Timothy Thomas

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

Daniel L Priebbenow, David J Leaver, Nguyen Nghi, Benjamin Cleary, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, David M Shackleford, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, et al.

Journal article  |  2020  |  Journal of Medicinal Chemistry

A high-throughput screen designed to discover new inhibitors of histone acetyltransferase KAT6A uncovered CTX-0124143 (1), a uniqu..

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

Andrew J Kueh, Samantha Eccles, Leonie Tang, Alexandra L Garnham, Rose E May, Marco J Herold, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2020  |  Molecular and Cellular Biology

HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac) but is dispensable for H4 acetylation and DNA replica..

Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers

Elizabeth C Page, Elizabeth K Bancroft, Mark N Brook, Melissa Assel, Mona Hassan Al Battat, Sarah Thomas, Natalie Taylor, Anthony Chamberlain, Jennifer Pope, Holly Ni Raghallaigh, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Eli Marie Grindedal, Paul James, Lyon Mascarenhas, Joanne McKinley, Lucy Side, Tessy Thomas, Christi van Asperen, et al.

Journal article  |  2019  |  European Urology

BACKGROUND: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluatin..

Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

Brianna J Klein, Suk Min Jang, Catherine Lachance, Wenyi Mi, Jie Lyu, Shun Sakuraba, Krzysztof Krajewski, Wesley W Wang, Simone Sidoli, Jiuyang Liu, Yi Zhang, Xiaolu Wang, Becka M Warfield, Andrew J Kueh, Anne K Voss, Tim Thomas, Benjamin A Garcia, Wenshe R Liu, Brian D Strahl, Hidetoshi Kono, et al.

Journal article  |  2019  |  Nature Communications

Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and me..

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

David J Leaver, Benjamin Cleary, Nguyen Nghi, Daniel L Priebbenow, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, Michael A Walters, et al.

Journal article  |  2019  |  Journal of Medicinal Chemistry

A high-throughput screen for inhibitors of the histone acetyltransferase, KAT6A, led to identification of an aryl sulfonohydrazide..

MOZ directs the distal-less homeobox gene expression program during craniofacial development

Hannah K Vanyai, Alexandra Garnham, Rose E May, Helen M McRae, Caitlin Collin, Stephen Wilcox, Gordon K Smyth, Tim Thomas, Anne K Voss

Journal article  |  2019  |  Development

Oral clefts are common birth defects. Individuals with oral clefts who have identical genetic mutations regularly present with var..

Are transplantable stem cells required for adult hematopoiesis?

Helen M McRae, Anne K Voss, Tim Thomas

Journal article  |  2019  |  Experimental Hematology

Hematopoietic stem cells (HSCs) have been studied intensely for more than half a century. As a result, the properties of HSCs have..

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

Rocio G Urdinguio, Virginia Lopez, Gustavo F Bayon, Rafael Diaz de la Guardia, Marta I Sierra, Estela Garcia-Torano, Raul F Perez, Maria G Garcia, Antonella Carella, Patricia C Pruneda, Cristina Prieto, Marija Dmitrijeva, Pablo Santamarina, Thalia Belmonte, Cristina Mangas, Elena Diaconu, Cecilia Ferrero, Juan Ramon Tejedor, Juan Luis Fernandez-Morera, Cristina Bravo, et al.

Journal article  |  2019  |  Nucleic Acids Research

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.

Journal article  |  2019  |  Blood

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.

Journal article  |  2019  |  Cell Reports

KAT8 selectively inhibits antiviral immunity by acetylating IRF3

Wanwan Huai, Xingguang Liu, Chunmei Wang, Yunkai Zhang, Xi Chen, Xiang Chen, Sheng Xu, Tim Thomas, Nan Li, Xuetao Cao

Journal article  |  2019  |  Journal of Experimental Medicine

Correction: KAT8 selectively inhibits antiviral immunity by acetylating IRF3.

