Clare Scott

Genomics of gynaecological carcinosarcomas and future treatment options.

Holly E Barker, Clare L Scott

Journal article  |  2020  |  Seminars in Cancer Biology

Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemoth..

Therapeutic options for mucinous ovarian carcinoma.

Kylie L Gorringe, Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, David DL Bowtell, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Sian Fereday, C Blake Gilks, Charlie Gourley, Alison M Hadley, Joy Hendley, Sally M Hunter, Scott H Kaufmann, et al.

Journal article  |  2020  |  Gynecologic Oncology

OBJECTIVE: Mucinous ovarian carcinoma (MOC) is an uncommon ovarian cancer histotype that responds poorly to conventional chemother..

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M Rosario Alonso, et al.

Journal article  |  2020  |  Nature Genetics

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underl..

Diverse mechanisms of PARP inhibitor resistance in ovarian cancer

Matthew John Wakefield, Ksenija Nesic, Olga Kondrashova, Clare L Scott

Journal article  |  2019  |  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Development and validation of a targeted gene sequencing panel for application to disparate cancers.

Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, Simon A Mueller, et al.

Journal article  |  2019  |  Scientific Reports

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..

iPREDICT: Incorporating complex profiling of patients to enrol onto molecularly directed cancer therapeutics. Preliminary results of the adult and paediatric

Kortnye Smith, Sophie O'Haire, Khuong-Quang Dong-Anh, Ben Markman, Hui Gan, Paul G Ekert, Ken O'Byrne, Michael Milward, Ben Solomon, Ben Tran, Clare Scott, Grant McArthur, Damien Kee, Andrew Fellowes, Huiling Xu, Melissa Martyn, Elly Lynch, Paula Lorgelly, Clara Gaff, Stephen Fox, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.

Journal article  |  2019  |  npj Breast Cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..

The molecular origin and taxonomy of mucinous ovarian carcinoma

Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, Michael S Anglesio, George Au-Yeung, Maret Bohm, David Dl Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, et al.

Journal article  |  2019  |  Nature Communications

Preclinical rare cancer research to inform clinical trial design

Holly E Barker, Clare L Scott

Journal article  |  2019  |  Nature Reviews Cancer

MUCINOUS OVARIAN CARCINOMA: THERAPEUTIC OPTIONS OLD AND NEW

K Gorringe, D Cheasley, M Wakefield, I Campbell, Y Antill, C Scott

Conference Proceedings  |  2019  |  Plenary sessions

Clarifying the role of EMSY in DNA repair in ovarian cancer

Olga Kondrashova, Clare L Scott

Journal article  |  2019  |  Cancer

MEK Inhibitor Therapy in Carcinomas With RAF1 Fusions: Inferior Response in a Patient With Pancreatic Acinar Cell Carcinoma

Christopher R McEvoy, Damien Kee, Owen WJ Prall, Timothy D Clay, Clare Scott, Anastasia Backhouse, Stephen B Fox, Andrew P Fellowes, Huiling Xu

Journal article  |  2019  |  JCO Precision Oncology

Clinical Utility of Real-Time Targeted Molecular Profiling in the Clinical Management of Ovarian Cancer: The ALLOCATE Study

Olga Kondrashova, Gwo-Yaw Ho, George Au-Yeung, Leakhena Leas, Tiffany Boughtwood, Kathryn Alsop, Giada Zapparoli, Alexander Dobrovic, Yi-An Ko, Arthur L Hsu, Clare J Love, Sebastian Lunke, Matthew J Wakefield, Orla McNally, Michael Quinn, Sumitra Ananda, Deborah Neesham, Anne Hamilton, Marisa Grossi, Alison Freimund, et al.

Journal article  |  2019  |  JCO Precision Oncology

A phase II clinical trial of ipilimumab/nivolumab combination immunotherapy in patients with rare upper gastrointestinal, neuroendocrine, and gynecological malignancies.

Oliver Klein, Damien Kee, Ben Markman, Rachael Chang Lee, Michael Michael, Linda R Mileshkin, Clare L Scott, Richelle Linklater, Sid Menon, Niall C Tebbutt, Jodie Palmer, Andreas Behren, Jonathan S Cebon

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

Elaine Sanij, Katherine Hannan, Shunfei Yan, Jiachen Xuan, Jessica Ahern, Keefe Chan, Jinbae Son, Olga Kondrashova, Elizabeth Lieschke, Matthew Wakefield, Anna Trigos, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Kum Kum Khanna, Linda Mileshkin, Grant McArthur, et al.

Journal article  |  2019

Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..

The FZD7-TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma.

Ming Tan, Mohammad Asad, Valerie Heong, Meng Kang Wong, Tuan Zea Tan, Jieru Ye, Kuee Theng Kuay, Jean Paul Thiery, Clare Scott, Ruby Yun-Ju Huang

Journal article  |  2019  |  Molecular Oncology

Frizzled family receptor 7 (FZD7), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer..

Decoding transcriptomic intra-tumour heterogeneity to guide personalised medicine in ovarian cancer

Tuan Zea Tan, Valerie Heong, Jieru Ye, Diana Lim, Jeffrey Low, Mahesh Choolani, Clare Scott, David Shao Peng Tan, Ruby Yun-Ju Huang

Journal article  |  2019  |  The Journal of Pathology

Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer

Chee Khoon Lee, Clare Scott, Geoffrey J Lindeman, Anne Hamilton, Elizabeth Lieschke, Emma Gibbs, Rebecca Asher, Heath Badger, Robin Paterson, Lauren Macnab, Edmond Michael Kwan, Prudence A Francis, Frances Boyle, Michael Friedlander

Journal article  |  2019  |  British Journal of Cancer

BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

Kevin K Lin, Maria I Harrell, Amit M Oza, Ana Oaknin, Isabelle Ray-Coquard, Anna V Tinker, Elena Helman, Marc R Radke, Carmen Say, Vo Lan-Thanh, Elaina Mann, Jeffrey D Isaacson, Lara Maloney, David M O'Malley, Setsuko K Chambers, Scott H Kaufmann, Clare L Scott, Gottfried E Konecny, Robert L Coleman, James X Sun, et al.

Journal article  |  2019  |  Cancer Discovery

Practical considerations for clinicians for transitioning patients on maintenance therapy with olaparib capsules to the tablet formulation of olaparib

Michael Friedlander, Catherine Shannon, Jeffrey Goh, Clare Scott, Linda Mileshkin

Journal article  |  2018  |  Asia-Pacific Journal of Clinical Oncology

The NOMINATOR trial - panel testing in the Australian context

Clare Scott

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

SRA737, a novel Chk1 inhibitor, shows efficacy in CCNE1-amplified and MYCN-overexpressing high-grade serous ovarian cancer patient-derived xenograft models

GY Ho, H Barker, C Vanderberg, O Kondrashova, E Kyran, E Lieschke, O McNally, A Hamilton, V Heong, R Hansen, S Milutinovic, B Strouse, M Hedrick, C Hassig, D Bowtell, W Matthew, C Scott

Conference Proceedings  |  2018  |  EUROPEAN JOURNAL OF CANCER

Long-term efficacy, tolerability and overall survival in patients with platinum-sensitive, recurrent high-grade serous ovarian cancer treated with maintenance olaparib capsules following response to chemotherapy

Michael Friedlander, Ursula Matulonis, Charlie Gourley, Andreas du Bois, Ignace Vergote, Gordon Rustin, Clare Scott, Werner Meier, Ronnie Shapira-Frommer, Tamar Safra, Daniela Matei, Vadim Shirinkin, Frederic Selle, Anitra Fielding, Elizabeth S Lowe, Emma L McMurtry, Stuart Spencer, Philip Rowe, Helen Mann, David Parry, et al.

