Kelly Smith

TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.

Shyam K Akula, Jack H Marciano, Youngshin Lim, David Exposito-Alonso, Norma K Hylton, Grace H Hwang, Jennifer E Neil, Nicole Dominado, Rosie K Bunton-Stasyshyn, Janet HT Song, Maya Talukdar, Aloisia Schmid, Lydia Teboul, Alisa Mo, Taehwan Shin, Benjamin Finander, Samantha G Beck, Rebecca C Yeh, Aoi Otani, Xuyu Qian, et al.

Journal article  |  2023  |  Proc Natl Acad Sci U S A

Sonic hedgehog signaling regulates processes of embryonic development across multiple tissues, yet factors regulating context-spec..

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath

Journal article  |  2023  |  ELIFE

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly an..

Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2

Samuel J Capon, Veronica Uribe, Nicole Dominado, Ophelia Ehrlich, Kelly A Smith

Journal article  |  2022  |  DEVELOPMENT

The endocardium plays important roles in the development and function of the vertebrate heart; however, few molecular markers of t..

Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Harriet P Lo, Ye-Wheen Lim, Zherui Xiong, Nick Martel, Charles Ferguson, Nicholas Ariotti, Jean Giacomotto, James Rae, Matthias Floetenmeyer, Shayli Varasteh Moradi, Ya Gao, Vikas A Tillu, Di Xia, Huang Wang, Samira Rahnama, Susan J Nixon, Michele Bastiani, Ryan D Day, Kelly A Smith, Nathan J Palpant, et al.

Journal article  |  2021  |  JOURNAL OF CELL BIOLOGY

The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role for the muscle-specific component, ..

The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function

Katarzyna Koltowska, Kazuhide S Okuda, Marleen Gloger, Maria Rondon-Galeano, Elizabeth Mason, Jiachen Xuan, Stefanie Dudczig, Huijun Chen, Hannah Arnold, Renae Skoczylas, Neil Bower, Scott Paterson, Anne Karine Lagendijk, Gregory J Baillie, Ignaty Leshchiner, Cas Simons, Kelly A Smith, Wolfram Goessling, Joan K Heath, Richard B Pearson, et al.

Journal article  |  2021  |  NATURE CELL BIOLOGY

The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network gro..

Getting to the Heart of Left-Right Asymmetry: Contributions from the Zebrafish Model

Kelly A Smith, Veronica Uribe

Journal article  |  2021  |  JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE

The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the organ itself is asymmetric. This..

The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm

Charlotte D Koopman, Jessica De Angelis, Swati P Iyer, Arie O Verkerk, Jason Da Silva, Geza Berecki, Angela Jeanes, Gregory J Baillie, Scott Paterson, Veronica Uribe, Ophelia Ehrlich, Samuel D Robinson, Laurence Garric, Steven Petrou, Cas Simons, Irina Vetter, Benjamin M Hogan, Teun P de Boer, Jeroen Bakkers, Kelly A Smith

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The establishment of cardiac function in the developing embryo is essential to ensure blood flow and, therefore, growth and surviv..

Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo

Smrita Chaudhury, Kazuhide S Okuda, Katarzyna Koltowska, Anne K Lagendijk, Scott Paterson, Gregory J Baillie, Cas Simons, Kelly A Smith, Benjamin M Hogan, Neil Bower

Journal article  |  2020  |  DEVELOPMENT

The lymphatic vasculature develops primarily from pre-existing veins. A pool of lymphatic endothelial cells (LECs) first sprouts f..

Talkin' 'bout regeneration: new advances in cardiac regeneration using the zebrafish

Kelly A Smith, Mathilda TM Mommersteeg

Journal article  |  2020  |  CURRENT OPINION IN PHYSIOLOGY

The adult human heart has a very poor capacity to repair itself following injury. During heart attack, an enormous amount of cardi..

The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage

Sungmin Baek, Tae Gyu Oh, Genevieve Secker, Drew L Sutton, Kazuhide S Okuda, Scott Paterson, Neil I Bower, John Toubia, Katarzyna Koltowska, Samuel J Capon, Gregory J Baillie, Cas Simons, George EO Muscat, Anne K Lagendijk, Kelly A Smith, Natasha L Harvey, Benjamin M Hogan

Journal article  |  2019  |  DEVELOPMENTAL CELL

The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The..