Nicole Haynes

Abscopal Regressions of Lymphoma After Involved-Site Radiation Therapy Confirmed by Positron Emission Tomography.

Michael P MacManus, Michael S Hofman, Rodney J Hicks, Belinda A Campbell, Andrew Wirth, John F Seymour, Nicole Haynes, Kate Burbury

Journal article  |  2020  |  International Journal of Radiation Oncology*Biology*Physics

PURPOSE: Patients with abscopal regressions of lymphoma after palliative involved-site radiation therapy (ISRT), detected on seque..

Development of small molecule STING agonists that can evoke host anti-cancer immune defences following local or systemic delivery

Nicole Haynes, Theresa Connor, Ben Morrow, Judy Doherty, Matthew Dennis, Jonathan Hubert, Sukhdeep Spall, Anthony Cuzzupe, Karen White, Susan Charman, Aaron Lock, Vicky Avery, Stewart Nuttall, Tom Peat, Olan Dolezal, Pat Pilling, Jezrael Revalde, Tin Yow, Greg Arndt, Hendrik Falk, et al.

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation

Pavel N Lobachevsky, Jessica Ventura, Lina Giannakandropoulou, Helen Forrester, Jason S Palazzolo, Nicole M Haynes, Andrew W Stevenson, Christopher J Hall, Joel Mason, Gerasimos Pollakis, Ioannis S Pateras, Vassilis Gorgoulis, Georgia I Terzoudi, John A Hamilton, Carl N Sprung, Alexandros G Georgakilas, Olga A Martin

Journal article  |  2019  |  International Journal of Radiation Oncology*Biology*Physics

A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy

Emily J Lelliott, Carleen Cullinane, Claire A Martin, Rachael Walker, Kelly M Ramsbottom, Fernando Souza-Fonseca-Guimaraes, Shatha Abuhammad, Jessica Michie, Laura Kirby, Richard J Young, Alison Slater, Peter Lau, Katrina Meeth, Jane Oliaro, Nicole Haynes, Grant A McArthur, Karen E Sheppard

Journal article  |  2019  |  Scientific Reports

Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4( )Foxp3(-) Cell-Mediated Modulation of CD103( ) Dendritic Cells

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Alexander J Davenport, Emma V Petley, Imran G House, Junyun Lai, Kevin Sek, Nicole Milenkovski, Liza B John, Sherly Mardiana, Clare Y Slaney, Joseph A Trapani, Sherene Loi, Michael H Kershaw, Nicole M Haynes, Phillip K Darcy

Journal article  |  2018  |  Cancer Immunology Research

Localized synchrotron radiation in mice induces persistent systemic genotoxic events mediated by the functional immune system

Jessica Ventura, Pavel Lobachevsky, Jason Palazzolo, Helen Forrester, Nicole Haynes, Alesia Ivashkevich, Andrew Stevenson, Christopher Hall, Vassilis Gorgoulis, John Hamilton, Alexandros Georgakilas, Calr Sprung, Olga A Martin

Conference Proceedings  |  2018  |  Clinical Research (Excluding Clinical Trials)

Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors

Edward Hammond, Nicole M Haynes, Carleen Cullinane, Todd Brennan, Darryn Bampton, Paul Handley, Tomislav Karoli, Fleur Lanksheer, Liwen Lin, Yiping Yang, Keith Dredge

Journal article  |  2018  |  Journal for ImmunoTherapy of Cancer

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses

Jessica Ventura, Pavel N Lobachevsky, Jason S Palazzolo, Helen Forrester, Nicole M Haynes, Alesia Ivashkevich, Andrew W Stevenson, Christopher J Hall, Andreas Ntargaras, Vasilis Kotsaris, Gerasimos Ch Pollakis, Gianna Potsi, Konstantinos Skordylis, Georgia Terzoudi, Ioannis S Pateras, Vassilis G Gorgoulis, Alexandros G Georgakilas, Carl N Sprung, Olga A Martin

Journal article  |  2017  |  Cancer Research

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2( ) Tumors

Mikolaj Medon, Eva Vidacs, Stephin J Vervoort, Jason Li, Misty R Jenkins, Kelly M Ramsbottom, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, Peter W Atadja, Michael A Henderson, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2017  |  Cancer Research

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Sherly Mardiana, Liza B John, Melissa A Henderson, Clare Y Slaney, Bianca von Scheidt, Lauren Giuffrida, Alexander J Davenport, Joseph A Trapani, Paul J Neeson, Sherene Loi, Nicole M Haynes, Michael H Kershaw, Paul A Beavis, Phillip K Darcy

Journal article  |  2017  |  Cancer Research

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

OMIP-032: Two multi-color immunophenotyping panels for assessing the innate and adaptive immune cells in the mouse mammary gland

