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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in suscept..
Displaying the 6 most recent projects by James Wiley.
Displaying the 206 most recent scholarly works by James Wiley.
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Nikolas A Patsopoulos, Sergio E Baranzini, Adams Santaniello, Parisa Shoostari, Chris Cotsapas, Garrett Wong, Ashley H Beecham, Tojo James, Joseph Replogle, Ioannis S Vlachos, Cristin McCabe, Tune H Pers, Aaron Brandes, Charles White, Brendan Keenan, Maria Cimpean, Phoebe Winn, Ioannis-Pavlos Panteliadis, Allison Robbins, Till FM Andlauer, et al.
Journal article | 2019 | Science
The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases
Amber Ou, Ben J Gu, James S Wiley
Journal article | 2018 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Loss of Function of P2X7 Receptor Scavenger Activity in Aging Mice A Novel Model for Investigating the Early Pathogenesis of Age-Related Macular Degeneration
Kirstan A Vessey, Ben J Gu, Andrew I Jobling, Joanna A Phipps, Ursula Greferath, Mai X Tran, Michael A Dixon, Paul N Baird, Robyn H Guymer, James S Wiley, Erica L Fletcher
Journal article | 2017 | The American Journal of Pathology
Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis
A Dessa Sadovnick, Ben J Gu, Anthony L Traboulsee, Cecily Q Bernales, Mary Encarnacion, Irene M Yee, Maria G Criscuoli, Xin Huang, Amber Ou, Carol J Milligan, Steven Petrou, James S Wiley, Carles Vilarino-Guell
Journal article | 2017 | Human Mutation
Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease
Ben J Gu, Xin Huang, Amber Ou, Alan Rembach, Christopher Fowler, Pavan K Avula, Adam Horton, James D Doecke, Victor L Villemagne, S Lance Macaulay, Paul Maruff, Erica L Fletcher, Robyn Guymer, James S Wiley, Colin L Masters
Journal article | 2016 | Acta Neuropathologica
A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis
Ben J Gu, Judith Field, Sebastien Dutertre, Amber Ou, Trevor J Kilpatrick, Jeannette Lechner-Scott, Rodney Scott, Rodney Lea, Bruce V Taylor, Jim Stankovich, Helmut Butzkueven, Melissa Gresle, Simon M Laws, Steven Petrou, Sabine Hoffjan, Denis A Akkad, Colin A Graham, Stanley Hawkins, Anna Glaser, Sahl Khalid Bedri, et al.
Journal article | 2015 | Human Molecular Genetics
The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function
Judith Field, Fernando Shahijanian, Stephen Schibeci, Laura Johnson, Melissa Gresle, Louise Laverick, Grant Parnell, Graeme Stewart, Fiona McKay, Trevor Kilpatrick, Helmut Butzkueven, David Booth
Journal article | 2015 | PLOS ONE
The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells
Fernando Shahijanian, Grant P Parnell, Fiona C McKay, Prudence N Gatt, Maryam Shojoei, Kate S O'Connor, Stephen D Schibeci, Fabienne Brilot, Christopher Liddle, Marcel Batten, Graeme J Stewart, David R Booth
Journal article | 2014 | Human Molecular Genetics
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Ashley H Beecham, Nikolaos A Patsopoulos, Dionysia K Xifara, Mary F Davis, Anu Kemppinen, Chris Cotsapas, Tejas S Shah, Chris Spencer, David Booth, An Goris, Annette Oturai, Janna Saarela, Bertrand Fontaine, Bernhard Hemmer, Claes Martin, Frauke Zipp, Sandra D'Alfonso, Filippo Martinelli-Boneschi, Bruce Taylor, Hanne F Harbo, et al.
