Charis En-Yi Teh

MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3( )regulatory T cells

Charis E Teh, Alissa K Robbins, Darren C Henstridge, Grant Dewson, Sarah T Diepstraten, Gemma Kelly, Mark A Febbraio, Sarah S Gabriel, Lorraine A O'Reilly, Andreas Strasser, Daniel HD Gray

Journal article  |  2020  |  Cell Death & Differentiation

FOXP3+ regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related d..

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams

Journal article  |  2020  |  Oncogene

Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..

Characterization of a novel human BFL-1-specific monoclonal antibody

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells

Charis E Teh, Jia-Nan Gong, David Segal, Tania Tan, Cassandra J Vandenberg, Pasquale L Fedele, Michael SY Low, George Grigoriadis, Simon J Harrison, Andreas Strasser, Andrew W Roberts, David CS Huang, Garry P Nolan, Daniel HD Gray, Melissa E Ko

Journal article  |  2020  |  Cell Death & Differentiation

Multiple myeloma is an incurable and fatal cancer of immunoglobulin-secreting plasma cells. Most conventional therapies aim to ind..

Deletion of self-reactive CCR7-thymocytes in the absence of MHC expression on thymic epithelial cells

Rushika C Wirasinha, Anna Chan, Jin Yan Yap, Daniel Y Hu, Charis E Teh, Daniel HD Gray, Christopher C Goodnow, Stephen R Daley

Journal article  |  2019  |  Cell Death & Differentiation

The selection of αβ T cells in the thymus is punctuated by checkpoints at which thymocytes differentiate or undergo apoptosis. Wav..

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella R Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E Lew, Ian J Majewski, Daniel HD Gray, David A Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David CS Huang, Andrew W Roberts

Journal article  |  2019  |  Cancer Discovery

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.

Journal article  |  2019  |  Cancer Discovery

Targeting Mcl-1 is a promising strategy to kill mantle cell lymphoma cells

Michael A Dengler, Charis E Teh, Marco J Herold, Andrew W Roberts, Jerry M Adams

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Rishu Agarwal, Yih-Chih Chan, Constantine S Tam, Tane Hunter, Dane Vassiliadis, Charis E Teh, Rachel Thijssen, Paul Yeh, Stephen Q Wong, Sarah Ftouni, Enid YN Lam, Mary Ann Anderson, Christiane Pott, Omer Gilan, Charles C Bell, Kathy Knezevic, Piers Blombery, Kathleen Rayeroux, Adrian Zordan, Jason Li, et al.

Journal article  |  2019  |  Nature Medicine

Combined BCL-2 and HDAC Targeting Has Potent and TP53 Independent Activity in AML

Jessica M Salmon, Giovanna Pomilio, Donia M Moujalled, Sarah Macraild, Charis E Teh, Sewa Riajl, Adam Ivey, Tse-Chieh Teh, Paul G Ekert, Laurence Kraus-Berthier, Ioana Kloos, Marie Schoumacher, Daniel Gray, Andrew H Wei

Conference Proceedings  |  2018  |  Blood

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jianan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas Lew, Ian Majewski, Daniel Gray, David Alan Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David Huang, Andrew W Roberts

Conference Proceedings  |  2018  |  Blood

Characterization of Blimp-1 function in effector regulatory T cells

Erika Cretney, Patrick SK Leung, Stephanie Trezise, Dane M Newman, Lucille C Rankin, Charis E Teh, Tracy L Putoczki, Daniel HD Gray, Gabrielle T Belz, Lisa A Mielke, Sheila Dias, Stephen L Nutt

Journal article  |  2018  |  Journal of Autoimmunity

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice

Kerstin Brinkmann, Stephanie Grabow, Craig D Hyland, Charis E Teh, Warren S Alexander, Marco J Herold, Andreas Strasser

Journal article  |  2017  |  Cell Death & Differentiation

Cell death and thymic tolerance

Stephen R Daley, Charis Teh, Daniel Y Hu, Andreas Strasser, Daniel HD Gray

Journal article  |  2017  |  Immunological Reviews

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment

Robyn L Schenk, Selma Tuzlak, Emma M Carrington, Yifan Zhan, Susanne Heinzel, Charis E Teh, Daniel H Gray, Lin Tai, Andrew M Lew, Andreas Villunger, Andreas Strasser, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, et al.

