Tim Thomas

Downregulation of the GHRH/GH/IGF1 axis in a mouse mode of Borjeson-Forssman-Lehman syndrome

Helen M McRae, Samantha Eccles, Lachlan Whitehead, Warren S Alexander, Jozef Gecz, Tim Thomas, Anne K Voss

Journal article  |  2020  |  DEVELOPMENT

Börjeson-Forssman-Lehmann syndrome (BFLS) is an intellectual disability and endocrine disorder caused by plant homeodomain finger ..

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

Daniel L Priebbenow, David J Leaver, Nguyen Nghi, Benjamin Cleary, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, David M Shackleford, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, et al.

Journal article  |  2020  |  JOURNAL OF MEDICINAL CHEMISTRY

A high-throughput screen designed to discover new inhibitors of histone acetyltransferase KAT6A uncovered CTX-0124143 (1), a uniqu..

Chromatin-Binding Protein PHF6 Regulates Activity-Dependent Transcriptional Networks to Promote Hunger Response

Linhua Gan, Jingjing Sun, Shuo Yang, Xiaocui Zhang, Wu Chen, Yiyu Sun, Xiaohua Wu, Cheng Cheng, Jing Yuan, Anan Li, Mark A Corbett, Mathew P Dixon, Tim Thomas, Anne K Voss, Jozef Gecz, Guang-Zhong Wang, Azad Bonni, Qian Li, Ju Huang

Journal article  |  2020  |  CELL REPORTS

Understanding the mechanisms of activity-dependent gene transcription underlying adaptive behaviors is challenging at neuronal-sub..

Action plan for hit identification (APHID): KAT6A as a case study

Xiangyan Yi, Lian Xue, Tim Thomas, Jonathan B Baell

Journal article  |  2020  |  FUTURE MEDICINAL CHEMISTRY

Here, we describe our action plan for hit identification (APHID) that guides the process of hit triage, with elimination of less t..

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

Andrew J Kueh, Samantha Eccles, Leonie Tang, Alexandra L Garnham, Rose E May, Marco J Herold, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2020  |  Molecular and Cellular Biology

HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac) but is dispensable for H4 acetylation and DNA replica..

HBO1 is required for the maintenance of leukaemia stem cells

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nguyen Nghi, et al.

Journal article  |  2020  |  NATURE

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..

Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers

Elizabeth C Page, Elizabeth K Bancroft, Mark N Brook, Melissa Assel, Mona Hassan Al Battat, Sarah Thomas, Natalie Taylor, Anthony Chamberlain, Jennifer Pope, Holly Ni Raghallaigh, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Eli Marie Grindedal, Paul James, Lyon Mascarenhas, Joanne McKinley, Lucy Side, Tessy Thomas, Christi van Asperen, et al.

Journal article  |  2019  |  EUROPEAN UROLOGY

BACKGROUND: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluatin..

Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

Brianna J Klein, Suk Min Jang, Catherine Lachance, Wenyi Mi, Jie Lyu, Shun Sakuraba, Krzysztof Krajewski, Wesley W Wang, Simone Sidoli, Jiuyang Liu, Yi Zhang, Xiaolu Wang, Becka M Warfield, Andrew J Kueh, Anne K Voss, Tim Thomas, Benjamin A Garcia, Wenshe R Liu, Brian D Strahl, Hidetoshi Kono, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and me..

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

David J Leaver, Benjamin Cleary, Nguyen Nghi, Daniel L Priebbenow, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, Michael A Walters, et al.

Journal article  |  2019  |  JOURNAL OF MEDICINAL CHEMISTRY

A high-throughput screen for inhibitors of the histone acetyltransferase, KAT6A, led to identification of an aryl sulfonohydrazide..

Are transplantable stem cells required for adult hematopoiesis?

Helen M McRae, Anne K Voss, Tim Thomas

Journal article  |  2019  |  EXPERIMENTAL HEMATOLOGY

Hematopoietic stem cells (HSCs) have been studied intensely for more than half a century. As a result, the properties of HSCs have..