Journal article | 2013 | Nature Genetics
A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration
Ben J Gu, Paul N Baird, Kirstan A Vessey, Kristen K Skarratt, Erica L Fletcher, Stephen J Fuller, Andrea J Richardson, Robyn H Guymer, James S Wiley
Journal article | 2013 | FASEB Journal
Non-synonymous polymorphisms in the P2RX (4) are related to bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients
Anke Wesselius, Martijn JL Bours, Niklas R Jorgensen, James Wiley, Ben Gu, Svenjhalmar van Helden, Lodewijk van Rhijn, Pieter C Dagnelie
Journal article | 2013 | Purinergic Signalling
Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures
Niklas R Jorgensen, Lise B Husted, Kristen K Skarratt, Leanne Stokes, Charlotte L Tofteng, Torben Kvist, Jens-Erik B Jensen, Pia Eiken, Kim Brixen, Stephen Fuller, Rory Clifton-Bligh, Alison Gartland, Peter Schwarz, Bente L Langdahl, James S Wiley
Journal article | 2012 | European Journal of Human Genetics
P2X7 Receptor-mediated Scavenger Activity of Mononuclear Phagocytes toward Non-opsonized Particles and Apoptotic Cells Is Inhibited by Serum Glycoproteins but Remains Active in Cerebrospinal Fluid
Ben J Gu, James A Duce, Valentina A Valova, Bruce Wong, Ashley I Bush, Steven Petrou, James S Wiley
Journal article | 2012 | Journal of Biological Chemistry
Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women
Alison Gartland, Kristen K Skarratt, Lynne J Hocking, Claire Parsons, Leanne Stokes, Niklas Rye Jorgensen, William D Fraser, David M Reid, James A Gallagher, James S Wiley
Journal article | 2012 | European Journal of Human Genetics
Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X(7) receptor-deficient mice
Catherine M Miller, Alana M Zakrzewski, Rowan J Ikin, Nicola R Boulter, Marilyn Katrib, Michael P Lees, Stephen J Fuller, James S Wiley, Nicholas C Smith
Journal article | 2011 | International Journal for Parasitology
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data
Joanne H Wang, Derek Pappas, Philip L De Jager, Daniel Pelletier, Paul IW de Bakker, Ludwig Kappos, Chris H Polman, Lori B Chibnik, David A Hafler, Paul M Matthews, Stephen L Hauser, Sergio E Baranzini, Jorge R Oksenberg
Journal article | 2011 | Genome Medicine: medicine in the post-genomic era
A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis
Judith Field, Sharon R Browning, Laura J Johnson, Patrick Danoy, Michael D Varney, Brian D Tait, Kaushal S Gandhi, Jac C Charlesworth, Robert N Heard, Graeme J Stewart, Trevor J Kilpatrick, Simon J Foote, Melanie Bahlo, Helmut Butzkueven, James Wiley, David R Booth, Bruce V Taylor, Matthew A Brown, Justin P Rubio, Jim Stankovich
Journal article | 2010 | PLoS One
Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors.
Jimmy NSN Tran, Aleta Pupovac, Rosanne M Taylor, James S Wiley, Scott N Byrne, Ronald Sluyter
Journal article | 2010 | Experimental Dermatology
Extracellular ATP via the activation of purinergic P2 receptors has an emerging role in cutaneous biology; however, the distributi..
Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis.
SE Jamieson, AL Peixoto-Rangel, AC Hargrave, L-A de Roubaix, EJ Mui, NR Boulter, EN Miller, SJ Fuller, JS Wiley, L Castellucci, K Boyer, RG Peixe, MJ Kirisits, L de Souza Elias, JJ Coyne, R Correa-Oliveira, M Sautter, NC Smith, MP Lees, CN Swisher, et al.
Journal article | 2010 | Genes & Immunity
Congenital Toxoplasma gondii infection can result in intracranial calcification, hydrocephalus and retinochoroiditis. Acquired inf..
P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages.
Michael P Lees, Stephen J Fuller, Rima McLeod, Nicola R Boulter, Catherine M Miller, Alana M Zakrzewski, Ernest J Mui, William H Witola, Jessica J Coyne, Aubrey C Hargrave, Sarra E Jamieson, Jenefer M Blackwell, James S Wiley, Nicholas C Smith
Journal article | 2010 | The Journal of Immunology
The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown..
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Melanie Bahlo, David R Booth, Simon A Broadley, Matthew A Brown, Simon J Foote, Lyn R Griffiths, Trevor J Kilpatrick, Jeanette Lechner-Scott, Pablo Moscato, Victoria M Perreau, Justin P Rubio, Rodney J Scott, Jim Stankovich, Graeme J Stewart, Bruce V Taylor, James Wiley, Glynnis Clarke, Mathew B Cox, Peter A Csurhes, Patrick Danoy, et al.
Journal article | 2009 | Nature Genetics
P2X7 gene polymorphisms do not appear to be a susceptibility gene locus in sporadic cases of systemic lupus erythematosus.
SL Forchap, A Anandacoomarasamy, J Wicks, F Di Virgilio, OR Baricordi, M Rubini, F Trotta, J Wiley, N Manolios
Journal article | 2008 | Tissue Antigens
The P2X(7) receptor is a ligand-gated cation-selective channel that mediates ATP-induced apoptosis of cells of the immune system. ..
Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL.
Dalemari Crowther-Swanepoel, Ruth Wild, Gabrielle Sellick, Martin JS Dyer, Francesca R Mauro, Robert JG Cuthbert, Viggo Jonsson, Estella Matutes, Claire Dearden, James Wiley, Stephen Fuller, Daniel Catovsky, Richard S Houlston
Journal article | 2008 | Blood
To address the proposition that familial B-cell chronic lymphocytic leukemia (CLL) may exhibit a more restricted phenotype than sp..