Journal article  |  2016  |  NATURE COMMUNICATIONS

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Eva M Putz, Kimberley Stannard, Jian-Guo Zhang, Charis Teh, Matt Firth, Takashi Ushiki, Christopher E Andoniou, Mariapia A Degli-Esposti, Phillip P Sharp, Caroline E Sanvitale, Giuseppe Infusini, Nicholas PD Liau, Edmond M Linossi, Christopher J Burns, Sebastian Carotta, et al.

Journal article  |  2016  |  Nature Immunology

Can you rely on Treg cells on the rebound?

Charis E Teh, Daniel HD Gray

Journal article  |  2014  |  European Journal of Immunology

Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation

CE Teh, K Horikawa, CN Arnold, B Beutler, EM Kucharska, CG Vinuesa, EM Bertram, CC Goodnow, A Enders

Journal article  |  2013  |  Genes & Immunity

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8(-) dendritic cells require the intramembrane endopeptidase SPPL2A

Hannes Bergmann, Mehmet Yabas, Alanna Short, Lisa Miosge, Nadine Barthel, Charis E Teh, Carla M Roots, Katherine R Bull, Yogesh Jeelall, Keisuke Horikawa, Belinda Whittle, Bhavani Balakishnan, Geoff Sjollema, Edward M Bertram, Fabienne Mackay, Andrew J Rimmer, Richard J Cornall, Matthew A Field, T Daniel Andrews, Christopher C Goodnow, et al.

Journal article  |  2013  |  The Journal of Experimental Medicine

ZBTB7B (Th-POK) Regulates the Development of IL-17-Producing CD1d-Restricted Mouse NKT Cells

Anselm Enders, Sanda Stankovic, Charis Teh, Adam P Uldrich, Mehmet Yabas, Torsten Juelich, John A Altin, Sandra Frankenreiter, Hannes Bergmann, Carla M Roots, Konstantinos Kyparissoudis, Chris C Goodnow, Dale I Godfrey

Journal article  |  2012  |  Journal of Immunology

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

Diego G Silva, Stephen R Daley, Jennifer Hogan, Sau K Lee, Charis E Teh, Daniel Y Hu, Kong-Peng Lam, Christopher C Goodnow, Carola G Vinuesa

Journal article  |  2011  |  DIABETES

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

Mehmet Yabas, Charis E Teh, Sandra Frankenreiter, Dennis Lal, Carla M Roots, Belinda Whittle, Daniel T Andrews, Yafei Zhang, Narci C Teoh, Jonathan Sprent, Lina E Tze, Edyta M Kucharska, Jennifer Kofler, Geoffrey C Farell, Stefan Broeer, Christopher C Goodnow, Anselm Enders

Journal article  |  2011  |  NATURE IMMUNOLOGY

Visualizing the Role of Cbl-b in Control of Islet-Reactive CD4 T Cells and Susceptibility to Type 1 Diabetes

Gerard F Hoyne, Eleanor Flening, Mehmet Yabas, Charis Teh, John A Altin, Katrina Randall, Christine BF Thien, Wallace Y Langdon, Christopher C Goodnow

Journal article  |  2011  |  Journal of Immunology

T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency

Charis E Teh, Stephen R Daley, Anselm Enders, Christopher C Goodnow

Journal article  |  2010  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells

Jun Wang, Seungsoo Lee, Charis En-Yi Teh, Karen Bunting, Lina Ma, M Frances Shannon

Journal article  |  2009  |  INTERNATIONAL IMMUNOLOGY