Wanwan Huai, Xingguang Liu, Chunmei Wang, Yunkai Zhang, Xi Chen, Xiang Chen, Sheng Xu, Tim Thomas, Nan Li, Xuetao Cao

Journal article  |  2019  |  Journal of Experimental Medicine

Early developmental arrest and impaired gastrointestinal homeostasis in U12-dependent splicing-defective Rnpc3-deficient mice

Karen Doggett, Ben B Williams, Sebastian Markmiller, Fan-Suo Geng, Janine Coates, Stephen Mieruszynski, Matthias Ernst, Tim Thomas, Joan K Heath

Journal article  |  2018  |  RNA

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

Anne K Voss, Tim Thomas

Journal article  |  2018  |  BioEssays

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B Baell, David J Leaver, Stefan J Hermans, Gemma L Kelly, Margs S Brennan, Natalie L Downer, Nghi Nguyen, Johannes Wichmann, Helen M Mcrae, Yuqing Yang, Ben Cleary, H Rachel Lagiakos, Stephen Mieruszynski, Guido Pacini, Hannah K Vanyai, Maria I Bergamasco, Rose E May, Bethany K Davey, Kimberly J Morgan, Andrew J Sealey, et al.

Journal article  |  2018  |  Nature

Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription

Farrah El-Saafin, Cynthia Curry, Tao Ye, Jean-Marie Garnier, Isabelle Kolb-Cheynel, Matthieu Stierle, Natalie L Downer, Mathew P Dixon, Luc Negroni, Imre Berger, Tim Thomas, Anne K Voss, William Dobyns, Didier Devys, Laszlo Tora

Journal article  |  2018  |  Human Molecular Genetics

Essential role for the histone acetyltransferase KAT7 in T cell development, fitness, and survival

Dane M Newman, Anne K Voss, Tim Thomas, Rhys S Allan

Journal article  |  2017  |  Journal of Leukocyte Biology

MOZ and BMI1 act synergistically to maintain hematopoietic stem cells

Bilal N Sheikh, Donald Metcalf, Anne K Voss, Tim Thomas

Journal article  |  2017  |  Experimental Hematology

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7

Isobel D Lawrenson, Danielle L Krebs, Edmond M Linossi, Jian-Guo Zhang, Tamara J McLennan, Caitlin Collin, Helen M Mcrae, Tatiana B Kolesnik, Katrina Koh, Joanne M Britto, Andrew J Kueh, Bilal N Sheikh, Farrah El-Saafin, Nicos A Nicola, Seong-Seng Tan, Jeffrey J Babon, Sandra E Nicholson, Warren S Alexander, Tim Thomas, Anne K Voss

Journal article  |  2017  |  Cerebral Cortex

MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells

Bilal N Sheikh, Yuqing Yang, Jaring Schreuder, Susan K Nilsson, Rebecca Bilardi, Sebastian Carotta, Helen M McRae, Donald Metcalf, Anne K Voss, Tim Thomas

Journal article  |  2016  |  Blood

Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity

Dane M Newman, Shinya Sakaguchi, Aaron Lun, Simon Preston, Marc Pellegrini, Kseniya Khamina, Andreas Bergthaler, Stephen L Nutt, Gordon K Smyth, Anne K Voss, Tim Thomas, Wilfried Ellmeier, Gabrielle T Belz, Rhys S Allan

Journal article  |  2016  |  Cell Reports

MOF maintains transcriptional programs regulating cellular stress response

BN Sheikh, W Bechtel-Walz, J Lucci, O Karpiuk, I Hild, B Hartleben, J Vornweg, M Helmstaedter, AH Sahyoun, V Bhardwaj, T Stehle, S Diehl, O Kretz, AK Voss, T Thomas, T Manke, TB Huber, A Akhtar

Journal article  |  2016  |  Oncogene

MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway

BN Sheikh, B Phipson, F El-Saafin, HK Vanyai, NL Downer, MJ Bird, AJ Kueh, RE May, GK Smyth, AK Voss, T Thomas

Journal article  |  2015  |  Oncogene

Response to Heard et al

Maryline Moulin, Anne K Voss, Tim Thomas, Wendy Wei-Lynn Wong, Wendy D Cook, Frank Koentgen, James Vince, John Silke, David L Vaux

Journal article  |  2015  |  The EMBO Journal

Mesodermal expression of Moz is necessary for cardiac septum development

Hannah K Vanyai, Tim Thomas, Anne K Voss

Journal article  |  2015  |  Developmental Biology

MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo

Bilal N Sheikh, Natalie L Downer, Belinda Phipson, Hannah K Vanyai, Andrew J Kueh, Davis J McCarthy, Gordon K Smyth, Tim Thomas, Anne K Voss

Journal article  |  2015  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

Bilal N Sheikh, Stanley CW Lee, Farrah El-Saafin, Hannah K Vanyai, Yifang Hu, Swee Heng Milon Pang, Stephanie Grabow, Andreas Strasser, Stephen L Nutt, Warren S Alexander, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2015  |  Blood

SOCS6 and SOCS7 Synergistically Regulate DAB1 Protein Levels and Cortical Neuron Migration.