Journal article  |  2018  |  British Journal of Cancer

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria Harrell, Giada Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B Pearson, John J Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J Hutt, Scott H Kaufmann, et al.

Journal article  |  2018  |  Nature Communications

TARGETING MYCN OVER-EXPRESSION WITH BRD4 INHIBITION IN THE PROLIFERATIVE C5 SUBTYPE OF HIGH GRADE SEROUS OVARIAN CANCER (HGSOC)

GY Ho, O Kondrashova, C Vandenberg, E Kyran, E Lieschke, V Heong, M Milevskiy, T Papenfuss, J Schroeder, J Weroha, M Dawson, D Bowtell, H Barker, M Wakefield, C Scott

Conference Proceedings  |  2018  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Health-related quality of life and patient-centred outcomes with olaparib maintenance after chemotherapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT Ov-21): a placebo-controlled, phase 3 randomised trial

Michael Friedlander, Val Gebski, Emma Gibbs, Lucy Davies, Ralph Bloomfield, Felix Hilpert, Lari B Wenzel, Daniel Eek, Manuel Rodrigues, Andrew Clamp, Richard T Penson, Diane Provencher, Jacob Korach, Tomasz Huzarski, Laura Vidal, Vanda Salutari, Clare Scott, Maria Ornella Nicoletto, Kenji Tamura, David Espinoza, et al.

Journal article  |  2018  |  The Lancet Oncology

Australian Ovarian Cancer Assortment Trial-Allocating ovarian cancer patients into clinical trials based on molecular profiling.

Olga Kondrashova, George Au-Yeung, Leakhena Leas, Gwo-Yaw Ho, Sebastian Lunke, Kathryn Alsop, Clare Scott, Anne Hamilton, Sumitra Ananda, Alison Freimund, Michael Quinn, Orla McNally, Nadia Traficante, Tiffany Cowie, Matthew Wakefield, Arthur Hsu, Alex Dobrovic, Michael Christie, Graham Taylor, David Bowtell, et al.

Conference Proceedings  |  2018  |  CLINICAL CANCER RESEARCH

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Nguyen Quynh-Nhu, Nadeen Zerafa, Seng H Liew, F Hamish Morgan, Andreas Strasser, Clare L Scott, Jock K Findlay, Martha Hickey, Karla J Hutt

Journal article  |  2018  |  Cell Death & Disease

Targeting DNA repair: the genome as a potential biomarker

Ksenija Nesic, Matthew Wakefield, Olga Kondrashova, Clare L Scott, Iain A McNeish

Journal article  |  2018  |  The Journal of Pathology

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

Olga Kondrashova, Minh Nguyen, Kristy Shield-Artin, Anna V Tinker, Nelson NH Teng, Maria I Harrell, Michael J Kuiper, Gwo-Yaw Ho, Holly Barker, Maria Jasin, Rohit Prakash, Elizabeth M Kass, Meghan R Sullivan, Gregory J Brunette, Kara A Bernstein, Robert L Coleman, Anne Floquet, Michael Friedlander, Ganessan Kichenadasse, David M O'Malley, et al.

Journal article  |  2017  |  Cancer Discovery

Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial.

Eric Pujade-Lauraine, Jonathan A Ledermann, Frédéric Selle, Val Gebski, Richard T Penson, Amit M Oza, Jacob Korach, Tomasz Huzarski, Andrés Poveda, Sandro Pignata, Michael Friedlander, Nicoletta Colombo, Philipp Harter, Keiichi Fujiwara, Isabelle Ray-Coquard, Susana Banerjee, Joyce Liu, Elizabeth S Lowe, Ralph Bloomfield, Patricia Pautier, et al.

Journal article  |  2017  |  The Lancet Oncology

BACKGROUND: Olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, has previously shown efficacy in a phase 2 study when given ..

Hedgehog inhibition impaired platinum response in high-grade serous ovarian cancer harboring high hedgehog ligand expression and mTOR pathway activation.

Gwo Yaw Ho, Elizabeth Lieschke, Elizabeth Kyran, Kristy Shield-Artin, Olga Kondrashova, Holly Barker, Robert Hollian, Aurelie Cazet, Phuong Thuan, Alex Swarbrick, Orla McNally, David Bowtell, Matthew Wakefield, Clare L Scott

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Mainstreaming cancer genetics: A model integrating germline BRCA testing into routine ovarian cancer clinics

Maira Kentwell, Eryn Dow, Yoland Antill, C David Wrede, Orla McNally, Emily Higgs, Anne Hamilton, Sumitra Ananda, Geoffrey J Lindeman, Clare L Scott

Journal article  |  2017  |  Gynecologic Oncology

Global Practices in PDX Programs

GY Ho, CL Scott, K Pham

Book Chapter  |  2017

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial

Elizabeth M Swisher, Kevin K Lin, Amit M Oza, Clare L Scott, Heidi Giordano, James Sun, Gottfried E Konecny, Robert L Coleman, Anna V Tinker, David M O'Malley, Rebecca S Kristeleit, Ling Ma, Katherine M Bell-McGuinn, James D Brenton, Janiel M Cragun, Ana Oaknin, Isabelle Ray-Coquard, Maria I Harrell, Elaina Mann, Scott H Kaufmann, et al.

Journal article  |  2017  |  The Lancet Oncology

Practical guidance on the use of olaparib capsules as maintenance therapy for women with BRCA mutations and platinum-sensitive recurrent ovarian cancer

Michael Friedlander, Susana Banerjee, Linda Mileshkin, Clare Scott, Catherine Shannon, Jeffrey Goh

Journal article  |  2016  |  Asia-Pacific Journal of Clinical Oncology

Secondary mutations in RAD51C and RAD51D are associated with acquired resistance to the PARP inhibitor rucaparib in patients with high-grade ovarian cancer

K Lin, AV Tinker, O Kondrashova, G Ho, M Wakefield, RL Coleman, DM O'Malley, A Floquet, J Sun, L Maloney, H Giordano, T Harding, M Raponi, IA McNeish, E Swisher, CL Scott

Conference Proceedings  |  2016  |  European Journal of Cancer

Quality of life during olaparib maintenance therapy in platinum-sensitive relapsed serous ovarian cancer

Jonathan A Ledermann, Philipp Harter, Charlie Gourley, Michael Friedlander, Ignace Vergote, Gordon Rustin, Clare Scott, Werner Meier, Ronnie Shapira-Frommer, Tamar Safra, Daniela Matei, Anitra Fielding, Bryan Bennett, David Parry, Stuart Spencer, Helen Mann, Ursula Matulonis

Journal article  |  2016  |  British Journal of Cancer

Overall survival in patients with platinum-sensitive recurrent serous ovarian cancer receiving olaparib maintenance monotherapy: an updated analysis from a randomised, placebo-controlled, double-blind, phase 2 trial

