Oanh Nguyen

A serological assay to detect SARS-CoV-2 seroconversion in humans

Fatima Amanat, Daniel Stadlbauer, Shirin Strohmeier, Thi HO Nguyen, Veronika Chromikova, Meagan McMahon, Kaijun Jiang, Guha Asthagiri Arunkumar, Denise Jurczyszak, Jose Polanco, Maria Bermudez-Gonzalez, Giulio Kleiner, Teresa Aydillo, Lisa Miorin, Daniel S Fierer, Luz Amarilis Lugo, Erna Milunka Kojic, Jonathan Stoever, Sean TH Liu, Charlotte Cunningham-Rundles, et al.

Journal article  |  2020  |  Nature Medicine

Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 serocon..

Monocyte apoptotic bodies are vehicles for influenza A virus propagation.

Georgia K Atkin-Smith, Mubing Duan, Damien J Zanker, Liyen Loh, Thi HO Nguyen, Marios Koutsakos, Tien Nguyen, Xiangrui Jiang, Julio Carrera, Thanh Kha Phan, Chuanxin Liu, Stephanie Paone, Sara Oveissi, Amy L Hodge, Amy A Baxter, Katherine Kedzierska, Jason M Mackenzie, Mark D Hulett, Pamuk Bilsel, Weisan Chen, et al.

Journal article  |  2020  |  Communications Biology

The disassembly of apoptotic cells into small membrane-bound vesicles termed apoptotic bodies (ApoBDs) is a hallmark of apoptosis;..

PEPTIDE-DEPENDENT T CELL CROSS-REACTIVITY DRIVES ALLORECOGNITION.

Nicole A Mifsud, Louise C Rowntree, Patricia T Illing, Pouya Faridi, Sian Llewellyn-Lacey, Kelly L Miners, Kristin Ladell, James E McLaren, Carine Farencl, Augustine Hyland, Jan Petersen, Jamie Ross-John, Thi HO Nguyen, David A Price, Linda Wool-Dridge, Tom C Kotsimbos, Anthony W Purcell

Conference Proceedings  |  2020  |  HLA

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

Irani Thevarajan, Thi HO Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien E van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven YC Tong, Sharon R Lewin, Katherine Kedzierska

Journal article  |  2020  |  Nature Medicine

Multiplex Screening Assay for Identifying Cytotoxic CD8( ) T Cell Epitopes

Chek Meng Poh, Jian Zheng, Rudragouda Channappanavar, Zi Wei Chang, Thi HO Nguyen, Laurent Renia, Katherine Kedzierska, Stanley Perlman, Leo LM Poon

Journal article  |  2020  |  Frontiers in Immunology

The cytotoxicity of epitope-specific CD8+ T cells is usually measured indirectly through IFNγ production. Existing assays that dir..

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8( ) T Cell Receptors

Louise C Rowntree, Heleen van den Heuvel, Jessica Sun, Lloyd J D'Orsogna, Thi HO Nguyen, Frans HJ Claas, Jamie Rossjohn, Tom C Kotsimbos, Anthony W Purcell, Nicole A Mifsud

Journal article  |  2020  |  Frontiers in Immunology

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unw..

Challenging immunodominance of influenza-specific CD8( ) T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

CE van de Sandt, EB Clemens, EJ Grant, LC Rowntree, S Sant, H Halim, J Crowe, AC Cheng, TC Kotsimbos, M Richards, A Miller, SYC Tong, J Rossjohn, THO Nguyen, S Gras, W Chen, K Kedzierska

Journal article  |  2019  |  Nature Communications

Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease ar..

Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses

Maria Auladell, Xiaoxiao Jia, Luca Hensen, Brandon Chua, Annette Fox, Thi HO Nguyen, Peter C Doherty, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

Journal article  |  2019  |  Immunology & Cell Biology

Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses

Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.

