Stem cells have the capacity to self-renew while retaining the ability to differentiate into at least one, but usually multiple, different cell types. Clearly a specific pattern of gene expression is required to maintain the stem cell in a proliferating but undifferentiated state.
Stem cells and progenitors are also unique in that they are able to initiate distinctly different programs of gene expression as they differentiate into different cell types. Stem cells of all types have attracted considerable interest in recent years and a great deal of emphasis has been placed on their potential to provide new treatments, particularly in the area of regenerative medicine. All existing stem cell therapies, as well as future therapies, depend on stem cells expressing the required pattern of genes at the correct time.
Find out more about Timothy Thomas' experience
Timothy Thomas' highlights
Timothy Thomas' selected work
Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in..
Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferas..
MOZ directs the distal-less homeobox gene expression program during craniofacial developme..
Displaying the 52 most recent scholarly works by Timothy Thomas.
HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells.
Andrew J Kueh, Samantha Eccles, Leonie Tang, Alexandra L Garnham, Rose E May, Marco J Herold, Gordon K Smyth, Anne K Voss, Tim Thomas
Journal article | 2020 | Molecular and Cellular Biology
HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac) but is dispensable for H4 acetylation and DNA replica..
Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers
Elizabeth C Page, Elizabeth K Bancroft, Mark N Brook, Melissa Assel, Mona Hassan Al Battat, Sarah Thomas, Natalie Taylor, Anthony Chamberlain, Jennifer Pope, Holly Ni Raghallaigh, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Eli Marie Grindedal, Paul James, Lyon Mascarenhas, Joanne McKinley, Lucy Side, Tessy Thomas, Christi van Asperen, et al.
Journal article | 2019 | European Urology
BACKGROUND: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluatin..
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
Brianna J Klein, Suk Min Jang, Catherine Lachance, Wenyi Mi, Jie Lyu, Shun Sakuraba, Krzysztof Krajewski, Wesley W Wang, Simone Sidoli, Jiuyang Liu, Yi Zhang, Xiaolu Wang, Becka M Warfield, Andrew J Kueh, Anne K Voss, Tim Thomas, Benjamin A Garcia, Wenshe R Liu, Brian D Strahl, Hidetoshi Kono, et al.
Journal article | 2019 | Nature Communications
Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and me..
Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A
David J Leaver, Benjamin Cleary, Nguyen Nghi, Daniel L Priebbenow, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, Michael A Walters, et al.
Journal article | 2019 | Journal of Medicinal Chemistry
A high-throughput screen for inhibitors of the histone acetyltransferase, KAT6A, led to identification of an aryl sulfonohydrazide..
MOZ directs the distal-less homeobox gene expression program during craniofacial development
Hannah K Vanyai, Alexandra Garnham, Rose E May, Helen M McRae, Caitlin Collin, Stephen Wilcox, Gordon K Smyth, Tim Thomas, Anne K Voss
Journal article | 2019 | Development
Oral clefts are common birth defects. Individuals with oral clefts who have identical genetic mutations regularly present with var..
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment
Rocio G Urdinguio, Virginia Lopez, Gustavo F Bayon, Rafael Diaz de la Guardia, Marta I Sierra, Estela Garcia-Torano, Raul F Perez, Maria G Garcia, Antonella Carella, Patricia C Pruneda, Cristina Prieto, Marija Dmitrijeva, Pablo Santamarina, Thalia Belmonte, Cristina Mangas, Elena Diaconu, Cecilia Ferrero, Juan Ramon Tejedor, Juan Luis Fernandez-Morera, Cristina Bravo, et al.
Journal article | 2019 | Nucleic Acids Research
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia
Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.
Journal article | 2019 | Blood
Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects
Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.
Journal article | 2019 | Cell Reports
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
Jonathan B Baell, David J Leaver, Stefan J Hermans, Gemma L Kelly, Margs S Brennan, Natalie L Downer, Nghi Nguyen, Johannes Wichmann, Helen M Mcrae, Yuqing Yang, Ben Cleary, H Rachel Lagiakos, Stephen Mieruszynski, Guido Pacini, Hannah K Vanyai, Maria I Bergamasco, Rose E May, Bethany K Davey, Kimberly J Morgan, Andrew J Sealey, et al.
Journal article | 2018 | Nature
Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription
Farrah El-Saafin, Cynthia Curry, Tao Ye, Jean-Marie Garnier, Isabelle Kolb-Cheynel, Matthieu Stierle, Natalie L Downer, Mathew P Dixon, Luc Negroni, Imre Berger, Tim Thomas, Anne K Voss, William Dobyns, Didier Devys, Laszlo Tora
Journal article | 2018 | Human Molecular Genetics
Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7
Isobel D Lawrenson, Danielle L Krebs, Edmond M Linossi, Jian-Guo Zhang, Tamara J McLennan, Caitlin Collin, Helen M Mcrae, Tatiana B Kolesnik, Katrina Koh, Joanne M Britto, Andrew J Kueh, Bilal N Sheikh, Farrah El-Saafin, Nicos A Nicola, Seong-Seng Tan, Jeffrey J Babon, Sandra E Nicholson, Warren S Alexander, Tim Thomas, Anne K Voss
Journal article | 2017 | Cerebral Cortex
Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity
Dane M Newman, Shinya Sakaguchi, Aaron Lun, Simon Preston, Marc Pellegrini, Kseniya Khamina, Andreas Bergthaler, Stephen L Nutt, Gordon K Smyth, Anne K Voss, Tim Thomas, Wilfried Ellmeier, Gabrielle T Belz, Rhys S Allan
Journal article | 2016 | Cell Reports
MOF maintains transcriptional programs regulating cellular stress response
BN Sheikh, W Bechtel-Walz, J Lucci, O Karpiuk, I Hild, B Hartleben, J Vornweg, M Helmstaedter, AH Sahyoun, V Bhardwaj, T Stehle, S Diehl, O Kretz, AK Voss, T Thomas, T Manke, TB Huber, A Akhtar
Journal article | 2016 | Oncogene
MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo
Bilal N Sheikh, Natalie L Downer, Belinda Phipson, Hannah K Vanyai, Andrew J Kueh, Davis J McCarthy, Gordon K Smyth, Tim Thomas, Anne K Voss
Journal article | 2015 | Proceedings of the National Academy of Sciences
MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development
Bilal N Sheikh, Stanley CW Lee, Farrah El-Saafin, Hannah K Vanyai, Yifang Hu, Swee Heng Milon Pang, Stephanie Grabow, Andreas Strasser, Stephen L Nutt, Warren S Alexander, Gordon K Smyth, Anne K Voss, Tim Thomas
Journal article | 2015 | Blood
SOCS6 and SOCS7 Synergistically Regulate DAB1 Protein Levels and Cortical Neuron Migration.
