Georgina Holloway

Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides

Christopher D Goodman, Vanessa Mollard, Theola Louie, Georgina A Holloway, Keith G Watson, Geoffrey I McFadden

Journal article  |  2014  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Malaria parasites retain a relict plastid (apicoplast) from a photosynthetic ancestor. The apicoplast is a useful drug target but ..

ChemInform Abstract: Discovery of Novel and Potent Benzhydryl-Tropane Trypanocides Highly Selective for Trypanosoma cruzi.

GA Holloway, JP Parisot, PM Novello, KG Watson, T Armstrong, RCA Thompson, IP Street, JB Baell

Journal article  |  2010  |  ChemInform

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.

Jonathan B Baell, Georgina A Holloway

Journal article  |  2010  |  J Med Chem

This report describes a number of substructural features which can help to identify compounds that appear as frequent hitters (pro..

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.

GA Holloway, JP Parisot, PM Novello, KG Watson, T Armstrong, RCA Thompson, IP Street, JB Baell

Journal article  |  2010  |  Bioorg Med Chem Lett

A benzhydryl tropinone oxime that is potently toxic to Trypanosoma cruzi has been previously identified. An SAR investigation dete..

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Georgina A Holloway, William N Charman, Alan H Fairlamb, Reto Brun, Marcel Kaiser, Edmund Kostewicz, Patrizia M Novello, John P Parisot, John Richardson, Ian P Street, Keith G Watson, Jonathan B Baell

Journal article  |  2009  |  Antimicrob Agents Chemother

High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel chemical classes of trypanothione..

Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4 '-Desmethoxyepisilvestrol

Tim E Adams, Mariana El Sous, Bill C Hawkins, Sebastian Hirner, Georgina Holloway, Mui Ling Khoo, David J Owen, G Paul Savage, Peter J Scammells, Mark A Rizzacasa

Journal article  |  2009  |  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of the anticancer 1,4-dioxane containing natural products silvestrol (1) and episilvestrol (2) is described by an ..

ChemInform Abstract: Total Synthesis of (-)-Episilvestrol (Ia) and (-)-Silvestrol (Ib).

Mariana El Sous, Mui Ling Khoo, Georgina Holloway, David Owen, Peter J Scammells, Mark A Rizzacasa

Journal article  |  2008  |  ChemInform

Total Synthesis of (−)-Episilvestrol and (−)-Silvestrol

Mariana El Sous, Mui Ling Khoo, Georgina Holloway, David Owen, Peter J Scammells, Mark A Rizzacasa

Journal article  |  2007  |  Angewandte Chemie

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.

Georgina A Holloway, Jonathan B Baell, Alan H Fairlamb, Patrizia M Novello, John P Parisot, John Richardson, Keith G Watson, Ian P Street

Journal article  |  2007  |  Bioorg Med Chem Lett

A high-throughput screening campaign of a library of 100,000 lead-like compounds identified 2-iminobenzimidazoles as a novel class..

Total synthesis of (-)-episilvestrol and (-)-silvestrol

Mariana El Sous, Mui Ling Khoo, Georgina Holloway, David Owen, Peter J Scammells, Mark A Rizzacasa

Journal article  |  2007  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sugar and spice... The total synthesis of the rare but potent anticancer natural product (-)-episilvestrol and its 5‴ epimer (-)-s..