Kate Dziegielewska

Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide

Liam M Koehn, Katarzyna M Dziegielewska, Kjeld Mollgard, Elodie Saudrais, Nathalie Strazielle, Jean-Francois Ghersi-Egea, Norman R Saunders, Mark D Habgood

Journal article  |  2019  |  SCIENTIFIC REPORTS

Recent Developments in Understanding Barrier Mechanisms in the Developing Brain: Drugs and Drug Transporters in Pregnancy, Susceptibility or Protection in the Fetal Brain?

Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood

Journal article  |  2019  |  ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59

Determinants of drug entry into the developing brain.

Liam Koehn, Mark Habgood, Yifan Huang, Katarzyna Dziegielewska, Norman Saunders

Journal article  |  2019  |  F1000Research

Background: A major concern for clinicians in prescribing medications to pregnant women and neonates is the possibility that drugs..

Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain

Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood

Journal article  |  2018  |  JOURNAL OF PHYSIOLOGY-LONDON

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development

Kjeld Mollgard, Katarzyna M Dziegielewska, Camilla B Holst, Mark D Habgood, Norman R Saunders

Journal article  |  2017  |  SCIENTIFIC REPORTS

General Introduction to Barrier Mechanisms in the Central Nervous System

Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood

Book Chapter  |  2017

General Introduction to Barrier Mechanisms in the Central Nervous System

NR SAUNDERS, KM Dziegielewska, K Møllgård,, MD Habgood

Book Chapter  |  2017

A bipedal mammalian model for spinal cord injury research: The tammar wallaby.

Norman R Saunders, Katarzyna M Dziegielewska, Sophie C Whish, Lyn A Hinds, Benjamin J Wheaton, Yifan Huang, Steve Henry, Mark D Habgood

Journal article  |  2017  |  F1000Res

Background: Most animal studies of spinal cord injury are conducted in quadrupeds, usually rodents. It is unclear to what extent f..

Delayed astrocytic contact with cerebral blood vessels in FGF-2 deficient mice does not compromise permeability properties at the developing blood-brain barrier

Norman R Saunders, Katarzyna M Dziegielewska, Klaus Unsicker, C Joakim Ek

Journal article  |  2016  |  Developmental Neurobiology

Neurotoxicology of barriers in the developing brain

NR Saunders, MD Habgood, KM Dziegielewska

Book Chapter  |  2016

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury.

Liam M Koehn, Natassya M Noor, Qing Dong, Sing-Yan Er, Lachlan D Rash, Glenn F King, Katarzyna M Dziegielewska, Norman R Saunders, Mark D Habgood

Journal article  |  2016  |  F1000Res

Tissue loss after spinal trauma is biphasic, with initial mechanical/haemorrhagic damage at the time of impact being followed by g..

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]

LM Koehn, Q Dong, SY Er, LD Rash, GF King, KM Dziegielewska, NR Saunders, MD Habgood

Journal article  |  2016  |  F1000Research

Tissue loss after spinal trauma is biphasic, with initial mechanical/haemorrhagic damage at the time of impact being followed by g..

The biological significance of brain barrier mechanisms: help or hindrance in drug delivery to the central nervous system?

Norman R Saunders, Mark D Habgood, Kjeld Møllgård, Katarzyna M Dziegielewska

Journal article  |  2016  |  F1000Res

Barrier mechanisms in the brain are important for its normal functioning and development. Stability of the brain's internal enviro..

Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood

Journal article  |  2015  |  FRONTIERS IN NEUROSCIENCE

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study

Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood, Matthew J Wakefield, Helen Lindsay, Nathalie Stratzielle, Jean-Francois Ghersi-Egea, Shane A Liddelow

Journal article  |  2015  |  FRONTIERS IN NEUROSCIENCE

Arrested development of the dorsal column following neonatal spinal cord injury in the opossum, Monodelphis domestica

Benjamin J Wheaton, Natassya M Noor, Katarzyna M Dziegielewska, Sophie Whish, Norman R Saunders

Journal article  |  2015  |  Cell and Tissue Research

The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions

Sophie Whish, Katarzyna M Dziegielewska, Kjeld Mollgard, Natassya M Noor, Shane A Liddelow, Mark D Habgood, Samantha J Richardson, Norman R Saunders

Journal article  |  2015  |  FRONTIERS IN NEUROSCIENCE

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

Norman R Saunders, Jean-Jacques Dreifuss, Katarzyna M Dziegielewska, Pia A Johansson, Mark D Habgood, Kjeld Mollgard, Hans-Christian Bauer