Ashleigh Unsworth, Robin Anderson, Nicole Haynes, Kara Britt

Journal article  |  2016  |  Cytometry Part A

Lethal giant larvae-1 deficiency enhances the CD8( ) effector T-cell response to antigen challenge in vivo

Kelly M Ramsbottom, Faruk Sacirbegovic, Edwin D Hawkins, Axel Kallies, Gabrielle T Belz, Vanessa Van Ham, Nicole M Haynes, Michael J Durrant, Patrick O Humbert, Sarah M Russell, Jane Oliaro

Journal article  |  2016  |  Immunology & Cell Biology

Building immunity to cancer with radiation therapy

Suresh J Haikerwal, Jim Hagekyriakou, Michael MacManus, Olga A Martin, Nicole M Haynes

Journal article  |  2015  |  Cancer Letters

The Curative Outcome of Radioimmunotherapy in a Mouse Breast Cancer Model Relies on mTOR Signaling

Inge Verbrugge, Alessia Gasparini, Nicole M Haynes, Jim Hagekyriakou, Mara Galli, Trina J Stewart, Scott I Abrams, Hideo Yagita, Marcel Verheij, Ricky W Johnstone, Jannie Borst, Jacques Neefjes

Journal article  |  2014  |  Radiation Research

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

Maya Kansara, Huei San Leong, Dan Mei Lin, Sophie Popkiss, Puiyi Pang, Dale W Garsed, Carl R Walkley, Carleen Cullinane, Jason Ellul, Nicole M Haynes, Rod Hicks, Marieke L Kuijjer, Anne-Marie Cleton-Jansen, Philip W Hinds, Mark J Smyth, David M Thomas

Journal article  |  2013  |  Journal of Clinical Investigation

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

Liza B John, Christel Devaud, Connie PM Duong, Carmen S Yong, Paul A Beavis, Nicole M Haynes, Melvyn T Chow, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2013  |  Clinical Cancer Research

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity

Edwin D Hawkins, Jane Oliaro, Axel Kallies, Gabrielle T Belz, Andrew Filby, Thea Hogan, Nicole Haynes, Kelly M Ramsbottom, Vanessa Van Ham, Tanja Kinwell, Benedict Seddon, Derek Davies, David Tarlinton, Andrew M Lew, Patrick O Humbert, Sarah M Russell

Journal article  |  2013  |  Nature Communications

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

Deborah A Knight, Shin Foong Ngiow, Ming Li, Tiffany Parmenter, Stephen Mok, Ashley Cass, Nicole M Haynes, Kathryn Kinross, Hideo Yagita, Richard C Koya, Thomas G Graeber, Antoni Ribas, Grant A McArthur, Mark J Smyth

Journal article  |  2013  |  Journal of Clinical Investigation

Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies

Inge Verbrugge, Mara Galli, Mark J Smyth, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2012  |  OncoImmunology

Evoking durable anti-cancer responses with blocking antibodies to PD-1 and PD-L1

Mara Galli, Phillip K Darcy, Nicole M Haynes

Journal article  |  2012  |  Translational Cancer Research

Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

Inge Verbrugge, Jim Hagekyriakou, Leslie L Sharp, Mara Galli, Alison West, Nicole M McLaughlin, Helene Duret, Hideo Yagita, Ricky W Johnstone, Mark J Smyth, Nicole M Haynes

Journal article  |  2012  |  Cancer Research

Immunotherapeutic strategies as adjuncts to local radiotherapy

Nicole M Haynes, Mark J Smyth

Journal article  |  2012  |  Immunotherapy

A Critical Role for Granzymes in Antigen Cross-Presentation through Regulating Phagocytosis of Killed Tumor Cells

Sabine Hoves, Vivien R Sutton, Nicole M Haynes, Edwin D Hawkins, Daniel Fernandez Ruiz, Nikola Baschuk, Karin A Sedelies, Maximilian Schnurr, John Stagg, Daniel M Andrews, Jose A Villadangos, Joseph A Trapani

Journal article  |  2011  |  Journal of Immunology

Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies

Ailsa J Christiansen, Alison West, Kellie-Marie Banks, Nicole M Haynes, Michele W Teng, Mark J Smyth, Ricky W Johnstone

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

Generation of Chimeric T-Cell Receptor Transgenes and Their Efficient Transfer in Primary Mouse T Lymphocytes

Linda J Howland, Nicole M Haynes, Phillip K Darcy

Journal article  |  2010  |  Methods in Molecular Biology

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

Lorraine A O' Reilly, Lin Tai, Lily Lee, Elizabeth A Kruse, Stephanie Grabow, W Douglas Fairlie, Nicole M Haynes, David M Tarlinton, Jian-Guo Zhang, Gabrielle T Belz, Mark J Smyth, Philippe Bouillet, Lorraine Robb, Andreas Strasser

Journal article  |  2009  |  Nature