Tim Thomas

Reference compounds for characterizing cellular injury in high-content cellular morphology assays.

Jayme L Dahlin, Bruce K Hua, Beth E Zucconi, Shawn D Nelson, Shantanu Singh, Anne E Carpenter, Jonathan H Shrimp, Evelyne Lima-Fernandes, Mathias J Wawer, Lawrence PW Chung, Ayushi Agrawal, Mary O'Reilly, Dalia Barsyte-Lovejoy, Magdalena Szewczyk, Fengling Li, Parnian Lak, Matthew Cuellar, Philip A Cole, Jordan L Meier, Tim Thomas, et al.

Journal article  |  2023  |  Nat Commun

Robust, generalizable approaches to identify compounds efficiently with undesirable mechanisms of action in complex cellular assay..

Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7.

Andrew J Kueh, Maria I Bergamasco, Anna Quaglieri, Belinda Phipson, Connie SN Li-Wai-Suen, Ingrid M Lönnstedt, Yifang Hu, Zhi-Ping Feng, Chris Woodruff, Rose E May, Stephen Wilcox, Alexandra L Garnham, Michael P Snyder, Gordon K Smyth, Terence P Speed, Tim Thomas, Anne K Voss

Journal article  |  2023  |  Cell Rep

In the conventional model of transcriptional activation, transcription factors bind to response elements and recruit co-factors, i..

FGF9 variant in 46,XY DSD patient suggests a role for dimerization in sex determination

Brittany Croft, Anthony D Bird, Makoto Ono, Stefanie Eggers, Stefan Bagheri-Fam, Janelle M Ryan, Alejandra P Reyes, Jocelyn van den Bergen, Anne Baxendale, Elizabeth M Thompson, Andrew J Kueh, Peter Stanton, Tim Thomas, Andrew H Sinclair, Vincent R Harley

Journal article  |  2022  |  CLINICAL GENETICS

46,XY gonadal dysgenesis (GD) is a Disorder/Difference of Sex Development (DSD) that can present with phenotypes ranging from ambi..

Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest

Johannes Wichmann, Catherine Pitt, Samantha Eccles, Alexandra L Garnham, Connie SN Li-Wai-Suen, Rose May, Elizabeth Allan, Stephen Wilcox, Marco J Herold, Gordon K Smyth, Brendon J Monahan, Tim Thomas, Anne K Voss

Journal article  |  2022  |  CELL DEATH & DISEASE

Histone acetylation is essential for initiating and maintaining a permissive chromatin conformation and gene transcription. Dysreg..

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria Bergamasco, Yunshun Chen, Rose E May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J Davis, Andreas Strasser, Gordon K Smyth, Tim Thomas, Anne K Voss

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Mutations in genes encoding general transcription factors cause neurological disorders. Despite clinical prominence, the consequen..

The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal

Yuqing Yang, Andrew J Kueh, Zoe L Grant, Waruni Abeysekera, Alexandra L Garnham, Stephen Wilcox, Craig D Hyland, Ladina Di Rago, Don Metcalf, Warren S Alexander, Leigh Coultas, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2022  |  BLOOD

The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylati..

The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance

Melanie Heinlein, Luke C Gandolfo, Kelin Zhao, Charis E Teh, Nghi Nguyen, Jonathan B Baell, Yael Goldfarb, Jakub Abramson, Johannes Wichmann, Anne K Voss, Andreas Strasser, Gordon K Smyth, Tim Thomas, Daniel HD Gray

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

The autoimmune regulator (AIRE) induces the transcription of thousands of peripheral tissue genes (PTGs) in thymic epithelial cell..

The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis (vol 148, dev199581, 2021)

Zoe L Grant, Peter F Hickey, Waruni Abeysekera, Lachlan Whitehead, Sabrina M Lewis, Robert CA Symons, Tracey M Baldwin, Daniela Amann-Zalcenstein, Alexandra L Garnham, Shalin H Naik, Gordon K Smyth, Tim Thomas, Anne K Voss, Leigh Coultas

Journal article  |  2021  |  DEVELOPMENT

Shalin H. Naik was inadvertently omitted from the author list. The complete list of authors, their affiliations, contributions and..

The people behind the papers - Zoe Grant, Tim Thomas, Anne Voss and Leigh Coultas

Zoe Grant, Tim Thomas, Anne Voss, Leigh Coultas

Journal article  |  2021  |  DEVELOPMENT

Abstract The histone acetyltransferase HBO1 (KAT1) is required for histone H3 lysine 14 acetylation, which is cruci..

The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis

Zoe L Grant, Peter F Hickey, Waruni Abeysekera, Lachlan Whitehead, Sabrina M Lewis, Robert CA Symons, Tracey M Baldwin, Daniela Amann-Zalcenstein, Alexandra L Garnham, Gordon K Smyth, Tim Thomas, Anne K Voss, Leigh Coultas

Journal article  |  2021  |  DEVELOPMENT

Blood vessel growth and remodelling are essential during embryonic development and disease pathogenesis. The diversity of endothel..