Analysis of a large multi-generational family provides insight into the genetics of chronic lymphocytic leukemia.
Stephen J Fuller, Elli Papaemmanuil, Leah McKinnon, Emily Webb, Gabrielle S Sellick, Lan-Phuong Dao-Ung, Kristen K Skarratt, Dalemari Crowther, Richard S Houlston, James S Wiley
Journal article | 2008 | British Journal of Haematology
We report the genetic analysis of a large multi-generational family composed of 144 individuals in which 11 members have been diag..
Inhibition of the human P2X7 receptor by a novel protein tyrosine kinase antagonist.
Anne N Shemon, Ronald Sluyter, Leanne Stokes, Paul W Manley, James S Wiley
Journal article | 2008 | Biochemical and Biophysical Research Communications
A panel of 18 protein tyrosine kinase antagonists were tested for their inhibitory effect on human P2X(7) receptor-mediated (86)Rb..
Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes.
Ronald Sluyter, Anne N Shemon, William E Hughes, Ryan O Stevenson, Jennifer G Georgiou, Guy D Eslick, Rosanne M Taylor, James S Wiley
Journal article | 2007 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Over three decades ago, Parker and Snow (Am J Physiol 223: 888-893, 1972) demonstrated that canine erythrocytes undergo an increas..
A quantitative method for routine measurement of cell surface P2X(7) receptor function in leucocyte subsets by two-colour time-resolved flow cytometry
Claudia Jursik, Ronald Sluyter, Jennifer G Georgiou, Stephen J Fuller, James S Wiley, Ben J Gu
Journal article | 2007 | Journal of Immunological Methods
P2X(7) receptor activation causes phosphatidylserine exposure in human erythrocytes.
Ronald Sluyter, Anne N Shemon, James S Wiley
Journal article | 2007 | Biochemical and Biophysical Research Communications
Activation of cation channels causes erythrocyte phosphatidylserine (PS) exposure and cell shrinkage. Human erythrocytes express t..
A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis.
Suran L Fernando, Bernadette M Saunders, Ronald Sluyter, Kristen K Skarratt, Hazel Goldberg, Guy B Marks, James S Wiley, Warwick J Britton
Journal article | 2007 | American Journal of Respiratory and Critical Care Medicine
RATIONALE: Genetic variation influences susceptibility to clinical tuberculosis (TB). Activation of the P2X(7) receptor on human m..
Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes.
Anne N Shemon, Ronald Sluyter, James S Wiley
Journal article | 2007 | Immunology and Cell Biology
Phospholipase D (PLD) is a ubiquitous enzyme that can be activated by extracellular adenosine 5'-triphosphate (ATP) or phorbol 12-..
The genetic control of susceptibility to Mycobacterium tuberculosis.
WJ Britton, SL Fernando, BM Saunders, R Sluyter, JS Wiley
Conference Proceedings | 2007 | Novartis Foundation Symposium
Mycobacterium tuberculosis is one of the most successful human pathogens, surviv ing in latent foci of infection in one third of h..
Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray
Larissa Belov, Stephen P Mulligan, Nicole Barber, Adrian Woolfson, Mike Scott, Kerryn Stoner, Jeremy S Chrisp, William A Sewell, Kenneth F Bradstock, Linda Bendall, Dana S Pascovici, Mervyn Thomas, Wendy Erber, Pauline Huang, Mary Sartor, Graham AR Young, James S Wiley, Surender Juneja, William G Wierda, Anthony R Green, et al.
Journal article | 2006 | British Journal of Haematology
Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status.
Mia Thorsélius, Alexander Kröber, Fiona Murray, Ulf Thunberg, Gerard Tobin, Andreas Bühler, Dirk Kienle, Emilia Albesiano, Rossana Maffei, Lan-Phuong Dao-Ung, James Wiley, Juhani Vilpo, Anna Laurell, Mats Merup, Göran Roos, Karin Karlsson, Nicholas Chiorazzi, Roberto Marasca, Hartmut Döhner, Stephan Stilgenbauer, et al.
Journal article | 2006 | Blood
We recently reported that Swedish VH3-21-using chronic lymphocytic leukemia (CLL) patients showed restricted immunoglobulin gene f..
A Thr357to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7function and impairs ATP-induced mycobacterial killing by macrophages
AN Shemon, R Sluyter, SL Fernando, AL Clarke, LP Dao-Ung, KK Skarratt, BM Saunders, ST Khai, BJ Gu, SJ Fuller, WJ Britton, S Petrou, JS Wiley
Journal article | 2006 | Journal of Biological Chemistry
Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes.
