Ka Yee Fung

Emerging roles for IL-11 in inflammatory diseases

Ka Yee Fung, Cynthia Louis, Riley D Metcalfe, Clara C Kosasih, Ian P Wicks, Michael DW Griffin, Tracy L Putoczki

Journal article  |  2021  |  CYTOKINE

Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignan..

Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

Silvia Alvarez-Diaz, Adele Preaudet, Andre L Samson, Paul M Nguyen, Ka Yee Fung, Alexandra L Garnham, Warren S Alexander, Andreas Strasser, Matthias Ernst, Tracy L Putoczki, James M Murphy

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Chronic inflammation of the large intestine is associated with an increased risk of developing colorectal cancer (CRC), the second..

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer

Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..

Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment

Ka Yee Fung, Paul M Nguyen, Tracy L Putoczki

Journal article  |  2020  |  TUMOR MICROENVIRONMENT: THE ROLE OF INTERLEUKINS, PT A

Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key regulator of mucosal homeostasis within the ga..

The expanding role of innate lymphoid cells and their T-cell counterparts in gastrointestinal cancers

Ka Yee Fung, Paul M Nguyen, Tracy Putoczki

Journal article  |  2019  |  MOLECULAR IMMUNOLOGY

Innate lymphoid cells (ILCs) contribute to the regulation of gastrointestinal (GI) homeostasis. Over the past 15 years, there has ..

Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis

Tania Rahman, Andrew S Brown, Elizabeth L Hartland, Ian R van Driel, Ka Yee Fung

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

We have examined the influence of depleting plasmacytoid dendritic cells (pDC) in mice on the immune response to the gut pathogen ..

Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

Virginie Deswaerte, Paul Nguyen, Alison West, Alison F Browning, Liang Yu, Saleela M Ruwanpura, Jesse Balic, Thaleia Livis, Charlotte Girard, Adele Preaudet, Hiroko Oshima, Ka Yee Fung, Hazel Tye, Meri Najdovska, Matthias Ernst, Masanobu Oshima, Cem Gabay, Tracy Putoczki, Brendan J Jenkins

Journal article  |  2018  |  CANCER RESEARCH

Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in i..

In Vivo Models of Inflammatory Bowel Disease and Colitis-Associated Cancer

Ka Yee Fung, Tracy Putoczki

Book Chapter  |  2018  |  Methods in Molecular Biology

A single layer of epithelial cells separates luminal antigens from the host immune system throughout the gastrointestinal tract. A..

Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingae

Yogitha N Srikhanta, Ka Yee Fung, Georgina L Pollock, Vicki Bennett-Wood, Benjamin P Howden, Elizabeth L Hartland

Journal article  |  2017  |  INFECTION AND IMMUNITY

Kingella kingae is a common etiological agent of pediatric osteoarticular infections. While current research has expanded our unde..

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

Andrew S Brown, Chao Yang, Ka Yee Fung, Annabell Bachem, Dorothee Bourges, Sammy Bedoui, Elizabeth L Hartland, Ian R van Driel

Journal article  |  2016  |  PLOS PATHOGENS

Legionella pneumophila is the causative agent of Legionnaires' disease, a potentially fatal lung infection. Alveolar macrophages s..