Jonathan A Ledermann, Philipp Harter, Charlie Gourley, Michael Friedlander, Ignace Vergote, Gordon Rustin, Clare Scott, Werner Meier, Ronnie Shapira-Frommer, Tamar Safra, Daniela Matei, Anitra Fielding, Stuart Spencer, Philip Rowe, Elizabeth Lowe, Darren Hodgson, Mika A Sovak, Ursula Matulonis

Journal article  |  2016  |  The Lancet Oncology

Patient-derived xenograft models of ovarian/gynecologic tumors

L Liang, I Mercado-Uribe, N Niu, Y Jiang, W Cheng, J Zhang, GB Mills, C Scott, AK Sood, J Liu

Book Chapter  |  2016

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Olaparib maintenance therapy in patients with platinum-sensitive, relapsed serous ovarian cancer and a BRCA mutation: Overall survival adjusted for postprogression poly(adenosine diphosphate ribose) polymerase inhibitor therapy

Ursula A Matulonis, Philipp Harter, Charlie Gourley, Michael Friedlander, Ignace Vergote, Gordon Rustin, Clare Scott, Werner Meier, Ronnie Shapira-Frommer, Tamar Safra, Daniela Matei, Anitra Fielding, Stuart Spencer, David Parry, Lynda Grinsted, Jonathan A Ledermann

Journal article  |  2016  |  Cancer

BCL2-modifying factor promotes germ cell loss during murine oogenesis

Kavitha Vaithiyanathan, Seng H Liew, Nadeen Zerafa, Thilini Gamage, Michele Cook, Lorraine A O'Reilly, Philippe Bouillet, Clare L Scott, Andreas Strasser, Jock K Findlay, Karla J Hutt

Journal article  |  2016  |  Reproduction

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David CS Huang, Lyubomir T Vassilev, Andreas Strasser

Journal article  |  2016  |  Cell Reports

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma

MJ Carter, KL Cox, SJ Blakemore, YD Bogdanov, L Happo, CL Scott, A Strasser, GK Packham, MS Cragg

Journal article  |  2016  |  Cell Death & Differentiation

NGS-based tumor genomic profiling to identify ovarian cancer patients who benefit from the PARP inhibitor rucaparib.

Iain A McNeish, Kevin K Lin, James X Sun, Sandra Goble, Amit Oza, Robert L Coleman, Clare L Scott, Gottfried Konecny, Anna V Tinker, David M O'Malley, Rebecca Kristeleit, Ling Ma, James D Brenton, Katherine Bell-McGuinn, Ana Oaknin, Alexandra Leary, Elaina Mann, Heidi Giordano, Roman Yelensky, Mitch Raponi, et al.

Conference Proceedings  |  2016  |  DNA Damage and Homologous Recombination

Germline BRCA1/2 testing practices in ovarian cancer: Current state and opportunities for new directions.

S Lheureux, K Karakasis, P Harter, C Scott, M Bacon, J Bryce, N Le Fur, E Pujade-Lauraine, AM Oza

Journal article  |  2016  |  Gynecologic Oncology

PURPOSE: Given the implications for clinical care and prevention in identifying a BRCA1/2 mutation, the objective of this study wa..

CART WHEEL

Clare Scott

Conference Proceedings  |  2015  |  Asia-Pacific Journal of Clinical Oncology

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

David D Bowtell, Steffen Boehm, Ahmed A Ahmed, Paul-Joseph Aspuria, Robert C Bast, Valerie Beral, Jonathan S Berek, Michael J Birrer, Sarah Blagden, Michael A Bookman, James D Brenton, Katherine B Chiappinelli, Filipe Correia Martins, George Coukos, Ronny Drapkin, Richard Edmondson, Christina Fotopoulou, Hani Gabra, Jerome Galon, Charlie Gourley, et al.

Journal article  |  2015  |  Nature Reviews Cancer

MOLECULAR CLASSIFICATION OF OVARIAN CANCER

Clare Scott

Conference Proceedings  |  2015  |  Asia-Pacific Journal of Clinical Oncology

A novel companion diagnostic predicts response to the PARP inhibitor rucaparib in ovarian cancer

James Sun, Lain McNeish, Robert L Coleman, Amit Oza, Clare Scott, David M O'Malley, Kevin K Lin, Christine Burns, Christine Vietz, Philip J Stephens, Murtaza Mehdi, Matthew Hawryluk, Heidi Giordano, Mitch Raponi, Lindsey Rolfe, Jeff Isaacson, Vincent A Miller, Andrew Allen, Elizabeth Swisher, Roman Yelensky

Conference Proceedings  |  2015  |  Clinical Research (Excluding Clinical Trials)

Frequency, severity and timing of common adverse events (AEs) with maintenance olaparib in patients (pts) with platinum-sensitive relapsed serous ovarian cancer (PSR SOC).

Ursula Matulonis, Michael Friedlander, Andreas Du Bois, Charlie Gourley, Ignace Vergote, Gordon JS Rustin, Clare L Scott, Werner Meier, Ronnie Shapira-Frommer, Tamar Safra, Daniela Matei, Anitra Fielding, Emma McMurtry, Stuart Spencer, Helen Mann, David Parry, Jonathan A Ledermann

Conference Proceedings  |  2015  |  Journal of Clinical Oncology

Results of ARIEL2: A Phase 2 trial to prospectively identify ovarian cancer patients likely to respond to rucaparib using tumor genetic analysis.

Iain A McNeish, Amit M Oza, Robert L Coleman, Clare L Scott, Gottfried E Konecny, Anna Tinker, David M O'Malley, James Brenton, Rebecca Sophie Kristeleit, Katherine Bell-McGuinn, Ana Oaknin, Alexandra Leary, Kevin Lin, Mitch Raponi, Heidi Giordano, Sandra Goble, Lindsey Rolfe, Roman Yelensky, Andrew R Allen, Elizabeth M Swisher

Conference Proceedings  |  2015  |  JOURNAL OF CLINICAL ONCOLOGY

Poly (ADP-Ribose) Polymerase Inhibitors: Recent Advances and Future Development

Clare L Scott, Elizabeth M Swisher, Scott H Kaufmann

Journal article  |  2015  |  Journal of Clinical Oncology

Prioritizing therapeutic targets using patient-derived xenograft models

KA Lodhia, AM Hadley, P Haluska, CL Scott

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

RARE CANCERS: HOW FAR HAVE WE COME AND WHERE SHOULD WE BE HEADING? EXTENDING EVIDENCE-BASED CARE TO PEOPLE WITH RARE CANCERS

Sumitra Ananda, Clare Scott

Journal article  |  2015  |  Cancer Forum

USING PATIENT-DERIVED XENOGRAFTS TO DEFINE ACTIONABLE ABERRATIONS IN HIGH-GRADE SEROUS CANCER

Clare Scott

Conference Proceedings  |  2014  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

UPDATED RESULTS OF ARIEL2, A PHASE 2 OPEN-LABEL STUDY TO IDENTIFY OVARIAN CANCER PATIENTS LIKELY TO RESPOND TO RUCAPARIB

I McNeish, RL Coleman, A Oza, G Konecny, DM O'Malley, G Kichenadasse, CL Scott, A Oaknin, A Floquet, D Park, JD Brenton, K Lin, S Shetty, H Giordano, M Raponi, L Rolfe, E Swisher

