Marissa Caldow

Time-resolved phosphoproteome and proteome analysis reveals kinase signaling on master transcription factors during myogenesis.

Di Xiao, Marissa Caldow, Hani Jieun Kim, Ronnie Blazev, Rene Koopman, Deborah Manandi, Benjamin L Parker, Pengyi Yang

Journal article  |  2022  |  iScience

Myogenesis is governed by signaling networks that are tightly regulated in a time-dependent manner. Although different protein kin..

Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Jin D Chung, Jennifer Trieu, Dominic J Hare, Peter J Crouch, Scott Ayton, Ashley Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2022  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the ..

Disruption of Hfe leads to skeletal muscle iron loading and reduction of hemoproteins involved in oxidative metabolism in a mouse model of hereditary hemochromatosis

Francesca M Alves, Marissa K Caldow, Sheridan L Helman, Scott Ayton, Ashley Bush, Gordon S Lynch, David M Frazer, Rene Koopman

Journal article  |  2022  |  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

• Hereditary hemochromatosis (HH) is a common iron loading condition often associated with fatigue and reduced exercise tolerance,..

Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice

Justin P Hardee, Marissa K Caldow, Audrey SM Chan, Stuart K Plenderleith, Jennifer Trieu, Rene Koopman, Gordon S Lynch

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Impaired oxidative capacity and mitochondrial function contribute to the dystrophic pathology in muscles of patients with Duchenne..

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Peter J Crouch, Scott Ayton, Ashley I Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2021  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the insidious loss of muscle mass and strength that occurs with age. However, few st..

Glycine Protects Muscle Cells From Wasting in vitro via mTORC1 Signaling

Marissa K Caldow, Daniel J Ham, Jennifer Trieu, Jin Dylan Chung, Gordon S Lynch, Rene Koopman

Journal article  |  2019  |  FRONTIERS IN NUTRITION

Glycine supplementation can protect skeletal muscles of mice from cancer-induced wasting, but the mechanisms underlying this prote..

Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice

Daniel J Ham, Anastasia Gardner, Tahnee L Kennedy, Jennifer Trieu, Timur Naim, Annabel Chee, Francesca M Alves, Marissa K Caldow, Gordon S Lynch, Rene Koopman

Journal article  |  2019  |  SCIENTIFIC REPORTS

Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and prem..

Choline administration attenuates aspects of the dystrophic pathology in mdx mice

FM Alves, MK Caldow, J Trieu, T Naim, MK Montgomery, MJ Watt, GS Lynch, R Koopman

Journal article  |  2019  |  Clinical Nutrition Experimental

Background & aims: Dystrophic muscle fibres are fragile and prone to breakage, leading to impaired Ca 2+ homeostasis and excessive..

Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury

Kristy Swiderski, Marissa K Caldow, Timur Naim, Jennifer Trieu, Annabel Chee, Rene Koopman, Gordon S Lynch

Journal article  |  2019  |  PLOS ONE

Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a persistent inflammatory response. ..

Muscle-specific deletion of SOCS3 does not reduce the anabolic response to leucine in a mouse model of acute inflammation

MK Caldow, DJ Ham, A Chee, J Trieu, T Naim, DI Stapleton, K Swiderski, GS Lynch, R Koopman

Journal article  |  2017  |  CYTOKINE

Excessive inflammation reduces skeletal muscle protein synthesis leading to wasting and weakness. The janus kinase/signal transduc..