Kate Sutherland

NOTCH Your Usual Suspect: MYC Charged with Controlling Neuroendocrine Cell-Fate in Small Cell Lung Cancer.

Jin Ng, Kate D Sutherland

Journal article  |  2020  |  Cancer Cell

Small cell lung cancer (SCLC) is highly heterogeneous. In this issue of Cancer Cell, Ireland et al. demonstrate that MYC mediates ..

Balancing the Count: Harmonizing Panel-Based Tumor Mutational Burden Assessment.

Kate D Sutherland, Joseph HA Vissers

Journal article  |  2020  |  Journal of Thoracic Oncology

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma.

Stephanie R Hyslop, Marliese Alexander, Alesha A Thai, Ariena Kersbergen, Andrew J Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P Ng, Benjamin J Solomon, Warren S Alexander, Kate D Sutherland, Emma C Josefsson

Journal article  |  2020  |  Oncogene

Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimenta..

Harnessing Natural Killer Immunity in Metastatic SCLC.

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  Journal of Thoracic Oncology

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

John T Poirier, Julie George, Taofeek K Owonikoko, Anton Berns, Elisabeth Brambilla, Lauren A Byers, David Carbone, Huanhuan J Chen, Camilla L Christensen, Caroline Dive, Anna Farago, Ramaswamy Govindan, Christine Hann, Matthew D Hellmann, Leora Horn, Jane E Johnson, Young S Ju, Sumin Kang, Mark Krasnow, James Lee, et al.

Journal article  |  2020  |  Journal of Thoracic Oncology

The outcomes of patients with SCLC have not yet been substantially impacted by the revolution in precision oncology, primarily owi..

Characterization of a novel human BFL-1-specific monoclonal antibody

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

Hua Zhang, Camilla L Christensen, Ruben Dries, Matthew G Oser, Jiehui Deng, Brian Diskin, Fei Li, Yuanwang Pan, Xuzhu Zhang, Yandong Yin, Eleni Papadopoulos, Val Pyon, Cassandra Thakurdin, Nicholas Kwiatkowski, Kandarp Jani, Alexandra R Rabin, Dayanne M Castro, Ting Chen, Heather Silver, Qingyuan Huang, et al.

Journal article  |  2020  |  Cancer Cell

Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene transcription. However, little is known about i..

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon, et al.

Journal article  |  2019  |  Cancer Cell

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Sarah A Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E Vince, Vivek Rathi, Gavin M Wright, Matthew E Ritchie, Kate D Sutherland

Journal article  |  2019  |  Nature Communications

FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium

Sarah A Best, Cassandra R Harapas, Ariena Kersbergen, Vivek Rathi, Marie-Liesse Asselin-Labat, Kate D Sutherland

Journal article  |  2018  |  Oncogene

Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs

Ariena Kersbergen, Sarah A Best, Sebastian Dworkin, Casey Ah-Cann, Michael E de Vries, Marie-Liesse Asselin-Labat, Matthew E Ritchie, Stephen M Jane, Kate D Sutherland

Journal article  |  2018  |  Developmental Biology

Interrogating the Metabolic Effects of Keap1 Inactivation in Adenocarcinoma

S Best, S Ding, A Kersbergen, B Reljic, K Sutherland

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

Sarah A Best, David P De Souza, Ariena Kersbergen, Antonia N Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H Gray, Matthew E Ritchie, Malcolm J McConville, Kate D Sutherland

Journal article  |  2018  |  Cell Metabolism

Combining Cell Type-Restricted Adenoviral Targeting with Immunostaining and Flow Cytometry to Identify Cells-of-Origin of Lung Cancer

Sarah A Best, Ariena Kersbergen, Marie-Liesse Asselin-Labat, Kate D Sutherland

Book Chapter  |  2018  |  Methods in Molecular Biology

"Keaping" a lid on lung cancer: the Keap1-Nrf2 pathway

Sarah A Best, Kate D Sutherland

Journal article  |  2018  |  Cell Cycle

Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway

Clare E Weeden, Yunshun Chen, Stephen B Ma, Yifang Hu, Georg Ramm, Kate D Sutherland, Gordon K Smyth, Marie-Liesse Asselin-Labat

Journal article  |  2017  |  PLOS Biology

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin

Giustina Ferone, Ji-Ying Song, Kate D Sutherland, Rajith Bhaskaran, Kim Monkhorst, Jan-Paul Lambooij, Natalie Proost, Gaetano Gargiulo, Anton Berns

Journal article  |  2016  |  Cancer Cell

Correction to Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer [Cancer Cell 29, 17-31, 2016]

M Serresi, G Gargiulo, N Proost, B Siteur, M Cesaroni, M Koppens, H Xie, KD Sutherland, D Hulsman, E Citterio, S Orkin, A Berns, M van Lohuizen