Journal article  |  2019  |  Nature Immunology

With a Little Help from T Follicular Helper Friends: Humoral Immunity to Influenza Vaccination

Marios Koutsakos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  The Journal of Immunology

Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska

Journal article  |  2019  |  Clinical & Translational Immunology

Distinguishing naive- from memory-derived human B cells during acute responses

Maria Auladell, Ho Nguyen Thi, Beatriz Garcillan, Fabienne Mackay, Katherine Kedzierska, Annette Fox

Journal article  |  2019  |  Clinical & Translational Immunology

The Drivers of Pathology in Zoonotic Avian influenza: The interplay Between Host and Pathogen

William SJ Horman, Thi HO Nguyen, Katherine Kedzierska, Andrew GD Bean, Daniel S Layton

Journal article  |  2018  |  Frontiers in Immunology

Single-Cell Approach to Influenza Specific CD8( ) T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

Sneha Sant, Ludiyine Grzelak, Zhongfang Wang, Angela Pizzollal, Manbs Koutsakos, Jane Crowe, Thomas Loudoyaris, Stuart I Mannering, Glen P Westall, Linda M Wakiml, Jamie Rossjohn, Stephanie Gras, Michael Richards, Jianqing Xu, Paul G Thomas, Liyen Loh, Thi H Nguyen, Katherine Kedzierska

Journal article  |  2018  |  Frontiers in Immunology

Age-Related Decline in Primary CD8( ) T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8( ) T Cells

Kylie M Quinn, Annette Fox, Kim L Harland, Brendan E Russ, Jasmine Li, Thi HO Nguyen, Liyen Loh, Moshe Olshanksy, Haroon Naeem, Kirill Tsyganov, Florian Wiede, Rosela Webster, Chantelle Blyth, Xavier YX Sng, Tony Tiganis, David Powell, Peter C Doherty, Stephen J Turner, Katherine Kedzierska, Nicole L La Gruta

Journal article  |  2018  |  Cell Reports

Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses

Louise C Rowntree, Thi HO Nguyen, Hanim Halim, Anthony W Purcell, Jamie Rossjohn, Stephanie Gras, Tom C Kotsimbos, Nicole A Mifsud

Journal article  |  2018  |  The Journal of Immunology

Clonally diverse CD38( )HLA-DR( )CD8( ) T cells persist during fatal H7N9 disease

Zhongfang Wang, Lingyan Zhu, Thi HO Nguyen, Yanmin Wan, Sneha Sant, Sergio M Quinones-Parra, Jeremy Chase Crawford, Auda A Eltahla, Simone Rizzetto, Rowena A Bull, Chenli Qiu, Marios Koutsakos, E Bridie Clemens, Liyen Loh, Tianyue Chen, Lu Liu, Pengxing Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, et al.

Journal article  |  2018  |  Nature Communications

Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nussing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi HO Nguyen, et al.

Journal article  |  2018  |  Science Translational Medicine

Innate and adaptive T cells in influenza disease

Simone Nuessing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2018  |  Frontiers of Medicine

Perturbed CD8( ) T cell immunity across universal influenza epitopes in the elderly

Thi HO Nguyen, Sneha Sant, Nicola L Bird, Emma J Grant, E Bridie Clemens, Marios Koutsakos, Sophie A Valkenburg, Stephanie Gras, Martha Lappas, Anthony Jaworowski, Jane Crowe, Liyen Loh, Katherine Kedzierska

Journal article  |  2018  |  Journal of Leukocyte Biology

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

Angela Pizzolla, Thi HO Nguyen, Sneha Sant, Jade Jaffar, Tom Loudovaris, Stuart I Mannering, Paul G Thomas, Glen P Westall, Katherine Kedzierska, Linda M Wakim

Journal article  |  2018  |  Journal of Clinical Investigation

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8( ) T cells more relevant to current infections

D Korenkov, THO Nguyen, I Isakova-Sivak, T Smolonogina, LE Brown, K Kedzierska, L Rudenko

