Ian Monk

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.

Andre Mu, William P Klare, Sarah L Baines, CN Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D Shah, Nitika Neha, et al.

Journal article  |  2023  |  Nat Commun

Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, w..

Stringent Response-Mediated Control of GTP Homeostasis Is Required for Long-Term Viability of Staphylococcus aureus.

Laura Carrilero, Lucy Urwin, Ezra Ward, Naznin R Choudhury, Ian R Monk, Claire E Turner, Timothy P Stinear, Rebecca M Corrigan

Journal article  |  2023  |  Microbiol Spectr

Staphylococcus aureus is an opportunistic bacterial pathogen that often results in difficult-to-treat infections. One mechanism us..

Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst.

Kira L Tomlinson, Sebastián A Riquelme, Swikrity Upadhyay Baskota, Marija Drikic, Ian R Monk, Timothy P Stinear, Ian A Lewis, Alice S Prince

Journal article  |  2023  |  Cell Rep

Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even in the setting o..

Staphylococcus aureus host interactions and adaptation

Benjamin P Howden, Stefano G Giulieri, Tania Wong Fok Lung, Sarah L Baines, Liam K Sharkey, Jean YH Lee, Abderrahman Hachani, Ian R Monk, Timothy P Stinear

Journal article  |  2023  |  NATURE REVIEWS MICROBIOLOGY

Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to dev..

Improved Genome Sequence of Australian Methicillin-Resistant Staphylococcus aureus Strain JKD6159

Ryan R Wick, Louise M Judd, Ian R Monk, Torsten Seemann, Timothy P Stinear

Journal article  |  2023  |  MICROBIOLOGY RESOURCE ANNOUNCEMENTS

Staphylococcus aureus strain JKD6159 represents a prominent community-acquired methicillin-resistant S. aureus (MRSA) clone in Aus..

Serine-threonine phosphoregulation by PknB and Stp contributes to quiescence and antibiotic tolerance in Staphylococcus aureus.

Markus Huemer, Srikanth Mairpady Shambat, Sanne Hertegonne, Judith Bergada-Pijuan, Chun-Chi Chang, Sandro Pereira, Alejandro Gómez-Mejia, Lies Van Gestel, Julian Bär, Clément Vulin, Sibylle Pfammatter, Timothy P Stinear, Ian R Monk, Jonathan Dworkin, Annelies S Zinkernagel

Journal article  |  2023  |  Sci Signal

Staphylococcus aureus can cause infections that are often chronic and difficult to treat, even when the bacteria are not antibioti..

Bacterial Two Component Systems: Overexpression and Purification: In Vitro and In Vivo Inhibitor Screens.

Alina Dietrich, Mike Gajdiss, Michael Türck, Ian Monk, Gabriele Bierbaum

Book Chapter  |  2023  |  Methods in Molecular Biology

Bacterial histidine kinases are promising targets for new antimicrobial agents. In antibacterial therapy, such agents could inhibi..

RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3 ' UTR required for intermediate vancomycin resistance (vol 13, 3558, 2022)

Daniel G Mediati, Julia L Wong, Wei Gao, Stuart McKellar, Chi Nam Ignatius Pang, Sylvania Wu, Winton Wu, Brandon Sy, Ian R Monk, Joanna M Biazik, Marc R Wilkins, Benjamin P Howden, Timothy P Stinear, Sander Granneman, Jai J Tree

Journal article  |  2022  |  NATURE COMMUNICATIONS

The original version of this Article incorrectly cited itself in Ref. 32. The correct Ref. 32 is: “McKellar, S.W., et al. RNase II..

Barriers to genetic manipulation of Enterococci: Current Approaches and Future Directions

Alexandra L Krause, Timothy P Stinear, Ian R Monk

Journal article  |  2022  |  FEMS MICROBIOLOGY REVIEWS

Enterococcus faecalis and Enterococcus faecium are Gram-positive commensal gut bacteria that can also cause fatal infections. To s..

RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3 ' UTR required for intermediate vancomycin resistance

Daniel G Mediati, Julia L Wong, Wei Gao, Stuart McKellar, Chi Nam Ignatius Pang, Sylvania Wu, Winton Wu, Brandon Sy, Ian R Monk, Joanna M Biazik, Marc R Wilkins, Benjamin P Howden, Timothy P Stinear, Sander Granneman, Jai J Tree

Journal article  |  2022  |  NATURE COMMUNICATIONS

Treatment of methicillin-resistant Staphylococcus aureus infections is dependent on the efficacy of last-line antibiotics includin..