Journal article  |  2016  |  Cancer Cell

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer

Michela Serresi, Gaetano Gargiulo, Natalie Proost, Bjorn Siteur, Matteo Cesaroni, Martijn Koppens, Huafeng Xie, Kate D Sutherland, Danielle Hulsman, Elisabetta Citterio, Stuart Orkin, Anton Berns, Maarten van Lohuizen

Journal article  |  2016  |  Cancer Cell

Cellular Mechanisms Underlying Intertumoral Heterogeneity

Kate D Sutherland, Jane E Visvader

Journal article  |  2015  |  Trends in Cancer

Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis

Min-chul Kwon, Natalie Proost, Ji-Ying Song, Kate D Sutherland, John Zevenhoven, Anton Berns

Journal article  |  2015  |  Genes & Development

The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression

Aliaksei Z Holik, Caitlin E Filby, Julie Pasquet, Kati Viitaniemi, John Ciciulla, Kate D Sutherland, Marie-Liesse Asselin-Labat

Journal article  |  2015  |  Respiratory Research

Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma

Kate D Sutherland, Ji-Ying Song, Min Chul Kwon, Natalie Proost, John Zevenhoven, Anton Berns

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.

Ivo J Huijbers, Rahmen Bin Ali, Colin Pritchard, Miranda Cozijnsen, Min-Chul Kwon, Natalie Proost, Ji-Ying Song, Hilda de Vries, Jitendra Badhai, Kate Sutherland, Paul Krimpenfort, Ewa M Michalak, Jos Jonkers, Anton Berns

Journal article  |  2014  |  EMBO Molecular Medicine

Human cancers modeled in Genetically Engineered Mouse Models (GEMMs) can provide important mechanistic insights into the molecular..

Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

Marie-Liesse Asselin-Labat, Kate D Sutherland, Francois Vaillant, David E Gyorki, Di Wu, Sheridan Holroyd, Kelsey Breslin, Teresa Ward, Wei Shi, Mary L Bath, Siddhartha Deb, Stephen B Fox, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Molecular and Cellular Biology

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

Kate D Sutherland, Natalie Proost, Inge Brouns, Dirk Adriaensen, Ji-Ying Song, Anton Berns

Journal article  |  2011  |  Cancer Cell

Cell of origin of lung cancer

Kate D Sutherland, Anton Berns

Journal article  |  2010  |  Molecular Oncology

Impaired Lactation in Mice Expressing Dominant-Negative FADD in Mammary Epithelium

Mark Shackleton, Lorraine A O'Reilly, Kate D Sutherland, Mary L Bath, Sarah Ellis, Andreas Strasser, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Developmental Dynamics

Knocking off SOCS genes in the mammary gland

Kate D Sutherland, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Cell Cycle

The molecular culprits underlying precocious mammary gland involution

Kate D Sutherland, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Journal of Mammary Gland Biology and Neoplasia

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

Marie-Liesse Asselin-Labat, Kate D Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C Forrest, Lynne Hartley, Lorraine Robb, Frank G Grosveld, Jacqueline van der Wees, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Nature Cell Biology

c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3

Kate D Sutherland, Francois Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2006  |  The EMBO Journal

Socs2 and Elf5 mediate prolactin-induced mammary gland development

J Harris, PM Stanford, K Sutherland, SR Oakes, MJ Naylor, FG Robertson, KD Blazek, M Kazlauskas, HN Hilton, S Wittlin, WS Alexander, GJ Lindeman, JE Visvader, CJ Ormandy

Journal article  |  2006  |  Molecular Endocrinology

Differential hypermethylation of SOCS genes in ovarian and breast carcinomas

KD Sutherland, GJ Lindeman, DYH Choong, S Wittlin, L Brentzell, W Phillips, IG Campbell, JE Visvader

Journal article  |  2004  |  Oncogene

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis

BA Croker, D Metcalf, L Robb, W Wei, S Mifsud, L DiRago, LA Cluse, KD Sutherland, L Hartley, E Williams, JG Zhang, DJ Hilton, NA Nicola, WS Alexander, AW Roberts

Journal article  |  2004  |  Immunity

Identification of Taxreb 107 as a lactogenic hormone responsive gene in mammary epithelial cells

S Wittlin, KD Sutherland, JE Visvader, GJ Lindeman

Journal article  |  2003  |  Biochimica et Biophysica Acta-Gene Structure & Expression

Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas

KD Sutherland, JE Visvader, DYH Choong, EYM Sum, GJ Lindeman, IG Campbell

Journal article  |  2003  |  International Journal of Cancer

CPAP is a novel Stat5-interacting cofactor that augments Stat5-mediated transcriptional activity

B Peng, KD Sutherland, EYM Sum, M Olayioye, S Wittlin, TK Tang, GJ Lindeman, JE Visvader

Journal article  |  2002  |  Journal of Molecular Endocrinology