Journal article  |  2014  |  FRONTIERS IN NEUROSCIENCE

Cellular Specificity of the Blood-CSF Barrier for Albumin Transfer across the Choroid Plexus Epithelium

Shane A Liddelow, Katarzyna M Dziegielewska, Kjeld Mollgard, Sophie C Whish, Natassya M Noor, Benjamin J Wheaton, Renate Gehwolf, Andrea Wagner, Andreas Traweger, Hannelore Bauer, Hans-Christian Bauer, Norman R Saunders

Journal article  |  2014  |  PLOS ONE

Age-Dependent Transcriptome and Proteome Following Transection of Neonatal Spinal Cord of Monodelphis domestica (South American Grey Short-Tailed Opossum)

Norman R Saunders, Natassya M Noor, Katarzyna M Dziegielewska, Benjamin J Wheaton, Shane A Liddelow, David L Steer, C Joakim Ek, Mark D Habgood, Matthew J Wakefield, Helen Lindsay, Jessie Truettner, Robert D Miller, A Ian Smith, W Dalton Dietrich

Journal article  |  2014  |  PLOS ONE

Weight-Bearing Locomotion in the Developing Opossum, Monodelphis domestica following Spinal Transection: Remodeling of Neuronal Circuits Caudal to Lesion

Benjamin J Wheaton, Natassya M Noor, Sophie C Whish, Jessie S Truettner, W Dalton Dietrich, Moses Zhang, Peter J Crack, Katarzyna M Dziegielewska, Norman R Saunders

Journal article  |  2013  |  PLoS One

Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection.

Ingrid Kratzer, Shane A Liddelow, Norman R Saunders, Kate M Dziegielewska, Nathalie Strazielle, Jean-Francois Ghersi-Egea

Journal article  |  2013  |  Fluids Barriers CNS

BACKGROUND: The choroid plexuses are the interface between the blood and the cerebrospinal fluid (CSF) contained within the ventri..

Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach

Shane A Liddelow, Katarzyna M Dziegielewska, C Joakim Ek, Mark D Habgood, Hannelore Bauer, Hans-Christian Bauer, Helen Lindsay, Matthew J Wakefield, Nathalie Strazielle, Ingrid Kratzer, Kjeld Mollgard, Jean-Francois Ghersi-Egea, Norman R Saunders

Journal article  |  2013  |  PLOS ONE

Expression and Cellular Distribution of Ubiquitin in Response to Injury in the Developing Spinal Cord of Monodelphis domestica

Natassya M Noor, Kjeld Mollgard, Benjamin J Wheaton, David L Steer, Jessie S Truettner, Katarzyna M Dziegielewska, W Dalton Dietrich, A Ian Smith, Norman R Saunders

Journal article  |  2013  |  PLoS One

Transporters of the blood-brain and blood-CSF interfaces in development and in the adult

Norman R Saunders, Richard Daneman, Katarzyna M Dziegielewska, Shane A Liddelow

Journal article  |  2013  |  Molecular Aspects of Medicine

Delayed development of specific thyroid hormone-regulated events in transthyretin null mice

Julie A Monk, Natalie A Sims, Katarzyna M Dziegielewska, Roy E Weiss, Robert G Ramsay, Samantha J Richardson

Journal article  |  2013  |  American Journal of Physiology - Endocrinology and Metabolism

Immune responses at brain barriers and implications for brain development and neurological function in later life.

Helen B Stolp, Shane A Liddelow, Inês Sá-Pereira, Katarzyna M Dziegielewska, Norman R Saunders

Journal article  |  2013  |  Front Integr Neurosci

For a long time the brain has been considered an immune-privileged site due to a muted inflammatory response and the presence of p..

Pathological Changes in the White Matter after Spinal Contusion Injury in the Rat

C Joakim Ek, Mark D Habgood, Ross Dennis, Katarzyna M Dziegielewska, Carina Mallard, Benjamin Wheaton, Norman R Saunders

Journal article  |  2012  |  PLoS One

Barriers in the developing brain and Neurotoxicology

C Joakim Ek, Katarzyna M Dziegielewska, Mark D Habgood, Norman R Saunders

Journal article  |  2012  |  NeuroToxicology

Molecular Characterisation of Transport Mechanisms at the Developing Mouse Blood-CSF Interface: A Transcriptome Approach

Shane A Liddelow, Sally Temple, Kjeld Mollgard, Renate Gehwolf, Andrea Wagner, Hannelore Bauer, Hans-Christian Bauer, Timothy N Phoenix, Katarzyna M Dziegielewska, Norman R Saunders

