Kate Sutherland

Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

Lahiru Gangoda, Robyn L Schenk, Sarah A Best, Christina Nedeva, Cynthia Louis, Damian B D'Silva, Kirsten Fairfax, Andrew G Jarnicki, Hamsa Puthalakath, Kate D Sutherland, Andreas Strasser, Marco J Herold

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Inflammation is a natural defence mechanism of the body to protect against pathogens. It is induced by immune cells, such as macro..

An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors

Huawu Yin, Yen-Hua Huang, Sarah A Best, Kate D Sutherland, David J Craik, Conan K Wang

Journal article  |  2021  |  ACS CHEMICAL BIOLOGY

Inhibiting the Nrf2:Keap1 interaction to trigger cytoprotective gene expression is a promising treatment strategy for oxidative st..

Exploring natural killer cell immunology as a therapeutic strategy in lung cancer

Jonas B Hess, Kate D Sutherland, Sarah A Best

Journal article  |  2021  |  TRANSLATIONAL LUNG CANCER RESEARCH

Cytotoxic immune cells are key in the control of tumor development and progression. Natural killer (NK) cells are the cytotoxic ar..

Delineating the roles of Grhl2 in craniofacial development through tissue-specific conditional deletion and epistasis approaches in mouse

Michael de Vries, Harley G Owens, Marina R Carpinelli, Darren Partridge, Ariena Kersbergen, Kate D Sutherland, Alana Auden, Peter J Anderson, Stephen M Jane, Sebastian Dworkin

Journal article  |  2021  |  DEVELOPMENTAL DYNAMICS

BACKGROUND: The highly conserved Grainyhead-like (Grhl) family of transcription factors play critical roles in the development of ..

Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy

Margaret A Potts, Jackson A McDonald, Kate D Sutherland, Marco J Herold

Journal article  |  2020  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The mutational landscape of human cancers is highly complex. While next generation sequencing aims to comprehensively catalogue so..

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

Sarah A Best, Cassandra J Vandenberg, Etna Abad, Lachlan Whitehead, Laia Guiu, Sheryl Ding, Margs S Brennan, Andreas Strasser, Marco J Herold, Kate D Sutherland, Ana Janic

Journal article  |  2020  |  CELL DEATH & DISEASE

TP53 is a critical tumor suppressor that is mutated in approximately 50% of human cancers. Unveiling the downstream target genes o..

Harnessing Natural Killer Immunity in Metastatic SCLC

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  JOURNAL OF THORACIC ONCOLOGY

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma

Stephanie R Hyslop, Marliese Alexander, Alesha A Thai, Ariena Kersbergen, Andrew J Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P Ng, Benjamin J Solomon, Warren S Alexander, Kate D Sutherland, Emma C Josefsson

Journal article  |  2020  |  Oncogene

Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimenta..

NOTCH Your Usual Suspect: MYC Charged with Controlling Neuroendocrine Cell-Fate in Small Cell Lung Cancer

Jin Ng, Kate D Sutherland

Journal article  |  2020  |  CANCER CELL

Small cell lung cancer (SCLC) is highly heterogeneous. In this issue of Cancer Cell, Ireland et al. demonstrate that MYC mediates ..

Balancing the Count: Harmonizing Panel-Based Tumor Mutational Burden Assessment.

Kate D Sutherland, Joseph HA Vissers

Journal article  |  2020  |  J Thorac Oncol