Nicole Haynes

Estrogen-induced immune changes within the normal mammary gland

Helen Tower, Genevieve Dall, Ashleigh Davey, Melanie Stewart, Patrick Lanteri, Meagan Ruppert, Maria Lambouras, Ibraheem Nasir, Serene Yeow, Phillip K Darcy, Wendy Ingman, Belinda Parker, Nicole M Haynes, Kara L Britt

Journal article  |  2022  |  SCIENTIFIC REPORTS

Breast cancer (BCa) incidence increases following aberrant hormone exposure, which has been linked to direct effects on estrogen r..

Basic cancer immunology for radiation oncologists

Joseph Sia, Paul J Neeson, Nicole M Haynes

Journal article  |  2022  |  JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY

Although the impressive clinical responses seen with modern cancer immunotherapy are currently limited to a subset of patients, th..

CAR-T Plus Radiotherapy: A Promising Combination for Immunosuppressive Tumors

Vicky Mengfei Qin, Nicole M Haynes, Criselle D'Souza, Paul J Neeson, Joe Jiang Zhu

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Radiotherapy (RT) is the standard-of-care treatment for more than half of cancer patients with localized tumors and is also used a..

Molecular and genomic characterisation of a panel of human anal cancer cell lines

Glen R Guerra, Joseph C Kong, Rosemary M Millen, Matthew Read, David S Liu, Sara Roth, Shienny Sampurno, Joseph Sia, Maria-Pia Bernardi, Timothy J Chittleborough, Corina C Behrenbruch, Jiasian Teh, Huiling Xu, Nicole M Haynes, Jiaan Yu, Richard Lupat, David Hawkes, Natasha Di Costanzo, Richard W Tothill, Catherine Mitchell, et al.

Journal article  |  2021  |  CELL DEATH & DISEASE

Anal cancer is a rare disease that has doubled in incidence over the last four decades. Current treatment and survival of patients..

CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Emily J Lelliott, Isabella Y Kong, Magnus Zethoven, Kelly M Ramsbottom, Luciano G Martelotto, Deborah Meyran, Joe Jiang Zhu, Matteo Costacurta, Laura Kirby, Jarrod J Sandow, Lydia Lim, Pilar M Dominguez, Izabela Todorovski, Nicole M Haynes, Paul A Beavis, Paul J Neeson, Edwin D Hawkins, Grant A McArthur, Ian A Parish, Ricky W Johnstone, et al.

Journal article  |  2021  |  CANCER DISCOVERY

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor-positive brea..

Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II) The Trans Tasman Radiation Oncology Group 13.01 Phase 2 Randomized Clinical Trial

Shankar Siva, Mathias Bressel, Tao Mai, Hien Le, Shalini Vinod, Harini de Silva, Sean Macdonald, Marketa Skala, Nicholas Hardcastle, Angela Rezo, David Pryor, Suki Gill, Braden Higgs, Kassandra Wagenfuehr, Rebecca Montgomery, Raef Awad, Brent Chesson, Thomas Eade, Wenchang Wong, Giuseppe Sasso, et al.

Journal article  |  2021  |  JAMA ONCOLOGY

IMPORTANCE: Evidence is lacking from randomized clinical trials to guide the optimal approach for stereotactic ablative body radio..

Regulatory T Cells Shape the Differential Impact of Radiation Dose-Fractionation Schedules on Host Innate and Adaptive Antitumor Immune Defenses

Joseph Sia, Jim Hagekyriakou, Ioana Chindris, Hassan Albarakati, Trevor Leong, Ramona Schlenker, Simon P Keam, Scott G Williams, Paul J Neeson, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PURPOSE: We examined how radiation dose per fraction (DPF) and total dose, as represented by biological effective dose (BED), can ..

Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma

Emily J Lelliott, Stefano Mangiola, Kelly M Ramsbottom, Magnus Zethoven, Lydia Lim, Peter KH Lau, Amanda J Oliver, Luciano G Martelotto, Laura Kirby, Claire Martin, Riyaben P Patel, Alison Slater, Carleen Cullinane, Anthony T Papenfuss, Nicole M Haynes, Grant A McArthur, Jane Oliaro, Karen E Sheppard

Journal article  |  2021  |  CANCER IMMUNOLOGY RESEARCH

Combined inhibition of BRAF, MEK, and CDK4/6 is currently under evaluation in clinical trials for patients with melanoma harboring..

OC-0080: Radiation therapy increases tumor vulnerability to natural killer cell-mediated control

JI Sia, I Chindris, J Hagekyriakou, R Johnstone, N Haynes

Conference Proceedings  |  2020  |  Radiotherapy and Oncology

Abscopal Regressions of Lymphoma After Involved-Site Radiation Therapy Confirmed by Positron Emission Tomography

Michael P MacManus, Michael S Hofman, Rodney J Hicks, Belinda A Campbell, Andrew Wirth, John F Seymour, Nicole Haynes, Kate Burbury

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PURPOSE: Patients with abscopal regressions of lymphoma after palliative involved-site radiation therapy (ISRT), detected on seque..