Conference Proceedings  |  2014  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Olaparib Maintenance Therapy in Patients With Platinum-Sensitive Relapsed Serous Ovarian Cancer: A Preplanned Retrospective Analysis of Outcomes by BRCA Status in a Randomised Phase 2 Trial EDITORIAL COMMENT

Jonathan Ledermann, Philipp Harter, Charlie Gourley, Michael Friedlander, Ignace Vergote, Gordon Rustin, Clare L Scott, Werner Meier, Ronnie Shapira-Frommer, Tamar Safra, Daniela Matei, Anitra Fielding, Stuart Spencer, Brian Dougherty, Maria Orr, Darren Hodgson, J Carl Barrett, Ursula Matulonis

Journal article  |  2014  |  Obstetrical & Gynecological Survey

PUMA regulates germ cell loss and primordial follicle endowment in mice

Michelle Myers, F Hamish Morgan, Seng H Liew, Nadeen Zerafa, Thilini Upeksha Gamage, Mai Sarraj, Michele Cook, Ileana Kapic, Antony Sutherland, Clare L Scott, Andreas Strasser, Jock K Findlay, Jeffrey B Kerr, Karla J Hutt

Journal article  |  2014  |  Reproduction

Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary

Sarah A Best, Karla J Hutt, Nai Yang Fu, Francois Vaillant, Seng H Liew, Lynne Hartley, Clare L Scott, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2014  |  Development

Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial

Jonathan Ledermann, Philipp Harter, Charlie Gourley, Michael Friedlander, Ignace Vergote, Gordon Rustin, Clare L Scott, Werner Meier, Ronnie Shapira-Frommer, Tamar Safra, Daniela Matei, Anitra Fielding, Stuart Spencer, Brian Dougherty, Maria Orr, Darren Hodgson, J Carl Barrett, Ursula Matulonis

Journal article  |  2014  |  The Lancet Oncology

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

Monique D Topp, Lynne Hartley, Michele Cook, Valerie Heong, Emma Boehm, Lauren McShane, Jan Pyman, Orla McNally, Sumitra Ananda, Marisol Harrell, Dariush Etemadmoghadam, Laura Galletta, Kathryn Alsop, Gillian Mitchell, Stephen B Fox, Jeffrey B Kerr, Karla J Hutt, Scott H Kaufmann, Elizabeth M Swisher, David D Bowtell, et al.

Journal article  |  2014  |  Molecular Oncology

Loss of the Proapoptotic BH3-Only Protein BCL-2 Modifying Factor Prolongs the Fertile Life Span in Female Mice1

Seng H Liew, Kavitha Vaithiyanathan, Michele Cook, Philippe Bouillet, Clare L Scott, JB Kerr, Andreas Strasser, Jock K Findlay, Karla J Hutt

Journal article  |  2014  |  Biology of Reproduction

Patient-derived xenograft models in gynecologic malignancies.

Clare L Scott, Helen J Mackay, Paul Haluska

Journal article  |  2014  |  American Society of Clinical Oncology Educational Book

In the era of targeted therapies, patients with gynecologic malignancies have not yet been major beneficiaries of this new class o..

Patient-derived xenograft models to improve targeted therapy in epithelial ovarian cancer treatment

CL Scott, MA Becker, P Haluska, G Samimi

Journal article  |  2013  |  Frontiers in Oncology

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

Ophelie Meynet, Barbara Zunino, Lina Happo, Ludivine A Pradelli, Johanna Chiche, Marie A Jacquin, Laura Mondragon, Jean-Francois Tanti, Bruno Taillan, Georges Garnier, Julie Reverso-Meinietti, Nicolas Mounier, Jean-Francois Michiels, Ewa M Michalak, Michel Carles, Clare L Scott, Jean-Ehrland Ricci

Journal article  |  2013  |  Blood

How to best preserve oocytes in female cancer patients exposed to DNA damage inducing therapeutics

K Hutt, JB Kerr, CL Scott, JK Findlay, A Strasser

Journal article  |  2013  |  Cell Death & Differentiation

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Liz J Valente, Daniel HD Gray, Ewa M Michalak, Josefina Pinon-Hofbauer, Alex Egle, Clare L Scott, Ana Janic, Andreas Strasser

Journal article  |  2013  |  Cell Reports

The zebrafish reference genome sequence and its relationship to the human genome.

Kerstin Howe, Matthew D Clark, Carlos F Torroja, James Torrance, Camille Berthelot, Matthieu Muffato, John E Collins, Sean Humphray, Karen McLaren, Lucy Matthews, Stuart McLaren, Ian Sealy, Mario Caccamo, Carol Churcher, Carol Scott, Jeffrey C Barrett, Romke Koch, Gerd-Jörg Rauch, Simon White, William Chow, et al.

Journal article  |  2013  |  Nature

Zebrafish have become a popular organism for the study of vertebrate gene function. The virtually transparent embryos of this spec..

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Paul Koenen, Susanne Heinzel, Emma M Carrington, Lina Happo, Warren S Alexander, Jian-Guo Zhang, Marco J Herold, Clare L Scott, Andrew M Lew, Andreas Strasser, Philip D Hodgkin

Journal article  |  2013  |  Nature Communications

Seven newly identified loci for autoimmune thyroid disease.

Jason D Cooper, Matthew J Simmonds, Neil M Walker, Oliver Burren, Oliver J Brand, Hui Guo, Chris Wallace, Helen Stevens, Gillian Coleman, undefined Wellcome Trust Case Control Consortium, Jayne A Franklyn, John A Todd, Stephen CL Gough

Journal article  |  2012  |  Human Molecular Genetics

Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of t..

Analyses of pig genomes provide insight into porcine demography and evolution.

Martien AM Groenen, Alan L Archibald, Hirohide Uenishi, Christopher K Tuggle, Yasuhiro Takeuchi, Max F Rothschild, Claire Rogel-Gaillard, Chankyu Park, Denis Milan, Hendrik-Jan Megens, Shengting Li, Denis M Larkin, Heebal Kim, Laurent AF Frantz, Mario Caccamo, Hyeonju Ahn, Bronwen L Aken, Anna Anselmo, Christian Anthon, Loretta Auvil, et al.

Journal article  |  2012  |  Nature

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, hu..

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

Jeffrey B Kerr, Karla J Hutt, Ewa M Michalak, Michele Cook, Cassandra J Vandenberg, Seng H Liew, Philippe Bouillet, Alea Mills, Clare L Scott, Jock K Findlay, Andreas Strasser

Journal article  |  2012  |  Molecular Cell

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

Jeffrey B Kerr, Karla J Hutt, Michele Cook, Terence P Speed, Andreas Strasser, Jock K Findlay, Clare L Scott

Journal article  |  2012  |  Nature Medicine

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

Kamil Wolyniec, Jake Shortt, Elisa de Stanchina, Yaara Levav-Cohen, Osnat Alsheich-Bartok, Igal Louria-Hayon, Vincent Corneille, Beena Kumar, Simone J Woods, Stephen Opat, Ricky W Johnstone, Clare L Scott, David Segal, Pier Paolo Pandolfi, Stephen Fox, Andreas Strasser, Yong-Hui Jiang, Scott W Lowe, Sue Haupt, Ygal Haupt

Journal article  |  2012  |  Blood

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.

