Kate Dziegielewska

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.

Liam M Koehn, Yifan Huang, Mark D Habgood, Kai Kysenius, Peter J Crouch, Katarzyna M Dziegielewska, Norman R Saunders

Journal article  |  2020  |  F1000Res

Background: Paracetamol (acetaminophen) is widely used in pregnancy and generally regarded as "safe" by regulatory authorities. Me..

Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide

Liam M Koehn, Katarzyna M Dziegielewska, Kjeld Mollgard, Elodie Saudrais, Nathalie Strazielle, Jean-Francois Ghersi-Egea, Norman R Saunders, Mark D Habgood

Journal article  |  2019  |  SCIENTIFIC REPORTS

Many pregnant women and prematurely born infants require medication for clinical conditions including cancer, cardiac defects and ..

Recent Developments in Understanding Barrier Mechanisms in the Developing Brain: Drugs and Drug Transporters in Pregnancy, Susceptibility or Protection in the Fetal Brain?

Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood

Journal article  |  2019  |  ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59

Efflux mechanisms situated in various brain barrier interfaces control drug entry into the adult brain; this review considers the ..

Determinants of drug entry into the developing brain.

Liam Koehn, Mark Habgood, Yifan Huang, Katarzyna Dziegielewska, Norman Saunders

Journal article  |  2019  |  F1000Res

Background: A major concern for clinicians in prescribing medications to pregnant women and neonates is the possibility that drugs..

Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain

Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood

Journal article  |  2018  |  JOURNAL OF PHYSIOLOGY-LONDON

Properties of the local internal environment of the adult brain are tightly controlled providing a stable milieu essential for its..

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development

Kjeld Mollgard, Katarzyna M Dziegielewska, Camilla B Holst, Mark D Habgood, Norman R Saunders

Journal article  |  2017  |  SCIENTIFIC REPORTS

Adult brain is protected from entry of drugs and toxins by specific mechanisms such as ABC (ATP-binding Cassette) efflux transport..

General Introduction to Barrier Mechanisms in the Central Nervous System

Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood

Book Chapter  |  2017  |  Agents and actions. Supplements

General Introduction to Barrier Mechanisms in the Central Nervous System

NR SAUNDERS, KM Dziegielewska, K Møllgård,, MD Habgood

Book Chapter  |  2017

A bipedal mammalian model for spinal cord injury research: The tammar wallaby.

Norman R Saunders, Katarzyna M Dziegielewska, Sophie C Whish, Lyn A Hinds, Benjamin J Wheaton, Yifan Huang, Steve Henry, Mark D Habgood

Journal article  |  2017  |  F1000Res

Background: Most animal studies of spinal cord injury are conducted in quadrupeds, usually rodents. It is unclear to what extent f..

Delayed astrocytic contact with cerebral blood vessels in FGF-2 deficient mice does not compromise permeability properties at the developing blood-brain barrier

Norman R Saunders, Katarzyna M Dziegielewska, Klaus Unsicker, C Joakim Ek

Journal article  |  2016  |  DEVELOPMENTAL NEUROBIOLOGY

The brain functions within a specialized environment tightly controlled by brain barrier mechanisms. Understanding the regulation ..