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Combination Of Radionuclide 177lu-Psma Therapy With Pembrolizumab In Patients With Metasta..
Development of small molecule STING agonists that can evoke host anti-cancer immune defenc..
A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irr..
Displaying the 6 most recent projects by Nicole Haynes.
The Combination Of Cdk4 And Mapk/Erk Pathway Inhibitor Therapy In Melanoma: Defining Melanoma Cell Intrinsic And Immune Mediated Responses
Early-stage melanomas can often be cured with surgery, but more advanced melanomas are harder to treat because standard melanoma treatments ..
Displaying the 27 most recent scholarly works by Nicole Haynes.
Abscopal Regressions of Lymphoma After Involved-Site Radiation Therapy Confirmed by Positron Emission Tomography.
Michael P MacManus, Michael S Hofman, Rodney J Hicks, Belinda A Campbell, Andrew Wirth, John F Seymour, Nicole Haynes, Kate Burbury
Journal article | 2020 | International Journal of Radiation Oncology*Biology*Physics
PURPOSE: Patients with abscopal regressions of lymphoma after palliative involved-site radiation therapy (ISRT), detected on seque..
Development of small molecule STING agonists that can evoke host anti-cancer immune defences following local or systemic delivery
Nicole Haynes, Theresa Connor, Ben Morrow, Judy Doherty, Matthew Dennis, Jonathan Hubert, Sukhdeep Spall, Anthony Cuzzupe, Karen White, Susan Charman, Aaron Lock, Vicky Avery, Stewart Nuttall, Tom Peat, Olan Dolezal, Pat Pilling, Jezrael Revalde, Tin Yow, Greg Arndt, Hendrik Falk, et al.
Conference Proceedings | 2019 | JOURNAL FOR IMMUNOTHERAPY OF CANCER
A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation
Pavel N Lobachevsky, Jessica Ventura, Lina Giannakandropoulou, Helen Forrester, Jason S Palazzolo, Nicole M Haynes, Andrew W Stevenson, Christopher J Hall, Joel Mason, Gerasimos Pollakis, Ioannis S Pateras, Vassilis Gorgoulis, Georgia I Terzoudi, John A Hamilton, Carl N Sprung, Alexandros G Georgakilas, Olga A Martin
Journal article | 2019 | International Journal of Radiation Oncology*Biology*Physics
A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy
Emily J Lelliott, Carleen Cullinane, Claire A Martin, Rachael Walker, Kelly M Ramsbottom, Fernando Souza-Fonseca-Guimaraes, Shatha Abuhammad, Jessica Michie, Laura Kirby, Richard J Young, Alison Slater, Peter Lau, Katrina Meeth, Jane Oliaro, Nicole Haynes, Grant A McArthur, Karen E Sheppard
Journal article | 2019 | Scientific Reports
Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4( )Foxp3(-) Cell-Mediated Modulation of CD103( ) Dendritic Cells
Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Alexander J Davenport, Emma V Petley, Imran G House, Junyun Lai, Kevin Sek, Nicole Milenkovski, Liza B John, Sherly Mardiana, Clare Y Slaney, Joseph A Trapani, Sherene Loi, Michael H Kershaw, Nicole M Haynes, Phillip K Darcy
Journal article | 2018 | Cancer Immunology Research
Localized synchrotron radiation in mice induces persistent systemic genotoxic events mediated by the functional immune system
Jessica Ventura, Pavel Lobachevsky, Jason Palazzolo, Helen Forrester, Nicole Haynes, Alesia Ivashkevich, Andrew Stevenson, Christopher Hall, Vassilis Gorgoulis, John Hamilton, Alexandros Georgakilas, Calr Sprung, Olga A Martin
Conference Proceedings | 2018 | Clinical Research (Excluding Clinical Trials)
Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors
Edward Hammond, Nicole M Haynes, Carleen Cullinane, Todd Brennan, Darryn Bampton, Paul Handley, Tomislav Karoli, Fleur Lanksheer, Liwen Lin, Yiping Yang, Keith Dredge
Journal article | 2018 | Journal for ImmunoTherapy of Cancer
Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses
Jessica Ventura, Pavel N Lobachevsky, Jason S Palazzolo, Helen Forrester, Nicole M Haynes, Alesia Ivashkevich, Andrew W Stevenson, Christopher J Hall, Andreas Ntargaras, Vasilis Kotsaris, Gerasimos Ch Pollakis, Gianna Potsi, Konstantinos Skordylis, Georgia Terzoudi, Ioannis S Pateras, Vassilis G Gorgoulis, Alexandros G Georgakilas, Carl N Sprung, Olga A Martin
Journal article | 2017 | Cancer Research
HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2( ) Tumors
Mikolaj Medon, Eva Vidacs, Stephin J Vervoort, Jason Li, Misty R Jenkins, Kelly M Ramsbottom, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, Peter W Atadja, Michael A Henderson, Ricky W Johnstone, Nicole M Haynes
Journal article | 2017 | Cancer Research
A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells
Sherly Mardiana, Liza B John, Melissa A Henderson, Clare Y Slaney, Bianca von Scheidt, Lauren Giuffrida, Alexander J Davenport, Joseph A Trapani, Paul J Neeson, Sherene Loi, Nicole M Haynes, Michael H Kershaw, Paul A Beavis, Phillip K Darcy
Journal article | 2017 | Cancer Research
A community-based model of rapid autopsy in end-stage cancer patients
Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.
