Pamela Leong

Longitudinal Study of Oral Microbiome Variation in Twins

Marcelo Freire, Ahmed Moustafa, Derek M Harkins, Manolito G Torralba, Yun Zhang, Pamela Leong, Richard Saffery, Michelle Bockmann, Claire Kuelbs, Toby Hughes, Jeffrey M Craig, Karen E Nelson

Journal article  |  2020  |  SCIENTIFIC REPORTS

Humans are host to a multitude of microorganisms that rapidly populate the body at birth, subject to a complex interplay that is d..

A twin study of body mass index and dental caries in childhood.

MJ Silva, NM Kilpatrick, JM Craig, DJ Manton, P Leong, H Ho, R Saffery, DP Burgner, KJ Scurrah

Journal article  |  2020  |  Scientific Reports

Sub-optimal nutrition and dental caries are both common with significant short and long-term implications for child health and dev..

Epigenetic Influences on Neurodevelopment at 11 Years of Age: Protocol for the Longitudinal Peri/Postnatal Epigenetic Twins Study at 11 Years of Age (PETS@11)

Pamela Leong, Yuk Jing Loke, Richard Saffery, Tim Silk, Alice Burnett, Elisha Josev, Katrina Scurrah, Christiane Theda, Anna Czajko, Emmanuel PK Pua, Marc L Seal, Jeffrey M Craig

Journal article  |  2019  |  TWIN RESEARCH AND HUMAN GENETICS

Neurodevelopment is sensitive to genetic and pre/postnatal environmental influences. These effects are likely mediated by epigenet..

Genetic and Early-Life Environmental Influences on Dental Caries Risk: A Twin Study

Mihiri J Silva, Nicky M Kilpatrick, Jeffrey M Craig, David J Manton, Pamela Leong, David P Burgner, Katrina J Scurrah

Journal article  |  2019  |  PEDIATRICS

OBJECTIVES: To explore the relative contributions of genetic and environmental influences on dental caries risk and to investigate..

Etiology of Hypomineralized Second Primary Molars: A Prospective Twin Study

MJ Silva, NM Kilpatrick, JM Craig, DJ Manton, P Leong, D Burgner, KJ Scurrah

Journal article  |  2019  |  JOURNAL OF DENTAL RESEARCH

The etiology of hypomineralized second primary molars (HSPM) is unclear, but genetic and environmental factors have been proposed...

Supragingival Plaque Microbiome Ecology and Functional Potential in the Context of Health and Disease

Josh L Espinoza, Derek M Harkins, Manolito Torralba, Andres Gomez, Sarah K Highlander, Marcus B Jones, Pamela Leong, Richard Saffery, Michelle Bockmann, Claire Kuelbs, Jason M Inman, Toby Hughes, Jeffrey M Craig, Karen E Nelson, Chris L Dupont

Journal article  |  2018  |  MBIO

To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we s..

Quantitation of the cellular content of saliva and buccal swab samples

Christiane Theda, Seo Hye Hwang, Anna Czajko, Yuk Jing Loke, Pamela Leong, Jeffrey M Craig

Journal article  |  2018  |  SCIENTIFIC REPORTS

Buccal swabs and saliva are the two most common oral sampling methods used for medical research. Often, these samples are used int..

Protocol for a longitudinal twin birth cohort study to unravel the complex interplay between early-life environmental and genetic risk factors in health and disease: the Chongqing Longitudinal Twin Study (LoTiS)

Chao Tong, Li Wen, Yinyin Xia, Pamela Leong, Lan Wang, Xin Fan, Ting-li Han, Jeffrey M Craig, Philip Baker, Richard Saffery, Hongbo Qi

Journal article  |  2018  |  BMJ OPEN

INTRODUCTION: Non-communicable diseases (NCD) now represent the major burden of adverse health in most countries. It is clear that..

Community-based population-level interventions for promoting child oral health

Andrea M de Silva, Shalika Hegde, Bridget Akudo Nwagbara, Hanny Calache, Mark G Gussy, Mona Nasser, Hannah R Morrice, Elisha Riggs, Pamela M Leong, Lisa K Meyenn, Reza Yousefi-Nooraie

Journal article  |  2016  |  COCHRANE DATABASE OF SYSTEMATIC REVIEWS

BACKGROUND: Dental caries and gingival and periodontal disease are commonly occurring, preventable chronic conditions. Even though..