Yen Ying Lim

Association of β-Amyloid Level, Clinical Progression, and Longitudinal Cognitive Change in Normal Older Individuals.

Laura M van der Kall, Thanh Truong, Samantha C Burnham, Vincent Doré, Rachel S Mulligan, Svetlana Bozinovski, Fiona Lamb, Pierrick Bourgeat, Jurgen Fripp, Stephanie Schultz, Yen Y Lim, Simon M Laws, David Ames, Christopher Fowler, Stephanie R Rainey-Smith, Ralph N Martins, Olivier Salvado, Joanne Robertson, Paul Maruff, Colin L Masters, et al.

Journal article  |  2021  |  Neurology

OBJECTIVE: To determine the effect of β-amyloid (Aβ) level on progression risk to mild cognitive impairment (MCI) or dementia and ..

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease

Nicolai Franzmeier, Jinyi Ren, Alexander Damm, Gemma Monte-Rubio, Merce Boada, Agustin Ruiz, Alfredo Ramirez, Frank Jessen, Emrah Duezel, Octavio Rodriguez Gomez, Tammie Benzinger, Alison Goate, Celeste M Karch, Anne M Fagan, Eric McDade, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Marc Suarez-Calvet, et al.

Journal article  |  2021  |  Molecular Psychiatry

In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met..

BDNF VAL66MET polymorphism and memory decline across the spectrum of Alzheimer's disease

Yen Ying Lim, Simon M Laws, Stephanie Perin, Robert H Pietrzak, Christopher Fowler, Colin L Masters, Paul Maruff

Journal article  |  2021  |  Genes Brain & Behavior

The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism has been shown to moderate the extent to which memory ..

Deferiprone to delay dementia (the 3D trial)

Scott Ayton, Michael Woodward, Kathryn A Ellis, Yen Ying Lim, Paul T Maruff, Patricia M Desmond, Olivier Salvado, Amir Fazlollahi, Christopher C Rowe, Leonid Churilov, Ashley I Bush

Journal article  |  2020  |  Alzheimer's & Dementia

Plasma Aβ biomarker associated with cognitive decline in preclinical Alzheimer’s disease

Yen Ying Lim, Paul T Maruff, Naoki Kaneko, Christopher J Fowler, Victor LL Villemagne, Takashi Kato, Christopher C Rowe, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Katsuhiko Yanagisawa, Colin L Masters, Akinori Nakamura

Conference Proceedings  |  2020  |  Alzheimer's & Dementia

Association of deficits in short-term learning and A beta and hippocampal volume in cognitively normal adults

Yen Ying Lim, Jenalle E Baker, Loren Bruns, Andrea Mills, Christopher Fowler, Jurgen Fripp, Stephanie R Rainey-Smith, David Ames, Colin L Masters, Paul Maruff

Journal article  |  2020  |  Neurology

Objective To determine the extent to which deficits in learning over 6 days are associated with β-amyloid–positive (Aβ+) and hippo..

Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance.

Yaakov Stern, Eider M Arenaza-Urquijo, David Bartrés-Faz, Sylvie Belleville, Marc Cantilon, Gael Chetelat, Michael Ewers, Nicolai Franzmeier, Gerd Kempermann, William S Kremen, Ozioma Okonkwo, Nikolaos Scarmeas, Anja Soldan, Chinedu Udeh-Momoh, Michael Valenzuela, Prashanthi Vemuri, Eero Vuoksimaa, undefined the Reserve, Resilience and Protective Factors PIA Empirical Definitions and Conceptual Frameworks Workgroup

Journal article  |  2020  |  Alzheimer's and Dementia

Several concepts, which in the aggregate get might be used to account for "resilience" against age- and disease-related changes, h..

Plasma Amyloid-beta Biomarker Associated with Cognitive Decline in Preclinical Alzheimer's Disease

Yen Ying Lim, Paul Maruff, Naoki Kaneko, James Doecke, Christopher Fowler, Victor L Villemagne, Takashi Kato, Christopher C Rowe, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Katsuhiko Yanagisawa, Colin L Masters, Akinori Nakamura

Journal article  |  2020  |  Journal of Alzheimer's Disease

BACKGROUND: Using immunoprecipitation-mass spectrometry, we recently developed and validated a plasma composite biomarker for the ..

Unsupervised assessment of cognition in the Healthy Brain Project: Implications for web-based registries of individuals at risk for Alzheimer's disease.

Stephanie Perin, Rachel F Buckley, Matthew P Pase, Nawaf Yassi, Alexandra Lavale, Peter H Wilson, Adrian Schembri, Paul Maruff, Yen Ying Lim

Journal article  |  2020  |  Alzheimer's and Dementia: Translational Research and Clinical Interventions

Introduction: Web-based platforms are used increasingly to assess cognitive function in unsupervised settings. The utility of cogn..

Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)

Andrew J Aschenbrenner, Bryan D James, Eric McDade, Guoqiao Wang, Yen Ying Lim, Tammie LS Benzinger, Carlos Cruchaga, Alison Goate, Chengjie Xiong, Richard Perrin, Virginia Buckles, Ricardo Allegri, Sarah B Berman, Jasmeer P Chhatwal, Anne Fagan, Martin Farlow, Antoinette O'Connor, Bernardino Ghetti, Neill Graff-Radford, Jill Goldman, et al.

Journal article  |  2020  |  Alzheimer's & Dementia