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Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32..
Displaying the 23 most recent scholarly works by Natasha Holmes.
Adverse reactions to vancomycin and cross-reactivity with other antibiotics
Joseph F De Luca, Natasha E Holmes, Jason A Trubiano
Journal article | 2020 | Current Opinion in Allergy & Clinical Immunology
PURPOSE OF REVIEW: Glycopeptide antibiotics such as vancomycin are frequently utilized to treat resistant Gram-positive infections..
Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype.
Nontaya Nakkam, Andrew Gibson, Effie Mouhtouris, Katherine C Konvinse, Natasha Holmes, Kyra Y Chua, Pooja Deshpande, Danmeng Li, David A Ostrov, Jason Trubiano, Elizabeth J Phillips
Journal article | 2020 | Journal of Allergy and Clinical Immunology
CAPSULE SUMMARY: All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to d..
Development and Validation of a Penicillin Allergy Clinical Decision Rule
Jason A Trubiano, Sara Vogrin, Kyra YL Chua, Jack Bourke, James Yun, Abby Douglas, Cosby A Stone, Roger Yu, Lauren Groenendijk, Natasha E Holmes, Elizabeth J Phillips
Journal article | 2020 | JAMA Internal Medicine
Importance: Penicillin allergy is a significant public health issue for patients, antimicrobial stewardship programs, and health s..
Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal beta-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia A Randomized Clinical Trial
Steven YC Tong, David C Lye, Dafna Yahav, Archana Sud, J Owen Robinson, Jane Nelson, Sophia Archuleta, Matthew A Roberts, Alan Cass, David L Paterson, Hong Foo, Mical Paul, Stephen D Guy, Adrian R Tramontana, Genevieve B Walls, Stephen McBride, Narin Bak, Niladri Ghosh, Benjamin A Rogers, Anna P Ralph, et al.
Journal article | 2020 | JAMA
Importance: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with mortality of more than 20%. Combining..
Using language descriptors to recognise delirium: a survey of clinicians and medical coders to identify delirium-suggestive words
Natasha E Holmes, Sobia Amjad, Marcus Young, David J Berlowitz, Rinaldo Bellomo
Journal article | 2019 | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
OBJECTIVE: To develop a library of delirium-suggestive words. DESIGN: Cross-sectional survey. SETTING: Single tertiary referral ho..
Bartonella Quintana prosthetic aortitis successfully treated with doxycycline
Zaal Meher-Homji, Stephen R Graves, Jason Trubiano, Natasha E Holmes
Journal article | 2019 | BMJ Case Reports
Bartonella quintana is a rare cause of culture-negative endovascular infection, characterised by intracellular persistence. We des..
High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing
Zaal Meher-Homji, Constantine S Tam, Jim Siderov, John Francis Seymour, Natasha E Holmes, Kyra YL Chua, Elizabeth J Phillips, Monica A Slavin, Jason A Trubiano
Journal article | 2019 | Leukemia & Lymphoma
The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study
Jason A Trubiano, Olivia Smibert, Abby Douglas, Misha Devchand, Belinda Lambros, Natasha E Holmes, Kyra Y Chua, Elizabeth J Phillips, Monica A Slavin
Journal article | 2018 | Open Forum Infectious Diseases
Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia
Stefano G Giulieri, Sarah L Baines, Romain Guerillot, Torsten Seemann, Anders Goncalves da Silva, Mark Schultz, Ruth C Massey, Natasha E Holmes, Timothy P Stinear, Benjamin P Howden
Journal article | 2018 | Genome Medicine
Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia
Natasha E Holmes, J Owen Robinson, Sebastiaan J van Hal, Wendy J Munckhof, Eugene Athan, Tony M Korman, Allen C Cheng, John D Turnidge, Paul DR Johnson, Benjamin P Howden
Journal article | 2018 | BMC Infectious Diseases
An unexpected diagnosis of human immunodeficiency virus-2 infection in an overseas visitor: a case report.
Asma Sohail, Lyndal Van Leer, Natasha Holmes
Journal article | 2017 | BMC Research Notes
BACKGROUND: Human immunodeficiency virus 2 infection is endemic in West Africa but is also found in parts of Europe, North and Sou..
Genetic and Molecular Predictors of High Vancomycin MIC in Staphylococcus aureus Bacteremia Isolates
Natasha E Holmes, John D Turnidge, Wendy J Munckhof, J Owen Robinson, Tony M Korman, Matthew VN O'Sullivan, Tara L Anderson, Sally A Roberts, Sanchia JC Warren, Geoffrey W Coombs, Hui-Leen Tan, Wei Gao, Paul DR Johnson, Benjamin P Howden
Journal article | 2014 | Journal of Clinical Microbiology
Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia
NE Holmes, JD Turnidge, WJ Munckhof, JO Robinson, TM Korman, MVN O'Sullivan, TL Anderson, SA Roberts, SJC Warren, W Gao, PDR Johnson, BP Howden
Journal article | 2013 | Clinical Microbiology and Infection
Genomic analysis of teicoplanin resistance emerging during treatment of vanB vancomycin-resistant Enterococcus faecium infections in solid organ transplant recipients including donor-derived cases
Natasha E Holmes, Susan A Ballard, Margaret MC Lam, Paul DR Johnson, M Lindsay Grayson, Timothy P Stinear, Benjamin P Howden
Journal article | 2013 | Journal of Antimicrobial Chemotherapy
Honours, Awards and Fellowships
Robert and Elizabeth Albert Travel Grant
Victoria Fellowship (Life Sciences)
Young Investigator Award
FRACP - Fellow of the Royal Australasian College of Physicians
Medicine And Radiology
International Society for Travel Medicine
Infectious Diseases Society of America
Society for Healthcare Epidemiology of America
International Society for Infectious Diseases
European Society for Clinical Microbiology and Infectious Diseases
American Society for Microbiology
Australian Society for Antimicrobials
Australasian Society for Infectious Diseases
Australian Medical Association
Certificate in Clinical and Translational Science
Graduate Diploma of Clinical Education
University of Melbourne
Doctor of Philosophy
University of Melbourne
Graduate Certificate in Clinical Teaching
University of Melbourne
Bachelor of Medicine and Bachelor of Surgery