ID Lawrenson, DL Krebs, EL Linossi, JG Zhang, TJ McLennan, C Collin, JM Britto, AJ Kueh, BN Sheikh, F El-Saafin, NA Nicola, S-S Tan, JJ babon, SE NICHOLSON, WS Alexander, T Thomas, AK voss

Journal article  |  2015  |  Cerebral Cortex

Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome.

Kai-Leng Tan, King-Hwa Ling, Chelsee A Hewitt, Pike-See Cheah, Ken Simpson, Lavinia Gordon, Melanie A Pritchard, Gordon K Smyth, Tim Thomas, Hamish S Scott

Journal article  |  2014  |  Genomics Data

The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromo..

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3

MN Koenig, E Naik, L Rohrbeck, MJ Herold, E Trounson, P Bouillet, T Thomas, AK Voss, A Strasser, L Coultas

Journal article  |  2014  |  Cell Death & Differentiation

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks

King-Hwa Ling, Chelsee A Hewitt, Kai-Leng Tan, Pike-See Cheah, Sharmili Vidyadaran, Mei-I Lai, Han-Chung Lee, Ken Simpson, Lavinia Hyde, Melanie A Pritchard, Gordon K Smyth, Tim Thomas, Hamish S Scott

Journal article  |  2014  |  BMC Genomics

Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ

Kim L Good-Jacobson, Yunshun Chen, Anne K Voss, Gordon K Smyth, Tim Thomas, David Tarlinton

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Excessive versus Physiologically Relevant Levels of Retinoic Acid in Embryonic Stem Cell Differentiation

Bilal N Sheikh, Natalie L Downer, Andrew J Kueh, Tim Thomas, Anne K Voss

Journal article  |  2014  |  Stem Cells

THE MONOCYTIC LEUKAEMIA ZINC FINGER (MOZ) PROTEIN IS A REPRESSOR OF CELLULAR SENESCENCE, AND HAPLOINSUFFICIENCY FOR MOZ INCREASES SURVIVAL 3-FOLD IN THE Es-MYC LYMPHOMA MODEL

Bilal Sheikh, Belinda Phipson, Stanley Lee, Farrah El-Saafin, Natalie Downer, Stephanie Grabow, Gordon Smyth, Andreas Strasser, Warren Alexander, Anne Voss, Tim Thomas

Conference Proceedings  |  2013  |  Experimental Hematology

Migration of Sympathetic Preganglionic Neurons in the Spinal Cord of a C3G-Deficient Mouse Suggests That C3G Acts in the Reelin Signaling Pathway

Yee Ping Yip, Tim Thomas, Anne K Voss, Joseph W Yip

Journal article  |  2012  |  Journal of Comparative Neurology

MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome

Anne K Voss, Hannah K Vanyai, Caitlin Collin, Mathew P Dixon, Tamara J McLennan, Bilal N Sheikh, Peter Scambler, Tim Thomas

Journal article  |  2012  |  Developmental Cell

IAPs limit activation of RIP kinases by TNF receptor 1 during development

Maryline Moulin, Holly Anderton, Anne K Voss, Tim Thomas, Wendy Wei-Lynn Wong, Aleksandra Bankovacki, Rebecca Feltham, Diep Chau, Wendy D Cook, John Silke, David L Vaux

Journal article  |  2012  |  EMBO Journal

Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells

Bilal N Sheikh, Mathew P Dixon, Tim Thomas, Anne K Voss

Journal article  |  2012  |  Journal of Cell Science

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

Jason Howitt, Jenny Lackovic, Ley-Hian Low, Adam Naguib, Alison Macintyre, Choo-Peng Goh, Jennifer K Callaway, Vicki Hammond, Tim Thomas, Matthew Dixon, Ulrich Putz, John Silke, Perry Bartlett, Baoli Yang, Sharad Kumar, Lloyd C Trotman, Seong-Seng Tan