Marjorie J Lindhurst, Victoria ER Parker, Felicity Payne, Julie C Sapp, Simon Rudge, Julie Harris, Alison M Witkowski, Qifeng Zhang, Matthijs P Groeneveld, Carol E Scott, Allan Daly, Susan M Huson, Laura L Tosi, Michael L Cunningham, Thomas N Darling, Joseph Geer, Zoran Gucev, V Reid Sutton, Christos Tziotzios, Adrian K Dixon, et al.

Journal article  |  2012  |  Nature Genetics

The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is critical for cellular growth and metabolism. Correspondingly, lo..

Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs

L Happo, B Phipson, GK Smyth, A Strasser, CL Scott

Journal article  |  2012  |  Cell Death & Disease

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

Jonathan Ledermann, Philipp Harter, Charlie Gourley, Michael Friedlander, Ignace Vergote, Gordon Rustin, Clare Scott, Werner Meier, Ronnie Shapira-Frommer, Tamar Safra, Daniela Matei, Euan Macpherson, Claire Watkins, James Carmichael, Ursula Matulonis

Journal article  |  2012  |  New England Journal of Medicine

The primordial follicle reserve is not renewed after chemical or gamma-irradiation mediated depletion

JB Kerr, L Brogan, M Myers, KJ Hutt, T Mladenovska, S Ricardo, K Hamza, CL Scott, A Strasser, JK Findlay

Journal article  |  2012  |  REPRODUCTION

A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(®) for methylome profiling.

Christine Clark, Priit Palta, Christopher J Joyce, Carol Scott, Elin Grundberg, Panos Deloukas, Aarno Palotie, Alison J Coffey

Journal article  |  2012  |  PLoS ONE

DNA methylation is one of the most studied epigenetic marks in the human genome, with the result that the desire to map the human ..

CART-WHEEL.org Can Facilitate Research Into Rare Gynecological Tumors

Susie Bae, Michael Friedlander, Clare L Scott

Journal article  |  2011  |  International Journal of Gynecologic Cancer

Challenges to the Development of New Agents for Molecularly Defined Patient Subsets: Lessons From BRCA1/2-Associated Breast Cancer

Susan M Domchek, Gillian Mitchell, Geoffrey J Lindeman, Nadine M Tung, Judith Balmana, Steven J Isakoff, Rita Schmutzler, M William Audeh, Niklas Loman, Clare Scott, Michael Friedlander, Bella Kaufman, Judy E Garber, Andrew Tutt, Mark E Robson

Journal article  |  2011  |  Journal of Clinical Oncology

An activating mutation of AKT2 and human hypoglycemia

K Hussain, B Challis, N Rocha, F Payne, M Minic, A Thompson, A Daly, C Scott, J Harris, BJL Smillie, DB Savage, U Ramaswami, P De Lonlay, S O'Rahilly, I Barroso, RK Semple

Journal article  |  2011  |  Science

The role of poly adenosine diphosphate ribose polymerase inhibitors in breast and ovarian cancer: Current status and future directions

Fiona Chionh, Gillian Mitchell, Geoffrey J Lindeman, Michael Friedlander, Clare L Scott

Journal article  |  2011  |  Asia-Pacific Journal of Clinical Oncology

The GENCODE exome: sequencing the complete human exome.

Alison J Coffey, Felix Kokocinski, Maria S Calafato, Carol E Scott, Priit Palta, Eleanor Drury, Christopher J Joyce, Emily M Leproust, Jen Harrow, Sarah Hunt, Anna-Elina Lehesjoki, Daniel J Turner, Tim J Hubbard, Aarno Palotie

Journal article  |  2011  |  European Journal of Human Genetics

Sequencing the coding regions, the exome, of the human genome is one of the major current strategies to identify low frequency and..

Type I Interferon Drives Dendritic Cell Apoptosis via Multiple BH3-Only Proteins following Activation by PolyIC In Vivo

Silvia A Fuertes Marraco, Clare L Scott, Philippe Bouillet, Annette Ives, Slavica Masina, David Vremec, Elisa S Jansen, Lorraine A O'Reilly, Pascal Schneider, Nicolas Fasel, Ken Shortman, Andreas Strasser, Hans Acha-Orbea

Journal article  |  2011  |  PLoS One

Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737

Adrian P Wiegmans, Amber E Alsop, Michael Bots, Leonie A Cluse, Steven P Williams, Kellie-Marie Banks, Rachael Ralli, Clare L Scott, Anna Frenzel, Andreas Villunger, Ricky W Johnstone

Journal article  |  2011  |  Cancer Research

CEP152 is a genome maintenance protein disrupted in Seckel syndrome.

Ersan Kalay, Gökhan Yigit, Yakup Aslan, Karen E Brown, Esther Pohl, Louise S Bicknell, Hülya Kayserili, Yun Li, Beyhan Tüysüz, Gudrun Nürnberg, Wieland Kiess, Manfred Koegl, Ingelore Baessmann, Kurtulus Buruk, Bayram Toraman, Saadettin Kayipmaz, Sibel Kul, Mevlit Ikbal, Daniel J Turner, Martin S Taylor, et al.

Journal article  |  2011  |  Nature Genetics

Functional impairment of DNA damage response pathways leads to increased genomic instability. Here we describe the centrosomal pro..

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Lina Happo, Mark S Cragg, Belinda Phipson, Jon M Haga, Elisa S Jansen, Marco J Herold, Grant Dewson, Ewa M Michalak, Cassandra J Vandenberg, Gordon K Smyth, Andreas Strasser, Suzanne Cory, Clare L Scott

Journal article  |  2010  |  Blood

Early diagosis of Werner's syndrome using exome-wide sequencingin a singe, atypical patient

E Raffan, LA Hurst, S Al Turki, G Carpenter, C Scott, A Daly, A Coffey, S Bhaskar, E Howard, N Khan, H Kington, A Palotie, DB Savag, M O'Driscoll, C Smith, S O'Rahilly, I Barroso, RK Semple

Journal article  |  2010  |  Frontiers in Endocrinology

A map of human genome variation from population-scale sequencing

David Altshuler, Richard M Durbin, Goncalo R Abecasis, David R Bentley, Aravinda Chakravarti, Andrew G Clark, Francis S Collins, Francisco M De la Vega, Peter Donnelly, Michael Egholm, Paul Flicek, Stacey B Gabriel, Richard A Gibbs, Bartha M Knoppers, Eric S Lander, Hans Lehrach, Elaine R Mardis, Gil A McVean, DebbieA Nickerson, Leena Peltonen, et al.

