Natasha Holmes

The Penicillin Allergy Delabeling Program: A Multicenter Whole-of-Hospital Health Services Intervention and Comparative Effectiveness Study

Kyra YL Chua, Sara Vogrin, Susan Bury, Abby Douglas, Natasha E Holmes, Nixon Tan, Natasha K Brusco, Rebecca Hall, Belinda Lambros, Jacinta Lean, Wendy Stevenson, Misha Devchand, Kent Garrett, Karin Thursky, M Lindsay Grayson, Monica A Slavin, Elizabeth J Phillips, Jason A Trubiano

Journal article  |  2021  |  CLINICAL INFECTIOUS DISEASES

BACKGROUND: Penicillin allergies are associated with inferior patient and antimicrobial stewardship outcomes. We implemented a who..

Are surgical masks manufactured from sterilisation wrap safe?

Sam E Grigg, Andrea Zampiron, Farzan Akbaridoust, Dileep Chandran, Natasha E Holmes, Paul DR Johnson, Ivan Marusic, Daryl Jones

Journal article  |  2021  |  INFECTION DISEASE & HEALTH

BACKGROUND: Due to regional shortages some health services have proposed using surgical masks manufactured from sterilisation wrap..

The Role of Immunological and Clinical Biomarkers to Predict Clinical COVID-19 Severity and Response to Therapy-A Prospective Longitudinal Study

Ana Copaescu, Fiona James, Effie Mouhtouris, Sara Vogrin, Olivia C Smibert, Claire L Gordon, George Drewett, Natasha E Holmes, Jason A Trubiano

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Background: The association of pro-inflammatory markers such as interleukin-6 (IL-6) and other biomarkers with severe coronavirus ..

Clinical manifestations of invasive meningococcal disease in Victoria with the emergence of serogroup W and serogroup Y Neisseria meningitidis

Michael T Birrell, Janet Strachan, Natasha E Holmes, Kerrie Stevens, Benjamin P Howden, Lucinda J Franklin, Mihaela Ivan, Jason C Kwong

Journal article  |  2021  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: Historically, Australian cases of invasive meningococcal disease (IMD) have been most frequently caused by Neisseria m..

Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A*32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype

Nontaya Nakkam, Andrew Gibson, Effie Mouhtouris, Katherine C Konvinse, Natasha E Holmes, Kyra Y Chua, Pooja Deshpande, Danmeng Li, David A Ostrov, Jason Trubiano, Elizabeth J Phillips

Journal article  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CAPSULE SUMMARY: All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to d..

High Precursor Frequency and Promiscuity in Αβ T Cell Receptor Pairing Underpin CD8 T-Cell Responses to an Immunodominant SARS-CoV-2 Nucleocapsid Epitope

Thi Nguyen, Louise Rowntree, Jan Petersen, B Chua, Luca Hensen, Lukasz Kedzierski, van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer Habel, Wuji Zhang, Lily Allen, Linda Earnest, Kai Yan Mak, Jennifer Juno, Kathleen Wragg, Francesca Mordant, Fatima Amanat, Florian Krammer, Denise Doolan, et al.

Journal article  |  2020

T-cell responses to SARS-CoV-2-derived peptide pools have been documented, however it remains largely unclear whether prominent SA..

COVID-MATCH65-A prospectively derived clinical decision rule for severe acute respiratory syndrome coronavirus 2

Jason A Trubiano, Sara Vogrin, Olivia C Smibert, Nada Marhoon, Adrian A Alexander, Kyra YL Chua, Fiona L James, Nicholas RL Jones, Sam E Grigg, Cecilia LH Xu, Nasreen Moini, Sam R Stanley, Michael T Birrell, Morgan T Rose, Claire L Gordon, Jason C Kwong, Natasha E Holmes

Journal article  |  2020  |  PLOS ONE

OBJECTIVES: We report on the key clinical predictors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and..

Clinical evaluation of four commercial immunoassays for the detection of antibodies against established SARS-CoV-2 infection

Kyra YL Chua, Sara Vogrin, Intissar Bittar, Jennifer H Horvath, Hari Wimaleswaran, Jason A Trubiano, Natasha E Holmes, Que Lam

Journal article  |  2020  |  PATHOLOGY

A comparison of the clinical performance of the Elecsys Anti-SARS-CoV-2, Liaison SARS-CoV-2 S1/S2 IgG, Access SARS-CoV-2 IgG and V..

Matched Case-Control Study of the Long-Term Impact of Beta-Lactam Antibiotic Allergy Testing

Jason A Trubiano, Nada Marhoon, Sara Vogrin, Kyra YL Chua, Natasha E Holmes

Journal article  |  2020  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Whereas the short-term impacts of antibiotic allergy testing on delabeling and antibiotic usage have been demonstrated, the long-t..

PEN-FAST: A validated penicillin allergy clinical decision rule - Implications for prescribing

J Trubiano, S Vogrin, K Chua, J Bourke, J Yun, A Douglas, C Stone, N Holmes, E Phillips

Conference Proceedings  |  2020  |  INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES