Peregrine Osborne

Recording of Electrically Evoked Neural Activity and Bladder Pressure Responses in Awake Rats Chronically Implanted With a Pelvic Nerve Array

Sophie C Payne, Nicole M Wiedmann, Calvin D Eiber, Agnes W Wong, Philipp Senn, Peregrine B Osborne, Janet R Keast, James B Fallon

Journal article  |  2020  |  FRONTIERS IN NEUROSCIENCE

Bioelectronic medical devices are well established and widely used in the treatment of urological dysfunction. Approved targets in..

Functional segregation within the pelvic nerve of male rats: a meso- and microscopic analysis

Martin M Bertrand, Nadja Korajkic, Peregrine B Osborne, Janet R Keast

Journal article  |  2020  |  JOURNAL OF ANATOMY

The pelvic splanchnic nerves are essential for pelvic organ function and have been proposed as targets for neuromodulation. We hav..

Sex differences inc-FosandEGR-1/Zif268 activity maps of rat sacral spinal cord following cystometry-induced micturition

Nicole M Wiedmann, Agnes W Wong, Janet R Keast, Peregrine B Osborne

Journal article  |  2020  |  JOURNAL OF COMPARATIVE NEUROLOGY

Storage and voiding of urine from the lower urinary tract (LUT) must be timed precisely to occur in appropriate behavioral context..

SPARC: A Multiscale Analysis of the Structure of the Rat Lower Urinary Tract (LUT) and Connectivity of Sensory and Autonomic Nerve Terminals

Janet Keast, Nicole Wiedmann, Alan Watson, Nathaniel Jenkins, Dane Gerneke, Peter Hunter, Peregrine Osborne

Conference Proceedings  |  2020  |  FASEB JOURNAL

SPARC: Building a Three-Dimensional Atlas of Spinal Cord Circuits Regulating Lower Urinary Tract Function

John-Paul Fuller-Jackson, Agnes Wong, Alan Watson, Nathaniel Jenkins, Janet Keast, Peregrine Osborne

Conference Proceedings  |  2020  |  FASEB JOURNAL

SPARC: Modelling a Bidirectional Bioelectric Pelvic Nerve Interface

Calvin Eiber, Martin Bertrand, Janet Keast, Peregrine Osborne

Conference Proceedings  |  2020  |  FASEB JOURNAL

SPARC: Minimally Invasive Recording of Neural Activity During Natural Voiding in Anaesthetized Rats

Sophie Payne, Peregrine Osborne, Janet Keast, James Fallon

Conference Proceedings  |  2020  |  FASEB JOURNAL

Identification of a Sacral, Visceral Sensory Transcriptome in Embryonic and Adult Mice

CJA Smith-Anttila, EA Mason, CA Wells, BJ Aronow, PB Osborne, JR Keast

Journal article  |  2020  |  ENEURO

Visceral sensory neurons encode distinct sensations from healthy organs and initiate pain states that are resistant to common anal..

Simulating bidirectional peripheral neural interfaces in EIDORS

Calvin D Eiber, Janet R Keast, Peregrine B Osborne

Conference Proceedings  |  2020  |  42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

Bioelectronic neural interfaces that deliver adaptive therapeutic stimulation in an intelligent manner must be able to sense and s..

Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow

GDC Mendis, G Berecki, E Morrisroe, S Pachernegg, M Li, M Varney, PB Osborne, CA Reid, S Halgamuge, S Petrou

Journal article  |  2019  |  SCIENTIFIC REPORTS

Determining the mechanism of action (MOA) of novel or naturally occurring compounds mostly relies on assays tailored for individua..