Valérie Tanneur, Christophe Duranton, Verena B Brand, Ciprian D Sandu, Canan Akkaya, Ravi S Kasinathan, Christian Gachet, Ronald Sluyter, Julian A Barden, James S Wiley, Florian Lang, Stephan M Huber
Journal article | 2006 | The FASEB Journal
In human erythrocytes, infection by the malaria parasite Plasmodium falciparum or oxidative stress induces a new organic osmolyte ..
A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci.
Gabrielle S Sellick, Emily L Webb, Ruth Allinson, Estella Matutes, Martin JS Dyer, Viggo Jonsson, Anton W Langerak, Francesca R Mauro, Stephen Fuller, James Wiley, Matthew Lyttelton, Vincenzo Callea, Martin Yuille, Daniel Catovsky, Richard S Houlston
Journal article | 2005 | The American Journal of Human Genetics
Chronic lymphocytic leukemia (CLL) and other B-cell lymphoproliferative disorders (LPDs) show clear evidence of familial aggregati..
Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.
Jennifer G Georgiou, Kristen K Skarratt, Stephen J Fuller, Christopher J Martin, Richard I Christopherson, James S Wiley, Ronald Sluyter
Journal article | 2005 | Journal of Investigative Dermatology
Monocyte-derived dendritic cells (Mo-DC) express functional P2X7 receptors; however, the expression of these receptors on tissue-d..
Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages.
Suran L Fernando, Bernadette M Saunders, Ronald Sluyter, Kristen K Skarratt, James S Wiley, Warwick J Britton
Journal article | 2005 | The Journal of Infectious Diseases
BACKGROUND: Stimulation of the P2X7 purinergic receptor (P2X7) in bacille Calmette-Guerin (BCG)-infected human macrophages with ex..
Filamin A mutations cause periventricular heterotopia with Ehlers-Danlos syndrome
VL Sheen, A Jansen, MH Chen, E Parrini, T Morgan, R Ravenscroft, V Ganesh, T Underwood, J Wiley, R Leventer, RR Vaid, DE Ruiz, GM Hutchins, J Menasha, J Willner, Y Geng, KW Gripp, L Nicholson, E Berry-Kravis, A Bodell, et al.
Journal article | 2005 | Neurology
P2X7 receptor polymorphism impairs extracellular adenosine 5'-triphosphate-induced interleukin-18 release from human monocytes.
R Sluyter, JG Dalitz, JS Wiley
Journal article | 2004 | Genes & Immunity
Interleukin (IL)-18 is an important proinflammatory cytokine processed and released from cells of the monocyte lineage by activati..
Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor.
Ronald Sluyter, Anne N Shemon, Julian A Barden, James S Wiley
Journal article | 2004 | Journal of Biological Chemistry
Canine erythrocytes are known to undergo a reversible increase in cation permeability when incubated with extracellular ATP. We ha..
Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.
Anne N Shemon, Ronald Sluyter, Arthur D Conigrave, James S Wiley
Journal article | 2004 | British Journal of Pharmacology
1 Extracellular ATP can activate a cation-selective channel/pore on human B-lymphocytes, known as the P2X7 receptor. Activation of..
Association of the 1513C polymorphism in the P2X7 gene with familial forms of chronic lymphocytic leukaemia.
Lan-Phuong Dao-Ung, Stephen J Fuller, Ronald Sluyter, Kristen K SkarRatt, Ulf Thunberg, Gerard Tobin, Karen Byth, Maria Ban, Richard Rosenquist, Graeme J Stewart, James S Wiley
Journal article | 2004 | British Journal of Haematology
Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes.
Ronald Sluyter, Anne N Shemon, James S Wiley
Journal article | 2004 | The Journal of Immunology
Priming of monocytes with LPS produces large quantities of intracellular, biologically inactive IL-1beta that can be processed and..
A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria.
Bernadette M Saunders, Suran L Fernando, Ronald Sluyter, Warwick J Britton, James S Wiley
Journal article | 2003 | The Journal of Immunology
Protective immunity to mycobacterial infections requires activation of the antibacterial mechanisms of infected macrophages. It ha..
Autoimmune hemolysis associated with primary biliary cirrhosis responding to ursodeoxycholic acid as sole treatment.
SJ Fuller, P Kumar, M Weltman, JS Wiley
Journal article | 2003 | American Journal of Hematology
Coombs' positive autoimmune hemolytic anemia (AIHA) has been rarely described in association with primary biliary cirrhosis (PBC)...
Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors.
Ronald Sluyter, James S Wiley
Journal article | 2002 | International Immunology
Dendritic cells (DC) express a number of P2X receptors including the P2X7/P2Z receptor whose activation by extracellular adenosine..
Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors.
BJ Gu, WY Zhang, LJ Bendall, IP Chessell, GN Buell, JS Wiley
Journal article | 2000 | American Journal of Physiology-Cell Physiology
Lymphocytes from normal subjects and patients with B-chronic lymphocytic leukemia (B-CLL) show functional responses to extracellul..
Transendothelial migration of lymphocytes in chronic lymphocytic leukaemia is impaired and involved down-regulation of both L-selectin and CD23.
JR Chen, BJ Gu, LP Dao, CJ Bradley, SP Mulligan, JS Wiley
Journal article | 1999 | British Journal of Haematology
Chronic lymphocytic leukaemia (B-CLL) is characterized by a progressive accumulation of B lymphocytes in blood and bone marrow and..
P2Z purinoceptor, a special receptor for apoptosis induced by ATP in human leukemic lymphocytes.
L Peng, CJ Bradley, JS Wiley
Journal article | 1999 | Chinese Medical Journal
OBJECTIVE: To investigate the role of purinergic P2Z receptors for apoptosis of human leukemic lymphocytes mediated by extracellul..
Role of bivalent cations and choline in ATP-induced apoptosis of human lymphocytes with P2Z receptors.
P Liming, JS Wiley
Journal article | 1999 | Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences
The role of bivalent cations and choline in ATP-induced apoptosis via P2Z purinoceptor was investigated in human leukemic lymphocy..
Activation of the P2Z/P2X7 receptor in human lymphocytes produces a delayed permeability lesion: involvement of phospholipase D.
KC Fernando, CE Gargett, JS Wiley
Journal article | 1999 | Archives of Biochemistry and Biophysics
Leukemic lymphocytes possess a cytolytic P2Z/P2X7 receptor which, when activated by extracellular ATP, opens a Ca2+- and Ba2+-perm..
Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel.
JS Wiley, CE Gargett, W Zhang, MB Snook, GP Jamieson
Journal article | 1998 | American Journal of Physiology-Cell Physiology
Extracellular ATP is known to trigger apoptosis of thymocytes and lymphocytes through a P2Z receptor at which ATP is a partial ago..
[Study on apoptosis of leukemic lymphocytes mediated by purinergic P2z receptors].
L Peng, CJ Bradley, JS Wiley
Journal article | 1998 | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
OBJECTIVE: To investigate the role of purinergic P2z receptors in human leukemic lymphocyte apoptosis induced by extracellular ade..
Flow cytometric studies of nucleoside transport regulation in single chromaffin cells.
RP Sen, EG Delicado, A Alvarez, AM Brocklebank, JS Wiley, MT Miras-Portugal
Journal article | 1998 | FEBS Letters
The present paper reveals that a fluorescent derivative of nitrobenzylthioinosine, 5-(SAENTA-x8)-fluorescein, is a highly specific..
The functional phenotype of the primitive plasma cell in patients with multiple myeloma correlates with the clinical state.
B Pope, RD Brown, J Gibson, A Petersen, J Wiley, DE Joshua
Journal article | 1997 | Leukemia & Lymphoma
The malignant plasma cells from patients with multiple myeloma display considerable phenotypic heterogeneity. All plasma cells exp..
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.
CE Gargett, JS Wiley
Journal article | 1997 | British Journal of Pharmacology
1. Extracellular adenosine 5'-triphosphate (ATP) is an agonist for a P2Z receptor on human lymphocytes which mediates opening of a..
Nucleoside transporters, bcl-2 and apoptosis in CLL cells exposed to nucleoside analogues in vitro.
AJ Petersen, RD Brown, J Gibson, B Pope, XF Luo, L Schutz, JS Wiley, DE Joshua
Journal article | 1996 | European Journal of Haematology
The purine nucleoside analogues fludarabine (F1) and chlorodeoxyadenosine (2-CdA) are considered to be cell cycle specific agents ..
Extracellular ATP causes of loss of L-selectin from human lymphocytes via occupancy of P2Z purinocepters.
GP Jamieson, MB Snook, PJ Thurlow, JS Wiley
Journal article | 1996 | Journal of Cellular Physiology
Lymphocytes from normal subjects or patients with chronic lymphocytic leukemia are known to possess receptors for extracellular AT..
Phospholipase D activation by P2Z-purinoceptor agonists in human lymphocytes is dependent on bivalent cation influx.
CE Gargett, EJ Cornish, JS Wiley
Journal article | 1996 | Biochemical Journal
The role of bivalent cations in ATP-stimulated phospholipase D (PLD) activity was investigated in human leukaemic lymphocytes. Cel..
