Kate Sutherland

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells (Feb,10.1038/s41418-023-01122-3, 2023)

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

The original version of this article contained a mistake. When preparing the revised version of this paper the authors omitted a n..

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah TT Diepstraten, Catherine Chang, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver MM Sieber, Jane Visvader, Gemma LL Kelly, Andreas Strasser

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of ..

Design and characterization of a heterobifunctional degrader of KEAP1

Hao Chen, Nghi H Nguyen, Charlene M Magtoto, Simon A Cobbold, Grace M Bidgood, Lizeth G Meza Guzman, Lachlan W Richardson, Jason Corbin, Amanda E Au, Bernhard C Lechtenberg, Rebecca Feltham, Kate D Sutherland, Christoph Grohmann, Sandra E Nicholson, Brad E Sleebs

Journal article  |  2023  |  REDOX BIOLOGY

The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway senses reac..

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

Christina E Sparbier, Andrea Gillespie, Juliana Gomez, Nishi Kumari, Ali Motazedian, Kah Lok Chan, Charles C Bell, Omer Gilan, Yih-Chih Chan, Sarah Popp, Daniel J Gough, Melanie A Eckersley-Maslin, Sarah-Jane Dawson, Paul J Lehner, Kate D Sutherland, Patricia Ernst, Gerard M McGeehan, Enid YN Lam, Marian L Burr, Mark A Dawson

Journal article  |  2023  |  NATURE CELL BIOLOGY

Precise control of activating H3K4me3 and repressive H3K27me3 histone modifications at bivalent promoters is essential for normal ..

Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing

Joseph B Hiatt, Holly Sandborg, Sarah M Garrison, Henry U Arnold, Sheng-You Liao, Justin P Norton, Travis J Friesen, Feinan Wu, Kate D Sutherland, Hugh Y Rienhoff Jr, Renato Martins, A McGarry Houghton, Shivani Srivastava, David MacPherson

Journal article  |  2022  |  CLINICAL CANCER RESEARCH

PURPOSE: The addition of immune checkpoint blockade (ICB) to platinum/etoposide chemotherapy changed the standard of care for smal..

Cross presentation: more exotic pathwaysEpigenetic repression of MHC class I antigen presentation enables immune evasion in cancer

Marian Burr, Christina Sparbier, Kah Lok Chan, Paul Lehner, Kate Sutherland, Mark Dawson

Journal article  |  2022  |  Molecular Immunology

Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer

Sarah A Best, Patrick M Gubser, Shalini Sethumadhavan, Ariena Kersbergen, Yashira L Negron Abril, Joshua Goldford, Katherine Sellers, Waruni Abeysekera, Alexandra L Garnham, Jackson A McDonald, Clare E Weeden, Dovile Anderson, David Pirman, Thomas P Roddy, Darren J Creek, Axel Kallies, Gillian Kingsbury, Kate D Sutherland

Journal article  |  2022  |  CELL METABOLISM

The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell growth and facilitate tumor development. G..

Killing SCLC: insights into how to target a shapeshifting tumor

Kate D Sutherland, Abbie S Ireland, Trudy G Oliver

Journal article  |  2022  |  GENES & DEVELOPMENT

Small cell lung cancer (SCLC) is a rapidly growing, highly metastatic, and relatively immune-cold lung cancer subtype. Historicall..

Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

Lahiru Gangoda, Robyn L Schenk, Sarah A Best, Christina Nedeva, Cynthia Louis, Damian B D'Silva, Kirsten Fairfax, Andrew G Jarnicki, Hamsa Puthalakath, Kate D Sutherland, Andreas Strasser, Marco J Herold

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Inflammation is a natural defence mechanism of the body to protect against pathogens. It is induced by immune cells, such as macro..

An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors

Huawu Yin, Yen-Hua Huang, Sarah A Best, Kate D Sutherland, David J Craik, Conan K Wang

Journal article  |  2021  |  ACS CHEMICAL BIOLOGY

Inhibiting the Nrf2:Keap1 interaction to trigger cytoprotective gene expression is a promising treatment strategy for oxidative st..