Journal article | 2016 | Nature Biotechnology
Lethal giant larvae-1 deficiency enhances the CD8( ) effector T-cell response to antigen challenge in vivo
Kelly M Ramsbottom, Faruk Sacirbegovic, Edwin D Hawkins, Axel Kallies, Gabrielle T Belz, Vanessa Van Ham, Nicole M Haynes, Michael J Durrant, Patrick O Humbert, Sarah M Russell, Jane Oliaro
Journal article | 2016 | Immunology & Cell Biology
The Curative Outcome of Radioimmunotherapy in a Mouse Breast Cancer Model Relies on mTOR Signaling
Inge Verbrugge, Alessia Gasparini, Nicole M Haynes, Jim Hagekyriakou, Mara Galli, Trina J Stewart, Scott I Abrams, Hideo Yagita, Marcel Verheij, Ricky W Johnstone, Jannie Borst, Jacques Neefjes
Journal article | 2014 | Radiation Research
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation
Maya Kansara, Huei San Leong, Dan Mei Lin, Sophie Popkiss, Puiyi Pang, Dale W Garsed, Carl R Walkley, Carleen Cullinane, Jason Ellul, Nicole M Haynes, Rod Hicks, Marieke L Kuijjer, Anne-Marie Cleton-Jansen, Philip W Hinds, Mark J Smyth, David M Thomas
Journal article | 2013 | Journal of Clinical Investigation
Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells
Liza B John, Christel Devaud, Connie PM Duong, Carmen S Yong, Paul A Beavis, Nicole M Haynes, Melvyn T Chow, Mark J Smyth, Michael H Kershaw, Phillip K Darcy
Journal article | 2013 | Clinical Cancer Research
Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity
Edwin D Hawkins, Jane Oliaro, Axel Kallies, Gabrielle T Belz, Andrew Filby, Thea Hogan, Nicole Haynes, Kelly M Ramsbottom, Vanessa Van Ham, Tanja Kinwell, Benedict Seddon, Derek Davies, David Tarlinton, Andrew M Lew, Patrick O Humbert, Sarah M Russell
Journal article | 2013 | Nature Communications
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors
Deborah A Knight, Shin Foong Ngiow, Ming Li, Tiffany Parmenter, Stephen Mok, Ashley Cass, Nicole M Haynes, Kathryn Kinross, Hideo Yagita, Richard C Koya, Thomas G Graeber, Antoni Ribas, Grant A McArthur, Mark J Smyth
Journal article | 2013 | JOURNAL OF CLINICAL INVESTIGATION
Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies
Inge Verbrugge, Jim Hagekyriakou, Leslie L Sharp, Mara Galli, Alison West, Nicole M McLaughlin, Helene Duret, Hideo Yagita, Ricky W Johnstone, Mark J Smyth, Nicole M Haynes
Journal article | 2012 | Cancer Research
A Critical Role for Granzymes in Antigen Cross-Presentation through Regulating Phagocytosis of Killed Tumor Cells
Sabine Hoves, Vivien R Sutton, Nicole M Haynes, Edwin D Hawkins, Daniel Fernandez Ruiz, Nikola Baschuk, Karin A Sedelies, Maximilian Schnurr, John Stagg, Daniel M Andrews, Jose A Villadangos, Joseph A Trapani
Journal article | 2011 | Journal of Immunology
Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies
Ailsa J Christiansen, Alison West, Kellie-Marie Banks, Nicole M Haynes, Michele W Teng, Mark J Smyth, Ricky W Johnstone
Journal article | 2011 | Proceedings of the National Academy of Sciences of the United States of America
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
Lorraine A O' Reilly, Lin Tai, Lily Lee, Elizabeth A Kruse, Stephanie Grabow, W Douglas Fairlie, Nicole M Haynes, David M Tarlinton, Jian-Guo Zhang, Gabrielle T Belz, Mark J Smyth, Philippe Bouillet, Lorraine Robb, Andreas Strasser
Journal article | 2009 | Nature
The Sir Peter Maccallum Department Of Oncology