Agonists for endothelial P2 purinoceptors trigger a signalling pathway producing Ca2 responses in lymphocytes adherent to endothelial cells.
JS Wiley, JR Chen, GP Jamieson, PJ Thurlow
Journal article | 1995 | Biochemical Journal
Recirculation of lymphocytes through the body involves their frequent adhesion to endothelial cells but little is known of the sig..
Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis.
J Pressacco, JS Wiley, GP Jamieson, C Erlichman, DW Hedley
Journal article | 1995 | British Journal of Cancer
Expression of the equilibrative, S-(p-nitrobenzyl)-6-thioinosine (NBMPR)-sensitive nucleoside transporter (es), a component of the..
Various cells release a stable small molecule that inhibits endothelium-dependent relaxation.
JJ Liu, B Xie, PJ Thurlow, JS Wiley, JR Chen
Journal article | 1995 | American Journal of Physiology-Heart and Circulatory Physiology
Previous studies have shown that neutrophils release a stable factor that inhibits endothelium-dependent relaxation. In the presen..
Reduction of pulmonary toxicity by prednisolone prophylaxis during all-trans retinoic acid treatment of acute promyelocytic leukemia. Australian Leukaemia Study Group.
JS Wiley, FC Firkin
Journal article | 1995 | Leukemia
All-trans retinoic acid (ATRA) induces complete remission (CR) in most cases of acute promyelocytic leukemia (APL) but its use is ..
Extracellular ATP increases NH4 permeability in human lymphocytes by opening a P2Z purinoceptor operated ion channel.
JR Chen, GP Jamieson, JS Wiley
Journal article | 1994 | Biochemical and Biophysical Research Communications
The permeability of lymphocytes to NH4+ was examined by measuring intracellular pH using the fluorescent pH-sensitive dye BCECF. A..
The P2Z-purinoceptor of human lymphocytes: actions of nucleotide agonists and irreversible inhibition by oxidized ATP.
JS Wiley, JR Chen, MB Snook, GP Jamieson
Journal article | 1994 | British Journal of Pharmacology
1. Extracellular adenosine triphosphate (ATP) is known to open a receptor-operated ion channel (P2Z class) in human lymphocytes wh..
Multiple myeloma: expression of nucleoside transporters on malignant plasma cells and their relationship to cellular proliferation.
AJ Petersen, RD Brown, BB Pope, GP Jamieson, AR Paterson, J Gibson, JS Wiley, DE Joshua
Journal article | 1994 | Leukemia & Lymphoma
The expression of nucleoside transporters is a limiting factor in the pharmacology of the nucleoside analogue, cytosine arabinosid..
X-linked pyridoxine-responsive sideroblastic anemia due to a Thr388-to-Ser substitution in erythroid 5-aminolevulinate synthase.
TC Cox, SS Bottomley, JS Wiley, MJ Bawden, CS Matthews, BK May
Journal article | 1994 | New England Journal of Medicine
BACKGROUND: X-linked sideroblastic anemia is usually associated with reduced 5-aminolevulinate synthase activity in erythroid cell..
Conjugates of fluorescein and saenta (5'-s-(2-aminoethyl)-iv6-(4-nitrobenzyl)-s -thioadenosine): Flow cytometry probes for the es nucleoside transporter elements of the plasma membrane
JK Buolamwini, ARP Paterson, WP Gati, JD Craik, CE Cass, JS Wiley, MJ Robins
Journal article | 1994 | Nucleosides and Nucleotides
ASSESSMENT OF PROLIFERATIVE RESPONSES TO GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) IN ACUTE MYELOID-LEUKEMIA USING A FLUORESCENT LIGAND FOR THE NUCLEOSIDE TRANSPORTER
JS WILEY, JS CEBON, GP JAMIESON, J SZER, J GIBSON, RK WOODRUFF, JJ MCKENDRICK, WP SHERIDAN, JC BIGGS, MB SNOOK, AM BROCKLEBANK, MC RALLINGS, ARP PATERSON
Journal article | 1994 | Leukemia
The ATP4- receptor-operated channel (P2Z class) of human lymphocytes allows Ba2 and ethidium uptake: inhibition of fluxes by suramin.
JS Wiley, R Chen, GP Jamieson
Journal article | 1993 | Archives of Biochemistry and Biophysics
It is now recognized that extracellular ATP can open a receptor-operated ion channel in a variety of cell types. In human lymphocy..
Flow cytometric quantitation of nucleoside transporter sites on human leukemic cells.
GP Jamieson, AM Brocklebank, MB Snook, WH Sawyer, JK Buolamwini, AR Paterson, JS Wiley
Journal article | 1993 | Cytometry
Quantitation of equilibrative, nitrobenzylthioinosine (NBMPR) sensitive (es) nucleoside transporters on blast cells isolated from ..