ID Lawrenson, DL Krebs, EL Linossi, JG Zhang, TJ McLennan, C Collin, JM Britto, AJ Kueh, BN Sheikh, F El-Saafin, NA Nicola, S-S Tan, JJ babon, SE NICHOLSON, WS Alexander, T Thomas, AK voss
Journal article | 2015 | Cerebral Cortex
Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome.
Kai-Leng Tan, King-Hwa Ling, Chelsee A Hewitt, Pike-See Cheah, Ken Simpson, Lavinia Gordon, Melanie A Pritchard, Gordon K Smyth, Tim Thomas, Hamish S Scott
Journal article | 2014 | Genomics Data
The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromo..
Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
King-Hwa Ling, Chelsee A Hewitt, Kai-Leng Tan, Pike-See Cheah, Sharmili Vidyadaran, Mei-I Lai, Han-Chung Lee, Ken Simpson, Lavinia Hyde, Melanie A Pritchard, Gordon K Smyth, Tim Thomas, Hamish S Scott
Journal article | 2014 | BMC Genomics
THE MONOCYTIC LEUKAEMIA ZINC FINGER (MOZ) PROTEIN IS A REPRESSOR OF CELLULAR SENESCENCE, AND HAPLOINSUFFICIENCY FOR MOZ INCREASES SURVIVAL 3-FOLD IN THE Es-MYC LYMPHOMA MODEL
Bilal Sheikh, Belinda Phipson, Stanley Lee, Farrah El-Saafin, Natalie Downer, Stephanie Grabow, Gordon Smyth, Andreas Strasser, Warren Alexander, Anne Voss, Tim Thomas
Conference Proceedings | 2013 | Experimental Hematology
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
Jason Howitt, Jenny Lackovic, Ley-Hian Low, Adam Naguib, Alison Macintyre, Choo-Peng Goh, Jennifer K Callaway, Vicki Hammond, Tim Thomas, Matthew Dixon, Ulrich Putz, John Silke, Perry Bartlett, Baoli Yang, Sharad Kumar, Lloyd C Trotman, Seong-Seng Tan
Journal article | 2012 | Journal of Cell Biology
An Efficient High-Throughput Screening Method for MYST Family Acetyltransferases, a New Class of Epigenetic Drug Targets
Hendrik Falk, Theresa Connor, Hong Yang, Karen J Loft, Joanne L Alcindor, George Nikolakopoulos, Regina N Surjadi, John D Bentley, Meghan K Hattarki, Olan Dolezal, James M Murphy, Brendon J Monahan, Thomas S Peat, Tim Thomas, Jonathan B Baell, John P Parisot, Ian P Street
Journal article | 2011 | Journal of Biomolecular Screening
Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome
Jill Clayton-Smith, James O'Sullivan, Sarah Daly, Sanjeev Bhaskar, Ruth Day, Beverley Anderson, Anne K Voss, Tim Thomas, Leslie G Biesecker, Philip Smith, Alan Fryer, Kate E Chandler, Bronwyn Kerr, May Tassabehji, Sally-Ann Lynch, Malgorzata Krajewska-Walasek, Shane McKee, Janine Smith, Elizabeth Sweeney, Sahar Mansour, et al.
Journal article | 2011 | American Journal of Human Genetics
Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice
Michael Kraft, Ion Cristian Cirstea, Anne Kathrin Voss, Tim Thomas, Ina Goehring, Bilal N Sheikh, Lavinia Gordon, Hamish Scott, Gordon K Smyth, Mohammad Reza Ahmadian, Udo Trautmann, Martin Zenker, Marco Tartaglia, Arif Ekici, Andre Reis, Helmuth-Guenther Doerr, Anita Rauch, Christian Thomas Thiel
Journal article | 2011 | Journal of Clinical Investigation
ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification
Samir Taoudi, Thomas Bee, Adrienne Hilton, Kathy Knezevic, Julie Scott, Tracy A Willson, Caitlin Collin, Tim Thomas, Anne K Voss, Benjamin T Kile, Warren S Alexander, John E Pimanda, Douglas J Hilton
Journal article | 2011 | Genes & Development
Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome
Chelsee A Hewitt, King-Hwa Ling, Tobias D Merson, Ken M Simpson, Matthew E Ritchie, Sarah L King, Melanie A Pritchard, Gordon K Smyth, Tim Thomas, Hamish S Scott, Anne K Voss
Journal article | 2010 | PLoS One
Displaying the most recent news article by Timothy Thomas.
Medical Biology (W.E.H.I.)
Doctor of Philosophy
University of Melbourne