zhibin Chen

Systematic Review of Cost-Effectiveness Analysis for Surgical and Neurostimulation Treatments for Drug-Resistant Epilepsy in Adults.

Nicholas Ngan Kee, Emma Foster, Clara Marquina, Andy Tan, Samantha ST Pang, Terence J O'Brien, Patrick Kwan, Graeme Jackson, Zhibin Chen, Zanfina Ademi

Journal article  |  2023  |  Neurology

BACKGROUND AND OBJECTIVES: Surgical and neurostimulator treatments are effective for reducing seizure burden in selected individua..

Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30-year cohort study.

Haris Hakeem, Bshra Ali A Alsfouk, Patrick Kwan, Martin J Brodie, Zhibin Chen

Journal article  |  2023  |  Epilepsia

OBJECTIVES: To assess the temporal trends in the use of second antiseizure (ASM) regimens and compare the efficacy of substitution..

Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta-analysis

Zining Liu, Peravina Thergarajan, Ana Antonic-Baker, Zhibin Chen, Paul B Sparks, Natasha A Lannin, Patrick Kwan, Nigel C Jones, Pablo M Casillas-Espinosa, Piero Perucca, Terence J O'Brien, Shobi Sivathamboo

Journal article  |  2023  |  EPILEPSIA OPEN

OBJECTIVE: Epilepsy is associated with an increased risk of cardiovascular disease and mortality. Whether cardiac structure and fu..

Risk of sudden unexpected death in epilepsy (SUDEP) with lamotrigine and other sodium channel-modulating antiseizure medications.

Russell Nightscales, Sarah Barnard, Juliana Laze, Zhibin Chen, Gerard Tao, Clarissa Auvrez, Shobi Sivathamboo, Mark J Cook, Patrick Kwan, Daniel Friedman, Samuel F Berkovic, Wendyl D'Souza, Piero Perucca, Orrin Devinsky, Terence J O'Brien

Journal article  |  2023  |  Epilepsia Open

OBJECTIVE: In vitro data prompted U.S Food and Drug Administration warnings that lamotrigine, a common sodium channel modulating a..

Treatment Outcomes of Newly Diagnosed Epilepsy: A Systematic Review and Meta-analysis

Mubeen Janmohamed, Haris Hakeem, Suyi Ooi, Suhailah Hakami, Lily Vu, Piero Perucca, Terence J O'Brien, Ana Antonic-Baker, Zhibin Chen, Patrick Kwan

Journal article  |  2022  |  CNS DRUGS

BACKGROUND AND OBJECTIVES: Understanding the multi-faceted treatment outcomes of newly diagnosed epilepsy is critical for developi..

Serum neurofilament light as a biomarker of vulnerability to a second mild traumatic brain injury.

William T O'Brien, David K Wright, Ashley LJJ van Emmerik, Jesse Bain, Robert Brkljaca, Jennaya Christensen, Glenn R Yamakawa, Zhibin Chen, Lauren P Giesler, Mujun Sun, Terence J O'Brien, Mastura Monif, Sandy R Shultz, Stuart J McDonald

Journal article  |  2022  |  Transl Res

A second mild traumatic brain injury (mTBI) sustained prior to neuropathological recovery can lead to exacerbated effects. Without..

Huntington's disease: Mortality and risk factors in an Australian cohort.

Emily Sun, Matthew Kang, Pierre Wibawa, Vivian Tsoukra, Zhibin Chen, Sarah Farrand, Dhamidhu Eratne, Wendy Kelso, Andrew Evans, Mark Walterfang, Dennis Velakoulis, Samantha M Loi

Journal article  |  2022  |  J Neurol Sci

INTRODUCTION: There has not been any examination of the risk factors associated with mortality in Huntington's Disease (HD) in an ..

Interictal and seizure-onset EEG patterns in malformations of cortical development: A systematic review

Lubna Shakhatreh, Mubeen Janmohamed, Ana Antonic Baker, Anna Willard, Joshua Laing, Maria Rychkova, Zhibin Chen, Patrick Kwan, Terence J O'Brien, Piero Perucca

Journal article  |  2022  |  NEUROBIOLOGY OF DISEASE

OBJECTIVES: Malformations of cortical development (MCDs) are common causes of drug-resistant epilepsy. The mechanisms underlying t..

Monitoring the acute and subacute recovery of cognitive ocular motor changes after a sports-related concussion

Georgia F Symons, William T O'Brien, Larry Abel, Zhibin Chen, Daniel M Costello, Terence J O'Brien, Scott Kolbe, Joanne Fielding, Sandy R Shultz, Meaghan Clough

Journal article  |  2022  |  CEREBRAL CORTEX

Identifying when recovery from a sports-related concussion (SRC) has occurred remains a challenge in clinical practice. This study..

Development and Validation of a Deep Learning Model for Predicting Treatment Response in Patients With Newly Diagnosed Epilepsy.

Haris Hakeem, Wei Feng, Zhibin Chen, Jiun Choong, Martin J Brodie, Si-Lei Fong, Kheng-Seang Lim, Junhong Wu, Xuefeng Wang, Nicholas Lawn, Guanzhong Ni, Xiang Gao, Mijuan Luo, Ziyi Chen, Zongyuan Ge, Patrick Kwan

Journal article  |  2022  |  JAMA Neurol

IMPORTANCE: Selection of antiseizure medications (ASMs) for epilepsy remains largely a trial-and-error approach. Under this approa..