Journal article  |  2012  |  PLoS One

Barrier mechanisms in the developing brain

Norman R Saunders, Shane A Liddelow, Katarzyna M Dziegielewska

Journal article  |  2012  |  Frontiers in Pharmacology

Age-Dependent Changes in the Proteome Following Complete Spinal Cord Transection in a Postnatal South American Opossum (Monodelphis domestica)

Natassya M Noor, David L Steer, Benjamin J Wheaton, C Joakim Ek, Jessie S Truettner, W Dalton Dietrich, Katarzyna M Dziegielewska, Samantha J Richardson, A Ian Smith, John L VandeBerg, Norman R Saunders

Journal article  |  2011  |  PLoS One

Spontaneous Development of Full Weight-Supported Stepping after Complete Spinal Cord Transection in the Neonatal Opossum, Monodelphis domestica

Benjamin J Wheaton, Jennifer K Callaway, C Joakim Ek, Katarzyna M Dziegielewska, Norman R Saunders

Journal article  |  2011  |  PLoS One

Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse

Helen B Stolp, Casmir Turnquist, Katarzyna M Dziegielewska, Norman R Saunders, Daniel C Anthony, Zoltan Molnar

Journal article  |  2011  |  Brain

SPARC/osteonectin, an endogenous mechanism for targeting albumin to the blood-cerebrospinal fluid interface during brain development

SA Liddelow, KM Dziegielewska, K Mollgard, TN Phoenix, S Temple, JL VandeBerg, NR Saunders

Journal article  |  2011  |  European Journal of Neuroscience

Modification of protein transfer across blood/cerebrospinal fluid barrier in response to altered plasma protein composition during development

SA Liddelow, KM Dziegielewska, JL VandeBerg, NM Noor, AM Potter, NR Saunders

Journal article  |  2011  |  European Journal of Neuroscience

Effects of neonatal systemic inflammation on blood-brain barrier permeability and behaviour in juvenile and adult rats.

HB Stolp, PA Johansson, MD Habgood, KM Dziegielewska, NR Saunders, CJ Ek

Journal article  |  2011  |  Cardiovascular Psychiatry and Neurology

Several neurological disorders have been linked to inflammatory insults suffered during development. We investigated the effects o..

Assessing Blood-Cerebrospinal Fluid Barrier Permeability in the Rat Embryo

Norman R Saunders, C Joakim Ek, Mark D Habgood, Pia Johansson, Shane Liddelow, Katarzyna M Dziegielewska

Book Chapter  |  2011  |  Methods in Molecular Biology

Development of the lateral ventricular choroid plexus in a marsupial, Monodelphis domestica.

Shane A Liddelow, Katarzyna M Dziegielewska, John L Vandeberg, Norman R Saunders

Journal article  |  2010  |  Cerebrospinal Fluid Research

BACKGROUND: Choroid plexus epithelial cells are the site of blood/cerebrospinal fluid (CSF) barrier and regulate molecular transfe..

Spatio-Temporal Progression of Grey and White Matter Damage Following Contusion Injury in Rat Spinal Cord

C Joakim Ek, Mark D Habgood, Jennifer K Callaway, Ross Dennis, Katarzyna M Dziegielewska, Pia A Johansson, Ann Potter, Benjamin Wheaton, Norman R Saunders

Journal article  |  2010  |  PLoS One

Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat

C Joakim Ek, Annamae Wong, Shane A Liddelow, Pia A Johansson, Katarzyna M Dziegielewska, Norman R Saunders

Journal article  |  2010  |  Toxicology Letters

The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9

Norman R Saunders, C Joakim Ek, Katarzyna M Dziegielewska

Journal article  |  2009  |  Nature Biotechnology

Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases

HB Stolp, KM Dziegielewska

Journal article  |  2009  |  Neuropathology and Applied Neurobiology

Factors involved in inflammation-induced developmental white matter damage

Helen B Stolp, C Joakim Ek, Pia A Johansson, Katarzyna M Dziegielewska, Nicole Bethge, Benjamin J Wheaton, Ann M Potter, Norman R Saunders

Journal article  |  2009  |  Neuroscience Letters

Cellular transfer of macromolecules across the developing choroid plexus of Monodelphis domestica

Shane A Liddelow, Katarzyna M Dziegielewska, C Joakim Ek, Pia A Johansson, Ann M Potter, Norman R Saunders

Journal article  |  2009  |  European Journal of Neuroscience

Low levels of Na, K-ATPase and carbonic anhydrase II during choroid plexus development suggest limited involvement in early CSF secretion

Pia Johansson, Katarzyna Dziegielewska, Norman Saunders

Journal article  |  2008  |  Neuroscience Letters

Barriers in the brain: a renaissance?