Journal article  |  2018  |  Human Vaccines & Immunotherapeutics

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8( ) T Cell-Lineage-Specific Function

Brendan E Russ, Moshe Olshansky, Jasmine Li, Michelle LT Nguyen, Linden J Gearing, Thi HO Nguyen, Matthew R Olson, Hayley A McQuilton, Simone Nussing, Georges Khoury, Damian FJ Purcell, Paul J Hertzog, Sudha Rao, Stephen J Turner

Journal article  |  2017  |  Cell Reports

Fc functional antibodies in humans with severe H7N9 and seasonal influenza

Hillary A Vanderven, Lu Liu, Fernanda Ana-Sosa-Batiz, Thi HO Nguyen, Yanmin Wan, Bruce Wines, P Mark Hogarth, Danielle Tilmanis, Arnold Reynaldi, Matthew S Parsons, Aeron C Hurt, Miles P Davenport, Tom Kotsimbos, Allen C Cheng, Katherine Kedzierska, Xiaoyan Zhang, Jianqing Xu, Stephen J Kent

Journal article  |  2017  |  JCI Insight

Quantifiable predictive features define epitope-specific T cell receptor repertoires

Pradyot Dash, Andrew J Fiore-Gartland, Tomer Hertz, George C Wang, Shalini Sharma, Aisha Souquette, Jeremy Chase Crawford, E Bridie Clemens, Thi HO Nguyen, Katherine Kedzierska, Nicole L La Gruta, Philip Bradley, Paul G Thomas

Journal article  |  2017  |  Nature

Resident memory CD8( ) T cells in the upper respiratory tract prevent pulmonary influenza virus infection

Angela Pizzolla, Thi HO Nguyen, Jeffrey M Smith, Andrew G Brooks, Katherine Kedzierska, William R Heath, Patrick C Reading, Linda M Wakim

Journal article  |  2017  |  Science Immunology

Understanding CD8( ) T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope

Thi HO Nguyen, Amabel CL Tan, Sue D Xiang, Anne Goubier, Kim L Harland, E Bridie Clemens, Magdalena Plebanski, Katherine Kedzierska

Journal article  |  2017  |  Clinical & Translational Immunology

Maintenance of the EBV-specific CD8 TCR alpha beta repertoire in immunosuppressed lung transplant recipients

Ho Nguyen Thi, Nicola L Bird, Emma J Grant, John J Miles, Paul G Thomas, Tom C Kotsimbos, Nicole A Mifsud, Katherine Kedzierska

Journal article  |  2017  |  Immunology & Cell Biology

Molecular basis for universal HLA-A(star)0201-restricted CD8( ) T-cell immunity against influenza viruses

Sophie A Valkenburg, Tracy M Josephs, E Bridie Clemens, Emma J Grant, Thi HO Nguyen, George C Wang, David A Price, Adrian Miller, Steven YC Tong, Paul G Thomas, Peter C Doherty, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Deciphering the clinical relevance of allo-human leukocyte antigen cross-reactivity in mediating alloimmunity following transplantation

Louise C Rowntree, Thi HO Nguyen, Stephanie Gras, Tom C Kotsimbos, Nicole A Mifsud

Journal article  |  2016  |  Current Opinion in Organ Transplantation

Knowns and unknowns of influenza B viruses

Marios Koutsakos, Ho Nguyen Thi, Wendy S Barclay, Katherine Kedzierska

Journal article  |  2016  |  Future Microbiology

Towards Future T Cell-Mediated Influenza Vaccines

Thi Hoang Oanh Nguyen, Marios Koutsakos, Emma Grant, Peter Doherty, Katherine Kedzierska

Journal article  |  2016  |  Infectious Diseases and Translational Medicine

Influenza A virus infections (IAVs) impact significantly on global health, being particularly problematic in children, the elderly..