All-trans retinoic acid in the treatment of acute promyelocytic leukaemia.
KL White, JS Wiley, T Frost, JJ McKendrick, RP Hermann, M Seldon, A Enno, R Bell, I Bunce, K Taylor
Journal article | 1992 | Australian and New Zealand journal of medicine
All-trans-retinoic acid (ATRA) is known to induce differentiation of promyelocytes in vitro and also to induce remission of acute ..
The ATP4- receptor-operated ion channel of human lymphocytes: inhibition of ion fluxes by amiloride analogs and by extracellular sodium ions.
JS Wiley, R Chen, MJ Wiley, GP Jamieson
Journal article | 1992 | Archives of Biochemistry and Biophysics
Extracellular ATP is known to increase the membrane permeability of a variety of cells. Addition of ATP to human leukemic lymphocy..
A new fluorescent probe for the equilibrative inhibitor-sensitive nucleoside transporter. 5'-S-(2-aminoethyl)-N6-(4-nitrobenzyl)-5'-thioadenosine (SAENTA)-chi 2-fluorescein.
JS Wiley, AM Brocklebank, MB Snook, GP Jamieson, WH Sawyer, JD Craik, CE Cass, MJ Robins, DP McAdam, AR Paterson
Journal article | 1991 | Biochemical Journal
The N6-(4-nitrobenzyl) derivative of adenosine is a tight-binding inhibitor of the equilibrative inhibitor-sensitive nucleoside tr..
Extracellular ATP stimulates an amiloride-sensitive sodium influx in human lymphocytes.
JS Wiley, GP Jamieson, W Mayger, EJ Cragoe, M Jopson
Journal article | 1990 | Archives of Biochemistry and Biophysics
Extracellular ATP has been shown to increase the Na+ permeability of human lymphocytes by 3 to 12-fold. The kinetics of this ATP-i..
Saturation of intracellular cytosine arabinoside triphosphate accumulation in human leukemic blast cells.
GP Jamieson, MB Snook, JS Wiley
Journal article | 1990 | Leukemia Research
Accumulation of cytosine arabinoside triphosphate (araCTP) from a range of cytosine arabinoside (araC) concentrations (1-50 microM..
Hereditary stomatocytosis: consistent association with an integral membrane protein deficiency.
SW Eber, WM Lande, TA Iarocci, WC Mentzer, P Höhn, JS Wiley, W Schröter
Journal article | 1989 | British Journal of Haematology
We studied the RBC membrane proteins of four patients, including a mother and daughter, with hereditary stomatocytosis. One- and t..
Nucleoside transport in acute leukaemia and lymphoma: close relation to proliferative rate.
JS Wiley, MB Snook, GP Jamieson
Journal article | 1989 | British Journal of Haematology
The proliferation of mammalian cells requires nucleosides which are provided either by de novo synthesis or by influx of nucleosid..
Transport and metabolism of 1-beta-D-arabinofuranosylcytosine in human ovarian adenocarcinoma cells.
GP Jamieson, MB Snook, TR Bradley, I Bertoncello, JS Wiley
Journal article | 1989 | Cancer Research
1-beta-D-Arabinofuranosylcytosine (araC) is an effective drug in the i.p. therapy of ovarian carcinoma but little is known of its ..
Cytosine arabinoside in the treatment of T-cell acute lymphoblastic leukemia.
JS Wiley, RK Woodruff, GP Jamieson, FC Firkin, WH Sawyer
Journal article | 1987 | Australian and New Zealand Journal of Medicine
The place of cytosine arabinoside (araC) in the treatment of T-cell acute lymphoblastic leukemia was studied by measuring nucleosi..
The use of 125I labelled staphylococcal protein A in the diagnosis of autoimmune thrombocytopenic purpura and other immune mediated thrombocytopenias.
JM Connellan, M Quinn, JS Wiley
Journal article | 1986 | Pathology
Platelet-associated immunoglobulin (IgG) has been measured directly on platelets from normal and thrombocytopenic subjects by a mo..
Nucleoside transport and cytosine arabinoside (araC) metabolism in human T lymphoblasts resistant to araC, thymidine and 6-methylmercaptopurine riboside.
I Young, GJ Young, JS Wiley, MB van der Weyden
Journal article | 1985 | European Journal of Cancer and Clinical Oncology
Alteration in cellular nucleoside transport characteristics, deoxynucleoside triphosphate (dNTP) pools and araCTP formation from c..
Effect of magnesium on passive fluxes of lithium in the human erythrocyte.