Journal article  |  2010  |  Nature

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

Ewa M Michalak, Cassandra J Vandenberg, Alex RD Delbridge, Li Wu, Clare L Scott, Jerry M Adams, Andreas Strasser

Journal article  |  2010  |  Genes & Development

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

M William Audeh, James Carmichael, Richard T Penson, Michael Friedlander, Bethan Powell, Katherine M Bell-McGuinn, Clare Scott, Jeffrey N Weitzel, Ana Oaknin, Niklas Loman, Karen Lu, Rita K Schmutzler, Ursula Matulonis, Mark Wickens, Andrew Tutt

Journal article  |  2010  |  The Lancet

Erratum: Target-enrichment strategies for next-generation sequencing (Nature Methods (2010) 7 (111-118))

L Mamanova, AJ Coffey, CE Scott, I Kozarewa, EH Turner, A Kumar, E Howard, J Shendure, DJ Turner

Journal article  |  2010  |  Nature Methods

c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway

Christine BF Thien, Samantha A Dagger, James H Steer, Frank Koentgen, Elisa S Jansen, Clare L Scott, Wallace Y Langdon

Journal article  |  2010  |  Journal of Biological Chemistry

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Nick Craddock, Matthew E Hurles, Niall Cardin, Richard D Pearson, Vincent Plagnol, Samuel Robson, Damjan Vukcevic, Chris Barnes, Donald F Conrad, Eleni Giannoulatou, Chris Holmes, Jonathan L Marchini, Kathy Stirrups, Martin D Tobin, Louise V Wain, Chris Yau, Jan Aerts, Tariq Ahmad, T Daniel Andrews, Hazel Arbury, et al.

Journal article  |  2010  |  Nature

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

Mark D McKenzie, Emma Jamieson, Elisa S Jansen, Clare L Scott, David CS Huang, Philippe Bouillet, Janette Allison, Thomas WH Kay, Andreas Strasser, Helen E Thomas

Journal article  |  2010  |  Diabetes

Target-enrichment strategies for next-generation sequencing.

Lira Mamanova, Alison J Coffey, Carol E Scott, Iwanka Kozarewa, Emily H Turner, Akash Kumar, Eleanor Howard, Jay Shendure, Daniel J Turner

Journal article  |  2010  |  Nature Methods

We have not yet reached a point at which routine sequencing of large numbers of whole eukaryotic genomes is feasible, and so it is..

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

Mark S Cragg, Claire Harris, Andreas Strasser, Clare L Scott

Journal article  |  2009  |  Nat. Rev. Cancer

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

Kylie D Mason, Cassandra J Vandenberg, Clare L Scott, Andrew H Wei, Suzanne Cory, David CS Huang, Andrew W Roberts

Journal article  |  2008  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

Mark S Cragg, Elisa S Jansen, Michele Cook, Claire Harris, Andreas Strasser, Clare L Scott

Journal article  |  2008  |  J. Clin. Invest.

The evolution of the DLK1-DIO3 imprinted domain in mammals

Carol A Edwards, Andrew J Mungall, Lucy Matthews, Edward Ryder, Dionne J Gray, Andrew J Pask, Geoffrey Shaw, Jennifer AM Graves, Jane Rogers, Ian Dunham, Marilyn B Renfree, Anne C Ferguson-Smith

Journal article  |  2008  |  PLoS Biology

Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21.

Robert Lyle, Paola Prandini, Kazutoyo Osoegawa, Boudewijn ten Hallers, Sean Humphray, Baoli Zhu, Eduardo Eyras, Robert Castelo, Christine P Bird, Sarantos Gagos, Carol Scott, Antony Cox, Samuel Deutsch, Catherine Ucla, Marc Cruts, Sophie Dahoun, Xinwei She, Frederique Bena, Sheng-Yue Wang, Christine Van Broeckhoven, et al.

Journal article  |  2007  |  Genome Research

The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial seque..

Genome-wide association study identifies novel breast cancer susceptibility loci

Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, et al.

Journal article  |  2007  |  Nature

Definition of the zebrafish genome using flow cytometry and cytogenetic mapping.

Jennifer L Freeman, Adeola Adeniyi, Ruby Banerjee, Stephanie Dallaire, Sean F Maguire, Jianxiang Chi, Bee Ling Ng, Cinthya Zepeda, Carol E Scott, Sean Humphray, Jane Rogers, Yi Zhou, Leonard I Zon, Nigel P Carter, Fengtang Yang, Charles Lee

Journal article  |  2007  |  BMC Genomics

BACKGROUND: The zebrafish (Danio rerio) is an important vertebrate model organism system for biomedical research. The syntenic con..

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis

Leigh Coultas, Susanna Terzano, Tim Thomas, Anne Voss, Kate Reid, Edouard G Stanley, Clare L Scott, Philippe Bouillet, Perry Bartlett, Jonathan Ham, Jerry M Adams, Andreas Strasser

Journal article  |  2007  |  J. Cell Sci.

Role of the chromobox protein CBX7 in lymphomagenesis

Clare L Scott, Jesus Gil, Eva Hernando, Julie Teruya-Feldstein, Masako Narita, Dolores Martinez, Tapio Visakorpi, David Mu, Carlos Cordon-Cardo, Gordon Peters, David Beach, Scott W Lowe

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

A high utility integrated map of the pig genome.

Sean J Humphray, Carol E Scott, Richard Clark, Brandy Marron, Clare Bender, Nick Camm, Jayne Davis, Andrew Jenks, Angela Noon, Manish Patel, Harminder Sehra, Fengtang Yang, Margarita B Rogatcheva, Denis Milan, Patrick Chardon, Gary Rohrer, Dan Nonneman, Pieter de Jong, Stacey N Meyers, Alan Archibald, et al.

Journal article  |  2007  |  Genome Biology

BACKGROUND: The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial econo..

A high-resolution map of synteny disruptions in gibbon and human genomes.

Lucia Carbone, Gery M Vessere, Boudewijn FH ten Hallers, Baoli Zhu, Kazutoyo Osoegawa, Alan Mootnick, Andrea Kofler, Johannes Wienberg, Jane Rogers, Sean Humphray, Carol Scott, R Alan Harris, Aleksandar Milosavljevic, Pieter J de Jong

Journal article  |  2006  |  PLoS Genetics

Gibbons are part of the same superfamily (Hominoidea) as humans and great apes, but their karyotype has diverged faster from the c..

Accurate and reliable high-throughput detection of copy number variation in the human genome.

Heike Fiegler, Richard Redon, Dan Andrews, Carol Scott, Robert Andrews, Carol Carder, Richard Clark, Oliver Dovey, Peter Ellis, Lars Feuk, Lisa French, Paul Hunt, Dimitrios Kalaitzopoulos, James Larkin, Lyndal Montgomery, George H Perry, Bob W Plumb, Keith Porter, Rachel E Rigby, Diane Rigler, et al.

Journal article  |  2006  |  Genome Research

This study describes a new tool for accurate and reliable high-throughput detection of copy number variation in the human genome. ..

Erratum: The DNA sequence and biological annotation of human chromosome 1 (Nature (2006) 441 (315-321))

SG Gregory, KF Barlow, KE McLay, R Kaul, D Swarbreck, A Dunham, CE Scott, KL Howe, K Woodfine, CCA Spencer, MC Jones, C Gillson, S Searle, Y Zhou, F Kokocinski, L McDonald, R Evans, K Phillips, A Atkinson, R Cooper, et al.

Journal article  |  2006  |  Nature

MLPA: a rapid, reliable, and sensitive method for detection and analysis of abnormalities of 22q.

JAS Vorstman, GR Jalali, EF Rappaport, AM Hacker, C Scott, BS Emanuel

Journal article  |  2006  |  Human Mutation

In this study, essential test characteristics of the recently described multiplex ligation-dependent probe amplification (MLPA) me..