The Presence of HLA-E-Restricted, CMV-Specific CD8( ) T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection

Lucy C Sullivan, Glen P Westall, Jacqueline ML Widjaja, Nicole A Mifsud, Thi HO Nguyen, Aislin C Meehan, Tom C Kotsimbos, Andrew G Brooks

Journal article  |  2015  |  PLOS ONE

Recognition of Distinct Cross-Reactive Virus-Specific CD8( ) T Cells Reveals a Unique TCR Signature in a Clinical Setting

Thi HO Nguyen, Louise C Rowntree, Daniel G Pellicci, Nicola L Bird, Andreas Handel, Lars Kjer-Nielsen, Katherine Kedzierska, Tom C Kotsimbos, Nicole A Mifsud

Journal article  |  2014  |  Journal of Immunology

Preexisting CD8 T-cell immunity to the H7N9 influenza a virus varies across ethnicities

S Quiñones-Parra, E Grant, L Loh, THO Nguyen, KA Campbell, SYC Tong, A Miller, PC Doherty, D Vijaykrishna, J Rossjohn, S Gras, K Kedzierska

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Preexisting CD8( ) T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Sergio Quinones-Parra, Emma Grant, Liyen Loh, Thi HO Nguyen, Kristy-Anne Campbell, Steven YC Tong, Adrian Miller, Peter C Doherty, Dhanasekaran Vijaykrishna, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Human leucocyte antigen-defined microchimerism early post-transplant does not predict for stable lung allograft function

LC Rowntree, J Bayliss, THO Nguyen, TC Kotsimbos, NA Mifsud

Journal article  |  2013  |  Clinical & Experimental Immunology

Endogenous-peptide-dependent alloreactivity: new scientific insights and clinical implications

LJ D'Orsogna, THO Nguyen, FHJ Claas, C Witt, NA Mifsud

Journal article  |  2013  |  Tissue Antigens

Impact of Commonly Used Transplant Immunosuppressive Drugs on Human NK Cell Function Is Dependent upon Stimulation Condition

Aislin C Meehan, Nicole A Mifsud, Thi HO Nguyen, Bronwyn J Levvey, Greg I Snell, Tom C Kotsimbos, Glen P Westall

Journal article  |  2013  |  PLoS ONE

Cross-Reactive Anti-Viral T Cells Increase Prior to an Episode of Viral Reactivation Post Human Lung Transplantation

Thi HO Nguyen, Glen P Westall, Tara E Bull, Aislin C Meehan, Nicole A Mifsud, Tom C Kotsimbos

Journal article  |  2013  |  PLoS ONE

Quantitative and Functional Diversity of Cross-Reactive EBV-Specific CD8( ) T Cells in a Longitudinal Study Cohort of Lung Transplant Recipients

Nicole A Mifsud, Thi Hoang Oanh Nguyen, Brian D Tait, Tom C Kotsimbos

Journal article  |  2010  |  Transplantation

Cross-presentation of HCMV chimeric protein enables generation and measurement of polyclonal T cells

Thi HO Nguyen, Lucy C Sullivan, Tom C Kotsimbos, Anthony P Schwarer, Nicole A Mifsud

Journal article  |  2010  |  Immunology and Cell Biology

Killer Ig-Like Receptor Ligand Mismatch Directs NK Cell Expansion In Vitro

Mingus JJ Rose, Andrew G Brooks, Lisbeth A Stewart, Thi H Nguyen, Anthony P Schwarer

Journal article  |  2009  |  Journal of Immunology

Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity

Thi HO Nguyen, Nicole A Mifsud, Lisbeth A Stewart, Mingus J Rose, Tamara L Etto, Nicholas A Williamson, Anthony W Purcell, Tom Kotsimbos, Anthony P Schwarer

Journal article  |  2008  |  Protein Expression and Purification

Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli

Tamara L Etto, Lisbeth A Stewart, Thi HO Nguyen, Nicholas A Williamson, Anthony W Purcell, Anthony P Schwarer

Journal article  |  2007  |  Protein Expression and Purification