Norman R Saunders, C Joakim Ek, Mark D Habgood, Katarzyna M Dziegielewska

Journal article  |  2008  |  Trends in Neurosciences

The blood-CSF barrier explained: When development is not immaturity

Pia A Johansson, Katarzyna M Dziegielewska, Shane A Liddelow, Norman R Saunders

Journal article  |  2008  |  Bioessays

Effect of minocycline on inflammation-induced damage to the blood-brain barrier and white matter during development

HB Stolp, CJ Ek, PA Johansson, KM Dziegielewska, AM Potter, MD Habgood, NR Saunders

Journal article  |  2007  |  European Journal of Neuroscience

Expression and localization of P2 nucleotide receptor subtypes during development of the lateral ventricular choroid plexus of the rat

PA Johansson, G Burnstock, KM Dziegielewska, E Guida, P McIntyre, NR Saunders

Journal article  |  2007  |  European Journal of Neuroscience

Age-related differences in the local cellular and molecular responses to injury in developing spinal cord of the opossum, Monodelphis domestica

MA Lane, JS Truettner, J-P Brunschwig, A Gomez, MB Bunge, WD Dietrich, KM Dziegielewska, CJ Ek, JL VandeBerg, NR Saunders

Journal article  |  2007  |  European Journal of Neuroscience

Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice

MD Habgood, N Bye, KM Dziegielewska, CJ Ek, MA Lane, A Potter, C Morganti-Kossmann, NR Saunders

Journal article  |  2007  |  European Journal of Neuroscience

Blood-CSF barrier function in the rat embryo

PA Johansson, KM Dziegielewska, CJ Ek, MD Habgood, SA Liddelow, AM Potter, HB Stolp, NR Saunders

Journal article  |  2006  |  European Journal of Neuroscience

Functional effectiveness of the blood brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)

CJ Ek, KM Dziegielewska, H Stolp, NR Saunders

Journal article  |  2006  |  Journal of Comparative Neurology

Recovery from Spinal Cord Injury: will Genomics and Proteomics of the South American Opossum Monodelphis domestica Provide an answer?

N SAUNDERS, K DZIEGIELEWSKA, M HABGOOD, M LANE, J Truettner, D Dietrich

Journal article  |  2006  |  Australian Biochemist

Aquaporin-1 in the choroid plexuses of developing mammalian brain

PA Johansson, KM Dziegielewska, CJ Ek, MD Habgood, K Mollgard, A Potter, M Schuliga, NR Saunders

Journal article  |  2005  |  Cell and Tissue Research

Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat

HB Stolp, KM Dziegielewska, CJ Ek, AM Potter, NR Saunders

Journal article  |  2005  |  European Journal of Neuroscience

Breakdown of the blood-brain barrier to proteins in white matter of the developing brain following systemic inflammation

HB Stolp, KM Dziegielewska, CJ Ek, MD Habgood, MA Lane, AM Potter, NR Saunders

Journal article  |  2005  |  Cell and Tissue Research

Development of the blood-cerebrospinal fluid barrier

CJ EK, KM DZIEGIELEWSKA, N SAUNDERS

Book Chapter  |  2005

Regeneration of supraspinal axons after complete transection of the thoracic spinal cord in neonatal opossums (Monodelphis domestica)

EJ Fry, HB Stolp, MA Lane, KM Dziegielewska, NR Saunders

Journal article  |  2003  |  Journal of Comparative Neurology

Structural characteristics and barrier properties of the choroid plexuses in developing brain of the opossum (Monodelphis domestica)

CJ Ek, MD Habgood, KM Dziegielewska, NR Saunders

Journal article  |  2003  |  Journal of Comparative Neurology

Spinal cord injuries: making the re-connection.

Norman R Saunders, Elizabeth J Fry, Michael Lane, Katarzyna M Dziegielewska

Journal article  |  2002  |  Biologist

Why is it that the skin and other tissues and organs can repair themselves, yet the spinal cord and brain cannot? Even more intrig..

The ins and outs of brain-barrier mechanisms.

Katarzyna M Dziegielewska, Norman R Saunders

Journal article  |  2002  |  Trends in Neurosciences

The 34th International Union of Physiological Sciences Congress, Satellite Symposium on 'Blood-brain barrier mechanisms from molec..

Permeability and route of entry for lipid-insoluble molecules across brain barriers in developing Monodelphis domestica

CJ Ek, MD Habgood, KM Dziegielewska, A Potter, NR Saunders

Journal article  |  2001  |  Journal of Physiology

Development of the choroid plexus

KM Dziegielewska, J Ek, MD Habgood, NR Saunders

Journal article  |  2001  |  Microscopy Research and Technique