Optimal selection of individuals for BRCA mutation testing - Reply

Paul A James, Rebecca Doherty, Marion Harris, Mary-Anne Young, Clare Scott

Journal article  |  2006  |  Journal of Clinical Oncology

Defining the apoptotic pathways underlying histone deacetylase inhibitor-mediated tumor therapy

Ralph K Lindemann, Andrea Newbold, Kate Whitecross, Anthony E Dear, Clare L Scott, Andrew Wei, Victoria Richon, Scott W Lowe, Ricky W Johnstone

Conference Proceedings  |  2006  |  European Journal of Cancer Supplements

The DNA sequence and biological annotation of human chromosome 1.

SG Gregory, KF Barlow, KE McLay, R Kaul, D Swarbreck, A Dunham, CE Scott, KL Howe, K Woodfine, CCA Spencer, MC Jones, C Gillson, S Searle, Y Zhou, F Kokocinski, L McDonald, R Evans, K Phillips, A Atkinson, R Cooper, et al.

Journal article  |  2006  |  Nature

The reference sequence for each human chromosome provides the framework for understanding genome function, variation and evolution..

Prenatal detection of unbalanced chromosomal rearrangements by array CGH.

L Rickman, H Fiegler, C Shaw-Smith, R Nash, V Cirigliano, G Voglino, BL Ng, C Scott, J Whittaker, M Adinolfi, NP Carter, M Bobrow

Journal article  |  2006  |  Journal of Medical Genetics

BACKGROUND: Karyotype analysis has been the standard method for prenatal cytogenetic diagnosis since the 1970s. Although highly re..

Optimal selection of individuals for BRCA mutation testing: A comparison of available methods

PA James, R Doherty, M Harris, BN Mukesh, A Milner, MA Young, C Scott

Journal article  |  2006  |  Journal of Clinical Oncology

Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.

D Yu, C Scott, WW Jia, A De Benedetti, BJ Williams, L Fazli, Y Wen, M Gleave, C Nelson, PS Rennie

Journal article  |  2006  |  Cancer Gene Therapy

To develop a gene therapy that would selectively kill prostate cancer cells while sparing normal cells, we have constructed lentiv..

Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource

GJ Mann, H Thorne, RL Balleine, PN Butow, CL Clarke, E Edkins, GM Evans, S Fereday, E Haan, M Gattas, GG Giles, J Goldblatt, JL Hopper, J Kirk, JA Leary, G Lindeman, E Niedermayr, KA Phillips, S Picken, GM Pupo, et al.

Journal article  |  2006  |  Breast Cancer Research

Facilitating genome navigation: survey sequencing and dense radiation-hybrid gene mapping.

Christophe Hitte, Jennifer Madeoy, Ewen F Kirkness, Catherine Priat, Travis D Lorentzen, Fabrice Senger, Dan Thomas, Thomas Derrien, Christina Ramirez, Carol Scott, Gwenaelle Evanno, Barbara Pullar, Edouard Cadieu, Vinay Oza, Kristelle Lourgant, David B Jaffe, Sandrine Tacher, Stéphane Dréano, Nadia Berkova, Catherine André, et al.

Journal article  |  2005  |  Nature Reviews Genetics

Accurate and comprehensive sequence coverage for large genomes has been restricted to only a few species of specific interest. Low..

Is Apaf-1 expression frequently abrogated in melanoma?

JD Allen, XD Zhang, CL Scott, GM Boyle, P Hersey, A Strasser

Journal article  |  2005  |  Cell Death Differ.

Comprehensive DNA copy number profiling of meningioma using a chromosome 1 tiling path microarray identifies novel candidate tumor suppressor loci.

Patrick G Buckley, Caroline Jarbo, Uwe Menzel, Tiit Mathiesen, Carol Scott, Simon G Gregory, Cordelia F Langford, Jan P Dumanski

Journal article  |  2005  |  Cancer Research

Meningiomas are common neoplasms of the meninges lining of the central nervous system. Deletions of 1p have been established as im..

The DNA sequence of the human X chromosome.

Mark T Ross, Darren V Grafham, Alison J Coffey, Steven Scherer, Kirsten McLay, Donna Muzny, Matthias Platzer, Gareth R Howell, Christine Burrows, Christine P Bird, Adam Frankish, Frances L Lovell, Kevin L Howe, Jennifer L Ashurst, Robert S Fulton, Ralf Sudbrak, Gaiping Wen, Matthew C Jones, Matthew E Hurles, T Daniel Andrews, et al.

Journal article  |  2005  |  Nature

The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We..

Tiling path resolution mapping of constitutional 1p36 deletions by array-CGH: contiguous gene deletion or "deletion with positional effect" syndrome?

R Redon, M Rio, SG Gregory, RA Cooper, H Fiegler, D Sanlaville, R Banerjee, C Scott, P Carr, C Langford, V Cormier-Daire, A Munnich, NP Carter, L Colleaux

Journal article  |  2005  |  Journal of Medical Genetics

Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags.

Simon J Hubbard, Darren V Grafham, Kevin J Beattie, Ian M Overton, Stuart R McLaren, Michael DR Croning, Paul E Boardman, James K Bonfield, Joan Burnside, Robert M Davies, Elizabeth R Farrell, Matthew D Francis, Sam Griffiths-Jones, Sean J Humphray, Christopher Hyland, Carol E Scott, Haizhou Tang, Ruth G Taylor, Cheryll Tickle, William RA Brown, et al.

Journal article  |  2005  |  Genome Research

We present an analysis of the chicken (Gallus gallus) transcriptome based on the full insert sequences for 19,626 cDNAs, combined ..

The DNA sequence and comparative analysis of human chromosome 10.

P Deloukas, ME Earthrowl, DV Grafham, M Rubenfield, L French, CA Steward, SK Sims, MC Jones, S Searle, C Scott, K Howe, SE Hunt, TD Andrews, JGR Gilbert, D Swarbreck, JL Ashurst, A Taylor, J Battles, CP Bird, R Ainscough, et al.

Journal article  |  2004  |  Nature

The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic D..

DNA sequence and analysis of human chromosome 9.

SJ Humphray, K Oliver, AR Hunt, RW Plumb, JE Loveland, KL Howe, TD Andrews, S Searle, SE Hunt, CE Scott, MC Jones, R Ainscough, JP Almeida, KD Ambrose, RIS Ashwell, AK Babbage, S Babbage, CL Bagguley, J Bailey, R Banerjee, et al.

Journal article  |  2004  |  Nature

Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphi..

The DNA sequence and analysis of human chromosome 13.

A Dunham, LH Matthews, J Burton, JL Ashurst, KL Howe, KJ Ashcroft, DM Beare, DC Burford, SE Hunt, S Griffiths-Jones, MC Jones, SJ Keenan, K Oliver, CE Scott, R Ainscough, JP Almeida, KD Ambrose, DT Andrews, RIS Ashwell, AK Babbage, et al.

Journal article  |  2004  |  Nature

Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 ..

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation

CL Scott, M Schuler, VS Marsden, A Egle, M Pellegrini, D Nesic, S Gerondakis, SL Nutt, DR Green, A Strasser

Journal article  |  2004  |  J. Cell Biol.

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization.

Yeun-Jun Chung, Jos Jonkers, Hannah Kitson, Heike Fiegler, Sean Humphray, Carol Scott, Sarah Hunt, Yuejin Yu, Ichiko Nishijima, Arno Velds, Henne Holstege, Nigel Carter, Allan Bradley

Journal article  |  2004  |  Genome Research

Microarray-based comparative genomic hybridization (CGH) has become a powerful method for the genome-wide detection of chromosomal..