JS Wiley, L Bonacquisto, AE Doyle
Journal article | 1985 | Clinical and Experimental Pharmacology and Physiology
Extracellular Mg2+ is known to inhibit the passive Na+ and K+ fluxes in the human erythrocyte. In this study the effect of extrace..
Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma.
JS Wiley, J Taupin, GP Jamieson, M Snook, WH Sawyer, LR Finch
Journal article | 1985 | Journal of Clinical Investigation
Cytosine arabinoside (araC) has proven efficacy in acute myeloid leukemia (AML), but its place in the treatment of acute lymphobla..
Estimation of platelet size by measurement of intracellular water space using an oil technique.
JS Wiley, MA Quinn, JM Connellan
Journal article | 1983 | Thrombosis Research
The intracellular water space of human platelets has been measured after equilibration with tritiated water and then separating th..
Hereditary spherocytosis of man. Defective cytoskeletal interactions in the erythrocyte membrane.
WH Sawyer, JS Hill, GJ Howlett, JS Wiley
Journal article | 1983 | Biochemical Journal
Hereditary spherocytosis (HS) is an inherited abnormality of red cell shape and results from defective interactions amongst the co..
Chronic lymphatic leukemia developing in a patient with multiple myeloma: immunologic demonstration of a clonally distinct second malignancy.
JR Zalcberg, FN Cornell, HJ Ireton, KM McGrath, R McLachlan, RK Woodruff, JS Wiley
Journal article | 1982 | Cancer
A patient with multiple myeloma who subsequently developed chronic lymphocytic leukemia is reported. Initial studies demonstrated ..
Hereditary spherocytosis of man. Altered binding of cytoskeletal components to the erythrocyte membrane.
JS Hill, WH Sawyer, GJ Howlett, JS Wiley
Journal article | 1982 | Biochemical Journal
Human erythrocytes possess a lattice work of extrinsic proteins on the inner face of the membrane (;cytoskeleton') that maintains ..
Cytosine arabinoside influx and nucleoside transport sites in acute leukemia.
JS Wiley, SP Jones, WH Sawyer, AR Paterson
Journal article | 1982 | Journal of Clinical Investigation
Although cytosine arabinoside (araC) can induce a remission in a majority of patients presenting with acute myeloblastic leukemia ..
Acanthocytosis and haemolytic anaemia due to the McLeod blood group.
RK Woodruff, JS Wiley, WR Bell, AJ McPherson, DS Ford
Journal article | 1981 | Australian and New Zealand Journal of Medicine
A fourteen-year-old boy presenting with marked acanthocytosis of the red blood cells and a compensated haemolytic anaemia was show..
Molecular stability of Hb Philly (alpha 2 beta 2 35(Cl) Tyr leads to Phe). Rhe relationship of hemoglobin stability to ligand state as defined by heat and mechanical shaking tests.
T Asakura, K Adachi, E Schwartz, J Wiley
Journal article | 1981 | Hemoglobin
The molecular stability of Hb Philly (alpha 2 beta 2 35(Cl) Tyr leads to Phe) with different ligand states was compared with that ..
Increased sodium permeability of erythrocytes in spontaneously hypertensive rats.
JS Wiley, JS Hutchinson, FA Mendelsohn, AE Doyle
Journal article | 1980 | Clinical and Experimental Pharmacology and Physiology
1. The Na permeability of red cells from spontaneously hypertensive rats (SHR) has been studied. In the Japanese Wister-Kyoto stra..
Hereditary stomatocytosis: association of low 2,3-diphosphoglycerate with increased cation pumping by the red cell.
JS Wiley, RA Cooper, K Adachi, T Asakura
Journal article | 1979 | British Journal of Haematology
The levels of glycolytic intermediates have been measured in red cells from patients with both overhydrated and dehydrated varieti..
Inhibition of cation cotransport by cholesterol enrichment of human red cell membranes.
JS Wiley, RA Cooper
Journal article | 1975 | Biochimica et Biophysica Acta (BBA) - Biomembranes
1. Human red cells were enriched with cholesterol by incubation with lipid dispersions having a high cholesterol: phospholipid mol..
Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect.
RA Cooper, EC Arner, JS Wiley, SJ Shattil
Journal article | 1975 | Journal of Clinical Investigation
Cholesterol-rich membranes are the hallmark of "spur" red cells. Spur cells accumulate cholesterol from cholesterol-rich serum lip..
Some aspects of adenosine triphosphate synthesis from adenine and adenosine in human red blood cells.
R Whittam, JS Wiley
Journal article | 1968 | The Journal of Physiology
1. The synthesis of ATP has been studied in human erythrocytes. Fresh cells showed no net synthesis of ATP when incubated with ade..
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