Journal article  |  2012  |  Journal of Cell Biology

An Efficient High-Throughput Screening Method for MYST Family Acetyltransferases, a New Class of Epigenetic Drug Targets

Hendrik Falk, Theresa Connor, Hong Yang, Karen J Loft, Joanne L Alcindor, George Nikolakopoulos, Regina N Surjadi, John D Bentley, Meghan K Hattarki, Olan Dolezal, James M Murphy, Brendon J Monahan, Thomas S Peat, Tim Thomas, Jonathan B Baell, John P Parisot, Ian P Street

Journal article  |  2011  |  Journal of Biomolecular Screening

Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome

Jill Clayton-Smith, James O'Sullivan, Sarah Daly, Sanjeev Bhaskar, Ruth Day, Beverley Anderson, Anne K Voss, Tim Thomas, Leslie G Biesecker, Philip Smith, Alan Fryer, Kate E Chandler, Bronwyn Kerr, May Tassabehji, Sally-Ann Lynch, Malgorzata Krajewska-Walasek, Shane McKee, Janine Smith, Elizabeth Sweeney, Sahar Mansour, et al.

Journal article  |  2011  |  American Journal of Human Genetics

Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice

Michael Kraft, Ion Cristian Cirstea, Anne Kathrin Voss, Tim Thomas, Ina Goehring, Bilal N Sheikh, Lavinia Gordon, Hamish Scott, Gordon K Smyth, Mohammad Reza Ahmadian, Udo Trautmann, Martin Zenker, Marco Tartaglia, Arif Ekici, Andre Reis, Helmuth-Guenther Doerr, Anita Rauch, Christian Thomas Thiel

Journal article  |  2011  |  Journal of Clinical Investigation

HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development

Andrew J Kueh, Mathew P Dixon, Anne K Voss, Tim Thomas

Journal article  |  2011  |  Molecular and Cellular Biology

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

Samir Taoudi, Thomas Bee, Adrienne Hilton, Kathy Knezevic, Julie Scott, Tracy A Willson, Caitlin Collin, Tim Thomas, Anne K Voss, Benjamin T Kile, Warren S Alexander, John E Pimanda, Douglas J Hilton

Journal article  |  2011  |  Genes & Development

Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome

Chelsee A Hewitt, King-Hwa Ling, Tobias D Merson, Ken M Simpson, Matthew E Ritchie, Sarah L King, Melanie A Pritchard, Gordon K Smyth, Tim Thomas, Hamish S Scott, Anne K Voss

Journal article  |  2010  |  PLoS One

Moz and Retinoic Acid Coordinately Regulate H3K9 Acetylation, Hox Gene Expression, and Segment Identity

Anne K Voss, Caitlin Collin, Mathew P Dixon, Tim Thomas

Journal article  |  2009  |  Developmental Cell

MYST family histone acetyltransferases take center stage in stem cells and development

Anne K Voss, Tim Thomas

Journal article  |  2009  |  Bioessays

Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture

Tim Thomas, Mathew P Dixon, Andrew J Kueh, Anne K Voss

Journal article  |  2008  |  Molecular and Cellular Biology

The genes coding for the MYST family histone acetyltransferases, Tip60 and Mof, are expressed at high levels during sperm development

Tim Thomas, Kate L Loveland, Anne K Voss

Journal article  |  2007  |  Gene Expr. Patterns

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

T Thomas, LM Corcoran, R Gugasyan, MP Dixon, T Brodnicki, SL Nutt, D Metcalf, AK Voss

Journal article  |  2006  |  Genes Dev.

The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms

R Gugasyan, A Voss, G Varigos, T Thomas, RJ Grumont, P Kaur, G Grigoriadis, S Gerondakis

Journal article  |  2004  |  Molecular and Cellular Biology

Querkopf, a histone acetyltransferase, is essential for embryonic neurogenesis

T Thomas, AK Voss

Journal article  |  2004  |  Front. Biosci.

Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3

SB Ting, T Wilanowski, A Auden, M Hall, AK Voss, T Thomas, V Parekh, JM Cunningham, SM Jane

Journal article  |  2003  |  Nature Medicine