The DNA sequence and analysis of human chromosome 6.

AJ Mungall, SA Palmer, SK Sims, CA Edwards, JL Ashurst, L Wilming, MC Jones, R Horton, SE Hunt, CE Scott, JGR Gilbert, ME Clamp, G Bethel, S Milne, R Ainscough, JP Almeida, KD Ambrose, TD Andrews, RIS Ashwell, AK Babbage, et al.

Journal article  |  2003  |  Nature

Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,98..

Average age-specific cumulative risk of breast cancer according to type and site of germline mutations in BRCA1 and BRCA2 estimated from multiple-case breast cancer families attending Australian family cancer clinics

CL Scott, MA Jenkins, MC Southey, TA Davis, JA Leary, DF Easton, KA Phillips, JL Hopper

Journal article  |  2003  |  Human Genetics

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

A Villunger, C Scott, P Bouillet, A Strasser

Journal article  |  2003  |  Blood

The usefulness of fluorine 18-labelled deoxyglucose positron emission tomography in the investigation of patients with cervical lymphadenopathy from an unknown primary tumor

GB Fogarty, LJ Peters, J Stewart, C Scott, D Rischin, RJ Hicks

Journal article  |  2003  |  Head & Neck

Initial sequencing and comparative analysis of the mouse genome.

undefined Mouse Genome Sequencing Consortium, Robert H Waterston, Kerstin Lindblad-Toh, Ewan Birney, Jane Rogers, Josep F Abril, Pankaj Agarwal, Richa Agarwala, Rachel Ainscough, Marina Alexandersson, Peter An, Stylianos E Antonarakis, John Attwood, Robert Baertsch, Jonathon Bailey, Karen Barlow, Stephan Beck, Eric Berry, Bruce Birren, Toby Bloom, et al.

Journal article  |  2002  |  Nature

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experime..

A physical map of the mouse genome.

Simon G Gregory, Mandeep Sekhon, Jacqueline Schein, Shaying Zhao, Kazutoyo Osoegawa, Carol E Scott, Richard S Evans, Paul W Burridge, Tony V Cox, Christopher A Fox, Richard D Hutton, Ian R Mullenger, Kimbly J Phillips, James Smith, Jim Stalker, Glen J Threadgold, Ewan Birney, Kristine Wylie, Asif Chinwalla, John Wallis, et al.

Journal article  |  2002  |  Nature

A physical map of a genome is an essential guide for navigation, allowing the location of any gene or other landmark in the chromo..

Dominant negative ATM mutations in breast cancer families

G Chenevix-Trench, AB Spurdle, M Gatei, H Kelly, A Marsh, XQ Chen, K Donn, M Cummings, D Nyholt, MA Jenkins, C Scott, GM Pupo, T Dork, R Bendix, J Kirk, K Tucker, MRE McCredie, JL Hopper, J Sambrook, GJ Mann, et al.

Journal article  |  2002  |  Journal of the National Cancer Institute

The DNA sequence and comparative analysis of human chromosome 20.

P Deloukas, LH Matthews, J Ashurst, J Burton, JG Gilbert, M Jones, G Stavrides, JP Almeida, AK Babbage, CL Bagguley, J Bailey, KF Barlow, KN Bates, LM Beard, DM Beare, OP Beasley, CP Bird, SE Blakey, AM Bridgeman, AJ Brown, et al.

Journal article  |  2001  |  Nature

The finished sequence of human chromosome 20 comprises 59,187,298 base pairs (bp) and represents 99.4% of the euchromatic DNA. A s..

A physical map of the human genome.

JD McPherson, M Marra, L Hillier, RH Waterston, A Chinwalla, J Wallis, M Sekhon, K Wylie, ER Mardis, RK Wilson, R Fulton, TA Kucaba, C Wagner-McPherson, WB Barbazuk, SG Gregory, SJ Humphray, L French, RS Evans, G Bethel, A Whittaker, et al.

Journal article  |  2001  |  Nature

The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence as..

The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.

DR Bentley, P Deloukas, A Dunham, L French, SG Gregory, SJ Humphray, AJ Mungall, MT Ross, NP Carter, I Dunham, CE Scott, KJ Ashcroft, AL Atkinson, K Aubin, DM Beare, G Bethel, N Brady, JC Brook, DC Burford, WD Burrill, et al.

Journal article  |  2001  |  Nature

We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by b..

Thrombopoietin signaling is required for in vivo expansion of IL-11-responsive hematopoietic progenitor cells in the steady state

CL Scott, L Robb, HH Nandurkar, R Mansfield, WS Alexander, CG Begley

Journal article  |  2001  |  Experimental Hematology

Effect of granulocyte-macrophage colony-stimulating factor on the generation of epidermal Langerhans cells

K Burnham, L Robb, CL Scott, M O'Keeffe, K Shortman

Journal article  |  2000  |  Journal of Interferon & Cytokine Research

Granulocyte-macrophage colony-stimulating factor is not responsible for residual thrombopoiesis in mpl null mice

CL Scott, L Robb, R Mansfield, WS Alexander, CG Begley

Journal article  |  2000  |  Experimental Hematology

Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3-specific receptor beta-chain-null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor

CL Scott, L Robb, B Papaevangeliou, R Mansfield, NA Nicola, CG Begley

Journal article  |  2000  |  Blood

Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10q.

J Guy, C Spalluto, A McMurray, T Hearn, M Crosier, L Viggiano, V Miolla, N Archidiacono, M Rocchi, C Scott, PA Lee, J Sulston, J Rogers, D Bentley, MS Jackson

Journal article  |  2000  |  Human Molecular Genetics

The organization of centromeric heterochromatin has been established in a number of eucaryotes but remains poorly defined in human..

Mice unresponsive to GM-CSF are unexpectedly resistant to cutaneous Leishmania major infection

CL Scott, L Roe, J Curtis, T Baldwin, L Robb, CG Begley, E Handman

Journal article  |  2000  |  Microbes and Infection

The DNA sequence of human chromosome 22

I Dunham, N Shimizu, BA Roe, S Chissoe, AR Hunt, JE Collins, R Bruskiewich, DM Beare, M Clamp, LJ Smink, R Ainscough, JP Almeida, A Babbage, C Bagguley, J Bailey, K Barlow, KN Bates, O Beasley, CP Bird, S Blakey, et al.

Journal article  |  1999  |  Nature

The beta common chain (beta c) of the granulocyte macrophage-colony stimulating factor, interleukin-3 and iaterleukin-5 receptors

CL Scott, CG Begley

Journal article  |  1999  |  The International Journal of Biochemistry & Cell Biology

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine

WS Alexander, R Starr, JE Fenner, GL Scott, E Handman, NS Sprigg, JE Corbin, AL Cornish, R Darwiche, CM Owczarek, TWH Kay, NA Nicola, PJ Hertzog, D Metcalf, DJ Hilton

Journal article  |  1999  |  Cell

Functional analysis of mature hematopoietic cells from mice lacking the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor

CL Scott, DA Hughes, D Cary, NA Nicola, CG Begley, L Robb

Journal article  |  1998  |  Blood

Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor

AW Roberts, S Foote, WS Alexander, C Scott, L Robb, D Metcalf

Journal article  |  1997  |  Blood